ClusterCAD: a computational platform for type I modular polyketide synthase design.

scientific article published on 11 October 2017

ClusterCAD: a computational platform for type I modular polyketide synthase design. is …
instance of (P31):
scholarly articleQ13442814

External links are
P8978DBLP publication IDjournals/nar/EngBBMMKBK18
P356DOI10.1093/NAR/GKX893
P8608Fatcat IDrelease_gkn62d32ifctnn2umljh3goeri
P932PMC publication ID5753242
P698PubMed publication ID29040649

P50authorJay KeaslingQ1684333
Tyler W H BackmanQ55188494
Constance B BaileyQ87618365
P2093author name stringPierre Baldi
Christophe Magnan
Héctor García Martín
Leonard Katz
Clara H Eng
P2860cites workInsights into Substrate Modification by Dehydratases from Type I Polyketide Synthases.Q50749527
Uncovering the formation and selection of benzylmalonyl-CoA from the biosynthesis of splenocin and enterocin reveals a versatile way to introduce amino acids into polyketide carbon scaffolds.Q50999683
Direct production of ivermectin-like drugs after domain exchange in the avermectin polyketide synthase of Streptomyces avermitilis ATCC31272.Q52610993
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Engineered intermodular and intramodular polyketide synthase fusionsQ73790571
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A tylosin ketoreductase reveals how chirality is determined in polyketidesQ27647542
Divergence of multimodular polyketide synthases revealed by a didomain structureQ27679312
SSpro/ACCpro 5: almost perfect prediction of protein secondary structure and relative solvent accessibility using profiles, machine learning and structural similarity.Q30362846
Multiple genetic modifications of the erythromycin polyketide synthase to produce a library of novel "unnatural" natural products.Q30650504
Elucidation of the cryptic epimerase activity of redox-inactive ketoreductase domains from modular polyketide synthases by tandem equilibrium isotope exchangeQ33951190
Minimum Information about a Biosynthetic Gene cluster.Q35748739
antiSMASH 3.0-a comprehensive resource for the genome mining of biosynthetic gene clustersQ35810231
Combinatorial biosynthesis of reduced polyketidesQ36328793
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Structure and mechanism of the 6-deoxyerythronolide B synthaseQ36747462
Coupled methyl group epimerization and reduction by polyketide synthase ketoreductase domains. Ketoreductase-catalyzed equilibrium isotope exchangeQ37398548
Engineering the acyltransferase substrate specificity of assembly line polyketide synthasesQ37677554
Beyond ethylmalonyl-CoA: the functional role of crotonyl-CoA carboxylase/reductase homologs in expanding polyketide diversityQ37962381
The structures of type I polyketide synthasesQ38031740
Stereocontrol within polyketide assembly linesQ38264057
The structural biology of biosynthetic megaenzymesQ38568948
On-line enzymatic tailoring of polyketides and peptides in thiotemplate systemsQ38727321
SBSPKSv2: structure-based sequence analysis of polyketide synthases and non-ribosomal peptide synthetases.Q38810972
SeMPI: a genome-based secondary metabolite prediction and identification web serverQ38814427
Bio-based production of fuels and industrial chemicals by repurposing antibiotic-producing type I modular polyketide synthases: opportunities and challengesQ39009631
Structural rearrangements of a polyketide synthase module during its catalytic cycleQ41456081
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Conserved amino acid residues correlating with ketoreductase stereospecificity in modular polyketide synthasesQ44507378
Biochemical analysis of the substrate specificity of the beta-ketoacyl-acyl carrier protein synthase domain of module 2 of the erythromycin polyketide synthaseQ45194819
Comprehensive in Vitro Analysis of Acyltransferase Domain Exchanges in Modular Polyketide Synthases and Its Application for Short-Chain Ketone Production.Q45951684
Alteration of Polyketide Stereochemistry from anti to syn by a Ketoreductase Domain Exchange in a Type I Modular Polyketide Synthase Subunit.Q45971460
In vitro analysis of carboxyacyl substrate tolerance in the loading and first extension modules of borrelidin polyketide synthase.Q46120822
Engineering a Polyketide Synthase for In Vitro Production of Adipic Acid.Q46557528
Exploiting the mosaic structure of trans-acyltransferase polyketide synthases for natural product discovery and pathway dissectionQ46788614
A polylinker approach to reductive loop swaps in modular polyketide synthasesQ47285596
Broadening substrate specificity of a chain-extending ketosynthase through a single active-site mutationQ48509192
Evaluating Ketoreductase Exchanges as a Means of Rationally Altering Polyketide StereochemistryQ48514837
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P433issueD1
P407language of work or nameEnglishQ1860
P304page(s)D509-D515
P577publication date2018-01-01
P1433published inNucleic Acids ResearchQ135122
P1476titleClusterCAD: a computational platform for type I modular polyketide synthase design
P478volume46

Reverse relations

cites work (P2860)
Q98282975A bimodular PKS platform that expands the biological design space
Q64897732Acyltransferases as Tools for Polyketide Synthase Engineering.
Q89841931Advanced Strategies for Production of Natural Products in Yeast
Q92571606Computational Tools for Discovering and Engineering Natural Product Biosynthetic Pathways
Q90380911Diversification of polyketide structures via synthase engineering
Q91987138Evolution and Diversity of Assembly-Line Polyketide Synthases
Q90711572MIBiG 2.0: a repository for biosynthetic gene clusters of known function
Q97421950Mini review: Genome mining approaches for the identification of secondary metabolite biosynthetic gene clusters in Streptomyces
Q64273675Natural Products and Synthetic Biology: Where We Are and Where We Need To Go
Q58556862Recent advances in the discovery and combinatorial biosynthesis of microbial 14-membered macrolides and macrolactones
Q61133243Reprogramming of the antimycin NRPS-PKS assembly lines inspired by gene evolution
Q96155794Repurposing Modular Polyketide Synthases and Non-ribosomal Peptide Synthetases for Novel Chemical Biosynthesis
Q89997592RetSynth: determining all optimal and sub-optimal synthetic pathways that facilitate synthesis of target compounds in chassis organisms
Q97425379Site directed mutagenesis as a precision tool to enable synthetic biology with engineered modular polyketide synthases
Q92209523Structural insights into dehydratase substrate selection for the borrelidin and fluvirucin polyketide synthases
Q48500475Synthetic biology of polyketide synthases.
Q68686996The Amipurimycin and Miharamycin Biosynthetic Gene Clusters: Unraveling the Origins of 2-Aminopurinyl Peptidyl Nucleoside Antibiotics

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