In-vitro stability and metabolism of a tacrine-silibinin codrug

scientific article published on 29 April 2013

In-vitro stability and metabolism of a tacrine-silibinin codrug is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1111/JPHP.12070
P698PubMed publication ID24236987

P2093author name stringXinyu Chen
Michael Decker
Birgit Kraus
Katharina Zenger
P2860cites workMitochondrial dysfunction in the pathogenesis of necrotic and apoptotic cell deathQ33832682
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The mitochondrial permeability transition pore and its involvement in cell death and in disease pathogenesisQ36733673
Immortal activated human hepatic stellate cells generated by ectopic telomerase expressionQ38291132
Tacrine-silibinin codrug shows neuro- and hepatoprotective effects in vitro and pro-cognitive and hepatoprotective effects in vivoQ39342911
Clinical Pharmacokinetics of TacrineQ40472033
Tacrine-induced Reactive Oxygen Species in a Human Liver Cell Line: The Role of Anethole Dithiolethione as a ScavengerQ40938500
Noninterference of cytochrome P4501A2 in the cytotoxicity of tacrine using genetically engineered V79 Chinese hamster cells for stable expression of the human or rat isoform and two human hepatocyte cell linesQ41128196
Hybrid molecules from xanomeline and tacrine: enhanced tacrine actions on cholinesterases and muscarinic M1 receptorsQ43160965
Design and synthesis of tacrine-ferulic acid hybrids as multi-potent anti-Alzheimer drug candidatesQ46649408
Tacrine and its analogues impair mitochondrial function and bioenergetics: a lipidomic analysis in rat brain.Q48760407
Re-evaluation of tacrine hepatotoxicity using gel entrapped hepatocytes.Q50473483
Design, synthesis, biological properties, and molecular modeling investigations of novel tacrine derivatives with a combination of acetylcholinesterase inhibition and cannabinoid CB1 receptor antagonism.Q51775443
Tacrine. A cause of fatal hepatotoxicity?Q53221544
Alzheimer's diseaseQ55880664
P433issue12
P304page(s)1765-1772
P577publication date2013-04-29
P1433published inJournal of Pharmacy and PharmacologyQ10532762
P1476titleIn-vitro stability and metabolism of a tacrine-silibinin codrug
P478volume65