CD8+ T Cell Response to Gammaherpesvirus Infection Mediates Inflammation and Fibrosis in Interferon Gamma Receptor-Deficient Mice

scientific article published on 28 August 2015

CD8+ T Cell Response to Gammaherpesvirus Infection Mediates Inflammation and Fibrosis in Interferon Gamma Receptor-Deficient Mice is …
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scholarly articleQ13442814

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P819ADS bibcode2015PLoSO..1035719O
P356DOI10.1371/JOURNAL.PONE.0135719
P932PMC publication ID4552722
P698PubMed publication ID26317335
P5875ResearchGate publication ID281553185

P50authorSamuel H SpeckQ94468728
Bethany B MooreQ37837380
P2093author name stringCarol A Wilke
Brian S Wakeman
Brigid M O'Flaherty
Cynthia L Courtney
AnaPatricia Garcia
Caline G Matar
P2860cites workRelationship of BAL and lung tissue CD4+ and CD8+ T lymphocytes, and their ratio in idiopathic pulmonary fibrosisQ81375344
A neutrophil elastase inhibitor prevents bleomycin-induced pulmonary fibrosis in miceQ83731941
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An assay for transforming growth factor-beta using cells transfected with a plasminogen activator inhibitor-1 promoter-luciferase constructQ72411299
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CD28 down-regulation on circulating CD4 T-cells is associated with poor prognoses of patients with idiopathic pulmonary fibrosisQ33529016
Virus-specific CD8(+) T cell numbers are maintained during gamma-herpesvirus reactivation in CD4-deficient miceQ33598134
Two kinetic patterns of epitope-specific CD8 T-cell responses following murine gammaherpesvirus 68 infectionQ33676647
Disruption of the murine gammaherpesvirus 68 M1 open reading frame leads to enhanced reactivation from latencyQ33798023
T-cell vaccination alters the course of murine herpesvirus 68 infection and the establishment of viral latency in mice.Q33824612
Murine gammaherpesvirus 68 LANA is essential for virus reactivation from splenocytes but not long-term carriage of viral genomeQ33966678
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Hospital-based historical cohort study of 234 histologically proven Japanese patients with IPF.Q34505771
Latent infection by γherpesvirus stimulates profibrotic mediator release from multiple cell typesQ34598816
Herpesvirus DNA is consistently detected in lungs of patients with idiopathic pulmonary fibrosisQ35027515
Ganciclovir antiviral therapy in advanced idiopathic pulmonary fibrosis: an open pilot studyQ35028793
Extensive phenotyping of individuals at risk for familial interstitial pneumonia reveals clues to the pathogenesis of interstitial lung disease.Q35153490
A gamma-herpesvirus sneaks through a CD8(+) T cell response primed to a lytic-phase epitopeQ35601591
The distribution of immunomodulatory cells in the lungs of patients with idiopathic pulmonary fibrosisQ35723493
Induction of lung fibrosis in the mouse by intratracheal instillation of fluorescein isothiocyanate is not T-cell-dependentQ35788056
Right place, right time: the evolving role of herpesvirus infection as a "second hit" in idiopathic pulmonary fibrosisQ35850237
Fibrotic disease and the T(H)1/T(H)2 paradigmQ35852270
Control of virus reactivation arrests pulmonary herpesvirus-induced fibrosis in IFN-gamma receptor-deficient miceQ35855163
CD8+ T lymphocytes in bronchoalveolar lavage in idiopathic pulmonary fibrosisQ35868884
γ-Herpesvirus reactivation differentially stimulates epitope-specific CD8 T cell responsesQ35884099
Pathogenesis of an infectious mononucleosis-like disease induced by a murine gamma-herpesvirus: role for a viral superantigen?Q36377221
Genetic studies provide clues on the pathogenesis of idiopathic pulmonary fibrosisQ36485998
A gammaherpesvirus-secreted activator of Vbeta4+ CD8+ T cells regulates chronic infection and immunopathologyQ36509873
Neutrophil elastase promotes myofibroblast differentiation in lung fibrosisQ36608140
The absence of M1 leads to increased establishment of murine gammaherpesvirus 68 latency in IgD-negative B cellsQ36667866
The role of inflammation in the pathogenesis of idiopathic pulmonary fibrosisQ36981609
Roles of T lymphocytes in pulmonary fibrosisQ36982241
Murine models of pulmonary fibrosis.Q36997546
Mechanisms of neutrophil accumulation in the lungs of patients with idiopathic pulmonary fibrosisQ37001168
Activation of alveolar macrophages via the alternative pathway in herpesvirus-induced lung fibrosisQ37098588
Murine gammaherpesvirus 68 infection of IFNgamma unresponsive mice: a small animal model for gammaherpesvirus-associated B-cell lymphoproliferative disease.Q37265443
Animal models of fibrotic lung diseaseQ37297925
TGF-beta and fibrosis in different organs - molecular pathway imprintsQ37524907
Viral infection and aging as cofactors for the development of pulmonary fibrosisQ37815487
The role of infection in the pathogenesis of idiopathic pulmonary fibrosis.Q38133505
Effects of elastase inhibitor on the epithelial cell apoptosis in bleomycin-induced pulmonary fibrosisQ38490506
Latent herpesvirus infection augments experimental pulmonary fibrosisQ39342306
The Epstein-Barr virus latent membrane protein 1 and transforming growth factor--β1 synergistically induce epithelial--mesenchymal transition in lung epithelial cells.Q39669856
Pathological changes in the spleens of gamma interferon receptor-deficient mice infected with murine gammaherpesvirus: a role for CD8 T cells.Q39879816
Alveolar epithelial cell injury with Epstein-Barr virus upregulates TGFbeta1 expression.Q39962123
Four tRNA-like sequences and a serpin homologue encoded by murine gammaherpesvirus 68 are dispensable for lytic replication in vitro and latency in vivoQ41065849
Peripheral blood mononuclear cell gene expression profiles predict poor outcome in idiopathic pulmonary fibrosisQ41830012
Murine gammaherpesvirus-68 infection causes multi-organ fibrosis and alters leukocyte trafficking in interferon-gamma receptor knockout miceQ42746685
Cryptogenic fibrosing alveolitis: lack of association with Epstein-Barr virus infectionQ43043836
A rearranged form of Epstein-Barr virus DNA is associated with idiopathic pulmonary fibrosisQ43662412
Impairment of bleomycin-induced lung fibrosis in CD28-deficient miceQ43699047
Protection from pulmonary fibrosis in the absence of CCR2 signalingQ43760123
Usual interstitial pneumonitis is a T-cell alveolitis.Q44468402
Epstein-Barr virus DNA in bronchoalveolar lavage fluid from patients with idiopathic pulmonary fibrosisQ45394865
The detection of Epstein-Barr virus DNA in lung tissue from patients with idiopathic pulmonary fibrosisQ45750246
CXCL6 antibody neutralization prevents lung inflammation and fibrosis in mice in the bleomycin modelQ46586534
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P433issue8
P407language of work or nameEnglishQ1860
P304page(s)e0135719
P577publication date2015-08-28
P1433published inPLOS OneQ564954
P1476titleCD8+ T Cell Response to Gammaherpesvirus Infection Mediates Inflammation and Fibrosis in Interferon Gamma Receptor-Deficient Mice
P478volume10

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cites work (P2860)
Q59350365A human gain-of-function STING mutation causes immunodeficiency and gammaherpesvirus-induced pulmonary fibrosis in mice
Q57099957Caspase-8 Collaborates with Caspase-11 to Drive Tissue Damage and Execution of Endotoxic Shock
Q92336443Fra-2-expressing macrophages promote lung fibrosis in mice
Q38839398Intramuscular Immunization of Mice with the Live-Attenuated Herpes Simplex Virus 1 Vaccine Strain VC2 Expressing Equine Herpesvirus 1 (EHV-1) Glycoprotein D Generates Anti-EHV-1 Immune Responses in Mice
Q47606264Murine Gammaherpesvirus 68: A Small Animal Model for Gammaherpesvirus-Associated Diseases
Q37576530Nanoparticle exposure reactivates latent herpesvirus and restores a signature of acute infection

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