Two transmembrane dimers of the bovine papillomavirus E5 oncoprotein clamp the PDGF β receptor in an active dimeric conformation.

scientific article

Two transmembrane dimers of the bovine papillomavirus E5 oncoprotein clamp the PDGF β receptor in an active dimeric conformation. is …
instance of (P31):
scholarly articleQ13442814

External links are
P819ADS bibcode2017PNAS..114E7262K
P356DOI10.1073/PNAS.1705622114
P8608Fatcat IDrelease_e4qxlf4mrbdpxktnlfof3fdxne
P932PMC publication ID5584431
P698PubMed publication ID28808001

P50authorJ Alfredo FreitesQ73199339
Francisco N BarreraQ73898477
P2093author name stringDonald M Engelman
Yury S Polikanov
Douglas J Tobias
Daniel DiMaio
Alexander G Karabadzhak
Anne P B Edwards
Lisa M Petti
Andrés Moya-Rodríguez
P2860cites workAn allosteric mechanism for activation of the kinase domain of epidermal growth factor receptorQ24293598
The BPV-1 E5 protein, the 16 kDa membrane pore-forming protein and the PDGF receptor exist in a complex that is dependent on hydrophobic transmembrane interactionsQ24337640
Comparison of simple potential functions for simulating liquid waterQ26778447
Structure of a c-kit product complex reveals the basis for kinase transactivationQ27641501
Hydrophobic Matching Controls the Tilt and Stability of the Dimeric Platelet-derived Growth Factor Receptor (PDGFR)   Transmembrane SegmentQ27679255
VMD: visual molecular dynamicsQ27860554
Scalable molecular dynamics with NAMDQ27860718
Update of the CHARMM all-atom additive force field for lipids: validation on six lipid typesQ29616710
Blue native electrophoresis for isolation of membrane protein complexes in enzymatically active formQ29619372
Multipass membrane protein structure prediction using RosettaQ30352314
Structure of Full-Length Human PDGFRβ Bound to Its Activating Ligand PDGF-B as Determined by Negative-Stain Electron Microscopy.Q30380246
Bovine papillomavirus E5 protein induces oligomerization and trans-phosphorylation of the platelet-derived growth factor beta receptorQ33575831
The bovine papillomavirus E5 protein requires a juxtamembrane negative charge for activation of the platelet-derived growth factor beta receptor and transformation of C127 cellsQ33644980
Molecular dynamics simulation of unsaturated lipid bilayers at low hydration: parameterization and comparison with diffraction studiesQ33907701
Structural role of the conserved cysteines in the dimerization of the viral transmembrane oncoprotein E5.Q34134605
CHARMM-GUI Membrane Builder toward realistic biological membrane simulationsQ34195752
Directed evolution of APEX2 for electron microscopy and proximity labeling.Q34449266
The E5 proteinsQ34754347
Multiple transmembrane amino acid requirements suggest a highly specific interaction between the bovine papillomavirus E5 oncoprotein and the platelet-derived growth factor beta receptorQ35000599
Cellular transformation by a transmembrane peptide: structural requirements for the bovine papillomavirus E5 oncoproteinQ35256418
Mutational analysis of the interaction between the bovine papillomavirus E5 transforming protein and the endogenous beta receptor for platelet-derived growth factor in mouse C127 cells.Q35846414
Mutational analysis of the beta-type platelet-derived growth factor receptor defines the site of interaction with the bovine papillomavirus type 1 E5 transforming protein.Q35849030
Identification of amino acids in the transmembrane and juxtamembrane domains of the platelet-derived growth factor receptor required for productive interaction with the bovine papillomavirus E5 proteinQ35895171
Hydrophobic Mismatch Drives the Interaction of E5 with the Transmembrane Segment of PDGF ReceptorQ35990329
Optimization of the additive CHARMM all-atom protein force field targeting improved sampling of the backbone φ, ψ and side-chain χ(1) and χ(2) dihedral anglesQ36546184
Ligand-independent activation of the platelet-derived growth factor beta receptor: requirements for bovine papillomavirus E5-induced mitogenic signalingQ36550896
The bovine papillomavirus type 1 E5 transforming protein specifically binds and activates the beta-type receptor for the platelet-derived growth factor but not other related tyrosine kinase-containing receptors to induce cellular transformationQ36622401
Specific interaction between the bovine papillomavirus E5 transforming protein and the beta receptor for platelet-derived growth factor in stably transformed and acutely transfected cellsQ36634049
Biological properties of the deer papillomavirus E5 gene in mouse C127 cells: growth transformation, induction of DNA synthesis, and activation of the platelet-derived growth factor receptorQ36797809
44-amino-acid E5 transforming protein of bovine papillomavirus requires a hydrophobic core and specific carboxyl-terminal amino acidsQ36846314
Stable association between the bovine papillomavirus E5 transforming protein and activated platelet-derived growth factor receptor in transformed mouse cellsQ37119249
The bovine papillomavirus E5 protein and the PDGF beta receptor: it takes two to tangoQ37319770
PDGF receptor signaling networks in normal and cancer cellsQ38202362
Compensatory mutants of the bovine papillomavirus E5 protein and the platelet-derived growth factor β receptor reveal a complex direct transmembrane interactionQ39113585
Role of glutamine 17 of the bovine papillomavirus E5 protein in platelet-derived growth factor beta receptor activation and cell transformation.Q39582036
Active and inactive orientations of the transmembrane and cytosolic domains of the erythropoietin receptor dimerQ40613603
Molecular examination of the transmembrane requirements of the platelet-derived growth factor beta receptor for a productive interaction with the bovine papillomavirus E5 oncoproteinQ40701066
Identification of the transmembrane dimer interface of the bovine papillomavirus E5 proteinQ40794484
Structural characterization of a C-terminally truncated E5 oncoprotein from papillomavirus in lipid bilayersQ41697433
The E5 oncoprotein of bovine papillomavirus is oriented asymmetrically in Golgi and plasma membranesQ42798650
The transmembrane domain of the E5 oncoprotein contains functionally discrete helical facesQ42817465
In vitro dimerization of the bovine papillomavirus E5 protein transmembrane domainQ43092375
Towards a structural understanding of the smallest known oncoprotein: investigation of the bovine papillomavirus E5 protein using solution-state NMR.Q45396281
Analysis of membrane protein complexes by blue native PAGE.Q50475140
Structural models of the bovine papillomavirus E5 protein.Q52229470
The E5 transforming gene of bovine papillomavirus encodes a small, hydrophobic polypeptide.Q54144933
Particle mesh Ewald: An N⋅log(N) method for Ewald sums in large systemsQ56750591
P433issue35
P407language of work or nameEnglishQ1860
P921main subjecttransmembrane proteinQ424204
P304page(s)E7262-E7271
P577publication date2017-08-14
P1433published inProceedings of the National Academy of Sciences of the United States of AmericaQ1146531
P1476titleTwo transmembrane dimers of the bovine papillomavirus E5 oncoprotein clamp the PDGF β receptor in an active dimeric conformation
P478volume114

Reverse relations

cites work (P2860)
Q92265666Membrane receptor activation mechanisms and transmembrane peptide tools to elucidate them
Q58762026Oral fibropapillomatosis and epidermal hyperplasia of the lip in newborn lambs associated with bovine Deltapapillomavirus

Search more.