A GH3-like domain in reaper is required for mitochondrial localization and induction of IAP degradation

scientific article published on 13 August 2003

A GH3-like domain in reaper is required for mitochondrial localization and induction of IAP degradation is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1074/JBC.M308055200
P698PubMed publication ID12917412

P2093author name stringDaniel A Colón-Ramos
Bruce Kaplan
Eugene C Gan
Michael R Olson
Sally Kornbluth
Christopher L Holley
P2860cites workReaper-induced apoptosis in a vertebrate systemQ33887900
Scythe: a novel reaper-binding apoptotic regulator.Q33889778
GH3, a novel proapoptotic domain in Drosophila Grim, promotes a mitochondrial death pathwayQ34089594
grim, a novel cell death gene in DrosophilaQ34387981
Mitochondria in apoptosis and human diseaseQ34567374
Altered cytochrome c display precedes apoptotic cell death in DrosophilaQ36255805
The role of ARK in stress-induced apoptosis in Drosophila cellsQ36324432
The proapoptotic function of Drosophila Hid is conserved in mammalian cellsQ36333384
Inhibition of reaper-induced apoptosis by interaction with inhibitor of apoptosis proteins (IAPs).Q36583948
Genetic control of programmed cell death in DrosophilaQ38468332
Unrestrained caspase-dependent cell death caused by loss of Diap1 function requires the Drosophila Apaf-1 homolog, DarkQ39647181
Induction of apoptosis by Drosophila reaper, hid and grim through inhibition of IAP functionQ40387062
Control of the cell death pathway by Dapaf-1, a Drosophila Apaf-1/CED-4-related caspase activatorQ40908820
HAC-1, a Drosophila homolog of APAF-1 and CED-4 functions in developmental and radiation-induced apoptosisQ40908826
Dark is a Drosophila homologue of Apaf-1/CED-4 and functions in an evolutionarily conserved death pathwayQ40918502
The Drosophila gene hid is a direct molecular target of Ras-dependent survival signalingQ40995001
Apoptosis induced by Drosophila reaper and grim in a human system. Attenuation by inhibitor of apoptosis proteins (cIAPs).Q41011027
The Drosophila caspase inhibitor DIAP1 is essential for cell survival and is negatively regulated by HID.Q41689719
Drosophila grim induces apoptosis in mammalian cells.Q42662756
Reaper is regulated by IAP-mediated ubiquitination.Q44226073
Degradation of DIAP1 by the N-end rule pathway is essential for regulating apoptosis.Q44401479
Hid, Rpr and Grim negatively regulate DIAP1 levels through distinct mechanismsQ46902175
Cell killing by the Drosophila gene reaperQ47070113
Ras promotes cell survival in Drosophila by downregulating hid expressionQ47070193
Morgue mediates apoptosis in the Drosophila melanogaster retina by promoting degradation of DIAP1.Q47070254
The head involution defective gene of Drosophila melanogaster functions in programmed cell deathQ47070937
The DIAP1 RING finger mediates ubiquitination of Dronc and is indispensable for regulating apoptosisQ47071463
Regulation of Drosophila IAP1 degradation and apoptosis by reaper and ubcD1.Q47072202
Drosophila Morgue is an F box/ubiquitin conjugase domain protein important for grim-reaper mediated apoptosisQ48303855
Distinct cell killing properties of the Drosophila reaper, head involution defective, and grim genes.Q52181655
Reversible inhibition of Hsp70 chaperone function by Scythe and ReaperQ24545641
Smac, a mitochondrial protein that promotes cytochrome c-dependent caspase activation by eliminating IAP inhibitionQ28115131
Identification of DIABLO, a mammalian protein that promotes apoptosis by binding to and antagonizing IAP proteinsQ28117928
A novel ubiquitin fusion system bypasses the mitochondria and generates biologically active Smac/DIABLOQ28201640
Characterization of the signal that directs Bcl-x(L), but not Bcl-2, to the mitochondrial outer membraneQ28580739
Reaper eliminates IAP proteins through stimulated IAP degradation and generalized translational inhibitionQ29035696
The biochemistry of apoptosisQ29547741
Characterization of XIAP-deficient miceQ33559119
P433issue45
P407language of work or nameEnglishQ1860
P921main subjectReaper Dmel_CG4319Q29818445
P304page(s)44758-44768
P577publication date2003-08-13
P1433published inJournal of Biological ChemistryQ867727
P1476titleA GH3-like domain in reaper is required for mitochondrial localization and induction of IAP degradation
P478volume278

Reverse relations

cites work (P2860)
Q39838763A lepidopteran orthologue of reaper reveals functional conservation and evolution of IAP antagonists
Q38672394Apoptosis in Drosophila: which role for mitochondria?
Q34346968Apoptosis, Stem Cells, and Tissue Regeneration
Q38936698Apoptotic Caspases in Promoting Cancer: Implications from Their Roles in Development and Tissue Homeostasis
Q37494540By design or by chance: cell death during Drosophila embryogenesis
Q41872250CDK7 regulates the mitochondrial localization of a tail-anchored proapoptotic protein, Hid
Q46447694Cloning and functional characterizations of an apoptogenic Hid gene in the Scuttle Fly, Megaselia scalaris (Diptera; Phoridae).
Q35005603Drosophila IAP antagonists form multimeric complexes to promote cell death
Q40122308Drosophila Omi, a mitochondrial-localized IAP antagonist and proapoptotic serine protease.
Q34348346Drosophila larvae lacking the bcl-2 gene, buffy, are sensitive to nutrient stress, maintain increased basal target of rapamycin (Tor) signaling and exhibit characteristics of altered basal energy metabolism
Q34346695Eggs over easy: cell death in the Drosophila ovary
Q38773463Induction of cell death by tospoviral protein NSs and the motif critical for cell death does not control RNA silencing suppression activity
Q37500083Inside an enigma: do mitochondria contribute to cell death in Drosophila?
Q36955417Lack of involvement of mitochondrial factors in caspase activation in a Drosophila cell-free system
Q47878238Mechanism of action of Drosophila Reaper in mammalian cells: Reaper globally inhibits protein synthesis and induces apoptosis independent of mitochondrial permeability.
Q34360469Michelob_x is the missing inhibitor of apoptosis protein antagonist in mosquito genomes
Q35165455Mitochondria in apoptosis: Bcl-2 family members and mitochondrial dynamics.
Q30504143Mitochondrial fusion is regulated by Reaper to modulate Drosophila programmed cell death
Q37800527Mitochondrial involvement in cell death of non-mammalian eukaryotes
Q40052989Mitochondrial localization of Reaper to promote inhibitors of apoptosis protein degradation conferred by GH3 domain-lipid interactions
Q33721855Monomerization of cytosolic mature smac attenuates interaction with IAPs and potentiation of caspase activation
Q38893753Programmed cell death acts at different stages of Drosophila neurodevelopment to shape the central nervous system.
Q42009642Reaper homologue IBM1 in silkworm Bombyx mori induces apoptosis upon baculovirus infection
Q36274969Reawakening the cellular death program in neoplasia through the therapeutic blockade of IAP function
Q26782579Regulation of Cell Death by IAPs and Their Antagonists
Q34988884Regulation of Drosophila melanogaster pro-apoptotic gene hid.
Q37147749Regulation of apoptosis in Drosophila
Q35830140Role of mitochondrial remodeling in programmed cell death in Drosophila melanogaster
Q35678287Screening of suppressors of bax-induced cell death identifies glycerophosphate oxidase-1 as a mediator of debcl-induced apoptosis in Drosophila.
Q36178805The need to connect: on the cell biology of synapses, behaviors, and networks in science
Q35151449The rb pathway and cancer therapeutics
Q36602674The role of mitochondria in apoptosis*.
Q42205706grim promotes programmed cell death of Drosophila microchaete glial cells

Search more.