Disinhibition opens the gate to pathological pain signaling in superficial neurokinin 1 receptor-expressing neurons in rat spinal cord.

scientific article published in February 2006

Disinhibition opens the gate to pathological pain signaling in superficial neurokinin 1 receptor-expressing neurons in rat spinal cord. is …
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scholarly articleQ13442814

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P356DOI10.1523/JNEUROSCI.4584-05.2006
P932PMC publication ID6793628
P698PubMed publication ID16467532

P50authorCarole TorsneyQ73193392
P2093author name stringAmy B MacDermott
P2860cites workAnalysis of fluorescently labeled substance P analogs: binding, imaging and receptor activationQ24799998
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Projection neurons in lamina I of rat spinal cord with the neurokinin 1 receptor are selectively innervated by substance p-containing afferents and respond to noxious stimulation.Q43999186
Partial peripheral nerve injury promotes a selective loss of GABAergic inhibition in the superficial dorsal horn of the spinal cord.Q44085191
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Spinal neurons that possess the substance P receptor are required for the development of central sensitization.Q44186001
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Neurokinin receptor 1-expressing spinal cord neurons in lamina I and III/IV of postnatal rats receive inputs from capsaicin sensitive fibersQ44660691
Removal of GABAergic inhibition facilitates polysynaptic A fiber-mediated excitatory transmission to the superficial spinal dorsal hornQ44686157
Electrophysiological characterisations of rat lamina I dorsal horn neurones and the involvement of excitatory amino acid receptorsQ44861674
Mechanical allodynia following contusion injury of the rat spinal cord is associated with loss of GABAergic inhibition in the dorsal hornQ44906074
Spinal neurons that express NK-1 receptors modulate descending controls that project through the dorsolateral funiculusQ45084899
Fos induction in lamina I projection neurons in response to noxious thermal stimuli.Q45244365
Morphological characterization of substance P receptor‐immunoreactive neurons in the rat spinal cord and trigeminal nucleus caudalisQ46090686
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Synaptic input of rat spinal lamina I projection and unidentified neurones in vitroQ46477227
Corelease of two fast neurotransmitters at a central synapse.Q47837764
A quantitative study of neurons which express neurokinin-1 or somatostatin sst2a receptor in rat spinal dorsal hornQ47987422
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Reorganization of the primary afferent termination in the rat spinal dorsal horn during post-natal developmentQ48271119
VR1-positive primary afferents contact NK1-positive spinoparabrachial neuronsQ48340488
Blocking caspase activity prevents transsynaptic neuronal apoptosis and the loss of inhibition in lamina II of the dorsal horn after peripheral nerve injury.Q48796677
Role of excitatory amino acid receptors in mono- and polysynaptic excitation in the cat spinal cordQ48857650
Alteration in synaptic inputs through C-afferent fibers to substantia gelatinosa neurons of the rat spinal dorsal horn during postnatal development.Q52164424
Inflammatory pain hypersensitivity mediated by phenotypic switch in myelinated primary sensory neurons.Q52198922
The contribution of GABAA and glycine receptors to central sensitization: disinhibition and touch-evoked allodynia in the spinal cord.Q52215885
Physiological properties of the lamina I spinoparabrachial neurons in the ratQ60679671
Behavioral and autonomic correlates of the tactile evoked allodynia produced by spinal glycine inhibition: effects of modulatory receptor systems and excitatory amino acid antagonistsQ69349896
The correlation between the distribution of the NK1 receptor and the actions of tachykinin agonists in the dorsal horn of the rat indicates that substance P does not have a functional role on substantia gelatinosa (lamina II) neuronsQ71662662
Receptor endocytosis and dendrite reshaping in spinal neurons after somatosensory stimulationQ71696623
The types of neuron in spinal dorsal horn which possess neurokinin-1 receptorsQ71706155
Spinoparabrachial tract neurons showing substance P receptor-like immunoreactivity in the lumbar spinal cord of the ratQ72346996
In vivo patch-clamp analysis of IPSCs evoked in rat substantia gelatinosa neurons by cutaneous mechanical stimulationQ73054571
Transmission of chronic nociception by spinal neurons expressing the substance P receptorQ73195551
Loss of GABA-immunoreactivity in the spinal dorsal horn of rats with peripheral nerve injury and promotion of recovery by adrenal medullary graftsQ73306331
Cells in laminae III and IV of the rat spinal cord that possess the neurokinin-1 receptor and have dorsally directed dendrites receive a major synaptic input from tachykinin-containing primary afferentsQ73470160
Neurokinin 1 receptor expression by neurons in laminae I, III and IV of the rat spinal dorsal horn that project to the brainstemQ73537433
Spinal lamina I neurons that express neurokinin 1 receptors: morphological analysisQ73755576
Inhibition of hyperalgesia by ablation of lamina I spinal neurons expressing the substance P receptorQ73763175
Activation of NMDA receptors drives action potentials in superficial dorsal horn from neonatal ratsQ73892213
Relationship of substance P to afferent characteristics of dorsal root ganglion neurones in guinea-pigQ73966403
Substance P receptor (neurokinin-1)-expressing neurons in lamina I of the spinal cord encode for the intensity of noxious stimulation: a c-Fos study in ratQ74529110
Cells in laminae III and IV of the rat spinal cord which possess the neurokinin-1 receptor receive monosynaptic input from myelinated primary afferentsQ77363124
Setting the tone: superficial dorsal horn projection neurons regulate pain sensitivityQ80579148
Abeta-fiber nociceptive primary afferent neurons: a review of incidence and properties in relation to other afferent A-fiber neurons in mammalsQ80820162
Neurokinin-1 receptors on lumbar spinothalamic neurons in the ratQ95825658
P433issue6
P407language of work or nameEnglishQ1860
P921main subjectDisinhibitionQ5282244
P304page(s)1833-1843
P577publication date2006-02-01
P1433published inJournal of NeuroscienceQ1709864
P1476titleDisinhibition opens the gate to pathological pain signaling in superficial neurokinin 1 receptor-expressing neurons in rat spinal cord
P478volume26

Reverse relations

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