Genetic interactions between protein phosphatases CaPtc2p and CaPph3p in response to genotoxins and rapamycin in Candida albicans

scientific article published on 19 November 2012

Genetic interactions between protein phosphatases CaPtc2p and CaPph3p in response to genotoxins and rapamycin in Candida albicans is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1111/1567-1364.12012
P698PubMed publication ID23083206
P5875ResearchGate publication ID232527400

P2093author name stringLinghuo Jiang
Jinrong Feng
Yinong Duan
Yunying Zhao
P2860cites workA PP4 phosphatase complex dephosphorylates RPA2 to facilitate DNA repair via homologous recombinationQ24299264
Ptc1, a type 2C Ser/Thr phosphatase, inactivates the HOG pathway by dephosphorylating the mitogen-activated protein kinase Hog1Q24551035
Dephosphorylation of cyclin-dependent kinases by type 2C protein phosphatasesQ24596999
The CUG codon is decoded in vivo as serine and not leucine in Candida albicansQ24629142
Regulation of phenotypic transitions in the fungal pathogen Candida albicansQ26829434
The YCR079w gene confers a rapamycin-resistant function and encodes the sixth type 2C protein phosphatase in Saccharomyces cerevisiae.Q27929855
Yeast pyruvate dehydrogenase complex is regulated by a concerted activity of two kinases and two phosphatasesQ27930852
Alternative splicing of PTC7 in Saccharomyces cerevisiae determines protein localizationQ27931047
Protein serine/threonine phosphatase Ptc2p negatively regulates the unfolded-protein response by dephosphorylating Ire1p kinase.Q27931120
Nbp2 targets the Ptc1-type 2C Ser/Thr phosphatase to the HOG MAPK pathwayQ27932327
Protein phosphatases pph3, ptc2, and ptc3 play redundant roles in DNA double-strand break repair by homologous recombination.Q27932643
Pph3-Psy2 is a phosphatase complex required for Rad53 dephosphorylation and replication fork restart during recovery from DNA damage.Q27933709
A phosphatase complex that dephosphorylates gammaH2AX regulates DNA damage checkpoint recoveryQ27933727
The checkpoint Saccharomyces cerevisiae Rad9 protein contains a tandem tudor domain that recognizes DNAQ27934159
Role of Ptc2 type 2C Ser/Thr phosphatase in yeast high-osmolarity glycerol pathway inactivationQ27934269
TPD1 of Saccharomyces cerevisiae encodes a protein phosphatase 2C-like activity implicated in tRNA splicing and cell separationQ27934539
Aup1p, a yeast mitochondrial protein phosphatase homolog, is required for efficient stationary phase mitophagy and cell survivalQ27934674
Regulation of cell wall beta-glucan assembly: PTC1 negatively affects PBS2 action in a pathway that includes modulation of EXG1 transcriptionQ27935093
The YHR076w gene encodes a type 2C protein phosphatase and represents the seventh PP2C gene in budding yeastQ27936210
Mds3 regulates morphogenesis in Candida albicans through the TOR pathwayQ27940288
The protein kinase Tor1 regulates adhesin gene expression in Candida albicansQ28474672
Suppressor of MEK null (SMEK)/protein phosphatase 4 catalytic subunit (PP4C) is a key regulator of hepatic gluconeogenesisQ28512561
Saccharomyces Ku70, mre11/rad50 and RPA proteins regulate adaptation to G2/M arrest after DNA damageQ29614221
Choreography of the DNA damage response: spatiotemporal relationships among checkpoint and repair proteinsQ29615270
Regulation of RAD53 by the ATM-like kinases MEC1 and TEL1 in yeast cell cycle checkpoint pathwaysQ29615271
The structure and regulation of protein phosphatasesQ29618929
Analyses of the effects of Rck2p mutants on Pbs2pDD-induced toxicity in Saccharomyces cerevisiae identify a MAP kinase docking motif, and unexpected functional inactivation due to acidic substitution of T379.Q30432811
Ptc1p regulates cortical ER inheritance via Slt2pQ30478036
Regulation of Saccharomyces Rad53 checkpoint kinase during adaptation from DNA damage-induced G2/M arrest.Q30657462
A toolbox for epitope-tagging and genome-wide location analysis in Candida albicansQ33389494
Pph3 dephosphorylation of Rad53 is required for cell recovery from MMS-induced DNA damage in Candida albicansQ34273948
Novel protein serine/threonine phosphatases: variety is the spice of lifeQ34435200
A unified view of the DNA-damage checkpointQ34560932
The contribution of the S-phase checkpoint genes MEC1 and SGS1 to genome stability maintenance in Candida albicansQ35078627
Protein phosphatase Pph3 and its regulatory subunit Psy2 regulate Rad53 dephosphorylation and cell morphogenesis during recovery from DNA damage in Candida albicansQ35530396
Critical role of DNA checkpoints in mediating genotoxic-stress-induced filamentous growth in Candida albicansQ35650832
Morphogenesis in Candida albicansQ35674379
Protein phosphatase 4--from obscurity to vital functionsQ36137554
Signalling and oxidant adaptation in Candida albicans and Aspergillus fumigatusQ36482511
Surviving the breakup: the DNA damage checkpoint.Q36521813
The Rad53 signal transduction pathway: Replication fork stabilization, DNA repair, and adaptationQ36543289
Phosphatases, DNA damage checkpoints and checkpoint deactivationQ37030472
PTC1 is required for vacuole inheritance and promotes the association of the myosin-V vacuole-specific receptor complexQ37112656
Normal function of the yeast TOR pathway requires the type 2C protein phosphatase Ptc1.Q38356043
Protein phosphatase PP4 is involved in NHEJ-mediated repair of DNA double-strand breaks.Q39325474
Cdc28 provides a molecular link between Hsp90, morphogenesis, and cell cycle progression in Candida albicansQ40396363
Rad53 regulates replication fork restart after DNA damage in Saccharomyces cerevisiae.Q41306056
Phosphoproteomic analysis reveals that PP4 dephosphorylates KAP-1 impacting the DNA damage responseQ42182193
Distinct phosphatases mediate the deactivation of the DNA damage checkpoint kinase Rad53.Q42435351
PP4 dephosphorylates Maf1 to couple multiple stress conditions to RNA polymerase III repressionQ42554572
Activation of Rad53 kinase in response to DNA damage and its effect in modulating phosphorylation of the lagging strand DNA polymerase.Q42687620
Mechanisms of checkpoint kinase Rad53 inactivation after a double-strand break in Saccharomyces cerevisiaeQ42738072
Functional characterization of the PP2C phosphatase CaPtc2p in the human fungal pathogen Candida albicansQ42966219
The protein kinase CaSch9p is required for the cell growth, filamentation and virulence in the human fungal pathogen Candida albicansQ43117347
PP2C phosphatases Ptc2 and Ptc3 are required for DNA checkpoint inactivation after a double-strand breakQ44384534
A central role for DNA replication forks in checkpoint activation and responseQ44455872
Evidence for antagonistic regulation of cell growth by the calcineurin and high osmolarity glycerol pathways in Saccharomyces cerevisiaeQ44635547
The serine/threonine protein phosphatase SIT4 modulates yeast-to-hypha morphogenesis and virulence in Candida albicansQ44734060
The MAP kinase-activated protein kinase Rck2p plays a role in rapamycin sensitivity in Saccharomyces cerevisiae and Candida albicansQ46485381
Rad52 depletion in Candida albicans triggers both the DNA-damage checkpoint and filamentation accompanied by but independent of expression of hypha-specific genes.Q46936614
Expression of CaPTC7 is developmentally regulated during serum-induced morphogenesis in the human fungal pathogen Candida albicans.Q52579065
Differential virulence of Candida albicansandC. dubliniensis: A role for Tor1 kinase?Q58490183
P433issue1
P921main subjectsirolimusQ32089
Candida albicansQ310443
P304page(s)85-96
P577publication date2012-11-19
P1433published inFEMS Yeast ResearchQ15751211
P1476titleGenetic interactions between protein phosphatases CaPtc2p and CaPph3p in response to genotoxins and rapamycin in Candida albicans
P478volume13

Reverse relations

cites work (P2860)
Q51533643CaTip41 regulates protein phosphatase 2A activity, CaRad53 deactivation and the recovery of DNA damage-induced filamentation to yeast form in Candida albicans.
Q46823417Cadmium-induced activation of high osmolarity glycerol pathway through its Sln1 branch is dependent on the MAP kinase kinase kinase Ssk2, but not its paralog Ssk22, in budding yeast
Q89789669Nucleotide Excision Repair Protein Rad23 Regulates Cell Virulence Independent of Rad4 in Candida albicans
Q51445175The putative ABC transporter encoded by the orf19.4531 plays a role in the sensitivity of Candida albicans cells to azole antifungal drugs.
Q50477597The putative transcription factor CaRtg3 is involved in tolerance to cations and antifungal drugs as well as serum-induced filamentation in Candida albicans.

Search more.