Ablation of STAT3 in the B Cell Compartment Restricts Gammaherpesvirus Latency In Vivo

scientific article published on 02 August 2016

Ablation of STAT3 in the B Cell Compartment Restricts Gammaherpesvirus Latency In Vivo is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1128/MBIO.00723-16
P932PMC publication ID4981709
P698PubMed publication ID27486189

P50authorLaurie T. KrugQ35703431
P2093author name stringHui-Chen Chang Foreman
Nancy C Reich
Valeria Poli
Gee Ho Park
Sandeep Steven Reddy
Thubten Ozula Sioux
P2860cites workInterleukin 10 is a potent growth and differentiation factor for activated human B lymphocytesQ24338522
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Normal and disease-related biological functions of Twist1 and underlying molecular mechanismsQ26824524
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STAT3 nuclear import is independent of tyrosine phosphorylation and mediated by importin-alpha3.Q28253106
Regulation and functions of Blimp-1 in T and B lymphocytesQ28274145
A gammaherpesvirus Bcl-2 ortholog blocks B cell receptor-mediated apoptosis and promotes the survival of developing B cells in vivoQ28539635
STATs in cancer inflammation and immunity: a leading role for STAT3Q29547203
Stats: transcriptional control and biological impactQ29547776
Stat3 as an oncogeneQ29614606
EBV latent membrane protein 1 activates Akt, NFkappaB, and Stat3 in B cell lymphomasQ30837949
Gammaherpesvirus-driven plasma cell differentiation regulates virus reactivation from latently infected B lymphocytesQ30943994
The MHV68 M2 protein drives IL-10 dependent B cell proliferation and differentiationQ33326982
Expansion of murine gammaherpesvirus latently infected B cells requires T follicular helpQ33553789
IL-21 imposes a type II EBV gene expression on type III and type I B cells by the repression of C- and activation of LMP-1-promoterQ33640213
Dissecting the host response to a gamma-herpesvirusQ33772250
Establishment and maintenance of long-term murine gammaherpesvirus 68 latency in B cells in the absence of CD40.Q33834753
Linkage between STAT regulation and Epstein-Barr virus gene expression in tumorsQ33866046
Roles of STAT3 defined by tissue-specific gene targetingQ33941404
Essential role of STAT3 in the control of the acute-phase response as revealed by inducible gene inactivation [correction of activation] in the liverQ33967216
Mutational switch of an IL-6 response to an interferon-gamma-like responseQ34031049
Viral latency and its regulation: lessons from the gamma-herpesvirusesQ34039189
Reversible methylation of promoter-bound STAT3 by histone-modifying enzymesQ34411003
Murine gammaherpesvirus M2 protein induction of IRF4 via the NFAT pathway leads to IL-10 expression in B cellsQ35082220
Kaposi's sarcoma-associated herpesvirus (KSHV) vIL-6 promotes cell proliferation and migration by upregulating DNMT1 via STAT3 activationQ35133354
Long-term latent murine Gammaherpesvirus 68 infection is preferentially found within the surface immunoglobulin D-negative subset of splenic B cells in vivoQ35155237
Functional heterogeneity in the CD4+ T cell response to murine γ-herpesvirus 68Q35164112
Interleukin 21 signaling in B cells is required for efficient establishment of murine gammaherpesvirus latencyQ35392834
Tonsillar memory B cells, latently infected with Epstein-Barr virus, express the restricted pattern of latent genes previously found only in Epstein-Barr virus-associated tumorsQ35414637
Different functional capacities of latent and lytic antigen-specific CD8 T cells in murine gammaherpesvirus infectionQ35444588
A critical role for STAT3 transcription factor signaling in the development and maintenance of human T cell memoryQ35586049
The Epstein-Barr virus latency BamHI-Q promoter is positively regulated by STATs and Zta interference with JAK/STAT activation leads to loss of BamHI-Q promoter activityQ35603820
Analysis of interleukin-21-induced Prdm1 gene regulation reveals functional cooperation of STAT3 and IRF4 transcription factorsQ35736556
Persistent activation of STAT3 by latent Kaposi's sarcoma-associated herpesvirus infection of endothelial cells.Q35784707
Cytokine production in the immune response to murine gammaherpesvirus 68.Q35860661
Inborn errors of human JAKs and STATsQ35908479
Progressive loss of CD8+ T cell-mediated control of a gamma-herpesvirus in the absence of CD4+ T cellsQ36367286
Control of gammaherpesvirus latency by latent antigen-specific CD8(+) T cellsQ36368986
Pathogenesis of an infectious mononucleosis-like disease induced by a murine gamma-herpesvirus: role for a viral superantigen?Q36377221
Regulatory B cells control T-cell autoimmunity through IL-21-dependent cognate interactions.Q36385029
A gammaherpesvirus-secreted activator of Vbeta4+ CD8+ T cells regulates chronic infection and immunopathologyQ36509873
Distinct transcriptional regulatory modules underlie STAT3's cell type-independent and cell type-specific functionsQ36619840
STAT3-mediated up-regulation of BLIMP1 Is coordinated with BCL6 down-regulation to control human plasma cell differentiation.Q36677337
A Regulatory Feedback between Plasmacytoid Dendritic Cells and Regulatory B Cells Is Aberrant in Systemic Lupus ErythematosusQ36718239
JAK-STAT signaling: from interferons to cytokinesQ36821751
Modulation of reactivation of latent herpes simplex virus 1 in ganglionic organ cultures by p300/CBP and STAT3.Q37010787
Regulatory CD8+ T cells associated with erosion of immune surveillance in persistent virus infection suppress in vitro and have a reversible proliferative defectQ37051205
Peritoneal cavity regulatory B cells (B10 cells) modulate IFN-γ+CD4+ T cell numbers during colitis development in miceQ37163714
NF-kappaB p50 plays distinct roles in the establishment and control of murine gammaherpesvirus 68 latencyQ37192183
Signal transducer and activator of transcription 3 (STAT3) mutations underlying autosomal dominant hyper-IgE syndrome impair human CD8(+) T-cell memory formation and function.Q37202661
Identification of infected B-cell populations by using a recombinant murine gammaherpesvirus 68 expressing a fluorescent proteinQ37232914
Signal transducer and activator of transcription 3 limits Epstein-Barr virus lytic activation in B lymphocytes.Q37252690
Naive and memory human B cells have distinct requirements for STAT3 activation to differentiate into antibody-secreting plasma cells.Q37322185
Suppressive CD8+ T cells arise in the absence of CD4 help and compromise control of persistent virusQ37372738
Function of mitochondrial Stat3 in cellular respirationQ37378567
B lymphocytes from patients with a hypomorphic mutation in STAT3 resist Epstein-Barr virus-driven cell proliferationQ37547616
STAT3 interrupts ATR-Chk1 signaling to allow oncovirus-mediated cell proliferationQ37687614
Diffuse Large B Cell Lymphoma in Hyper-IgE Syndrome Due To STAT3 MutationQ37791014
Pathogenesis and host control of gammaherpesviruses: lessons from the mouseQ37827143
The JAK-STAT pathway at twentyQ38004201
Acute-Phase Response Factor, a Nuclear Factor Binding to Acute-Phase Response Elements, is Rapidly Activated by Interleukin-6 at the Posttranslational LevelQ38323301
Stat3 is required for ALK-mediated lymphomagenesis and provides a possible therapeutic targetQ38326252
STAT3 Regulates Lytic Activation of Kaposi's Sarcoma-Associated Herpesvirus.Q38838049
Modulation of Kaposi's sarcoma-associated herpesvirus interleukin-6 function by hypoxia-upregulated protein 1.Q38985652
A murid gamma-herpesviruses exploits normal splenic immune communication routes for systemic spread.Q39005502
Signal transduction by human herpesvirus 8 viral interleukin-6 (vIL-6) is modulated by the nonsignaling gp80 subunit of the IL-6 receptor complex and is distinct from signaling induced by human IL-6.Q39290036
B cells regulate murine gammaherpesvirus 68 latencyQ39593978
Mitochondrial STAT3 supports Ras-dependent oncogenic transformation.Q39675800
Immune control of the number and reactivation phenotype of cells latently infected with a gammaherpesvirusQ39684093
Constitutively active Stat3 enhances neu-mediated migration and metastasis in mammary tumors via upregulation of CtenQ39730145
A positive autoregulatory loop of LMP1 expression and STAT activation in epithelial cells latently infected with Epstein-Barr virus.Q39736828
Upregulation of STAT3 marks Burkitt lymphoma cells refractory to Epstein-Barr virus lytic cycle induction by HDAC inhibitorsQ39778922
Blimp-1-dependent plasma cell differentiation is required for efficient maintenance of murine gammaherpesvirus latency and antiviral antibody responsesQ39778958
Interleukin-6 induces an epithelial-mesenchymal transition phenotype in human breast cancer cells.Q39828317
Pathological changes in the spleens of gamma interferon receptor-deficient mice infected with murine gammaherpesvirus: a role for CD8 T cells.Q39879816
The expression pattern of Epstein-Barr virus latent genes in vivo is dependent upon the differentiation stage of the infected B cellQ40843575
Interleukin-6 in biology and medicineQ40850225
Role of Stat3 in lipopolysaccharide-induced IL-10 gene expression.Q40867360
A Kaposi's sarcoma-associated herpesvirus-encoded cytokine homolog (vIL-6) activates signaling through the shared gp130 receptor subunitQ41098043
Immature and Transitional B Cells Are Latency Reservoirs for a GammaherpesvirusQ41232435
Critical role for Stat3 in T-dependent terminal differentiation of IgG B cells.Q42741704
Maintenance of long term gamma-herpesvirus B cell latency is dependent on CD40-mediated development of memory B cellsQ42799697
KSHV-GPCR and CXCR2 transforming capacity and angiogenic responses are mediated through a JAK2-STAT3-dependent pathwayQ42818551
Kaposi's sarcoma-associated herpesvirus kaposin B induces unique monophosphorylation of STAT3 at serine 727 and MK2-mediated inactivation of the STAT3 transcriptional repressor TRIM28.Q43079558
Novel roles of unphosphorylated STAT3 in oncogenesis and transcriptional regulationQ45261333
Epstein-Barr virus-derived EBNA2 regulates STAT3 activationQ45388419
Murine gammaherpesvirus-68-induced interleukin-10 increases viral burden, but limits virus-induced splenomegaly and leukocytosisQ45735512
Clinical features, STAT3 gene mutations and Th17 cell analysis in nine children with hyper-IgE syndrome in mainland ChinaQ46972270
EBV persistence in memory B cells in vivo.Q52037383
Interleukin-10 receptor signaling through the JAK-STAT pathway. Requirement for two distinct receptor-derived signals for anti-inflammatory action.Q52176801
IL-10 Potentiates Differentiation of Human Induced Regulatory T Cells via STAT3 and Foxo1.Q53347772
Pathogenesis of Murine Gammaherpesvirus-68 Infection in Interleukin-6-Deficient MiceQ55877051
P433issue4
P577publication date2016-08-02
P1433published inmBioQ15817061
P1476titleAblation of STAT3 in the B Cell Compartment Restricts Gammaherpesvirus Latency In Vivo
P478volume7

Reverse relations

cites work (P2860)
Q93018091Epstein-Barr Virus and Innate Immunity: Friends or Foes?
Q56345322Kaposi sarcoma-associated herpesvirus latency locus renders B cells hyperresponsive to secondary infections
Q60949741Kaposi's Sarcoma-Associated Herpesvirus-Encoded Viral IL-6 (vIL-6) Enhances Immunoglobulin Class-Switch Recombination
Q52668677Porcine MKRN1 modulates the replication and pathogenesis of PCV2 by inducing capsid protein ubiquitination and degradation.
Q47425387The regulatory role of protein phosphorylation in human gammaherpesvirus associated cancers.
Q40077951The replication and transcription activator of murine gammaherpesvirus 68 cooperatively enhances cytokine-activated, STAT3-mediated gene expression.

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