A gammaherpesvirus-secreted activator of Vbeta4+ CD8+ T cells regulates chronic infection and immunopathology

scientific article published on 10 March 2008

A gammaherpesvirus-secreted activator of Vbeta4+ CD8+ T cells regulates chronic infection and immunopathology is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1084/JEM.20071135
P932PMC publication ID2275388
P698PubMed publication ID18332178
P5875ResearchGate publication ID5520434

P50authorAna L MoraQ88209782
Samuel H SpeckQ94468728
Laurie T. KrugQ35703431
P2093author name stringAndrew G Evans
Janice M Moser
Veranika Pozharskaya
P2860cites workComplete sequence and genomic analysis of murine gammaherpesvirus 68Q24672530
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Host and viral genetics of chronic infection: a mouse model of gamma-herpesvirus pathogenesisQ33718374
The murine gammaherpesvirus 68 M2 gene is required for efficient reactivation from latently infected B cellsQ33782281
Disruption of the murine gammaherpesvirus 68 M1 open reading frame leads to enhanced reactivation from latencyQ33798023
Requirement for CD40 ligand, CD4(+) T cells, and B cells in an infectious mononucleosis-like syndromeQ33823904
T-cell vaccination alters the course of murine herpesvirus 68 infection and the establishment of viral latency in mice.Q33824612
Mice deficient in the X-linked lymphoproliferative disease gene sap exhibit increased susceptibility to murine gammaherpesvirus-68 and hypo-gammaglobulinemiaQ40635781
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An optimized CD4 T-cell response can control productive and latent gammaherpesvirus infectionQ40909600
Four tRNA-like sequences and a serpin homologue encoded by murine gammaherpesvirus 68 are dispensable for lytic replication in vitro and latency in vivoQ41065849
Murine gamma-herpesvirus 68 causes severe large-vessel arteritis in mice lacking interferon-gamma responsiveness: a new model for virus-induced vascular disease.Q41077197
Murine gammaherpesvirus 68 encodes tRNA-like sequences which are expressed during latencyQ41102143
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T cell reactivity during infectious mononucleosis and persistent gammaherpesvirus infection in mice.Q51024787
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Bacterial Superantigens Bypass Lck-Dependent T Cell Receptor Signaling by Activating a Gα11-Dependent, PLC-β-Mediated PathwayQ58662320
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Murine gamma-herpesvirus-68: a mouse model for infectious mononucleosis?Q73252181
Murine gamma-herpesvirus infection causes V(beta)4-specific CDR3-restricted clonal expansions within CD8(+) peripheral blood T lymphocytesQ74080454
Changing patterns of dominance in the CD8+ T cell response during acute and persistent murine gamma-herpesvirus infectionQ77402434
Apparent MHC-independent stimulation of CD8+ T cells in vivo during latent murine gammaherpesvirus infectionQ78025433
The M4 gene of gammaHV68 encodes a secreted glycoprotein and is required for the efficient establishment of splenic latencyQ81265129
CD4 T cell control of acute and latent murine gammaherpesvirus infection requires IFNgammaQ81860691
Ongoing viral replication is required for gammaherpesvirus 68-induced vascular damageQ33827354
Gamma interferon blocks gammaherpesvirus reactivation from latencyQ34233053
Disruption of the M2 gene of murine gammaherpesvirus 68 alters splenic latency following intranasal, but not intraperitoneal, inoculationQ34331333
Characterization of a spontaneous 9.5-kilobase-deletion mutant of murine gammaherpesvirus 68 reveals tissue-specific genetic requirements for latencyQ34340874
Regulation of cellular and humoral immune responses by the SLAM and SAP families of molecules.Q34597428
Gammaherpesvirus persistence alters key CD8 T-cell memory characteristics and enhances antiviral protectionQ35024174
Selective gene expression of latent murine gammaherpesvirus 68 in B lymphocytesQ35149225
Different functional capacities of latent and lytic antigen-specific CD8 T cells in murine gammaherpesvirus infectionQ35444588
Control of virus reactivation arrests pulmonary herpesvirus-induced fibrosis in IFN-gamma receptor-deficient miceQ35855163
An Epstein-Barr virus-associated superantigenQ36367270
Progressive loss of CD8+ T cell-mediated control of a gamma-herpesvirus in the absence of CD4+ T cellsQ36367286
Control of gammaherpesvirus latency by latent antigen-specific CD8(+) T cellsQ36368986
Pathogenesis of an infectious mononucleosis-like disease induced by a murine gamma-herpesvirus: role for a viral superantigen?Q36377221
Murine gammaherpesvirus M2 gene is latency-associated and its protein a target for CD8(+) T lymphocytes.Q36398571
Murine gammaherpesvirus 68 genes both induce and suppress lymphoproliferative diseaseQ36424579
The gammaherpesvirus 68 latency-associated nuclear antigen homolog is critical for the establishment of splenic latencyQ36524534
Pathogenesis of murine gammaherpesvirus infection in mice deficient in CD4 and CD8 T cells.Q36651788
The function of programmed cell death 1 and its ligands in regulating autoimmunity and infectionQ36737159
Gamma interferon blocks gammaherpesvirus reactivation from latency in a cell type-specific mannerQ36759837
The m4 gene of murine gammaherpesvirus modulates productive and latent infection in vivoQ36944359
Activation of alveolar macrophages via the alternative pathway in herpesvirus-induced lung fibrosisQ37098588
Direct binding of the Mtv7 superantigen (Mls-1) to soluble MHC class II molecules.Q39388125
Identification and initial characterization of the murine gammaherpesvirus 68 gene M3, encoding an abundantly secreted proteinQ39551333
Cloning and mutagenesis of the murine gammaherpesvirus 68 genome as an infectious bacterial artificial chromosomeQ39592358
B cells regulate murine gammaherpesvirus 68 latencyQ39593978
Immune control of the number and reactivation phenotype of cells latently infected with a gammaherpesvirusQ39684093
Critical role for a high-affinity chemokine-binding protein in gamma-herpesvirus-induced lethal meningitisQ39737732
Murid herpesvirus 4 strain 68 M2 protein is a B-cell-associated antigen important for latency but not lymphocytosisQ39864114
Mature B cells are required for acute splenic infection, but not for establishment of latency, by murine gammaherpesvirus 68.Q39876421
Pathological changes in the spleens of gamma interferon receptor-deficient mice infected with murine gammaherpesvirus: a role for CD8 T cells.Q39879816
IFN-gamma action in the media of the great elastic arteries, a novel immunoprivileged siteQ39906384
Murine Vbeta3+ and Vbeta7+ T cell subsets are specific targets for the HERV-K18 Env superantigenQ40241608
Signaling lymphocyte activation molecule-associated protein is a negative regulator of the CD8 T cell response in miceQ40388457
Epstein-Barr virus latent membrane protein LMP-2A is sufficient for transactivation of the human endogenous retrovirus HERV-K18 superantigenQ40541072
Forced lytic replication impairs host colonization by a latency-deficient mutant of murine gammaherpesvirus-68.Q40600121
P433issue3
P407language of work or nameEnglishQ1860
P304page(s)669-684
P577publication date2008-03-10
P1433published inJournal of Experimental MedicineQ3186912
P1476titleA gammaherpesvirus-secreted activator of Vbeta4+ CD8+ T cells regulates chronic infection and immunopathology
P478volume205

Reverse relations

cites work (P2860)
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