Synthesis and antiviral activities of 1,2,3-triazole functionalized thymidines: 1,3-dipolar cycloaddition for efficient regioselective diversity generation

scientific article

Synthesis and antiviral activities of 1,2,3-triazole functionalized thymidines: 1,3-dipolar cycloaddition for efficient regioselective diversity generation is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1177/095632020501600604
P698PubMed publication ID16331842
P5875ResearchGate publication ID7437460

P50authorErik De ClercqQ13578863
Jan BalzariniQ31332118
Adel AmerQ60607551
Paul F TorrenceQ116791662
P2093author name stringEarl R Kern
Longhu Zhou
Michael Korn
Robert Burda
P2860cites workA stepwise huisgen cycloaddition process: copper(I)-catalyzed regioselective "ligation" of azides and terminal alkynesQ28219495
9-(2-Phosphonylmethoxyethyl)adenine (PMEA) effectively inhibits retrovirus replication in vitro and simian immunodeficiency virus infection in rhesus monkeysQ28328373
Synthesis and biological activity of several amino analogues of thymidineQ28329976
Peptidotriazoles on solid phase: [1,2,3]-triazoles by regiospecific copper(i)-catalyzed 1,3-dipolar cycloadditions of terminal alkynes to azidesQ33958790
Synthesis of 3'-deoxy-3'-[4-(pyrimidin-1-yl)methyl-1,2,3-triazol-1-yl]thymidine via 1,3-dipolar cycloadditionQ40606641
A novel selective broad-spectrum anti-DNA virus agentQ40804246
1,2,3-Triazole-[2',5'-bis-O-(tert-butyldimethylsilyl)-beta-D- ribofuranosyl]-3'-spiro-5"-(4"-amino-1",2"-oxathiole 2",2"-dioxide) (TSAO) analogues: synthesis and anti-HIV-1 activityQ42275461
Synthesis of N3,5'-cyclo-4-(beta-D-ribofuranosyl)-vic-triazolo[4,5-b]pyridin-5-one, a novel compound with anti-hepatitis C virus activityQ42988824
Bioconjugation by copper(I)-catalyzed azide-alkyne [3 + 2] cycloadditionQ44358246
Adding amino acids with novel reactivity to the genetic code of Saccharomyces cerevisiaeQ44593485
Regioselective synthesis of 1,2,3-triazole derivatives via 1,3-dipolar cycloaddition reactions in waterQ44638108
1,2,4-Diazaphosphole nucleosides. Synthesis, structure, and antitumor activity of nucleosides with a lambda 3 phosphorus atomQ44747853
Determining the geometries of transition States by use of antihydrophobic additives in waterQ44983771
Mechanism of cysteine desulfurase Slr0387 from Synechocystis sp. PCC 6803: kinetic analysis of cleavage of the persulfide intermediate by chemical reductantsQ45067264
In situ click chemistry: enzyme inhibitors made to their own specificationsQ45093957
A chemoenzymatic approach to glycopeptide antibioticsQ45126062
Cell surface labeling of Escherichia coli via copper(I)-catalyzed [3+2] cycloadditionQ46077110
Copper(I)-catalyzed synthesis of azoles. DFT study predicts unprecedented reactivity and intermediatesQ46376078
Hydrophobic acceleration of Diels-Alder reactionsQ55968152
P433issue6
P921main subjectcycloadditionQ898648
P304page(s)375-383
P577publication date2005-01-01
P1433published inAntiviral Chemistry & ChemotherapyQ2853412
P1476titleSynthesis and antiviral activities of 1,2,3-triazole functionalized thymidines: 1,3-dipolar cycloaddition for efficient regioselective diversity generation
P478volume16

Reverse relations

cites work (P2860)
Q398845843'-(1,2,3-Triazol-1-yl)-3'-deoxythymidine analogs as substrates for human and Ureaplasma parvum thymidine kinase for structure-activity investigations.
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Q35064875Chemoenzymatic synthesis of 3'-deoxy-3'-(4-substituted-triazol-1-YL)-5-methyluridine
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Q56956039Cu(I)-Catalyzed Efficient Synthesis of 2′-Triazolo-nucleoside Conjugates
Q37341554Cu(I)-catalyzed Huisgen azide-alkyne 1,3-dipolar cycloaddition reaction in nucleoside, nucleotide, and oligonucleotide chemistry
Q39433884Design, synthesis, antiviral and cytostatic evaluation of novel isoxazolidine nucleotide analogues with a 1,2,3-triazole linker
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Q39064037The synthesis, antiviral, cytostatic and cytotoxic evaluation of a new series of acyclonucleotide analogues with a 1,2,3-triazole linker