Synthesis and evaluation of pyrazolone compounds as SARS-coronavirus 3C-like protease inhibitors

scientific article published on 25 September 2010

Synthesis and evaluation of pyrazolone compounds as SARS-coronavirus 3C-like protease inhibitors is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1016/J.BMC.2010.09.050
P698PubMed publication ID20947359

P2093author name stringPo-Huang Liang
R Ramajayam
Kian-Pin Tan
Hun-Ge Liu
P2860cites workCoronavirus main proteinase (3CLpro) structure: basis for design of anti-SARS drugsQ27641252
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Structure-based design, synthesis, and biological evaluation of peptidomimetic SARS-CoV 3CLpro inhibitorsQ27648126
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Structural Basis of Inhibition Specificities of 3C and 3C-like Proteases by Zinc-coordinating and Peptidomimetic CompoundsQ27653428
Coronavirus as a possible cause of severe acute respiratory syndromeQ28200848
Characterization of a novel coronavirus associated with severe acute respiratory syndromeQ28202401
A novel coronavirus associated with severe acute respiratory syndromeQ29617553
Conservation of amino acids in human rhinovirus 3C protease correlates with broad-spectrum antiviral activity of rupintrivir, a novel human rhinovirus 3C protease inhibitor.Q30448643
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Discovery of potent anilide inhibitors against the severe acute respiratory syndrome 3CL proteaseQ33217732
Cinanserin is an inhibitor of the 3C-like proteinase of severe acute respiratory syndrome coronavirus and strongly reduces virus replication in vitroQ33788800
New developments for the design, synthesis and biological evaluation of potent SARS-CoV 3CL(pro) inhibitorsQ35620215
Small molecules targeting severe acute respiratory syndrome human coronavirusQ35970698
Design, synthesis, and evaluation of 3C protease inhibitors as anti-enterovirus 71 agents.Q39967863
Synthesis, docking studies, and evaluation of pyrimidines as inhibitors of SARS-CoV 3CL proteaseQ43056416
Myocardial protection of MCI-186 in rabbit ischemia-reperfusion.Q44127913
Virtual screening of novel noncovalent inhibitors for SARS-CoV 3C-like proteinase.Q44843229
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Characterization of SARS main protease and inhibitor assay using a fluorogenic substrateQ44899503
High-throughput screening identifies inhibitors of the SARS coronavirus main proteinaseQ45110672
Polyprotein cleavage mechanism of SARS CoV Mpro and chemical modification of the octapeptideQ45121648
Synthesis and evaluation of keto-glutamine analogues as potent inhibitors of severe acute respiratory syndrome 3CLproQ45164294
Design and synthesis of cinanserin analogs as severe acute respiratory syndrome coronavirus 3CL protease inhibitorsQ46338365
Synthesis and evaluation of isatin derivatives as effective SARS coronavirus 3CL protease inhibitorsQ46493211
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Design and synthesis of peptidomimetic severe acute respiratory syndrome chymotrypsin-like protease inhibitorsQ46775721
A new lead for nonpeptidic active-site-directed inhibitors of the severe acute respiratory syndrome coronavirus main protease discovered by a combination of screening and docking methodsQ46775741
Identification of novel small-molecule inhibitors of severe acute respiratory syndrome-associated coronavirus by chemical genetics.Q47924234
Protective effects of MCI-186 on cerebral ischemia: possible involvement of free radical scavenging and antioxidant actions.Q48162562
Effects of a novel free radical scavenger, MCl-186, on ischemic brain damage in the rat distal middle cerebral artery occlusion model.Q48719184
Stable Benzotriazole Esters as Mechanism-Based Inactivators of the Severe Acute Respiratory Syndrome 3CL ProteaseQ58239652
Discovering severe acute respiratory syndrome coronavirus 3CL protease inhibitors: virtual screening, surface plasmon resonance, and fluorescence resonance energy transfer assaysQ79340566
Development of potent inhibitors of the coxsackievirus 3C proteaseQ80279253
Structure-based design and synthesis of highly potent SARS-CoV 3CL protease inhibitorsQ80849382
A pyrimidine-pyrazolone nucleoside chimera with potent in vitro anti-orthopoxvirus activityQ83126753
Individual and common inhibitors of coronavirus and picornavirus main proteasesQ83232837
P433issue22
P407language of work or nameEnglishQ1860
P921main subjectCoronaviridaeQ1134583
SARSr-CoVQ278567
SARS-CoV-1Q85438966
P304page(s)7849-7854
P577publication date2010-09-25
P1433published inBioorganic & Medicinal ChemistryQ2904200
P1476titleSynthesis and evaluation of pyrazolone compounds as SARS-coronavirus 3C-like protease inhibitors
P478volume18

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cites work (P2860)
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Q35923992An Overview of Severe Acute Respiratory Syndrome-Coronavirus (SARS-CoV) 3CL Protease Inhibitors: Peptidomimetics and Small Molecule Chemotherapy.
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Q95630795Chemistry and Biology of SARS-CoV-2
Q46223071Design, synthesis, and biological evaluation of novel dipeptide-type SARS-CoV 3CL protease inhibitors: structure-activity relationship study
Q38720941Discovery of unsymmetrical aromatic disulfides as novel inhibitors of SARS-CoV main protease: Chemical synthesis, biological evaluation, molecular docking and 3D-QSAR study
Q93180376Drug Development and Medicinal Chemistry Efforts Toward SARS-Coronavirus and Covid-19 Therapeutics
Q51781897Efficient one-pot synthesis of novel and diverse tetrahydroquinolines bearing pyranopyrazoles using organocatalyzed domino Knoevenagel/hetero Diels-Alder reactions.
Q27697642Fused-ring structure of decahydroisoquinolin as a novel scaffold for SARS 3CL protease inhibitors
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Q43280688Middle East Respiratory Syndrome and Severe Acute Respiratory Syndrome: Current Therapeutic Options and Potential Targets for Novel Therapies
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