| scholarly article | Q13442814 |
| P50 | author | David M. Clarke | Q57542976 |
| Tip W. Loo | Q43098486 | ||
| P2093 | author name string | David M Clarke | |
| Tip W Loo | |||
| P2860 | cites work | Crystal structure of the multidrug transporter P-glycoprotein from Caenorhabditis elegans | Q27673547 |
| Refined structures of mouse P-glycoprotein | Q27680445 | ||
| Targeting multidrug resistance in cancer | Q29616803 | ||
| Structure of a bacterial multidrug ABC transporter | Q29617308 | ||
| A novel electron paramagnetic resonance approach to determine the mechanism of drug transport by P-glycoprotein | Q30309937 | ||
| Catalytic transitions in the human MDR1 P-glycoprotein drug binding sites | Q30518005 | ||
| Methanethiosulfonate derivatives of rhodamine and verapamil activate human P-glycoprotein at different sites | Q33193592 | ||
| Interaction of LDS-751 and rhodamine 123 with P-glycoprotein: evidence for simultaneous binding of both drugs | Q33225292 | ||
| Efficient inhibition of P-glycoprotein-mediated multidrug resistance with a monoclonal antibody | Q33611565 | ||
| Projection structure of P-glycoprotein by electron microscopy. Evidence for a closed conformation of the nucleotide binding domains | Q46808331 | ||
| Identification of putative binding sites of P-glycoprotein based on its homology model | Q46823202 | ||
| Catalytic cycle of ATP hydrolysis by P-glycoprotein: evidence for formation of the E.S reaction intermediate with ATP-gamma-S, a nonhydrolyzable analogue of ATP. | Q46910980 | ||
| The stabilities of various thiol compounds used in protein purifications | Q57479868 | ||
| Stereochemical modeling of disulfide bridges. Criteria for introduction into proteins by site-directed mutagenesis | Q69398900 | ||
| A method for the determination of inorganic phosphate in the presence of labile organic phosphate and high concentrations of protein: application to lens ATPases | Q69825502 | ||
| Role of the D-loops in allosteric control of ATP hydrolysis in an ABC transporter | Q83521766 | ||
| Biochemical, cellular, and pharmacological aspects of the multidrug transporter | Q33636699 | ||
| Characterization of an asymmetric occluded state of P-glycoprotein with two bound nucleotides: implications for catalysis | Q33748171 | ||
| Multidrug-resistance gene (P-glycoprotein) is expressed by endothelial cells at blood-brain barrier sites | Q33832954 | ||
| The drug transporter P-glycoprotein limits oral absorption and brain entry of HIV-1 protease inhibitors | Q34065800 | ||
| Formation and transfer of disulphide bonds in living cells | Q34157680 | ||
| Internal duplication and homology with bacterial transport proteins in the mdr1 (P-glycoprotein) gene from multidrug-resistant human cells. | Q34559072 | ||
| Expression of a full-length cDNA for the human "MDR1" gene confers resistance to colchicine, doxorubicin, and vinblastine | Q34620070 | ||
| P-glycoprotein retains drug-stimulated ATPase activity upon covalent linkage of the two nucleotide binding domains at their C-terminal ends | Q34695826 | ||
| Understanding polyspecificity of multidrug ABC transporters: closing in on the gaps in ABCB1 | Q35007411 | ||
| Conformational analysis of human ATP-binding cassette transporter ABCB1 in lipid nanodiscs and inhibition by the antibodies MRK16 and UIC2. | Q35604412 | ||
| Structure of a multidrug transporter | Q36083039 | ||
| Rhodamine inhibitors of P-glycoprotein: an amide/thioamide "switch" for ATPase activity | Q36103906 | ||
| The ATPase activity of the P-glycoprotein drug pump is highly activated when the N-terminal and central regions of the nucleotide-binding domains are linked closely together | Q36137412 | ||
| Evidence for two nonidentical drug-interaction sites in the human P-glycoprotein | Q36589430 | ||
| P-glycoprotein function involves conformational transitions detectable by differential immunoreactivity | Q36712329 | ||
| On the origin of large flexibility of P-glycoprotein in the inward-facing state | Q36967408 | ||
| Modulation of P-glycoprotein at the blood-brain barrier: opportunities to improve central nervous system pharmacotherapy | Q37080236 | ||
| ABC efflux pump-based resistance to chemotherapy drugs. | Q37543408 | ||
| Identification of the distance between the homologous halves of P-glycoprotein that triggers the high/low ATPase activity switch. | Q37653308 | ||
| Disulfide bonding in protein biophysics | Q37973761 | ||
| Mechanism of the ABC transporter ATPase domains: catalytic models and the biochemical and biophysical record | Q38058157 | ||
| Identification of residues in the drug translocation pathway of the human multidrug resistance P-glycoprotein by arginine mutagenesis | Q39828462 | ||
| Nucleotide binding, ATP hydrolysis, and mutation of the catalytic carboxylates of human P-glycoprotein cause distinct conformational changes in the transmembrane segments | Q40106045 | ||
| Rescue of DeltaF508 and other misprocessed CFTR mutants by a novel quinazoline compound | Q40367010 | ||
| The dileucine motif at the COOH terminus of human multidrug resistance P-glycoprotein is important for folding but not activity | Q40492449 | ||
| Substrate-induced conformational changes in the transmembrane segments of human P-glycoprotein. Direct evidence for the substrate-induced fit mechanism for drug binding. | Q40667534 | ||
| Cross-linking of human multidrug resistance P-glycoprotein by the substrate, tris-(2-maleimidoethyl)amine, is altered by ATP hydrolysis. Evidence for rotation of a transmembrane helix. | Q40795985 | ||
| Drug-stimulated ATPase activity of human P-glycoprotein is blocked by disulfide cross-linking between the nucleotide-binding sites. | Q40880583 | ||
| Covalent modification of human P-glycoprotein mutants containing a single cysteine in either nucleotide-binding fold abolishes drug-stimulated ATPase activity | Q41293154 | ||
| Rapid purification of human P-glycoprotein mutants expressed transiently in HEK 293 cells by nickel-chelate chromatography and characterization of their drug-stimulated ATPase activities. | Q41295094 | ||
| P-glycoprotein. Associations between domains and between domains and molecular chaperones | Q41295494 | ||
| P-glycoprotein Is Stably Inhibited by Vanadate-induced Trapping of Nucleotide at a Single Catalytic Site | Q41310191 | ||
| Membrane topology of a cysteine-less mutant of human P-glycoprotein | Q41380800 | ||
| Locking intracellular helices 2 and 3 together inactivates human P-glycoprotein. | Q41848364 | ||
| Processing mutations disrupt interactions between the nucleotide binding and transmembrane domains of P-glycoprotein and the cystic fibrosis transmembrane conductance regulator (CFTR). | Q41993227 | ||
| Drug rescue distinguishes between different structural models of human P-glycoprotein | Q42681206 | ||
| Relation between the turnover number for vinblastine transport and for vinblastine-stimulated ATP hydrolysis by human P-glycoprotein | Q42797493 | ||
| Human P-glycoprotein is active when the two halves are clamped together in the closed conformation | Q43098331 | ||
| Monoclonal antibody MRK16 reverses the multidrug resistance of multidrug-resistant transgenic mice | Q43843005 | ||
| Corrector VX-809 stabilizes the first transmembrane domain of CFTR. | Q44348057 | ||
| Simultaneous binding of two different drugs in the binding pocket of the human multidrug resistance P-glycoprotein | Q44543802 | ||
| Properties of P-glycoprotein with mutations in the "catalytic carboxylate" glutamate residues | Q45028072 | ||
| Nucleotide-induced structural changes in P-glycoprotein observed by electron microscopy. | Q46416788 | ||
| Nucleotide binding to the multidrug resistance P-glycoprotein as studied by ESR spectroscopy | Q46756646 | ||
| P433 | issue | 36 | |
| P407 | language of work or name | English | Q1860 |
| P304 | page(s) | 24749-24758 | |
| P577 | publication date | 2014-07-22 | |
| P1433 | published in | Journal of Biological Chemistry | Q867727 |
| P1476 | title | Cysteines introduced into extracellular loops 1 and 4 of human P-glycoprotein that are close only in the open conformation spontaneously form a disulfide bond that inhibits drug efflux and ATPase activity | |
| P478 | volume | 289 |
| Q36778842 | Identification of an Extracellular Gate for the Proton-coupled Folate Transporter (PCFT-SLC46A1) by Cysteine Cross-linking |
| Q43099273 | Mapping the Binding Site of the Inhibitor Tariquidar That Stabilizes the First Transmembrane Domain of P-glycoprotein. |
| Q93032460 | Reversal effect of FW-04-806, a macrolide dilactone compound, on multidrug resistance mediated by ABCB1 and ABCG2 in vitro and in vivo |
| Q36984552 | Thiol-Disulfide Exchange Reactions in the Mammalian Extracellular Environment |
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