Nucleotide binding to the multidrug resistance P-glycoprotein as studied by ESR spectroscopy

scientific article

Nucleotide binding to the multidrug resistance P-glycoprotein as studied by ESR spectroscopy is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1021/BI0512445
P698PubMed publication ID16229490

P50authorIna L UrbatschQ112180825
P2093author name stringPia D Vogel
Gregory Tombline
Sabine Delannoy
Alan E Senior
P2860cites workRETRACTED: Structure of the ABC transporter MsbA in complex with ADP.vanadate and lipopolysaccharideQ34418541
P433issue42
P407language of work or nameEnglishQ1860
P921main subjectmultiple drug resistanceQ643839
P304page(s)14010-14019
P577publication date2005-10-01
P1433published inBiochemistryQ764876
P1476titleNucleotide binding to the multidrug resistance P-glycoprotein as studied by ESR spectroscopy
P478volume44

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cites work (P2860)
Q34586418ABC multidrug transporters: structure, function and role in chemoresistance.
Q33748171Characterization of an asymmetric occluded state of P-glycoprotein with two bound nucleotides: implications for catalysis
Q38972586Cysteines introduced into extracellular loops 1 and 4 of human P-glycoprotein that are close only in the open conformation spontaneously form a disulfide bond that inhibits drug efflux and ATPase activity.
Q35668939Dynamic ligand-induced conformational rearrangements in P-glycoprotein as probed by fluorescence resonance energy transfer spectroscopy
Q45918162Effects of small molecule modulators on ATP binding to skeletal ryanodine receptor.
Q37012424Human P-glycoprotein contains a greasy ball-and-socket joint at the second transmission interface.
Q37653308Identification of the distance between the homologous halves of P-glycoprotein that triggers the high/low ATPase activity switch.
Q41909706In silico identified targeted inhibitors of P-glycoprotein overcome multidrug resistance in human cancer cells in culture
Q34573936In silico screening for inhibitors of p-glycoprotein that target the nucleotide binding domains
Q39957087Is ATP binding responsible for initiating drug translocation by the multidrug transporter ABCG2?
Q35181545Kinetic validation of the models for P-glycoprotein ATP hydrolysis and vanadate-induced trapping. Proposal for additional steps.
Q41848364Locking intracellular helices 2 and 3 together inactivates human P-glycoprotein.
Q43012033Nucleotide binding to the human multidrug resistance protein 3, MRP3.
Q46416788Nucleotide-induced structural changes in P-glycoprotein observed by electron microscopy.
Q34695826P-glycoprotein retains drug-stimulated ATPase activity upon covalent linkage of the two nucleotide binding domains at their C-terminal ends
Q48313444Shedding light on drug transport: structure and function of the P-glycoprotein multidrug transporter (ABCB1).
Q36852670Structural basis of p38α regulation by hematopoietic tyrosine phosphatase
Q36678114Structure of the cytosolic part of the subunit b-dimer of Escherichia coli F0F1-ATP synthase
Q36137412The ATPase activity of the P-glycoprotein drug pump is highly activated when the N-terminal and central regions of the nucleotide-binding domains are linked closely together
Q38873295The Transmission Interfaces Contribute Asymmetrically to the Assembly and Activity of Human P-glycoprotein
Q39850928The interaction between the measles virus nucleoprotein and the Interferon Regulator Factor 3 relies on a specific cellular environment
Q36354417The translocation mechanism of P-glycoprotein.
Q38663320Transmembrane segment 7 of human P-glycoprotein forms part of the drug-binding pocket
Q40312181Using a cysteine-less mutant to provide insight into the structure and mechanism of CFTR.

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