Oral administration of Ginsenoside Rg1 prevents cardiac toxicity induced by doxorubicin in mice through anti-apoptosis

scientific article published on 31 July 2017

Oral administration of Ginsenoside Rg1 prevents cardiac toxicity induced by doxorubicin in mice through anti-apoptosis is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.18632/ONCOTARGET.19698
P932PMC publication ID5663555
P698PubMed publication ID29137383

P2093author name stringYi Wang
Hua Liu
Jianhua Huang
Jiayi Zhang
Yue Lu
Chen Zhu
Haiman Mu
P2860cites workIdentification of the molecular basis of doxorubicin-induced cardiotoxicityQ34308627
Beneficial effects of ginsenoside-Rg1 on ischemia-induced angiogenesis in diabetic miceQ34461859
Estrogen-like activity of ginsenoside Rg1 derived from Panax notoginseng.Q34525953
Protecting against anthracycline-induced myocardial damage: a review of the most promising strategiesQ34563378
Doxorubicin pathways: pharmacodynamics and adverse effectsQ35048393
Pretreatment with angiotensin-converting enzyme inhibitor improves doxorubicin-induced cardiomyopathy via preservation of mitochondrial functionQ35214168
Cannabidiol Protects against Doxorubicin-Induced Cardiomyopathy by Modulating Mitochondrial Function and BiogenesisQ35707221
Combined Salvianolic Acid B and Ginsenoside Rg1 Exerts Cardioprotection against Ischemia/Reperfusion Injury in Rats.Q35747697
Molecular determinants of the physiological adaptation to stress in the cardiomyocyte: a focus on AKT.Q35937270
Curcumin Downregulates Phosphate Carrier and Protects against Doxorubicin Induced Cardiomyocyte ApoptosisQ36002825
Melissa officinalis Protects against Doxorubicin-Induced Cardiotoxicity in Rats and Potentiates Its Anticancer Activity on MCF-7 CellsQ36202577
An Alpha-1A Adrenergic Receptor Agonist Prevents Acute Doxorubicin Cardiomyopathy in Male MiceQ36247553
Bcl-2 family members and apoptosis, taken to heartQ36581944
Protection against doxorubicin-induced myocardial dysfunction in mice by cardiac-specific expression of carboxyl terminus of hsp70-interacting proteinQ37024066
Bcl-2 family proteins: the sentinels of the mitochondrial apoptosis pathway.Q37143362
MAPK signalling in cardiovascular health and disease: molecular mechanisms and therapeutic targetsQ37254485
Ginsenoside-Re ameliorates ischemia and reperfusion injury in the heart: a hemodynamics approachQ37283786
VEGF-B gene therapy inhibits doxorubicin-induced cardiotoxicity by endothelial protectionQ37469455
Doxorubicin-induced cardiomyopathy: from molecular mechanisms to therapeutic strategiesQ37998724
Rg1 prevents myocardial hypoxia/reoxygenation injury by regulating mitochondrial dynamics imbalance via modulation of glutamate dehydrogenase and mitofusin 2.Q38817739
Ghrelin inhibits doxorubicin cardiotoxicity by inhibiting excessive autophagy through AMPK and p38-MAPK.Q39024492
Activating glucocorticoid receptor-ERK signaling pathway contributes to ginsenoside Rg1 protection against β-amyloid peptide-induced human endothelial cells apoptosisQ39174095
Cardioprotective Effects of 20(S)-Ginsenoside Rh2 against Doxorubicin-Induced Cardiotoxicity In Vitro and In VivoQ39249531
Procyanidins produce significant attenuation of doxorubicin-induced cardiotoxicity via suppression of oxidative stressQ39895409
Carvedilol Administration Can Prevent Doxorubicin-Induced Cardiotoxicity: A Double-Blind Randomized Trial.Q40005337
Ginsenosides may reverse the dexamethasone-induced down-regulation of glucocorticoid receptor.Q40473607
Bcl-2 prevents Bax oligomerization in the mitochondrial outer membraneQ40816351
Heat shock protein 20 interacting with phosphorylated Akt reduces doxorubicin-triggered oxidative stress and cardiotoxicityQ42585599
Erdosteine prevents doxorubicin-induced cardiotoxicity in rats.Q44539267
A truncated form of DNA topoisomerase IIβ associates with the mtDNA genome in mammalian mitochondriaQ44602456
Melissa officinalis extract induces apoptosis and inhibits proliferation in colon cancer cells through formation of reactive oxygen speciesQ46760458
Protective effect of lycopene on adriamycin-induced cardiotoxicity and nephrotoxicityQ46834320
Ginsenoside Rg3 antagonizes adriamycin-induced cardiotoxicity by improving endothelial dysfunction from oxidative stress via upregulating the Nrf2-ARE pathway through the activation of akt.Q53362130
Chrysin attenuates cardiomyocyte apoptosis and loss of intermediate filaments in a mouse model of mitoxantrone cardiotoxicity.Q53453631
Akt-mTOR Pathway Inhibits Apoptosis and Fibrosis in Doxorubicin-Induced Cardiotoxicity Following Embryonic Stem Cell Transplantation.Q54373272
Ginsenoside-Rg1 induces vascular endothelial growth factor expression through the glucocorticoid receptor-related phosphatidylinositol 3-kinase/Akt and beta-catenin/T-cell factor-dependent pathway in human endothelial cells.Q54536901
Cytofluorescence detection of adriamycin-mitochondria interactions in isolated, perfused rat heartQ57768881
The protective effect of a purified extract of Withania somnifera against doxorubicin-induced cardiac toxicity in ratsQ80371962
Ginsenoside Rg1 enhances endothelial progenitor cell angiogenic potency and prevents senescence in vitroQ85070136
P433issue48
P407language of work or nameEnglishQ1860
P921main subjectdoxorubicinQ18936
P304page(s)83792-83801
P577publication date2017-07-31
P1433published inOncotargetQ1573155
P1476titleOral administration of Ginsenoside Rg1 prevents cardiac toxicity induced by doxorubicin in mice through anti-apoptosis
P478volume8

Reverse relations

cites work (P2860)
Q59792845Ginsenoside Rg1 Prevents Doxorubicin-Induced Cardiotoxicity through the Inhibition of Autophagy and Endoplasmic Reticulum Stress in Mice
Q92618623Protective Effect of Ginsenoside Rg1 on Oxidative Damage Induced by Hydrogen Peroxide in Chicken Splenic Lymphocytes
Q64249100Ursolic acid prevents doxorubicin-induced cardiac toxicity in mice through eNOS activation and inhibition of eNOS uncoupling

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