Design, synthesis, biological evaluation, NMR and DFT studies of structurally simplified trimethoxy benzamides as selective P-glycoprotein inhibitors: the role of molecular flatness.

scientific article published on 22 June 2016

Design, synthesis, biological evaluation, NMR and DFT studies of structurally simplified trimethoxy benzamides as selective P-glycoprotein inhibitors: the role of molecular flatness. is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1111/CBDD.12811
P698PubMed publication ID27331911

P50authorDomenico AlbergaQ56985710
Carlo AdamoQ57146241
Giuseppe Felice MangiatordiQ57163014
Orazio NicolottiQ42702402
P2093author name stringMauro Niso
Francesco Leonetti
Angela Stefanachi
Nicola Antonio Colabufo
Saverio Cellamare
Piero Tardia
P2860cites workUse of the Hydrophobic Substituent Constant in a Comparative Molecular Field Analysis (CoMFA) on a Set of Anilides Inhibiting the Hill ReactionQ58855859
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Structure-activity relationships, ligand efficiency, and lipophilic efficiency profiles of benzophenone-type inhibitors of the multidrug transporter P-glycoproteinQ39373185
Potent galloyl-based selective modulators targeting multidrug resistance associated protein 1 and P-glycoproteinQ39438136
Multi-drug-resistance-reverting agents: 2-aryloxazole and 2-arylthiazole derivatives as potent BCRP or MRP1 inhibitorsQ39895966
4-Biphenyl and 2-naphthyl substituted 6,7-dimethoxytetrahydroisoquinoline derivatives as potent P-gp modulatorsQ40012957
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The role of ligand efficiency metrics in drug discovery.Q53297758
P433issue6
P921main subjectmolecular designQ55213915
P304page(s)820-831
P577publication date2016-06-22
P1433published inChemical Biology and Drug DesignQ15749458
P1476titleDesign, synthesis, biological evaluation, NMR and DFT studies of structurally simplified trimethoxy benzamides as selective P-glycoprotein inhibitors: the role of molecular flatness.
P478volume88

Reverse relations

Q38698576Investigating Structural Requirements for the Antiproliferative Activity of Biphenyl Nicotinamides.cites workP2860