FRA16D common chromosomal fragile site oxido-reductase (FOR/WWOX) protects against the effects of ionizing radiation in Drosophila

scientific article published in September 2005

FRA16D common chromosomal fragile site oxido-reductase (FOR/WWOX) protects against the effects of ionizing radiation in Drosophila is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1038/SJ.ONC.1208806
P698PubMed publication ID16007179

P2093author name stringRobert I Richards
Yinghong Liu
Louise V O'Keefe
Sonia Dayan
Robert Saint
Alison Perkins
P2860cites workWWOX binds the specific proline-rich ligand PPXY: identification of candidate interacting proteinsQ24324259
WWOX: a candidate tumor suppressor gene involved in multiple tumor typesQ24555184
The tumor spectrum in FHIT-deficient miceQ24555215
Functional association between Wwox tumor suppressor protein and p73, a p53 homologQ24633799
Solution structure and ligand recognition of the WW domain pair of the yeast splicing factor Prp40Q27640080
Hyaluronidase induction of a WW domain-containing oxidoreductase that enhances tumor necrosis factor cytotoxicityQ28142657
JNK1 physically interacts with WW domain-containing oxidoreductase (WOX1) and inhibits WOX1-mediated apoptosisQ28201854
The common fragile site FRA16D and its associated gene WWOX are highly conserved in the mouse at Fra8E1Q28215998
The fragile genes FHIT and WWOX are inactivated coordinately in invasive breast carcinomaQ28255650
Down-regulation of WW domain-containing oxidoreductase induces Tau phosphorylation in vitro. A potential role in Alzheimer's diseaseQ28260248
Physical and functional interactions between the Wwox tumor suppressor protein and the AP-2gamma transcription factorQ34368745
Drosophila p53 preserves genomic stability by regulating cell deathQ34959692
Parkin, a gene implicated in autosomal recessive juvenile parkinsonism, is a candidate tumor suppressor gene on chromosome 6q25-q27Q35022507
Parkin gene alterations in hepatocellular carcinomaQ40564245
Specific association between alcohol intake, high grade of differentiation and 4q34-q35 deletions in hepatocellular carcinomas identified by high resolution allelotypingQ40750117
Alterations in the common fragile site gene Parkin in ovarian and other cancersQ44653680
Characterization of a conserved aphidicolin-sensitive common fragile site at human 4q22 and mouse 6C1: possible association with an inherited disease and cancerQ45001863
Alternative transcripts of the candidate tumor suppressor gene, WWOX, are expressed at high levels in human breast tumorsQ48313552
Identification of homozygous deletions at chromosome 16q23 in aflatoxin B1 exposed hepatocellular carcinomaQ74434735
P433issue43
P407language of work or nameEnglishQ1860
P921main subjectDrosophilaQ312154
WW domain containing oxidoreductase Dmel_CG7221Q29817400
P304page(s)6590-6596
P577publication date2005-09-01
P1433published inOncogeneQ1568657
P1476titleFRA16D common chromosomal fragile site oxido-reductase (FOR/WWOX) protects against the effects of ionizing radiation in Drosophila
P478volume24

Reverse relations

cites work (P2860)
Q28257656Disabled-1 is a large common fragile site gene, inactivated in multiple cancers
Q34470652Drosophila orthologue of WWOX, the chromosomal fragile site FRA16D tumour suppressor gene, functions in aerobic metabolism and regulates reactive oxygen species
Q58123045Modeling WWOX Loss of Function : What Have We Learned?
Q36953585The JNK inhibitor SP600129 enhances apoptosis of HCC cells induced by the tumor suppressor WWOX.
Q27321940Tumor Suppressor WWOX Contributes to the Elimination of Tumorigenic Cells in Drosophila melanogaster
Q46666593Tumor suppressor WWOX moderates the mitochondrial respiratory complex.
Q28080638WWOX, the chromosomal fragile site FRA16D spanning gene: its role in metabolism and contribution to cancer
Q21262994Zfra affects TNF-mediated cell death by interacting with death domain protein TRADD and negatively regulates the activation of NF-kappaB, JNK1, p53 and WOX1 during stress response

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