Palladium-Catalyzed [3+3] Annulation between Diarylamines and α,β-Unsaturated Acids through CH Activation: Direct Access to 4-Substituted 2-Quinolinones

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Palladium-Catalyzed [3+3] Annulation between Diarylamines and α,β-Unsaturated Acids through CH Activation: Direct Access to 4-Substituted 2-Quinolinones is …
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scholarly articleQ13442814

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P356DOI10.1002/CHEM.201500774
P698PubMed publication ID25899388
P5875ResearchGate publication ID275363124

P2093author name stringDebabrata Maiti
Rajesh Kancherla
Togati Naveen
P2860cites workA farnesyltransferase inhibitor prevents both the onset and late progression of cardiovascular disease in a progeria mouse modelQ24657266
Fragment-based ligand design of novel potent inhibitors of tankyrasesQ27684619
Phase III trial of gemcitabine plus tipifarnib compared with gemcitabine plus placebo in advanced pancreatic cancerQ33360410
Second generation analogues of the cancer drug clinical candidate tipifarnib for anti-Chagas disease drug discovery.Q33879398
Cationic Pd(II)-catalyzed Fujiwara-Moritani reactions at room temperature in waterQ34108251
Aromatic substitution of olefins. VI. Arylation of olefins with palladium(II) acetateQ34535495
Farnesyl protein transferase inhibitor ZARNESTRA R115777 - history of a discoveryQ35137612
A mild, palladium-catalyzed method for the dehydrohalogenation of alkyl bromides: synthetic and mechanistic studiesQ36206042
Ligand-enabled methylene C(sp3)-H bond activation with a Pd(II) catalystQ36405081
Rational modification of a candidate cancer drug for use against Chagas diseaseQ37274008
Palladium(II)-catalyzed C-H activation/C-C cross-coupling reactions: versatility and practicalityQ37294999
Towards mild metal-catalyzed C-H bond activationQ37888484
Insights through AM1 calculations into the structural requirement of 3,4,6-substituted-2-quinolone analogs towards FMS kinase inhibitory activityQ38431503
Palladium-catalyzed aerobic dehydrogenation of substituted cyclohexanones to phenolsQ38468279
The synthesis and structure-activity relationships of 4-aryl-3-aminoquinolin-2-ones: a new class of calcium-dependent, large conductance, potassium (maxi-K) channel openers targeted for post-stroke neuroprotectionQ38522580
Selective activation of apoptosis by a novel set of 4-aryl-3-(3-aryl-1-oxo-2-propenyl)-2(1H)-quinolinones through a Myc-dependent pathwayQ39917196
Synthesis and in vitro anti-hepatitis B virus activities of 4-aryl-6-chloro-quinolin-2-one and 5-aryl-7-chloro-1,4-benzodiazepine derivativesQ39975359
Rh-Catalyzed decarbonylative coupling with alkynes via C-C activation of isatinsQ41558627
Allylic C-H acetoxylation with a 4,5-diazafluorenone-ligated palladium catalyst: a ligand-based strategy to achieve aerobic catalytic turnoverQ41970172
Pd-catalyzed aerobic oxidative coupling of arenes: evidence for transmetalation between two Pd(II)-aryl intermediatesQ42107834
Ligand-enabled triple C-H activation reactions: one-pot synthesis of diverse 4-aryl-2-quinolinones from propionamidesQ42753736
Design, synthesis, and activity of achiral analogs of 2-quinolones and indoles as non-thiol farnesyltransferase inhibitorsQ42816255
Ligand-controlled C(sp³)-H arylation and olefination in synthesis of unnatural chiral α-amino acidsQ42920887
Palladium-catalyzed intramolecular amidation of C(sp2)-H bonds: synthesis of 4-aryl-2-quinolinonesQ43072170
Synthesis and biological evaluation of new 1,2-dihydro-4-hydroxy-2-oxo-3-quinolinecarboxamides for treatment of autoimmune disorders: structure-activity relationshipQ44823676
Synthesis of 2-quinolones via palladium-catalyzed carbonylative annulation of internal alkynes by N-substituted o-iodoanilinesQ45074658
Iridium-catalyzed, intermolecular hydroamination of unactivated alkenes with indoles.Q45975888
Mechanism of Pd(OAc)2/pyridine catalyst reoxidation by O2: influence of labile monodentate ligands and identification of a biomimetic mechanism for O2 activation.Q46134647
On the interpretation of deuterium kinetic isotope effects in C-H bond functionalizations by transition-metal complexesQ46145223
Synthesis of beta-, gamma-, and delta-lactams via Pd(II)-catalyzed C-H activation reactionsQ46333074
Towards ideal synthesis: alkenylation of aryl C-H bonds by a Fujiwara-Moritani reaction.Q46472332
Regioselective Heck reaction of aliphatic olefins and aryl halidesQ46991296
4-Aryl-3-(hydroxyalkyl)quinolin-2-ones: novel maxi-K channel opening relaxants of corporal smooth muscle targeted for erectile dysfunctionQ48826377
3-Thio-quinolinone maxi-K openers for the treatment of erectile dysfunction.Q50671069
4-Aryl-3-(mercapto)quinolin-2-ones: novel maxi-K channel opening relaxants of corporal smooth muscle.Q50671437
Indirect ortho functionalization of substituted toluenes through ortho olefination of N,N-dimethylbenzylamines tuned by the acidity of reaction conditions.Q50682203
Practical route to 2-quinolinones via a Pd-catalyzed C-H bond activation/C-C bond formation/cyclization cascade reaction.Q50988873
Selective arylation and vinylation at the α position of vinylarenes.Q51274379
Intermolecular Mizoroki-Heck reaction of aliphatic olefins with high selectivity for substitution at the internal position.Q51371956
Palladium-catalyzed C-S activation/aryne insertion/coupling sequence: synthesis of functionalized 2-quinolinones.Q51745400
Copper-catalyzed domino cycloaddition/C-N coupling/cyclization/(C-H arylation): an efficient three-component synthesis of nitrogen polyheterocycles.Q53091018
Aromatic substitution of styrene-palladium chloride complexQ56482534
O2insertion into a palladium(ii)-hydride bond: Observation of mechanistic crossover between HX-reductive-elimination and hydrogen-atom-abstraction pathwaysQ58482024
P433issue23
P407language of work or nameEnglishQ1860
P304page(s)8360-8364
P577publication date2015-04-21
P1433published inChemistry—A European JournalQ898737
P1476titlePalladium-Catalyzed [3+3] Annulation between Diarylamines and α,β-Unsaturated Acids through CH Activation: Direct Access to 4-Substituted 2-Quinolinones
P478volume21

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Q61799838Palladium-Catalysed Synthesis and Transformation of Quinolonescites workP2860