Protein kinase C isozymes and their selectivity towards ruboxistaurin

scientific article published in July 2008

Protein kinase C isozymes and their selectivity towards ruboxistaurin is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1002/PROT.21942
P698PubMed publication ID18214957

P50authorCatharine WhitesideQ113565363
P2093author name stringLakshmi P Kotra
Lianhu Wei
Sishi Tang
Victor Xiao
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Protein kinase C: structure, function, and regulationQ28618608
The hydrophobic phosphorylation motif of conventional protein kinase C is regulated by autophosphorylationQ28646394
Calculating structures and free energies of complex molecules: combining molecular mechanics and continuum modelsQ29616389
Phase II study of PKC-alpha antisense oligonucleotide aprinocarsen in combination with gemcitabine and carboplatin in patients with advanced non-small cell lung cancerQ33370385
What are the dielectric "constants" of proteins and how to validate electrostatic models?Q34325469
Crystal structure of the catalytic domain of human atypical protein kinase C-iota reveals interaction mode of phosphorylation site in turn motifQ34446130
Protein kinase C: structural and spatial regulation by phosphorylation, cofactors, and macromolecular interactionsQ34466011
Protein kinase C activation and the development of diabetic complicationsQ34469779
Potential new medical therapies for diabetic retinopathy: protein kinase C inhibitorsQ34626222
Mesangial cell protein kinase C isozyme activation in the diabetic milieuQ34629037
Regulation of the ABC kinases by phosphorylation: protein kinase C as a paradigmQ35031770
Selective protein kinase C inhibitors and their applicationsQ35610642
Ruboxistaurin, a protein kinase C beta inhibitor, as an emerging treatment for diabetes microvascular complicationsQ36256287
Electrostatic interactions in the GCN4 leucine zipper: substantial contributions arise from intramolecular interactions enhanced on bindingQ36281595
Activation of protein kinase C by tyrosine phosphorylation in response to H2O2.Q36590164
Regulation of membrane trafficking and endocytosis by protein kinase C: emerging role of the pericentrion, a novel protein kinase C-dependent subset of recycling endosomesQ36688504
Structural and functional diversities of a family of signal transducing protein kinases, protein kinase C family; two distinct classes of PKC, conventional cPKC and novel nPKC.Q37261630
Electrostatic interactions in macromolecules: theory and applicationsQ37938174
Free energy via molecular simulation: applications to chemical and biomolecular systemsQ38648060
Protein kinase Cdelta activation by interleukin-1beta stabilizes inducible nitric-oxide synthase mRNA in pancreatic beta-cellsQ40841049
Protein kinase C isozymes and substratesQ41099683
Regulation of protein kinase C.Q41382903
(S)-13-[(dimethylamino)methyl]-10,11,14,15-tetrahydro-4,9:16, 21-dimetheno-1H, 13H-dibenzo[e,k]pyrrolo[3,4-h][1,4,13]oxadiazacyclohexadecene-1,3(2H)-d ione (LY333531) and related analogues: isozyme selective inhibitors of protein kinase C betaQ42555309
Use of MM-PBSA in reproducing the binding free energies to HIV-1 RT of TIBO derivatives and predicting the binding mode to HIV-1 RT of efavirenz by docking and MM-PBSA.Q43678172
Synthesis, in vitro pharmacology, and molecular modeling of syn-huprines as acetylcholinesterase inhibitors.Q43821288
Potential tumor-selective nitroimidazolylmethyluracil prodrug derivatives: inhibitors of the angiogenic enzyme thymidine phosphorylase.Q44272700
Theoretical studies on the inhibition mechanism of cyclooxygenase-2. Is there a unique recognition site?Q44388134
Staurosporine: a prototype of a novel class of inhibitors of tumor cell invasion?Q44485095
Catalytic domain crystal structure of protein kinase C-theta (PKCtheta).Q45057148
Converging free energy estimates: MM-PB(GB)SA studies on the protein-protein complex Ras-Raf.Q45952403
Calculation and prediction of binding free energies for the matrix metalloproteinasesQ46980158
The intrinsic ATPase activity of protein kinase C is catalyzed at the active site of the enzymeQ48466812
Design of improved protein inhibitors of HIV-1 cell entry: Optimization of electrostatic interactions at the binding interface.Q50762559
A fast flexible docking method using an incremental construction algorithm.Q52298930
Parametrized Models of Aqueous Free Energies of Solvation Based on Pairwise Descreening of Solute Atomic Charges from a Dielectric MediumQ57402396
P433issue1
P407language of work or nameEnglishQ1860
P304page(s)447-460
P577publication date2008-07-01
P1433published inProteinsQ7251514
P1476titleProtein kinase C isozymes and their selectivity towards ruboxistaurin
P478volume72

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cites work (P2860)
Q27321219A small-molecule screen for enhanced homing of systemically infused cells
Q39349244Dual inhibition of classical protein kinase C-α and protein kinase C-β isoforms protects against experimental murine diabetic nephropathy.
Q51732685Inhibition of protein kinase C in diabetic nephropathy--where do we stand?
Q37992101Protein kinase C βII in diabetic complications: survey of structural, biological and computational studies
Q30391488Structural Models for the Design of PKMzeta Inhibitors with Neurobiological Indications
Q37399929Targeting the protein kinase C family in the diabetic kidney: lessons from analysis of mutant mice

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