Inhibition of the severe acute respiratory syndrome 3CL protease by peptidomimetic alpha,beta-unsaturated esters

scientific article published in September 2005

Inhibition of the severe acute respiratory syndrome 3CL protease by peptidomimetic alpha,beta-unsaturated esters is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1016/J.BMC.2005.05.065
P698PubMed publication ID15994085
P5875ResearchGate publication ID7750257

P50authorChi-Huey WongQ906334
Jim-Min FangQ39503115
P2093author name stringChih-Jung Kuo
Po-Huang Liang
Jiun-Jie Shie
Yih-Shyun E Cheng
Hung-Jyun Huang
Tun-Hsun Kuo
Yin-Ta Wu
Jia-Tsrong Jan
P2860cites workActive human immunodeficiency virus protease is required for viral infectivityQ24647696
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The crystal structures of severe acute respiratory syndrome virus main protease and its complex with an inhibitorQ27642450
Coronavirus as a possible cause of severe acute respiratory syndromeQ28200848
Characterization of a novel coronavirus associated with severe acute respiratory syndromeQ28202401
In vitro antiviral activity of AG7088, a potent inhibitor of human rhinovirus 3C proteaseQ28343611
Structure-based design, synthesis, and biological evaluation of irreversible human rhinovirus 3C protease inhibitors. 4. Incorporation of P1 lactam moieties as L-glutamine replacementsQ28373315
Identification of a novel coronavirus in patients with severe acute respiratory syndromeQ29615907
A novel coronavirus associated with severe acute respiratory syndromeQ29617553
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Evaluation of metal-conjugated compounds as inhibitors of 3CL protease of SARS-CoV.Q33206632
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Biosynthesis, Purification, and Substrate Specificity of Severe Acute Respiratory Syndrome Coronavirus 3C-like ProteinaseQ34270281
Synthesis and biological evaluation of 3-heterocyclyl-7,8,9,10-tetrahydro-(7,10-ethano)-1,2,4-triazolo[3,4-a]phthalazines and analogues as subtype-selective inverse agonists for the GABA(A)alpha5 benzodiazepine binding site.Q34328765
Small molecules targeting severe acute respiratory syndrome human coronavirusQ35970698
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Viral proteinases: weakness in strengthQ38138706
Use of an aqueous soluble tetrazolium/formazan assay to measure viability and proliferation of lymphokine-dependent cell linesQ41579098
Comparative full-length genome sequence analysis of 14 SARS coronavirus isolates and common mutations associated with putative origins of infectionQ42600546
Rapid diversity-oriented synthesis in microtiter plates for in situ screening: discovery of potent and selective alpha-fucosidase inhibitors.Q44610505
3C-like proteinase from SARS coronavirus catalyzes substrate hydrolysis by a general base mechanismQ44839752
Identification of novel inhibitors of the SARS coronavirus main protease 3CLpro.Q44861300
Characterization of SARS main protease and inhibitor assay using a fluorogenic substrateQ44899503
Virtual screening for SARS-CoV protease based on KZ7088 pharmacophore pointsQ44904083
Discovery of picomolar slow tight-binding inhibitors of alpha-fucosidaseQ45067883
High-throughput screening identifies inhibitors of the SARS coronavirus main proteinaseQ45110672
Polyprotein cleavage mechanism of SARS CoV Mpro and chemical modification of the octapeptideQ45121648
Synthesis and evaluation of keto-glutamine analogues as potent inhibitors of severe acute respiratory syndrome 3CLproQ45164294
Identification of novel small-molecule inhibitors of severe acute respiratory syndrome-associated coronavirus by chemical genetics.Q47924234
Binding mechanism of coronavirus main proteinase with ligands and its implication to drug design against SARS.Q51661127
P433issue17
P407language of work or nameEnglishQ1860
P304page(s)5240-5252
P577publication date2005-09-01
P1433published inBioorganic & Medicinal ChemistryQ2904200
P1476titleInhibition of the severe acute respiratory syndrome 3CL protease by peptidomimetic alpha,beta-unsaturated esters
P478volume13

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cites work (P2860)
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Q99237635Antivirals Against Coronaviruses: Candidate Drugs for SARS-CoV-2 Treatment?
Q45227423Aryl methylene ketones and fluorinated methylene ketones as reversible inhibitors for severe acute respiratory syndrome (SARS) 3C-like proteinase
Q95601929Boceprevir, GC-376, and calpain inhibitors II, XII inhibit SARS-CoV-2 viral replication by targeting the viral main protease
Q96431581Boceprevir, GC-376, and calpain inhibitors II, XII inhibit SARS-CoV-2 viral replication by targeting the viral main protease
Q36534375Coronaviruses and their therapy
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