Two live attenuated Shigella flexneri 2a strains WRSf2G12 and WRSf2G15: a new combination of gene deletions for 2nd generation live attenuated vaccine candidates

scientific article published on 30 May 2012

Two live attenuated Shigella flexneri 2a strains WRSf2G12 and WRSf2G15: a new combination of gene deletions for 2nd generation live attenuated vaccine candidates is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1016/J.VACCINE.2012.05.003
P698PubMed publication ID22658966

P2093author name stringMalabi M Venkatesan
Ryan T Ranallo
Suramya Fonseka
Robert W Kaminski
Sejal Thakkar
Lisa A Bedford
Tara L Boren
P2860cites workLambda Red-mediated recombinogenic engineering of enterohemorrhagic and enteropathogenic E. coliQ24804947
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Attenuated Shigella flexneri 2a vaccine strain CVD 1204 expressing colonization factor antigen I and mutant heat-labile enterotoxin of enterotoxigenic Escherichia coliQ33597022
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Vaccination against shigellosis with attenuated Shigella flexneri 2a strain SC602Q33876803
Shigella flexneri 2a strain CVD 1207, with specific deletions in virG, sen, set, and guaBA, is highly attenuated in humansQ34003433
Parameters underlying successful protection with live attenuated mutants in experimental shigellosisQ34006071
Phase I evaluation of delta virG Shigella sonnei live, attenuated, oral vaccine strain WRSS1 in healthy adultsQ34120926
Community-based safety, immunogenicity, and transmissibility study of the Shigella sonnei WRSS1 vaccine in Israeli volunteersQ34194587
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Deletion in the Shigella enterotoxin genes further attenuates Shigella flexneri 2a bearing guanine auxotrophy in a phase 1 trial of CVD 1204 and CVD 1208.Q39146446
Further characterization of Shigella sonnei live vaccine candidates WRSs2 and WRSs3-plasmid composition, invasion assays and Sereny reactionsQ39461241
Isolation and characterization of a Shigella flexneri invasin complex subunit vaccineQ39517102
Shigella enterotoxin-2 is a type III effector that participates in Shigella-induced interleukin 8 secretion by epithelial cellsQ39610195
Immunogenicity and characterization of WRSF2G11: a second generation live attenuated Shigella flexneri 2a vaccine strain.Q40460000
Two studies evaluating the safety and immunogenicity of a live, attenuated Shigella flexneri 2a vaccine (SC602) and excretion of vaccine organisms in North American volunteers.Q40469794
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Developing live Shigella vaccines using lambda Red recombineeringQ41452880
Shigella sonnei vaccine candidates WRSs2 and WRSs3 are as immunogenic as WRSS1, a clinically tested vaccine candidate, in a primate model of infection.Q43432983
Two msbB genes encoding maximal acylation of lipid A are required for invasive Shigella flexneri to mediate inflammatory rupture and destruction of the intestinal epitheliumQ43982547
A novel caspase-1/toll-like receptor 4-independent pathway of cell death induced by cytosolic Shigella in infected macrophagesQ44118567
Construction and evaluation of a double mutant of Shigella flexneri as a candidate for oral vaccination against shigellosisQ44965347
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New animal model of shigellosis in the Guinea pig: its usefulness for protective efficacy studies.Q53579124
Prevalence of Shigella Enterotoxin 1 among Shigella Clinical Isolates of Diverse SerotypesQ54601009
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Invasive Shigella flexneri activates NF-kappa B through a lipopolysaccharide-dependent innate intracellular response and leads to IL-8 expression in epithelial cellsQ73948765
Safety and immunogenicity of an intranasal Shigella flexneri 2a Invaplex 50 vaccineQ84592118
P433issue34
P407language of work or nameEnglishQ1860
P921main subjectShigella flexneriQ1644417
attenuated vaccineQ1810913
P304page(s)5159-5171
P577publication date2012-05-30
P1433published inVaccineQ7907941
P1476titleTwo live attenuated Shigella flexneri 2a strains WRSf2G12 and WRSf2G15: a new combination of gene deletions for 2nd generation live attenuated vaccine candidates
P478volume30

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cites work (P2860)
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Q35887055Vaccines for viral and bacterial pathogens causing acute gastroenteritis: Part II: Vaccines for Shigella, Salmonella, enterotoxigenic E. coli (ETEC) enterohemorragic E. coli (EHEC) and Campylobacter jejuni.

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