Clinical Pharmacokinetics of Tacrine

scientific article published on June 1, 1995

Clinical Pharmacokinetics of Tacrine is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

External links are
P6179Dimensions Publication ID1016507865
P356DOI10.2165/00003088-199528060-00003
P698PubMed publication ID7656503

P2093author name stringB. K. Park
S. Madden
V. Spaldin
P2860cites workEvaluation of HP 029 (Velnacrine Maleate) in Alzheimer's DiseaseaQ33296510
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Serum concentrations of tacrine hydrochloride predict its adverse effects in Alzheimer's diseaseQ34731347
Tacrine (tetrahydroaminoacridine; THA) and lecithin in senile dementia of the Alzheimer type: a multicentre trial. Groupe Français d'Etude de la TetrahydroaminoacridineQ35168053
The human hepatic cytochromes P450 involved in drug metabolismQ36258518
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THA--a review of the literature and its use in treatment of five overdose patientsQ40287766
Tacrine. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic efficacy in Alzheimer's diseaseQ40392124
Open trial of tacrine therapy in 70 HIV-infected patients.Q41893410
Hepatotoxic effects of tacrine administration in patients with Alzheimer's diseaseQ42603612
Measurements of tacrine and monoamines in brain by in vivo microdialysis argue against release of monoamines by tacrine at therapeutic dosesQ42713800
Pharmacokinetics of tetrahydroaminoacridine: relations to clinical and biochemical effects in Alzheimer patientsQ43852948
Comparison of the chromatographic characteristics of metabolites of tacrine hydrochloride in human serum and urine with those of in vitro metabolic products from hepatic microsomesQ44091007
A controlled trial of tacrine in Alzheimer's disease. The Tacrine Study GroupQ44110810
Distribution of tacrine across the blood-brain barrier in awake, freely moving rats using in vivo microdialysis samplingQ48360983
A double-blind, placebo-controlled multicenter study of tacrine for Alzheimer's disease. The Tacrine Collaborative Study GroupQ48418557
A 30-week randomized controlled trial of high-dose tacrine in patients with Alzheimer's disease. The Tacrine Study Group.Q52026922
Tetrahydroaminoacridine-lecithin combination treatment in patients with intermediate-stage Alzheimer's disease. Results of a Canadian double-blind, crossover, multicenter study.Q52057810
Velnacrine in Alzheimer's Disease : An Initial Appraisal of its Clinical Potential.Q52058562
Oral tetrahydroaminoacridine in long-term treatment of senile dementia, Alzheimer type.Q52259713
Disposition of propranolol. V. Drug accumulation and steady-state concentrations during chronic oral administration in man.Q52939660
Tacrine for treating Alzheimer's diseaseQ53179456
Alzheimer's drug trial put on hold.Q53192415
Tacrine for Alzheimer's disease. Which patient, what dose?Q53206871
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Blocking Effect of Tetrahydroaminacrin on a New Psychotomimetic AgentQ58959978
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Determination of tacrine hydrochloride in human serum by chloroform extraction, reversed-phase high-performance liquid chromatography and fluorimetric detectionQ68049023
Characterisation of theophylline metabolism by human liver microsomes. Inhibition and immunochemical studiesQ68142727
Hepatotoxicity of tetrahydroaminoacridine in isolated rat hepatocytes: effect of glutathione and vitamin EQ68431139
Tacrine and lecithin in Alzheimer's diseaseQ68780451
Cigarette smoking and theophylline metabolism: effects of phenytoinQ69208179
Determination of tacrine and its 1-hydroxy metabolite in plasma using column liquid chromatography with ultraviolet detectionQ69385939
Quantitative whole-body autoradiographic determination of tacrine tissue distribution in rats following intravenous or oral doseQ69398829
Identification of 9-hydroxylamine-1,2,3,4-tetrahydroacridine as a hepatic microsomal metabolite of tacrine by high-performance liquid chromatography and electrochemistryQ69613356
Tetrahydroaminoacridine and Alzheimer's diseaseQ69893614
Stereoselective hydroxylation of tacrine in rats and humansQ72458240
Bioactivation and irreversible binding of the cognition activator tacrine using human and rat liver microsomal preparations. Species differenceQ72658526
An investigation into the formation of stable, protein-reactive and cytotoxic metabolites from tacrine in vitro. Studies with human and rat liver microsomesQ72870562
Suxamethonium "extension" by tetrahydroaminacrineQ79444210
Some aspects of the pharmacology of morphine with special reference to its antagonism by 5-amino-acridine and other chemically related compoundsQ80641191
Treatment of Intractable Pain with Morphine and TetrahydroaminacrineQ84946602
P433issue6
P407language of work or nameEnglishQ1860
P921main subjectpharmacokineticsQ323936
P304page(s)449-457
P577publication date1995-06-01
P1433published inClinical PharmacokineticsQ5133788
P1476titleClinical Pharmacokinetics of Tacrine
P478volume28

Reverse relations

cites work (P2860)
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