Protein phosphatases pph3, ptc2, and ptc3 play redundant roles in DNA double-strand break repair by homologous recombination.

scientific article

Protein phosphatases pph3, ptc2, and ptc3 play redundant roles in DNA double-strand break repair by homologous recombination. is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1128/MCB.01168-10
P932PMC publication ID3028631
P698PubMed publication ID21135129

P50authorJames E. HaberQ37373309
P2093author name stringJin Li
Jung-Ae Kim
Wade M Hicks
Sue Yen Tay
P2860cites workA PP4 phosphatase complex dephosphorylates RPA2 to facilitate DNA repair via homologous recombinationQ24299264
Multiple pathways of recombination induced by double-strand breaks in Saccharomyces cerevisiaeQ24548535
Break-induced replication requires all essential DNA replication factors except those specific for pre-RC assembly.Q27930164
Rad9 BRCT domain interaction with phosphorylated H2AX regulates the G1 checkpoint in budding yeastQ27930415
In vivo roles of Rad52, Rad54, and Rad55 proteins in Rad51-mediated recombination.Q27930596
CDK-dependent phosphorylation of Sld2 and Sld3 initiates DNA replication in budding yeastQ27932774
Pph3-Psy2 is a phosphatase complex required for Rad53 dephosphorylation and replication fork restart during recovery from DNA damage.Q27933709
A phosphatase complex that dephosphorylates gammaH2AX regulates DNA damage checkpoint recoveryQ27933727
The Saccharomyces cerevisiae orthologue of the human protein phosphatase 4 core regulatory subunit R2 confers resistance to the anticancer drug cisplatin.Q27934196
Phosphorylation of Sld2 and Sld3 by cyclin-dependent kinases promotes DNA replication in budding yeast.Q27935340
DNA end resection, homologous recombination and DNA damage checkpoint activation require CDK1Q27938100
Role of Dot1-dependent histone H3 methylation in G1 and S phase DNA damage checkpoint functions of Rad9.Q27939003
Checkpoint activation in response to double-strand breaks requires the Mre11/Rad50/Xrs2 complexQ28215094
Saccharomyces Ku70, mre11/rad50 and RPA proteins regulate adaptation to G2/M arrest after DNA damageQ29614221
Regulation of RAD53 by the ATM-like kinases MEC1 and TEL1 in yeast cell cycle checkpoint pathwaysQ29615271
Regulation of Saccharomyces Rad53 checkpoint kinase during adaptation from DNA damage-induced G2/M arrest.Q30657462
XRCC1 phosphorylation by CK2 is required for its stability and efficient DNA repairQ34115511
Distribution and dynamics of chromatin modification induced by a defined DNA double-strand breakQ34354650
Arrest, adaptation, and recovery following a chromosome double-strand break in Saccharomyces cerevisiaeQ35132557
Surviving the breakup: the DNA damage checkpoint.Q36521813
Role of DNA replication proteins in double-strand break-induced recombination in Saccharomyces cerevisiaeQ36701282
Emerging roles of nuclear protein phosphatasesQ36743535
Chromatin assembly factors Asf1 and CAF-1 have overlapping roles in deactivating the DNA damage checkpoint when DNA repair is completeQ37078952
Mec1/Tel1-dependent phosphorylation of Slx4 stimulates Rad1-Rad10-dependent cleavage of non-homologous DNA tailsQ41788300
Activation of Rad53 kinase in response to DNA damage and its effect in modulating phosphorylation of the lagging strand DNA polymerase.Q42687620
Mechanisms of checkpoint kinase Rad53 inactivation after a double-strand break in Saccharomyces cerevisiaeQ42738072
A recombination execution checkpoint regulates the choice of homologous recombination pathway during DNA double-strand break repairQ43172930
Acetylated lysine 56 on histone H3 drives chromatin assembly after repair and signals for the completion of repairQ43217577
Replication protein A2 phosphorylation after DNA damage by the coordinated action of ataxia telangiectasia-mutated and DNA-dependent protein kinase.Q43814418
Recovery from checkpoint-mediated arrest after repair of a double-strand break requires Srs2 helicaseQ44111120
PP2C phosphatases Ptc2 and Ptc3 are required for DNA checkpoint inactivation after a double-strand breakQ44384534
Repair of DNA double strand breaks: in vivo biochemistry.Q53616221
Saccharomyces cerevisiae Rad9 acts as a Mec1 adaptor to allow Rad53 activation.Q53662825
CDC5 and CKII control adaptation to the yeast DNA damage checkpointQ73763022
Physical monitoring of HO-induced homologous recombinationQ78114425
P433issue3
P407language of work or nameEnglishQ1860
P921main subjectcell biologyQ7141
Phosphoprotein phosphatase PP4 catalytic subunit PPH3 YDR075WQ27549979
P304page(s)507-516
P577publication date2010-12-06
P1433published inMolecular and Cellular BiologyQ3319478
P1476titleProtein phosphatases pph3, ptc2, and ptc3 play redundant roles in DNA double-strand break repair by homologous recombination
P478volume31

Reverse relations

cites work (P2860)
Q92636595Cell Cycle and DNA Repair Regulation in the Damage Response: Protein Phosphatases Take Over the Reins
Q90355409Checkpoint Responses to DNA Double-Strand Breaks
Q90243921DAF-16 and SMK-1 Contribute to Innate Immunity During Adulthood in Caenorhabditis elegans
Q41153815Delineation of the role of chromatin assembly and the Rtt101Mms1 E3 ubiquitin ligase in DNA damage checkpoint recovery in budding yeast.
Q37467753Dynamics of yeast histone H2A and H2B phosphorylation in response to a double-strand break
Q50463654Effects of deletion of different PP2C protein phosphatase genes on stress responses in Saccharomyces cerevisiae
Q46496271Genetic interactions between protein phosphatases CaPtc2p and CaPph3p in response to genotoxins and rapamycin in Candida albicans
Q43714758Involvement of two type 2C protein phosphatases BcPtc1 and BcPtc3 in the regulation of multiple stress tolerance and virulence of Botrytis cinerea
Q27932588PP2A and Aurora differentially modify Cdc13 to promote telomerase release from telomeres at G2/M phase
Q90212650PP4 phosphatase cooperates in recombinational DNA repair by enhancing double-strand break end resection
Q27938975Phosphatase complex Pph3/Psy2 is involved in regulation of efficient non-homologous end-joining pathway in the yeast Saccharomyces cerevisiae
Q42182193Phosphoproteomic analysis reveals that PP4 dephosphorylates KAP-1 impacting the DNA damage response
Q33649550Preserving Yeast Genetic Heritage through DNA Damage Checkpoint Regulation and Telomere Maintenance.
Q27313309Protein phosphatase 4 promotes chromosome pairing and synapsis, and contributes to maintaining crossover competence with increasing age
Q63965487Quantitative sensing and signalling of single-stranded DNA during the DNA damage response
Q28534339Rad5 template switch pathway of DNA damage tolerance determines synergism between cisplatin and NSC109268 in Saccharomyces cerevisiae
Q64094867Ser/Thr protein phosphatases in fungi: structure, regulation and function
Q38831197Slx4 scaffolding in homologous recombination and checkpoint control: lessons from yeast.
Q40643093Stabilization of the metaphase spindle by Cdc14 is required for recombinational DNA repair.
Q36291440Termination of Replication Stress Signaling via Concerted Action of the Slx4 Scaffold and the PP4 Phosphatase
Q26827821What goes on must come off: phosphatases gate-crash the DNA damage response
Q44916228Yeast PP4 interacts with ATR homolog Ddc2-Mec1 and regulates checkpoint signaling.