Cancer-associated fibroblasts enhance metastatic potential of lung cancer cells through IL-6/STAT3 signaling pathway

scientific article published on 28 June 2017

Cancer-associated fibroblasts enhance metastatic potential of lung cancer cells through IL-6/STAT3 signaling pathway is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.18632/ONCOTARGET.18814
P932PMC publication ID5652691
P698PubMed publication ID29100297

P2093author name stringKe Xu
Qinghua Zhou
Limin Wang
Huimin Wang
Limin Cao
Xiang Wu
Qicheng Zhang
Zhaowei Meng
Boning Liu
P2860cites workIsothiocyanates induce oxidative stress and suppress the metastasis potential of human non-small cell lung cancer cellsQ21261317
Epithelial-to-endothelial transition and cancer stem cells: two cornerstones of vasculogenic mimicry in malignant tumorsQ26749164
Tumor-stroma interaction: Revealing fibroblast-secreted exosomes as potent regulators of Wnt-planar cell polarity signaling in cancer metastasisQ26830701
Cancer incidence and mortality worldwide: sources, methods and major patterns in GLOBOCAN 2012Q27861047
TGF-β Negatively Regulates CXCL1 Chemokine Expression in Mammary Fibroblasts through Enhancement of Smad2/3 and Suppression of HGF/c-Met Signaling MechanismsQ28547113
Fibroblasts in cancerQ29547753
Lung cancerQ29615473
Microenvironmental regulation of tumor progression and metastasisQ29615504
Prognostic gene-expression signature of carcinoma-associated fibroblasts in non-small cell lung cancerQ30499935
Synthesis and secretion of platelet-derived growth factor by human breast cancer cell linesQ34339034
Autocrine TGF-beta and stromal cell-derived factor-1 (SDF-1) signaling drives the evolution of tumor-promoting mammary stromal myofibroblastsQ34358613
Cancer-Associated Fibroblasts Promote Proliferation of Endometrial Cancer CellsQ34901877
Matrix metalloproteinase (MMP)-9 in cancer-associated fibroblasts (CAFs) is suppressed by omega-3 polyunsaturated fatty acids in vitro and in vivoQ35107715
Contribution of microRNAs in understanding the pancreatic tumor microenvironment involving cancer associated stellate and fibroblast cellsQ35666501
TGFβ1 secreted by cancer-associated fibroblasts induces epithelial-mesenchymal transition of bladder cancer cells through lncRNA-ZEB2NAT.Q35830257
Crosstalk with cancer-associated fibroblasts induces resistance of non-small cell lung cancer cells to epidermal growth factor receptor tyrosine kinase inhibitionQ36365503
Overexpression of TGF-beta by infiltrated granulocytes correlates with the expression of collagen mRNA in pancreatic cancerQ36695742
Constitutive activation of STAT3 in breast cancer cells: A reviewQ36711689
Hierarchical paracrine interaction of breast cancer associated fibroblasts with cancer cells via hMAPK-microRNAs to drive ER-negative breast cancer phenotypeQ36838871
Cross-species functional analysis of cancer-associated fibroblasts identifies a critical role for CLCF1 and IL-6 in non-small cell lung cancer in vivo.Q37377875
Cancer-associated fibroblasts induce epithelial-mesenchymal transition of breast cancer cells through paracrine TGF-β signallingQ37559049
TIPE2 suppresses angiogenesis and non-small cell lung cancer (NSCLC) invasiveness via inhibiting Rac1 activation and VEGF expression.Q37641756
DDA suppresses angiogenesis and tumor growth of colorectal cancer in vivo through decreasing VEGFR2 signalingQ37665271
Molecular mechanisms of metastasis in breast cancer--clinical applicationsQ37801264
A humanized anti-IL-6 antibody (ALD518) in non-small cell lung cancerQ37945265
Interleukin-6 signaling pathway in targeted therapy for cancerQ38014987
Cancer-associated fibroblasts as another polarized cell type of the tumor microenvironmentQ38204745
Revisiting STAT3 signalling in cancer: new and unexpected biological functionsQ38262473
Proinflammatory cytokine interleukin-6 in prostate carcinogenesisQ38265575
Molecular mechanism underlying the tumor-promoting functions of carcinoma-associated fibroblasts.Q38354860
Interleukin-6 as an emerging regulator of renal cell cancerQ38571156
Antiangiogenic therapy in oncology: current status and future directionsQ38725587
Neurokinin-1 receptor mediated breast cancer cell migration by increased expression of MMP-2 and MMP-14.Q38753292
LATS2 as a poor prognostic marker regulates non-small cell lung cancer invasion by modulating MMPs expressionQ38755009
Cancer development, chemoresistance, epithelial to mesenchymal transition and stem cells: A snapshot of IL-6 mediated involvement.Q38762062
Cancer-associated fibroblasts promote hepatocellular carcinoma metastasis through chemokine-activated hedgehog and TGF-β pathwaysQ38769001
Estrogen receptor α in cancer associated fibroblasts suppresses prostate cancer invasion via reducing CCL5, IL6 and macrophage infiltration in the tumor microenvironmentQ38801346
Hepatic Carcinoma—Associated Fibroblasts Promote an Adaptative Response in Colorectal Cancer Cells That Inhibit Proliferation and Apoptosis: Nonresistant Cells Die by Nonapoptotic Cell DeathQ38826311
The biology and function of fibroblasts in cancerQ38828825
Cancer-associated fibroblasts promote angiogenesis in gastric cancer through galectin-1 expressionQ38839374
Concise Review: Stem Cells and Epithelial-Mesenchymal Transition in Cancer: Biological Implications and Therapeutic Targets.Q38850621
MiR-26a enhances metastasis potential of lung cancer cells via AKT pathway by targeting PTENQ39299200
Control of tumor and microenvironment cross-talk by miR-15a and miR-16 in prostate cancerQ39550421
Differences between CAFs and their paired NCF from adjacent colonic mucosa reveal functional heterogeneity of CAFs, providing prognostic informationQ41135217
Pulmonary Fibroblasts Induce Epithelial Mesenchymal Transition and Some Characteristics of Stem Cells in Non-Small Cell Lung CancerQ44736647
Benzodithiophenes potentiate differentiation of acute promyelocytic leukemia cells by lowering the threshold for ligand-mediated corepressor/coactivator exchange with retinoic acid receptor alpha and enhancing changes in all-trans-retinoic acid-reguQ46685705
Simultaneous blocking of IL-6 and IL-8 is sufficient to fully inhibit CAF-induced human melanoma cell invasivenessQ51361969
Transforming growth factor-beta1 induces desmoplasia in an experimental model of human pancreatic carcinomaQ60609781
P433issue44
P407language of work or nameEnglishQ1860
P921main subjectcancer-associated fibroblastQ42417562
metastatic potentialQ122615215
P304page(s)76116-76128
P577publication date2017-06-28
P1433published inOncotargetQ1573155
P1476titleCancer-associated fibroblasts enhance metastatic potential of lung cancer cells through IL-6/STAT3 signaling pathway
P478volume8

Reverse relations

cites work (P2860)
Q55655406Bone Marrow Adipocyte: An Intimate Partner With Tumor Cells in Bone Metastasis.
Q58101680Cancer Associated Fibroblasts: Naughty Neighbors That Drive Ovarian Cancer Progression
Q92565907Cancer associated fibroblasts are distinguishable from peri-tumor fibroblasts by biological characteristics in TSCC
Q64062565Cancer-associated fibroblasts contribute to cisplatin resistance by modulating ANXA3 in lung cancer cells
Q89285980Cancer-associated fibroblasts enhance cell proliferation and metastasis of colorectal cancer SW480 cells by provoking long noncoding RNA UCA1
Q64236929Cancer-associated fibroblasts induce epithelial-mesenchymal transition of bladder cancer cells through paracrine IL-6 signalling
Q64057515Collagens and Cancer associated fibroblasts in the reactive stroma and its relation to Cancer biology
Q58765211Downregulation of hypermethylated in cancer-1 by - promotes adriamycin resistance in breast cancer cells
Q64944634Expression of Immune System-Related Membrane Receptors CD40, RANK, BAFFR and LTβR is Associated with Clinical Outcome of Operated Non-Small-Cell Lung Cancer Patients.
Q52668325How to Hit Mesenchymal Stromal Cells and Make the Tumor Microenvironment Immunostimulant Rather Than Immunosuppressive.
Q59808317Humanization of the Prostate Microenvironment Reduces Homing of PC3 Prostate Cancer Cells to Human Tissue-Engineered Bone
Q90069409Liver sinusoidal endothelial cell ICAM-1 mediated tumor/endothelial crosstalk drives the development of liver metastasis by initiating inflammatory and angiogenic responses
Q92258941Ovatodiolide Suppresses Oral Cancer Malignancy by Down-Regulating Exosomal Mir-21/STAT3/β-Catenin Cargo and Preventing Oncogenic Transformation of Normal Gingival Fibroblasts
Q131604203Possible cancer-causing capacity of COVID-19: Is SARS-CoV-2 an oncogenic agent?
Q92114995Roles of omental and bone marrow adipocytes in tumor biology
Q57493684SSeCKS/Akap12 suppresses metastatic melanoma lung colonization by attenuating Src-mediated pre-metastatic niche crosstalk
Q60914167The Adaptive Complexity of Cancer
Q64268422The Interplay between MicroRNAs and Cellular Components of Tumour Microenvironment (TME) on Non-Small-Cell Lung Cancer (NSCLC) Progression
Q90043597The Metabolic Remodelling in Lung Cancer and Its Putative Consequence in Therapy Response
Q91839800The Metastasis Potential Promoting Capacity of Cancer-Associated Fibroblasts Was Attenuated by Cisplatin via Modulating KRT8
Q90372098The lung microenvironment: an important regulator of tumour growth and metastasis

Search more.