CXCL6 antibody neutralization prevents lung inflammation and fibrosis in mice in the bleomycin model

scientific article published on 23 August 2013

CXCL6 antibody neutralization prevents lung inflammation and fibrosis in mice in the bleomycin model is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1189/JLB.0313140
P698PubMed publication ID23975892
P5875ResearchGate publication ID256101464

P50authorIsabelle CouillinQ40398559
Paul ProostQ54449101
Sofie StruyfQ37066514
Bernhard RyffelQ40398470
P2093author name stringJacques Van Snick
Isabelle Couillin
Catherine Uyttenhove
Rodrigo Guabiraba
Louis Fauconnier
Anne-Gaëlle Besnard
Nathalie Rouxel
P2860cites workCyclooxygenase-2-dependent expression of angiogenic CXC chemokines ENA-78/CXC Ligand (CXCL) 5 and interleukin-8/CXCL8 in human non-small cell lung cancerQ40583103
Role of the chemokine receptor CXCR2 in bleomycin-induced pulmonary inflammation and fibrosisQ42442718
Expression of functional toll-like receptor-2 and -4 on alveolar epithelial cells.Q42459176
Tissue inhibitor of metalloproteinase-1 deficiency amplifies acute lung injury in bleomycin-exposed miceQ42575229
Extracellular ATP is a danger signal activating P2X7 receptor in lung inflammation and fibrosisQ43044973
Cytokine profile of bronchoalveolar lavage fluid in patients with combined pulmonary fibrosis and emphysemaQ44285852
ENA-78 is an important angiogenic factor in idiopathic pulmonary fibrosisQ46319754
Murine CXCR1 is a functional receptor for GCP-2/CXCL6 and interleukin-8/CXCL8.Q46976911
Protective role of IFN-gamma in collagen-induced arthritis conferred by inhibition of mycobacteria-induced granulocyte chemotactic protein-2 production.Q52575972
Differential usage of the CXC chemokine receptors 1 and 2 by interleukin-8, granulocyte chemotactic protein-2 and epithelial-cell-derived neutrophil attractant-78Q28278512
Pulmonary fibrosis: pathogenesis, etiology and regulationQ28388425
Induction of CXCL5 during inflammation in the rodent lung involves activation of alveolar epitheliumQ28570741
CXCL5 regulates chemokine scavenging and pulmonary host defense to bacterial infectionQ28589805
Resolving inflammation: dual anti-inflammatory and pro-resolution lipid mediatorsQ29615694
Neutrophils in the activation and regulation of innate and adaptive immunityQ29620082
Critical role of endothelial CXCR2 in LPS-induced neutrophil migration into the lungQ30439575
Duffy antigen receptor for chemokines and CXCL5 are essential for the recruitment of neutrophils in a multicellular model of rheumatoid arthritis synoviumQ33652016
Integrating mechanisms of pulmonary fibrosisQ35106452
Amine-reactive OVA multimers for auto-vaccination against cytokines and other mediators: perspectives illustrated for GCP-2 in L. major infectionQ35168395
Oxidative stress and airway inflammation in severe exacerbations of COPD.Q35537579
Essential roles of the CC chemokine ligand 3-CC chemokine receptor 5 axis in bleomycin-induced pulmonary fibrosis through regulation of macrophage and fibrocyte infiltration.Q35781428
Role of CXCL5 in leukocyte recruitment to the lungs during secondhand smoke exposureQ36110564
Matrix metalloproteinases in asthma and COPD.Q36134365
Bronchial mucosal inflammation and upregulation of CXC chemoattractants and receptors in severe exacerbations of asthmaQ36225732
Neutrophils cascading their way to inflammationQ36315860
Pathophysiology of exacerbations of chronic obstructive pulmonary diseaseQ36458964
Chemokine/cytokine cocktail in idiopathic pulmonary fibrosisQ36493970
Glucocorticoid-attenuated response genes encode intercellular mediators, including a new C-X-C chemokineQ36688455
Murine models of pulmonary fibrosis.Q36997546
The evolution of mammalian chemokine genes.Q37740571
Inflammasome-IL-1-Th17 response in allergic lung inflammationQ37965499
Topical antisense oligonucleotide therapy against LIX, an enterocyte-expressed CXC chemokine, reduces murine colitis.Q40385488
P433issue6
P921main subjectantibodyQ79460
P304page(s)1317-1323
P577publication date2013-08-23
P1433published inJournal of Leukocyte BiologyQ1524048
P1476titleCXCL6 antibody neutralization prevents lung inflammation and fibrosis in mice in the bleomycin model
P478volume94

Reverse relations

cites work (P2860)
Q35758535CD8+ T Cell Response to Gammaherpesvirus Infection Mediates Inflammation and Fibrosis in Interferon Gamma Receptor-Deficient Mice
Q64055054CXCL6 Promotes Renal Interstitial Fibrosis in Diabetic Nephropathy by Activating JAK/STAT3 Signaling Pathway
Q58779664CXCL6-EGFR-induced Kupffer cells secrete TGF-β1 promoting hepatic stellate cell activation via the SMAD2/BRD4/C-MYC/EZH2 pathway in liver fibrosis
Q89964203Editorial: Innovative Biologics and Drugs to Target Renal Inflammation
Q34711894Ets homologous factor regulates pathways controlling response to injury in airway epithelial cells
Q40544331Genome-wide association studies identify susceptibility loci affecting respiratory disease in Chinese Erhualian pigs under natural conditions
Q107377157Identification of key signaling pathways induced by SARS-CoV2 that underlie thrombosis and vascular injury in COVID-19 patients
Q35903156Lung Infection by Human Bocavirus Induces the Release of Profibrotic Mediator Cytokines In Vivo and In Vitro
Q47655196MicroRNA Signature of Cigarette Smoking and Evidence for a Putative Causal Role of MicroRNAs in Smoking-Related Inflammation and Target Organ Damage.
Q38744738MnTBAP Inhibits Bleomycin-Induced Pulmonary Fibrosis by Regulating VEGF and Wnt Signaling
Q35571108NMDA Receptor Antagonist Attenuates Bleomycin-Induced Acute Lung Injury
Q27321863Prostatic inflammation induces fibrosis in a mouse model of chronic bacterial infection
Q41160324Relationships among injury, fibrosis, and time in human kidney transplants.
Q38181073The epithelium in idiopathic pulmonary fibrosis: breaking the barrier
Q41213879The neutrophil-recruiting chemokine GCP-2/CXCL6 is expressed in cystic fibrosis airways and retains its functional properties after binding to extracellular DNA.
Q89789591The secretome profiling of a pediatric airway epithelium infected with hRSV identified aberrant apical/basolateral trafficking and novel immune modulating (CXCL6, CXCL16, CSF3) and antiviral (CEACAM1) proteins
Q35196311Tumor necrosis factor: a mechanistic link between angiotensin-II-induced cardiac inflammation and fibrosis.
Q36865803Vaccinia vaccine-based immunotherapy arrests and reverses established pulmonary fibrosis.

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