The dileucine motif at the COOH terminus of human multidrug resistance P-glycoprotein is important for folding but not activity

scientific article

The dileucine motif at the COOH terminus of human multidrug resistance P-glycoprotein is important for folding but not activity is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1074/JBC.M411483200
P698PubMed publication ID15542593

P2093author name stringDavid M Clarke
M Claire Bartlett
Tip W Loo
P2860cites workDNA sequencing with chain-terminating inhibitorsQ22066207
A Golgi-associated PDZ domain protein modulates cystic fibrosis transmembrane regulator plasma membrane expressionQ24291900
A C-terminal motif found in the beta2-adrenergic receptor, P2Y1 receptor and cystic fibrosis transmembrane conductance regulator determines binding to the Na+/H+ exchanger regulatory factor family of PDZ proteinsQ24316901
ATP binding to the motor domain from an ABC transporter drives formation of a nucleotide sandwich dimerQ24602726
Cooperative, ATP-dependent association of the nucleotide binding cassettes during the catalytic cycle of ATP-binding cassette transportersQ24602798
The E. coli BtuCD structure: a framework for ABC transporter architecture and mechanismQ27638959
Identification of the cystic fibrosis gene: cloning and characterization of complementary DNAQ28119124
Accessory protein facilitated CFTR-CFTR interaction, a molecular mechanism to potentiate the chloride channel activityQ28142263
Multidrug resistance in cancer: role of ATP-dependent transportersQ28208049
Increased diffusional mobility of CFTR at the plasma membrane after deletion of its C-terminal PDZ binding motifQ33195731
A PDZ-interacting domain in CFTR is an apical membrane polarization signalQ33902133
Structure of MsbA from Vibrio cholera: a multidrug resistance ABC transporter homolog in a closed conformationQ34208379
Familial persistent hyperinsulinemic hypoglycemia of infancy and mutations in the sulfonylurea receptorQ34417118
Defective trafficking and function of KATP channels caused by a sulfonylurea receptor 1 mutation associated with persistent hyperinsulinemic hypoglycemia of infancyQ34502736
Internal duplication and homology with bacterial transport proteins in the mdr1 (P-glycoprotein) gene from multidrug-resistant human cells.Q34559072
The C terminus of SUR1 is required for trafficking of KATP channelsQ38322919
Transmembrane organization of mouse P-glycoprotein determined by epitope insertion and immunofluorescenceQ38358911
Identification and characterization of functionally important elements in the multidrug resistance protein 1 COOH-terminal regionQ40508859
The drug-binding pocket of the human multidrug resistance P-glycoprotein is accessible to the aqueous medium.Q40513676
Site-specific recombination: developments and applicationsQ40535474
Processing mutations located throughout the human multidrug resistance P-glycoprotein disrupt interactions between the nucleotide binding domains.Q40537131
Location of the rhodamine-binding site in the human multidrug resistance P-glycoprotein.Q40704865
PDZ domain interaction controls the endocytic recycling of the cystic fibrosis transmembrane conductance regulatorQ40712140
Introduction of the most common cystic fibrosis mutation (Delta F508) into human P-glycoprotein disrupts packing of the transmembrane segments.Q40724271
Identification and pharmacological correction of a membrane trafficking defect associated with a mutation in the sulfonylurea receptor causing familial hyperinsulinismQ40791919
Localization of sequences within the C-terminal domain of the cystic fibrosis transmembrane conductance regulator which impact maturation and stabilityQ40850802
Cystic fibrosis transmembrane conductance regulator has an altered structure when its maturation is inhibitedQ40891143
ATP hydrolysis cycles and mechanism in P-glycoprotein and CFTR.Q40891617
The transmembrane domains of the human multidrug resistance P-glycoprotein are sufficient to mediate drug binding and trafficking to the cell surface.Q40934272
Superfolding of the partially unfolded core-glycosylated intermediate of human P-glycoprotein into the mature enzyme is promoted by substrate-induced transmembrane domain interactions.Q41034671
The minimum functional unit of human P-glycoprotein appears to be a monomer.Q41155410
Rapid purification of human P-glycoprotein mutants expressed transiently in HEK 293 cells by nickel-chelate chromatography and characterization of their drug-stimulated ATPase activities.Q41295094
P-glycoprotein. Associations between domains and between domains and molecular chaperonesQ41295494
Membrane topology of a cysteine-less mutant of human P-glycoproteinQ41380800
Defective intracellular transport and processing of CFTR is the molecular basis of most cystic fibrosisQ41714520
Defining the drug-binding site in the human multidrug resistance P-glycoprotein using a methanethiosulfonate analog of verapamil, MTS-verapamilQ43560244
Determining the dimensions of the drug-binding domain of human P-glycoprotein using thiol cross-linking compounds as molecular rulersQ43717027
Sulfonylureas correct trafficking defects of ATP-sensitive potassium channels caused by mutations in the sulfonylurea receptorQ44715007
Identification of Residues within the Drug-binding Domain of the Human Multidrug Resistance P-glycoprotein by Cysteine-scanning Mutagenesis and Reaction with DibromobimaneQ57976930
Identification of Residues in the Drug-binding Domain of Human P-glycoproteinQ57976933
Correction of Defective Protein Kinesis of Human P-glycoprotein Mutants by Substrates and ModulatorsQ57976939
P433issue4
P407language of work or nameEnglishQ1860
P921main subjectmultiple drug resistanceQ643839
P304page(s)2522-2528
P577publication date2004-11-12
P1433published inJournal of Biological ChemistryQ867727
P1476titleThe dileucine motif at the COOH terminus of human multidrug resistance P-glycoprotein is important for folding but not activity
P478volume280

Reverse relations

cites work (P2860)
Q37119826A conserved hydrophobic tetrad near the C terminus of the secretory Na+-K+-2Cl- cotransporter (NKCC1) is required for its correct intracellular processing
Q38972586Cysteines introduced into extracellular loops 1 and 4 of human P-glycoprotein that are close only in the open conformation spontaneously form a disulfide bond that inhibits drug efflux and ATPase activity.
Q35763112Dileucine and PDZ-binding motifs mediate synaptic adhesion-like molecule 1 (SALM1) trafficking in hippocampal neurons
Q36082562Distinct N-glycan glycosylation of P-glycoprotein isolated from the human uterine sarcoma cell line MES-SA/Dx5
Q36379776Insight in eukaryotic ABC transporter function by mutation analysis
Q39354491Natural Products as Alternative Choices for P-Glycoprotein (P-gp) Inhibition.
Q41993227Processing mutations disrupt interactions between the nucleotide binding and transmembrane domains of P-glycoprotein and the cystic fibrosis transmembrane conductance regulator (CFTR).
Q28509174RPN2 gene confers docetaxel resistance in breast cancer
Q38873295The Transmission Interfaces Contribute Asymmetrically to the Assembly and Activity of Human P-glycoprotein
Q43227854The cytoplasmic tail dileucine motif LL572 determines the glycosylation pattern of membrane-type 1 matrix metalloproteinase.
Q34745166The polarization of the G-protein activated potassium channel GIRK5 to the vegetal pole of Xenopus laevis oocytes is driven by a di-leucine motif

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