Targeting β-catenin in hepatocellular cancers induced by coexpression of mutant β-catenin and K-Ras in mice

scientific article published on 16 December 2016

Targeting β-catenin in hepatocellular cancers induced by coexpression of mutant β-catenin and K-Ras in mice is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1002/HEP.28975
P932PMC publication ID5397318
P698PubMed publication ID27981621

P50authorSatdarshan P MongaQ88533584
P2093author name stringXin Chen
Rong Zhang
Michael Oertel
Minakshi Poddar
Shanthi Ganesh
Junyan Tao
Sucha Singh
Marc Abrams
Emily Xu
P2860cites workThe Ras-ERK and PI3K-mTOR pathways: cross-talk and compensationQ24616946
β-Catenin Signaling and Roles in Liver Homeostasis, Injury, and TumorigenesisQ28087660
Phosphorylation and functional inactivation of TSC2 by Erk implications for tuberous sclerosis and cancer pathogenesisQ28246808
Ras oncogenes: split personalitiesQ29615405
COSMIC: exploring the world's knowledge of somatic mutations in human cancerQ29615725
Annual Report to the Nation on the Status of Cancer, 1975-2012, featuring the increasing incidence of liver cancerQ30746254
Role of leukocyte cell-derived chemotaxin 2 as a biomarker in hepatocellular carcinomaQ33706930
Ras pathway activation in hepatocellular carcinoma and anti-tumoral effect of combined sorafenib and rapamycin in vivoQ34268708
Complete response of Ctnnb1-mutated tumours to β-catenin suppression by locked nucleic acid antisense in a mouse hepatocarcinogenesis modelQ34989670
SKP2 cooperates with N-Ras or AKT to induce liver tumor development in miceQ35273519
Oncogenic β-catenin triggers an inflammatory response that determines the aggressiveness of hepatocellular carcinoma in miceQ35698850
Mutant IDH inhibits HNF-4α to block hepatocyte differentiation and promote biliary cancerQ35842729
Exome sequencing of hepatocellular carcinomas identifies new mutational signatures and potential therapeutic targetsQ36104399
Glutamine synthetase activity fuels nucleotide biosynthesis and supports growth of glutamine-restricted glioblastoma.Q36330223
Integrative transcriptome analysis reveals common molecular subclasses of human hepatocellular carcinomaQ36547263
Postponing the Hypoglycemic Response to Partial Hepatectomy Delays Mouse Liver RegenerationQ36753754
Direct Pharmacological Inhibition of β-Catenin by RNA Interference in Tumors of Diverse OriginQ37231321
Beta-catenin regulates vitamin C biosynthesis and cell survival in murine liverQ37459941
Hydrodynamic transfection for generation of novel mouse models for liver cancer researchQ38183539
Nanotechnological carriers for cancer chemotherapy: the state of the art.Q38319607
The Ras/MAPK pathway and hepatocarcinoma: pathogenesis and therapeutic implicationsQ38400354
Genetic Landscape and Biomarkers of Hepatocellular Carcinoma.Q38534459
Glutamine depletion by crisantaspase hinders the growth of human hepatocellular carcinoma xenograftsQ38970692
β-catenin activation in a novel liver progenitor cell type is sufficient to cause hepatocellular carcinoma and hepatoblastomaQ38993024
AKT (v-akt murine thymoma viral oncogene homolog 1) and N-Ras (neuroblastoma ras viral oncogene homolog) coactivation in the mouse liver promotes rapid carcinogenesis by way of mTOR (mammalian target of rapamycin complex 1), FOXM1 (forkhead box M1)/Q39459058
L-Asparaginase and inhibitors of glutamine synthetase disclose glutamine addiction of β-catenin-mutated human hepatocellular carcinoma cells.Q39491727
The global decrease in cancer mortality: trends and disparities.Q40070789
Kras(G12D) and p53 mutation cause primary intrahepatic cholangiocarcinomaQ42045560
Accelerated liver regeneration and hepatocarcinogenesis in mice overexpressing serine-45 mutant beta-catenin.Q42182074
Conditional deletion of beta-catenin reveals its role in liver growth and regenerationQ42504022
Modeling a human hepatocellular carcinoma subset in mice through coexpression of met and point-mutant β-catenin.Q42711666
New targets of beta-catenin signaling in the liver are involved in the glutamine metabolismQ44226601
Ubiquitous activation of Ras and Jak/Stat pathways in human HCC.Q53347351
Differential effects of inactivated Axin1 and activated beta-catenin mutations in human hepatocellular carcinomasQ80238304
P433issue5
P407language of work or nameEnglishQ1860
P304page(s)1581-1599
P577publication date2017-02-06
P1433published inHepatologyQ15724398
P1476titleTargeting β-catenin in hepatocellular cancers induced by coexpression of mutant β-catenin and K-Ras in mice
P478volume65

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cites work (P2860)
Q64996715Axis inhibition protein 1 (Axin1) Deletion-Induced Hepatocarcinogenesis Requires Intact β-Catenin but Not Notch Cascade in Mice.
Q88072465Bromodomain and Extraterminal (BET) Proteins Regulate Hepatocyte Proliferation in Hepatocyte-Driven Liver Regeneration
Q90569988CyclinD1 inhibits dicer and crucial miRNA expression by chromatin modification to promote the progression of intrahepatic cholangiocarcinoma
Q49952320Efficacy of MEK inhibition in a K-Ras-driven cholangiocarcinoma preclinical model.
Q97426639Hepatoblastoma: current knowledge and promises from preclinical studies
Q100533943Maladaptive regeneration - the reawakening of developmental pathways in NASH and fibrosis
Q49433039Norcantharidin alone or in combination with crizotinib induces autophagic cell death in hepatocellular carcinoma by repressing c-Met-mTOR signaling
Q64097554Promotion of growth factor signaling as a critical function of β-catenin during HCC progression
Q64100898Silencing LGR6 Attenuates Stemness and Chemoresistance via Inhibiting Wnt/β-Catenin Signaling in Ovarian Cancer
Q50156185The Effect of Selective c-MET Inhibitor on Hepatocellular Carcinoma in the MET-Active, β-Catenin-Mutated Mouse Model
Q91754947The HGF-MET axis coordinates liver cancer metabolism and autophagy for chemotherapeutic resistance
Q52331269The transcription factor 7 like 2‑binding protein TIP5 activates β‑catenin/transcription factor signaling in hepatocellular carcinoma.
Q42513643Thyroid Hormone Receptor-β Agonist GC-1 Inhibits Met-β-Catenin-Driven Hepatocellular Cancer.
Q52782089WNTing no RASt for hepatocellular carcinoma.
Q93209106Wnt-β-catenin signalling in liver development, health and disease
Q50070375Wnt/β-Catenin Signaling in Liver Development, Homeostasis, and Pathobiology
Q91833707β-Catenin and Yes-Associated Protein 1 Cooperate in Hepatoblastoma Pathogenesis
Q49547317β-Catenin mRNA Silencing and MEK Inhibition Display Synergistic Efficacy in Preclinical Tumor Models

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