| scholarly article | Q13442814 |
| P356 | DOI | 10.1021/AC8022839 |
| P698 | PubMed publication ID | 19154107 |
| P50 | author | Neil Spooner | Q60852362 |
| P2093 | author name string | Matt Barfield | |
| Rakesh Lad | |||
| P433 | issue | 4 | |
| P407 | language of work or name | English | Q1860 |
| P921 | main subject | pharmacokinetics | Q323936 |
| P304 | page(s) | 1557-1563 | |
| P577 | publication date | 2009-02-01 | |
| P1433 | published in | Analytical Chemistry | Q485223 |
| P1476 | title | Dried blood spots as a sample collection technique for the determination of pharmacokinetics in clinical studies: considerations for the validation of a quantitative bioanalytical method | |
| P478 | volume | 81 |
| Q47735823 | A bioanalytical strategy utilizing dried blood spot sampling and LC-MS/MS in discovery toxicology studies |
| Q53359634 | A device for dried blood microsampling in quantitative bioanalysis: overcoming the issues associated blood hematocrit. |
| Q39996250 | A digital microfluidic method for dried blood spot analysis |
| Q51483725 | A disposable sampling device to collect volume-measured DBS directly from a fingerprick onto DBS paper. |
| Q41474335 | A method for the direct injection and analysis of small volume human blood spots and plasma extracts containing high concentrations of organic solvents using revered-phase 2D UPLC/MS. |
| Q43943752 | A simple assay for determination of levetiracetam in rat dried blood spots by LC-MS/MS. |
| Q57728123 | A validated LC–MS/MS method for the quantification of piperacillin/tazobactam on dried blood spot |
| Q37954706 | Absolute quantitation of protein therapeutics in biological matrices by enzymatic digestion and LC-MS. |
| Q51749151 | Accurate weighing and dilution-assisted plasma microsampling (AWADA-PM): an easy-to-implement and rugged strategy. |
| Q58045578 | Addressing the challenge of limited sample volumes inin vitrostudies with capillary-scale microfluidic LC–MS/MS |
| Q37812335 | Advances in mass spectrometry applied to pharmaceutical metabolomics. |
| Q28083408 | Alternative matrices for therapeutic drug monitoring of immunosuppressive agents using LC-MS/MS |
| Q42716470 | Analysis of cyclosporin A, tacrolimus, sirolimus, and everolimus in dried blood spot samples using liquid chromatography tandem mass spectrometry |
| Q30488470 | Antileishmanial Activity of Compounds Derived from the Medicines for Malaria Venture Open Access Box Against Intracellular Leishmania major Amastigotes |
| Q45400105 | Application of DBS for Quantitative Assessment of the Peptide Exendin-4; Comparison of Plasma and DBS Method by UHPLC–MS/MS |
| Q47191113 | Application of DBS sampling in combination with LC-MS/MS for pharmacokinetic evaluation of a compound with species-specific blood-to-plasma partitioning |
| Q33810432 | Application of dried blood spot sampling combined with LC-MS/MS for genotyping and phenotyping of CYP450 enzymes in healthy volunteers |
| Q45519269 | Application of dried spot cards as a rapid sample treatment method for determining hydroxytyrosol metabolites in human urine samples. Comparison with microelution solid-phase extraction |
| Q47305301 | Application of matrix-assisted laser desorption/ionization mass spectrometry imaging in combination with LC-MS in pharmacokinetic study of metformin |
| Q42806904 | Application of the DBS Methodology to a Toxicokinetic Study in Rats and Transferability of Analysis Between Bioanalytical Laboratories |
| Q24621760 | Applications of CYP450 testing in the clinical setting |
| Q41584077 | Applying dried blood spot sampling with LCMS quantification in the clinical development phase of tasquinimod |
| Q37830698 | Approaches for the rapid identification of drug metabolites in early clinical studies |
| Q82482374 | Assessment of DBS Technology for The Detection of Therapeutic Antibodies |
| Q50469847 | Assessment of the within- and between-lot variability of Whatman™ FTA(®) DMPK and 903(®) DBS papers and their suitability for the quantitative bioanalysis of small molecules |
| Q51291293 | Automated dried blood spots standard and QC sample preparation using a robotic liquid handler |
| Q43508896 | Automated high-capacity on-line extraction and bioanalysis of dried blood spot samples using liquid chromatography/high-resolution accurate mass spectrometry. |
| Q30392488 | Breath biomarkers in toxicology |
| Q38259485 | Challenges and opportunities in mass spectrometric analysis of proteins from dried blood spots |
| Q33717140 | Challenges in conducting clinical trials in children: approaches for improving performance |
| Q83940517 | Combination of ELISA and dried blood spot technique for the quantification of large molecules using exenatide as a model |
| Q47812705 | Comparative study on microsampling techniques in metabolic fingerprinting studies applying gas chromatography-MS analysis |
| Q47449721 | Comparison of blood microsampling with DBS and conventional blood collection techniques used in a midazolam biostudy |
| Q42806931 | DBS Sampling Can be Used to Stabilize Prodrugs in Drug Discovery Rodent Studies without the Addition of Esterase Inhibitors |
| Q49116051 | DBS and beyond |
| Q51788759 | DBS direct elution: optimizing performance in high-throughput quantitative LC-MS/MS analysis. |
| Q82482325 | DBS: A UK (MHRA) Regulatory Perspective |
| Q42806899 | Determination of Naproxen Using DBS: Evaluation & Pharmacokinetic Comparison of Human Plasma Versus Human Blood DBS |
| Q53546561 | Determination of Synacthen(®) in dried blood spots for doping control analysis using liquid chromatography tandem mass spectrometry. |
| Q37359919 | Determination of efavirenz in human dried blood spots by reversed-phase high-performance liquid chromatography with UV detection |
| Q42806923 | Determination of mycophenolic acid and its phenyl glucuronide in human plasma, ultrafiltrate, blood, DBS and dried plasma spots |
| Q53664909 | Determination of tamoxifen and endoxifen in dried blood spots using LC-MS/MS and the effect of coated DBS cards on recovery and matrix effects. |
| Q84290290 | Determination of ubiquinone in blood by high-performance liquid chromatography with post-column fluorescence derivatization using 2-cyanoacetamide |
| Q82483202 | Development and Validation of an HPLC–MS/MS Method for The Analysis of Dexamethasone from Pig Synovial Fluid Using Dried Matrix Spotting |
| Q37651224 | Development of a bile acid-based newborn screen for Niemann-Pick disease type C |
| Q45272755 | Diagnostic analysis of veterinary dried blood spots for toxic heavy metals exposure |
| Q37894587 | Direct analysis of dried blood spots coupled with mass spectrometry: concepts and biomedical applications. |
| Q36687732 | Direct and quantitative analysis of underivatized acylcarnitines in serum and whole blood using paper spray mass spectrometry |
| Q58692660 | Dried Blood Spot Sampling with LC-MS Analysis for Routine Therapeutic Caffeine Monitoring in Neonates |
| Q63246774 | Dried Blood Spots for Global Health Diagnostics and Surveillance: Opportunities and Challenges |
| Q40988516 | Dried blood spot analysis for rat and dog studies: validation, hematocrit, toxicokinetics and incurred sample reanalysis |
| Q36364155 | Dried blood spot analysis for therapeutic drug monitoring of linezolid in patients with multidrug-resistant tuberculosis |
| Q44713342 | Dried blood spot bioanalysis: an evaluation of techniques and opportunities for reduction and refinement in mouse and juvenile rat toxicokinetic studies |
| Q49044992 | Dried blood spot punches for confirmation of suspected γ-hydroxybutyric acid intoxications: validation of an optimized GC-MS procedure |
| Q36620231 | Dried blood spots and sparse sampling: a practical approach to estimating pharmacokinetic parameters of caffeine in preterm infants. |
| Q38130331 | Dried blood spots in bioanalysis of antimalarials: relevance and challenges in quantitative assessment of antimalarial drugs |
| Q37986127 | Dried blood spots in toxicology: from the cradle to the grave? |
| Q37859735 | Dried blood spots, pharmacokinetic studies and better medicines for children. |
| Q34402589 | Dried matrix on paper disks: the next generation DBS microsampling technique for managing the hematocrit effect in DBS analysis |
| Q53394043 | Dried matrix spot direct analysis: evaluating the robustness of a direct elution technique for use in quantitative bioanalysis. |
| Q47698799 | Drug Pharmacokinetics Determined by Real-Time Analysis of Mouse Breath |
| Q50047803 | Drug monitoring by volumetric absorptive microsampling: method development considerations to mitigate hematocrit effects |
| Q44969588 | Effect of ambient humidity on the rate at which blood spots dry and the size of the spot produced. |
| Q51795347 | Effect of time on recovery of plasma microsamples for the quantitative determination of vancomycin. |
| Q38201783 | Emerging liquid chromatography-mass spectrometry technologies improving dried blood spot analysis |
| Q39104736 | Ensuring the collection of high-quality dried blood spot samples across multisite clinical studies |
| Q38263726 | Ethics of drug research in the pediatric intensive care unit |
| Q39791872 | Evaluation of blood microsampling techniques and sampling sites for the analysis of drugs by HPLC-MS. |
| Q44686846 | Evaluation of dried blood spots for the quantification of therapeutic monoclonal antibodies and detection of anti-drug antibodies |
| Q39674767 | Evaluation of dry blood spot technique for quantification of an Anti-CD20 monoclonal antibody drug in human blood samples |
| Q54562543 | Evaluation of peripheral blood microsampling techniques in combination with liquid chromatography-high resolution mass spectrometry for the determination of drug pharmacokinetics in clinical studies. |
| Q82482333 | Exploring the Feasibility of Using the DBS Technique for Metabolite Radioprofiling |
| Q35180197 | Gas chromatography-electron ionization-mass spectrometry quantitation of valproic acid and gabapentin, using dried plasma spots, for therapeutic drug monitoring in in-home medical care |
| Q37872318 | GlaxoSmithKline's experience of incurred sample reanalysis for dried blood spot samples |
| Q89726179 | Hematocrit, blood volume, and surface area of dried blood spots - a quantitative model |
| Q42806912 | Human DBS Sampling with LC–MS/MS for Enantioselective Determination of Metoprolol and its Metabolite O -Desmethyl Metoprolol |
| Q34051573 | Impact of internal standard addition on dried blood spot analysis in bioanalytical method development |
| Q41984975 | Impact of various factors on radioactivity distribution in different DBS papers |
| Q24635308 | Innovative clinical trial design for pediatric therapeutics |
| Q51579422 | Internal standard tracked dilution to overcome challenges in dried blood spots and robotic sample preparation for liquid chromatography/tandem mass spectrometry assays. |
| Q38167829 | Is SPME a destination or just another station for bioanalysis? |
| Q56794668 | LC-MS/MS method for the simultaneous determination of tenofovir, emtricitabine, elvitegravir and rilpivirine in dried blood spots |
| Q47616652 | Liquid chromatography tandem-mass spectrometry (LC-MS/MS) and dried blood spot sampling applied to pharmacokinetics studies in animals: Correlation of classic and block design |
| Q42925424 | Liquid chromatography/tandem mass spectrometry sensitivity enhancement via online sample dilution and trapping: applications in microdosing and dried blood spot (DBS) bioanalysis |
| Q51547285 | Liquid extraction surface analysis (LESA) of food surfaces employing chip-based nano-electrospray mass spectrometry. |
| Q53394045 | Metabolite profiles from dried blood spots for metabonomic studies using UPLC combined with orthogonal acceleration ToF-MS: effects of different papers and sample storage stability. |
| Q38187157 | Methods for pharmacokinetic analysis in young children |
| Q37841718 | Microassay of drugs and modern measurement techniques |
| Q38153799 | Microsample analyses via DBS: challenges and opportunities. |
| Q44643057 | Microscale bioanalysis |
| Q40167311 | Multiplexed extraction and quantitative analysis of pharmaceuticals from DBS samples using digital microfluidics |
| Q45283063 | New bioanalytical technologies and concepts: worth the effort? |
| Q39771042 | New ionization methods and miniature mass spectrometers for biomedicine: DESI imaging for cancer diagnostics and paper spray ionization for therapeutic drug monitoring |
| Q53156995 | On-line solid-phase extraction high-performance liquid chromatography-tandem mass spectrometry for the quantitative analysis of tacrolimus in whole blood hemolyzate. |
| Q51647093 | Optimization of an automated IS addition system for use in high-throughput quantitative DBS analysis. |
| Q37203671 | Optimizing operational efficiencies in early phase trials: The Pediatric Trials Network experience |
| Q29042538 | Paper Spray for Direct Analysis of Complex Mixtures Using Mass Spectrometry |
| Q37854632 | Peptide and protein drug analysis by MS: challenges and opportunities for the discovery environment |
| Q34051083 | Performance and storage integrity of dried blood spots for PCB, BFR and pesticide measurements |
| Q38985344 | Personalized monitoring of therapeutic salicylic acid in dried blood spots using a three-layer setup and desorption electrospray ionization mass spectrometry. |
| Q82483142 | Pharmacokinetic Considerations as to When to Use Dried Blood Spot Sampling |
| Q28551880 | Pharmacokinetic Study of Praziquantel Enantiomers and Its Main Metabolite R-trans-4-OH-PZQ in Plasma, Blood and Dried Blood Spots in Opisthorchis viverrini-Infected Patients |
| Q36438116 | Pharmacokinetic studies in infants using minimal-risk study designs |
| Q88984605 | Pharmacokinetics of Praziquantel in Schistosoma mansoni- and Schistosoma haematobium-Infected School- and Preschool-Aged Children |
| Q37884058 | Plasma protein binding and blood-free concentrations: which studies are needed to develop a drug? |
| Q37976124 | Preclinical in vivo ADME studies in drug development: a critical review |
| Q38266632 | Procedures and practices for the validation of bioanalytical methods using dried blood spots: a review |
| Q58087700 | Quantification of Cocaine and Cocaine Metabolites in Dried Blood Spots from a Controlled Administration Study Using LC-MS/MS |
| Q39833392 | Quantification of Warfarin in Dried Rat Plasma Spots by High-Performance Liquid Chromatography with Tandem Mass Spectrometry |
| Q34596844 | Quantification of rifapentine, a potent antituberculosis drug, from dried blood spot samples using liquid chromatographic-tandem mass spectrometric analysis |
| Q56828522 | Quantification of valproic acid in dried blood spots |
| Q45323294 | Quantitation of therapeutic proteins following direct trypsin digestion of dried blood spot samples and detection by LC-MS-based bioanalytical methods in drug discovery |
| Q40427519 | Quantitative bioanalytical validation of fosfomycin in human whole blood with volumetric absorptive microsampling |
| Q37067098 | Quantitative paper spray mass spectrometry analysis of drugs of abuse |
| Q34800374 | Rapid DNA extraction from dried blood spots on filter paper: potential applications in biobanking |
| Q45733811 | Rapid analysis of dried blood spot samples with sub-2-µm LC-MS/MS. |
| Q44886525 | Rapid and simple LC-MS/MS screening of 64 novel psychoactive substances using dried blood spots |
| Q90153173 | Rapid profiling of triglycerides in human breast milk using liquid extraction surface analysis Fourier transform mass spectrometry reveals new very long chain fatty acids and differences within individuals |
| Q37901027 | Sample preparation prior to the LC-MS-based metabolomics/metabonomics of blood-derived samples |
| Q47387427 | Semi-automated direct elution of dried blood spots for the quantitative determination of guanfacine in human blood |
| Q35690824 | Silica coated paper substrate for paper-spray analysis of therapeutic drugs in dried blood spots |
| Q64104944 | Simultaneous Determination of Selegiline, Desmethylselegiline, R/S-methamphetamine, and R/S-amphetamine on Dried Urine Spots by LC/MS/MS: Application to a Pharmacokinetic Study in Urine |
| Q38130332 | State-of-the-art dried blood spot analysis: an overview of recent advances and future trends. |
| Q46477574 | Storage of oral fluid as dried spots on alginate and chitosan foam - a new concept for oral fluid collection |
| Q51367228 | Systematic evaluation of the root cause of non-linearity in liquid chromatography/tandem mass spectrometry bioanalytical assays and strategy to predict and extend the linear standard curve range. |
| Q59157172 | Targeted Metabolomics of Dried Blood Spot Extracts |
| Q43323352 | The Application of Dried Blood Spot Sampling in Global Clinical Trials |
| Q85111375 | The Need for Modeling and Simulation to Design Clinical Investigations in Children |
| Q58805777 | The Use of Dried Blood Spots for the Quantification of Antihypertensive Drugs |
| Q46424871 | The advantages of microflow LC-MS/MS compared with conventional HPLC-MS/MS for the analysis of methotrexate from human plasma |
| Q50795852 | The application of capillary microsampling in GLP toxicology studies |
| Q35669293 | The pharmacokinetics and pharmacodynamics of danirixin (GSK1325756)--a selective CXCR2 antagonist --in healthy adult subjects |
| Q34079756 | The pharmacokinetics of conventional and bioenhanced tablet formulations of danirixin (GSK1325756) following oral administration in healthy, elderly, human volunteers |
| Q35193675 | The science of laboratory and project management in regulated bioanalysis |
| Q47909387 | The use of a membrane filtration device to form dried plasma spots for the quantitative determination of guanfacine in whole blood |
| Q38253959 | The use of mass spectrometry to analyze dried blood spots |
| Q42806889 | Use of DBS sample collection to determine circulating drug concentrations in clinical trials: practicalities and considerations. |
| Q48221188 | Use of conventional bioanalytical devices to automate DBS extractions in liquid-handling dispensing tips |
| Q42739574 | Use of dried blood spots in drug development: pharmacokinetic considerations |
| Q36910958 | Use of dried plasma spots for the quantification of iothalamate in clinical studies |
| Q30922388 | Using dried blood spot sampling to improve data quality and reduce animal use in mouse pharmacokinetic studies |
| Q45998866 | Utilization of DBS Within Drug Discovery: Development of a Serial Microsampling Pharmacokinetic Study in Mice |
| Q36730131 | Validation and Clinical Evaluation of a Novel Method To Measure Miltefosine in Leishmaniasis Patients Using Dried Blood Spot Sample Collection. |
| Q42806737 | Validation of Individual Quantitative Methods for Determination of Cytochrome P450 Probe Substrates in Human Dried Blood Spots with HPLC–MS/MS |
| Q82483218 | Validation of a High-Sensitivity Assay for Zatebradine in Dried Blood Spots of Human Blood at Pg/Ml Concentrations Using HILIC–MS/MS |
| Q33770850 | Validation of a bioanalytical method for the quantification of a therapeutic peptide, ramoplanin, in human dried blood spots using LC-MS/MS. |
| Q39523488 | Validation of a ligand binding assay using dried blood spot sampling |
| Q38685967 | Veterinary utility of dried blood spots for analysis of toxic chlorinated hydrocarbons. |
| Q39558718 | What is next for dried blood spots? |
| Q50494818 | Will 'green' aspects of dried blood spot sampling accelerate its implementation and acceptance in the pharmaceutical industry? |
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