Coupled methyl group epimerization and reduction by polyketide synthase ketoreductase domains. Ketoreductase-catalyzed equilibrium isotope exchange

scientific article published on 29 October 2013

Coupled methyl group epimerization and reduction by polyketide synthase ketoreductase domains. Ketoreductase-catalyzed equilibrium isotope exchange is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1021/JA408944S
P8608Fatcat IDrelease_jif3gtfgt5glzhkqx2pv77ixku
P932PMC publication ID3865775
P698PubMed publication ID24161343
P5875ResearchGate publication ID258101647

P50authorChaitan KhoslaQ5068124
P2093author name stringDavid E Cane
Ashish Garg
P2860cites workA tylosin ketoreductase reveals how chirality is determined in polyketidesQ27647542
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Proton transfer in the mechanism of triosephosphate isomeraseQ28290766
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Divergent evolution in the enolase superfamily: the interplay of mechanism and specificityQ34373851
Understanding enzymic catalysis: the importance of short, strong hydrogen bondsQ34741072
Structure-based dissociation of a type I polyketide synthase moduleQ35995962
Structure and mechanism of the 6-deoxyerythronolide B synthaseQ36747462
Stereochemistry of reductions catalyzed by methyl-epimerizing ketoreductase domains of polyketide synthasesQ36977455
Stereochemical problems in macrolide antibioticsQ40006260
The biochemical basis for stereochemical control in polyketide biosynthesisQ41275766
Stereospecificity of ketoreductase domains of the 6-deoxyerythronolide B synthaseQ42033944
Top-down mass spectrometry on low-resolution instruments: characterization of phosphopantetheinylated carrier domains in polyketide and non-ribosomal biosynthetic pathwaysQ42046587
Facile detection of acyl and peptidyl intermediates on thiotemplate carrier domains via phosphopantetheinyl elimination reactions during tandem mass spectrometryQ42126323
Modular organization of genes required for complex polyketide biosynthesisQ42627871
Stereospecificity of ketoreductase domains 1 and 2 of the tylactone modular polyketide synthaseQ43164898
Organization of the enzymatic domains in the multifunctional polyketide synthase involved in erythromycin formation in Saccharopolyspora erythraeaQ43466600
A model of structure and catalysis for ketoreductase domains in modular polyketide synthasesQ44270898
Conserved amino acid residues correlating with ketoreductase stereospecificity in modular polyketide synthasesQ44507378
The structure of a ketoreductase determines the organization of the beta-carbon processing enzymes of modular polyketide synthases.Q45952293
An unusually large multifunctional polypeptide in the erythromycin-producing polyketide synthase of Saccharopolyspora erythraeaQ48248704
The Molecular Basis of Celmer's Rules: The Stereochemistry of the Condensation Step in Chain Extension on the Erythromycin Polyketide Synthase†Q58374497
Molecular Basis of Celmer's Rules: Stereochemistry of Catalysis by Isolated Ketoreductase Domains from Modular Polyketide SynthasesQ60301836
Molecular basis of Celmer’s rules: role of the ketosynthase domain in epimerisation and demonstration that ketoreductase domains can have altered product specificity with unnatural substratesQ60301873
Molecular basis of celmer's rules: the role of two ketoreductase domains in the control of chirality by the erythromycin modular polyketide synthaseQ60301883
Molecular recognition of diketide substrates by a beta-ketoacyl-acyl carrier protein synthase domain within a bimodular polyketide synthaseQ73891849
MACROLIDE STEREOCHEMISTRY. 3. A CONFIGURATIONAL MODEL FOR MACROLIDE ANTIBIOTICSQ78347173
Employing modular polyketide synthase ketoreductases as biocatalysts in the preparative chemoenzymatic syntheses of diketide chiral building blocksQ82249285
Complex enzymes in microbial natural product biosynthesis, part B: polyketides, aminocoumarins and carbohydrates. PrefaceQ83638561
P433issue44
P407language of work or nameEnglishQ1860
P304page(s)16324-16327
P577publication date2013-10-29
P1433published inJournal of the American Chemical SocietyQ898902
P1476titleCoupled methyl group epimerization and reduction by polyketide synthase ketoreductase domains. Ketoreductase-catalyzed equilibrium isotope exchange
P478volume135

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cites work (P2860)
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