| review article | Q7318358 |
| scholarly article | Q13442814 |
| P356 | DOI | 10.1021/CR9000226 |
| P698 | PubMed publication ID | 19583429 |
| P50 | author | Frances J. Sharom | Q41198909 |
| P2093 | author name string | Paul D W Eckford | |
| P2860 | cites work | Inhibition of vinblastine efflux mediated by P-glycoprotein by grapefruit juice components in caco-2 cells | Q77578309 |
| P433 | issue | 7 | |
| P921 | main subject | chemotherapy | Q974135 |
| P304 | page(s) | 2989-3011 | |
| P577 | publication date | 2009-07-01 | |
| P1433 | published in | Chemical Reviews | Q900502 |
| P1476 | title | ABC efflux pump-based resistance to chemotherapy drugs | |
| P478 | volume | 109 |
| Q86177360 | 6,7-Dimethoxy-2-{2-[4-(1H-1,2,3-triazol-1-yl)phenyl]ethyl}-1,2,3,4-tetrahydroisoquinolines as superior reversal agents for P-glycoprotein-mediated multidrug resistance |
| Q28476421 | A gene optimization strategy that enhances production of fully functional P-glycoprotein in Pichia pastoris |
| Q33912745 | A high throughput flow cytometric assay platform targeting transporter inhibition |
| Q39604692 | A new ATP-binding cassette protein is involved in intracellular haem trafficking in Leishmania |
| Q30503884 | A novel non-natural nucleoside that influences P-glycoprotein activity and mediates drug resistance |
| Q40790212 | A salt bridge in intracellular loop 2 is essential for folding of human p-glycoprotein. |
| Q34393952 | A selective ATP-binding cassette subfamily G member 2 efflux inhibitor revealed via high-throughput flow cytometry |
| Q55278614 | Advancements in the oral delivery of Docetaxel: challenges, current state-of-the-art and future trends. |
| Q34661740 | An asymmetric post-hydrolysis state of the ABC transporter ATPase dimer. |
| Q49108887 | An intracellular anchor regulates the distribution of bioactive molecules. |
| Q33275167 | An overview of the role of cancer stem cells in spine tumors with a special focus on chordoma |
| Q39308117 | Analysis of bypass signaling in EGFR pathway and profiling of bypass genes for predicting response to anticancer EGFR tyrosine kinase inhibitors |
| Q52730308 | Anticancer evaluation and molecular modeling of multi-targeted kinase inhibitors based pyrido[2,3-d]pyrimidine scaffold. |
| Q64099153 | Antiproliferative Aspidosperma-Type Monoterpenoid Indole Alkaloids from Inhibit Tubulin Polymerization |
| Q36509179 | Antitumor Agents 291 Expanded B-Ring Modification Study of 6,8,8-Triethyl Desmosdumotin B Analogues as Multidrug-Resistance Selective Agents |
| Q34153747 | Antitumor Agents. 280. Multidrug Resistance-Selective Desmosdumotin B Analogues |
| Q39596096 | Aurones as modulators of ABCG2 and ABCB1: synthesis and structure-activity relationships |
| Q38162494 | Basics and recent advances in peptide and protein drug delivery |
| Q27026080 | Biophysics of cell membrane lipids in cancer drug resistance: Implications for drug transport and drug delivery with nanoparticles |
| Q64066866 | Breast Tumor Cells Highly Resistant to Drugs Are Controlled Only by the Immune Response Induced in an Immunocompetent Mouse Model |
| Q42735675 | Cancer stem cell subsets and their relationships |
| Q30454423 | Catalytic and transport cycles of ABC exporters |
| Q51067255 | Cationic oligo(p-phenylene vinylene) materials for combating drug resistance of cancer cells by light manipulation. |
| Q64174494 | Cationic pillar[6]arene/ATP host-guest recognition: selectivity, inhibition of ATP hydrolysis, and application in multidrug resistance treatment |
| Q38803576 | Caveolin-1 affects tumor drug resistance in esophageal squamous cell carcinoma by regulating expressions of P-gp and MRP1. |
| Q37087781 | Cell-selective biological activity of rhodium metalloinsertors correlates with subcellular localization |
| Q36161028 | Changes in the intestinal absorption mechanism of icariin in the nanocavities of cyclodextrins |
| Q28478263 | Characterization of Abcc4 gene amplification in stepwise-selected mouse J774 macrophages resistant to the topoisomerase II inhibitor ciprofloxacin |
| Q33748171 | Characterization of an asymmetric occluded state of P-glycoprotein with two bound nucleotides: implications for catalysis |
| Q88687685 | Characterization of carfilzomib-resistant non-small cell lung cancer cell lines |
| Q54298598 | Characterization of human colorectal cancer MDR1/P-gp Fab antibody. |
| Q53792034 | Charge is Major Determinant of Activation of the Ligand-Responsive Multidrug Resistance Gene Regulator, BmrR. |
| Q50043617 | Coarse-grained molecular dynamics simulations reveal lipid access pathways in P-glycoprotein. |
| Q37612789 | Complex Interplay between the P-Glycoprotein Multidrug Efflux Pump and the Membrane: Its Role in Modulating Protein Function |
| Q91652201 | Conformational changes in a multidrug resistance ABC transporter DrrAB: Fluorescence-based approaches to study substrate binding |
| Q53074496 | Conformational dynamics in binding-protein-independent mutant of the Escherichia coli maltose transporter, MalG511 and its interaction with maltose binding protein. |
| Q42773508 | Construction and application of a Rh-Pt DNA metalloinsertor conjugate |
| Q37037938 | Crocin suppresses multidrug resistance in MRP overexpressing ovarian cancer cell line |
| Q28078369 | Curcumin as a Modulator of P-Glycoprotein in Cancer: Challenges and Perspectives |
| Q38972586 | Cysteines introduced into extracellular loops 1 and 4 of human P-glycoprotein that are close only in the open conformation spontaneously form a disulfide bond that inhibits drug efflux and ATPase activity. |
| Q39693239 | Design and synthesis of Selenazole-containing peptides for cocrystallization with P-glycoprotein. |
| Q52681086 | Design, synthesis and biological evaluation of novel peptides as potential agents with anti-tumor and multidrug resistance-reversing activities. |
| Q51688651 | Design, synthesis, biological evaluation, NMR and DFT studies of structurally simplified trimethoxy benzamides as selective P-glycoprotein inhibitors: the role of molecular flatness. |
| Q42231090 | Determining P-glycoprotein-drug interactions: evaluation of reconstituted P-glycoprotein in a liposomal system and LLC-MDR1 polarized cell monolayers |
| Q35384689 | Development of a novel class of tubulin inhibitor from desmosdumotin B with a hydroxylated bicyclic B-ring |
| Q37658420 | Development of purine-derived 18F-labeled pro-drug tracers for imaging of MRP1 activity with PET. |
| Q36893304 | Different administration strategies with paclitaxel induce distinct phenotypes of multidrug resistance in breast cancer cells |
| Q33814552 | Direct assessment of P-glycoprotein efflux to determine tumor response to chemotherapy. |
| Q33802134 | Directed evolution of P-glycoprotein cysteines reveals site-specific, non-conservative substitutions that preserve multidrug resistance. |
| Q35152093 | Distinct conformational spectrum of homologous multidrug ABC transporters |
| Q38243039 | Diversity in ABC transporters: type I, II and III importers |
| Q53595926 | Do adsorbed drugs onto P-glycoprotein influence its efflux capability? |
| Q57436538 | Dodging Drug-Resistant Cancer with Diamonds |
| Q42681206 | Drug rescue distinguishes between different structural models of human P-glycoprotein |
| Q38342677 | Drug transporters in the central nervous system |
| Q38939076 | Dual effects of quercetin in doxorubicin-induced nephrotoxicity in rats and its modulation of the cytotoxic activity of doxorubicin on human carcinoma cells. |
| Q38796974 | Dual-Functional Nanographene Oxide as Cancer-Targeted Drug-Delivery System to Selectively Induce Cancer-Cell Apoptosis |
| Q35308685 | Engineering polymeric aptamers for selective cytotoxicity. |
| Q64279874 | Enhanced expression of ten-eleven translocation 1 reverses gemcitabine resistance in cholangiocarcinoma accompanied by a reduction in P-glycoprotein expression |
| Q35100733 | Epirubicin-adsorbed nanodiamonds kill chemoresistant hepatic cancer stem cells |
| Q97524878 | Erdafitinib Antagonizes ABCB1-Mediated Multidrug Resistance in Cancer Cells |
| Q39885064 | Evidence against a role of P-glycoprotein in the clearance of the Alzheimer's disease Aβ1-42 peptides |
| Q33866011 | Exploring the cellular accumulation of metal complexes |
| Q83906120 | Flow cytometry-based assessment of mitoxantrone efflux from leukemic blasts varies with response to induction chemotherapy in acute myeloid leukemia |
| Q34613849 | Fluorescent substrates for flow cytometric evaluation of efflux inhibition in ABCB1, ABCC1, and ABCG2 transporters |
| Q35130652 | Gemcitabine Cytotoxicity: Interaction of Efflux and Deamination |
| Q36594649 | Glucose Modulation Induces Lysosome Formation and Increases Lysosomotropic Drug Sequestration via the P-Glycoprotein Drug Transporter. |
| Q24300652 | Histone methyltransferase MLL1 regulates MDR1 transcription and chemoresistance |
| Q51709549 | HrtBA and menaquinones control haem homeostasis in Lactococcus lactis. |
| Q37012424 | Human P-glycoprotein contains a greasy ball-and-socket joint at the second transmission interface. |
| Q37653308 | Identification of the distance between the homologous halves of P-glycoprotein that triggers the high/low ATPase activity switch. |
| Q37708100 | Identification of the metabolic alterations associated with the multidrug resistant phenotype in cancer and their intercellular transfer mediated by extracellular vesicles |
| Q36108251 | Improving cancer chemotherapy with modulators of ABC drug transporters |
| Q37541732 | In silico analysis of the binding of anthelmintics to Caenorhabditis elegansP-glycoprotein 1. |
| Q41909706 | In silico identified targeted inhibitors of P-glycoprotein overcome multidrug resistance in human cancer cells in culture |
| Q28833675 | Induction of P-glycoprotein expression and activity by Aconitum alkaloids: Implication for clinical drug-drug interactions |
| Q37964754 | Inflammation-mediated changes in drug transporter expression/activity: implications for therapeutic drug response |
| Q47562583 | Inhibit or Evade Multidrug Resistance P-Glycoprotein in Cancer Treatment. |
| Q38150978 | Interaction of the efflux transporters ABCB1 and ABCG2 with imatinib, nilotinib, and dasatinib. |
| Q35708089 | Interactions between antidepressants and P-glycoprotein at the blood-brain barrier: clinical significance of in vitro and in vivo findings |
| Q38698576 | Investigating Structural Requirements for the Antiproliferative Activity of Biphenyl Nicotinamides. |
| Q39291649 | Investigating cellular responses to novel chemotherapeutics in renal cell carcinoma using SR-FTIR spectroscopy |
| Q38001734 | Investigational ABC transporter inhibitors |
| Q92820975 | Ivermectin-induced changes in the expression of cytochromes P450 and efflux transporters in Haemonchus contortus female and male adults |
| Q35181545 | Kinetic validation of the models for P-glycoprotein ATP hydrolysis and vanadate-induced trapping. Proposal for additional steps. |
| Q41848364 | Locking intracellular helices 2 and 3 together inactivates human P-glycoprotein. |
| Q37708834 | Low expression of miR-381 is a favorite prognosis factor and enhances the chemosensitivity of osteosarcoma |
| Q33860877 | MDM2 antagonist nutlin-3a reverses mitoxantrone resistance by inhibiting breast cancer resistance protein mediated drug transport |
| Q37566253 | Marine natural products with P-glycoprotein inhibitor properties |
| Q38058157 | Mechanism of the ABC transporter ATPase domains: catalytic models and the biochemical and biophysical record |
| Q46088676 | Mechanisms of Drug Resistance in Cancer: The Role of Extracellular Vesicles |
| Q34167090 | Metadherin interference inhibits proliferation and enhances chemo-sensitivity to doxorubicin in diffuse large B cell lymphoma |
| Q51598522 | Method to Screen Multidrug Transport Inhibitors Using Yeast Overexpressing a Human MDR Transporter. |
| Q98471206 | MiR-93 suppresses tumorigenesis and enhances chemosensitivity of breast cancer via dual targeting E2F1 and CCND1 |
| Q91644097 | Midostaurin Reverses ABCB1-Mediated Multidrug Resistance, an in vitro Study |
| Q34411540 | Modification of marine natural product ningalin B and SAR study lead to potent P-glycoprotein inhibitors |
| Q38339772 | Molecular basis of the polyspecificity of P-glycoprotein (ABCB1): recent biochemical and structural studies |
| Q44488182 | Molecular insight into conformational transmission of human P-glycoprotein. |
| Q37685914 | Multifunctional Nanographene Oxide for Targeted Gene-Mediated Thermochemotherapy of Drug-resistant Tumour |
| Q27301793 | Multiple Drug Transport Pathways through Human P-Glycoprotein |
| Q33739302 | Multivalent peptidic linker enables identification of preferred sites of conjugation for a potent thialanstatin antibody drug conjugate |
| Q42370180 | Mycoplasma-associated multidrug resistance of hepatocarcinoma cells requires the interaction of P37 and Annexin A2. |
| Q39578651 | Nanodiamond therapeutic delivery agents mediate enhanced chemoresistant tumor treatment |
| Q36355946 | Natural paniceins from mediterranean sponge inhibit the multidrug resistance activity of Patched and increase chemotherapy efficiency on melanoma cells |
| Q64255413 | Newly Synthesized Oxygenated Xanthones as Potential P-Glycoprotein Activators: , , and Studies |
| Q36459196 | Odyssey of a cancer nanoparticle: from injection site to site of action |
| Q34233172 | Oncogene-specific formation of chemoresistant murine hepatic cancer stem cells |
| Q38877337 | Optimizing the macrocyclic diterpenic core toward the reversal of multidrug resistance in cancer |
| Q59135870 | Ovarian hormones modulate multidrug resistance transporters in the ovary |
| Q35987083 | Over-expression of Thioredoxin-1 mediates growth, survival, and chemoresistance and is a druggable target in diffuse large B-cell lymphoma |
| Q93007127 | Overcoming Resistance to Platinum-Based Drugs in Ovarian Cancer by Salinomycin and Its Derivatives-An In Vitro Study |
| Q37954295 | Overcoming multidrug resistance in human cancer cells by natural compounds |
| Q36397699 | Overcoming multidrug-resistance in vitro and in vivo using the novel P-glycoprotein inhibitor 1416 |
| Q57798467 | Overexpression of HIF-1α contributes to melphalan resistance in multiple myeloma cells by activation of ERK1/2, Akt, and NF-κB |
| Q52723564 | Overexpression of the ABC transporter AvtAB increases avermectin production in Streptomyces avermitilis. |
| Q36699096 | P-glycoprotein is fully active after multiple tryptophan substitutions |
| Q37732337 | P-glycoprotein related drug interactions: clinical importance and a consideration of disease states |
| Q39508030 | Peptide-chlorambucil conjugates combat pgp-dependent drug efflux |
| Q27014176 | Polymer nanogels: a versatile nanoscopic drug delivery platform |
| Q39233284 | Predicting Chemotherapy Resistance in AML. |
| Q30409962 | Proteins that bind and move lipids: MsbA and NPC1. |
| Q51330694 | Quantitative evaluation of ABC transporter-mediated drug resistance based on the determination of the anticancer activity of camptothecin against breast cancer stem cells using TIRF. |
| Q38804090 | RANK-RANKL interactions are involved in cell adhesion-mediated drug resistance in multiple myeloma cell lines |
| Q37869444 | Recent attempts at RNAi-mediated P-glycoprotein downregulation for reversal of multidrug resistance in cancer |
| Q38718358 | Redox-Activatable ATP-Depleting Micelles with Dual Modulation Characteristics for Multidrug-Resistant Cancer Therapy. |
| Q64100479 | Regulation of P-glycoprotein by Bajijiasu in vitro and in vivo by activating the Nrf2-mediated signalling pathway |
| Q89818966 | Replacing the eleven native tryptophans by directed evolution produces an active P-glycoprotein with site-specific, non-conservative substitutions |
| Q38055067 | Reversal of ATP-binding cassette drug transporter activity to modulate chemoresistance: why has it failed to provide clinical benefit? |
| Q37709400 | Reversible dimers of the atypical antipsychotic quetiapine inhibit p-glycoprotein-mediated efflux in vitro with increased binding affinity and in situ at the blood-brain barrier. |
| Q39485731 | Self-Assembling Doxorubicin Prodrug Forming Nanoparticles and Effectively Reversing Drug Resistance In Vitro and In Vivo |
| Q37573748 | Simultaneous delivery of anti-miR21 with doxorubicin prodrug by mimetic lipoprotein nanoparticles for synergistic effect against drug resistance in cancer cells |
| Q39426133 | Single-vesicle estimation of ATP-binding cassette transporters in microfluidic channels |
| Q35167707 | Snapshots of ligand entry, malleable binding and induced helical movement in P-glycoprotein |
| Q89660212 | Sterically Stabilised Polymeric Mesoporous Silica Nanoparticles Improve Doxorubicin Efficiency: Tailored Cancer Therapy |
| Q33577108 | Structural basis of inhibition of lipid-linked oligosaccharide flippase PglK by a conformational nanobody |
| Q53835459 | Structural model, functional modulation by ivermectin and tissue localization of Haemonchus contortus P-glycoprotein-13. |
| Q27679289 | Structures of P-glycoprotein reveal its conformational flexibility and an epitope on the nucleotide-binding domain |
| Q28477594 | Structuring detergents for extracting and stabilizing functional membrane proteins |
| Q47669250 | Substrate-induced conformational changes in the nucleotide-binding domains of lipid bilayer-associated P-glycoprotein during ATP hydrolysis |
| Q93184868 | Synthesis and antitumor activity of novel pyridinium fullerene derivatives |
| Q52684130 | Synthesis and biological evaluation of novel aliphatic acid-conjugated antimicrobial peptides as potential agents with anti-tumor, multidrug resistance-reversing activity and enhanced stability. |
| Q48121843 | Synthesis and biological evaluation of novel peptides based on antimicrobial peptides as potential agents with antitumor and multidrug resistance-reversing activities. |
| Q34796487 | Synthesis and biological evaluation of pentacyclic strychnos alkaloids as selective modulators of the ABCC10 (MRP7) efflux pump |
| Q58605028 | Synthesis and evaluation of an AZD2461 [F]PET probe in non-human primates reveals the PARP-1 inhibitor to be non-blood-brain barrier penetrant |
| Q48170548 | Synthesis of a Fluorescent Analogue of Paclitaxel That Selectively Binds Microtubules and Sensitively Detects Efflux by P-Glycoprotein |
| Q48199383 | Synthesis of an Orthogonally Protected Polyhydroxylated Cyclopentene from l-Sorbose |
| Q36709245 | Targeted delivery of doxorubicin through conjugation with EGF receptor-binding peptide overcomes drug resistance in human colon cancer cells |
| Q47726651 | Targeted inhibitors of P-glycoprotein increase chemotherapeutic-induced mortality of multidrug resistant tumor cells |
| Q33763765 | Targeting the Achilles heel of multidrug-resistant cancer by exploiting the fitness cost of resistance |
| Q39379394 | Telomerase and drug resistance in cancer. |
| Q58854476 | Terpenoids from Maytenus Species and Assessment of Their Reversal Activity against a Multidrug-Resistant Leishmania tropica Line |
| Q36137412 | The ATPase activity of the P-glycoprotein drug pump is highly activated when the N-terminal and central regions of the nucleotide-binding domains are linked closely together |
| Q37941756 | The P-glycoprotein multidrug transporter. |
| Q59329173 | The effects of crocetin, extracted from saffron, in chemotherapy against the incidence of multiple drug resistance phenotype |
| Q38152293 | The network of P-glycoprotein and microRNAs interactions |
| Q37760941 | The permeability P-glycoprotein: a focus on enantioselectivity and brain distribution |
| Q39196784 | The therapeutic potential of targeting ABC transporters to combat multi-drug resistance. |
| Q39326387 | Thiorhodamines containing amide and thioamide functionality as inhibitors of the ATP-binding cassette drug transporter P-glycoprotein (ABCB1). |
| Q36544451 | URGCP/URG4 promotes apoptotic resistance in bladder cancer cells by activating NF-κB signaling |
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| Q93007759 | Unraveling the journey of cancer stem cells from origin to metastasis |
| Q58697844 | VS-4718 Antagonizes Multidrug Resistance in ABCB1- and ABCG2-Overexpressing Cancer Cells by Inhibiting the Efflux Function of ABC Transporters |
| Q39620499 | Vascular effects dominate solid tumor response to treatment with combretastatin A-4-phosphate |
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