Targeting oral cancer stemness and chemoresistance by isoliquiritigenin-mediated GRP78 regulation

scientific article published on 28 September 2017

Targeting oral cancer stemness and chemoresistance by isoliquiritigenin-mediated GRP78 regulation is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.18632/ONCOTARGET.21338
P932PMC publication ID5706844
P698PubMed publication ID29212198

P2093author name stringPei-Ming Chu
Yi-Wen Liao
Pei-Ling Hsieh
Cheng-Chia Yu
Fang-Wei Hu
Ming-Yi Lu
P2860cites workOpinion: migrating cancer stem cells - an integrated concept of malignant tumour progressionQ28271211
Dietary Compound Isoliquiritigenin Inhibits Breast Cancer Neoangiogenesis via VEGF/VEGFR-2 Signaling PathwayQ28385231
Suppression of miR-204 enables oral squamous cell carcinomas to promote cancer stemness, EMT traits, and lymph node metastasisQ28387038
Cancer drug resistance: an evolving paradigmQ29616694
Tumour stem cells and drug resistanceQ29617742
Identification of a subpopulation of cells with cancer stem cell properties in head and neck squamous cell carcinomaQ29620604
ABCG2 is required to control the sonic hedgehog pathway in side population cells with stem-like properties.Q33966214
Nonadhesive Culture System as a Model of Rapid Sphere Formation with Cancer Stem Cell PropertiesQ34168436
Bmi-1 Regulates Snail Expression and Promotes Metastasis Ability in Head and Neck Squamous Cancer-Derived ALDH1 Positive CellsQ34170082
Targeting the mechanisms of resistance to chemotherapy and radiotherapy with the cancer stem cell hypothesisQ34218232
Elimination of head and neck cancer initiating cells through targeting glucose regulated protein78 signalingQ34331960
Isoliquiritigenin induces growth inhibition and apoptosis through downregulating arachidonic acid metabolic network and the deactivation of PI3K/Akt in human breast cancerQ34349485
The unfolded protein response regulator GRP78/BiP as a novel target for increasing chemosensitivity in malignant gliomas.Q34702354
Isoliquiritigenin induces apoptosis and inhibits xenograft tumor growth of human lung cancer cells by targeting both wild type and L858R/T790M mutant EGFR.Q34774462
Isoliquiritigenin inhibits the proliferation of human renal carcinoma Caki cells through the ROS-mediated regulation of the Jak2/STAT3 pathwayQ46358702
Dietary compound isoliquiritigenin targets GRP78 to chemosensitize breast cancer stem cells via β-catenin/ABCG2 signalingQ46475690
Isoliquiritigenin, a flavonoid from licorice, relaxes guinea-pig tracheal smooth muscle in vitro and in vivo: role of cGMP/PKG pathwayQ46480563
Critical role of the stress chaperone GRP78/BiP in tumor proliferation, survival, and tumor angiogenesis in transgene-induced mammary tumor development.Q46742618
Cyclooxygenase-2 plays a suppressive role for induction of apoptosis in isoliquiritigenin-treated mouse colon cancer cellsQ46884208
Isoliquiritigenin as a cause of DNA damage and inhibitor of ataxia-telangiectasia mutated expression leading to G2/M phase arrest and apoptosis in oral squamous cell carcinomaQ52976397
Isoliquiritigenin, one of the antispasmodic principles of Glycyrrhiza ularensis roots, acts in the lower part of intestineQ79486481
Analgesic and Uterine Relaxant Effects of Isoliquiritigenin, a Flavone from Glycyrrhiza glabraQ83569425
Targeting CD133 in the enhancement of chemosensitivity in oral squamous cell carcinoma-derived side population cancer stem cellsQ86419308
Cancer stem cells: The challenges aheadQ86523719
Vasorelaxant effect of isoliquiritigenin, a novel soluble guanylate cyclase activator, in rat aortaQ34793336
A critical role for GRP78/BiP in the tumor microenvironment for neovascularization during tumor growth and metastasisQ34803685
Aldehyde dehydrogenase 1 is a putative marker for cancer stem cells in head and neck squamous cancer.Q34981591
Dietary compound isoliquiritigenin prevents mammary carcinogenesis by inhibiting breast cancer stem cells through WIF1 demethylationQ35833171
Cancer stem cells: impact, heterogeneity, and uncertaintyQ35857599
The evolving concept of cancer and metastasis stem cellsQ36145729
Reassessment of the role of induction chemotherapy for head and neck cancerQ36524702
GRP78 confers the resistance to 5-FU by activating the c-Src/LSF/TS axis in hepatocellular carcinomaQ36545246
Mechanisms of chemoresistance in cancer stem cellsQ36591484
GRP78 is overexpressed in glioblastomas and regulates glioma cell growth and apoptosisQ36926745
Pten null prostate tumorigenesis and AKT activation are blocked by targeted knockout of ER chaperone GRP78/BiP in prostate epitheliumQ37039595
Global epidemiology of oral and oropharyngeal cancerQ37274268
Blockade of Cripto binding to cell surface GRP78 inhibits oncogenic Cripto signaling via MAPK/PI3K and Smad2/3 pathwaysQ37359214
Upregulation of Glucose-Regulated Protein 78 in Metastatic Cancer Cells Is Necessary for Lung Metastasis ProgressionQ37391501
ABCG2: the key to chemoresistance in cancer stem cells?Q37587219
Synthetic Isoliquiritigenin Inhibits Human Tongue Squamous Carcinoma Cells through Its Antioxidant Mechanism.Q37624825
Isoliquiritigenin induces apoptosis and autophagy and inhibits endometrial cancer growth in miceQ37687402
Cancer stem cells and self-renewal.Q37763416
Targeting cancer stem cells to suppress acquired chemotherapy resistanceQ38149736
Chemical approaches to targeting drug resistance in cancer stem cells.Q38211209
Sox2 expression involvement in the oncogenicity and radiochemoresistance of oral cancer stem cellsQ38302628
Wnt/β-catenin signalling maintains self-renewal and tumourigenicity of head and neck squamous cell carcinoma stem-like cells by activating Oct4.Q38437805
Cell surface GRP78 facilitates hepatoma cells proliferation and migration by activating IGF-IR.Q38847254
Photodynamic therapy with 5-aminolevulinic acid (ALA) impairs tumor initiating and chemo-resistance property in head and neck cancer-derived cancer stem cellsQ39029356
Andrographolide impedes cancer stemness and enhances radio-sensitivity in oral carcinomas via miR-218 activationQ39123992
Prognosis of oral squamous cell carcinoma patients with level IV/V metastasis: An observational studyQ39138334
Cancer stem cells: The root of tumor recurrence and metastases.Q39160322
The epithelial-mesenchymal transition mediator S100A4 maintains cancer-initiating cells in head and neck cancersQ39618327
Glucose-regulated protein 78 as a novel effector of BRCA1 for inhibiting stress-induced apoptosisQ39942224
Isoliquiritigenin isolated from the roots of Glycyrrhiza uralensis inhibits LPS-induced iNOS and COX-2 expression via the attenuation of NF-kappaB in RAW 264.7 macrophagesQ40009722
N,N-diethylaminobenzaldehyde (DEAB) as a substrate and mechanism-based inhibitor for human ALDH isoenzymesQ40091613
Activation and cross-talk between Akt, NF-kappaB, and unfolded protein response signaling in 1-LN prostate cancer cells consequent to ligation of cell surface-associated GRP78.Q40303607
Isoliquiritigenin induces apoptosis of human bladder cancer T24 cells via a cyclin-dependent kinase-independent mechanismQ40977936
A lymphocyte cell surface heat shock protein homologous to the endoplasmic reticulum chaperone, immunoglobulin heavy chain binding protein BIP.Q41105188
Impairment of tumor‐initiating stem‐like property and reversal of epithelial–mesenchymal transdifferentiation in head and neck cancer by resveratrol treatmentQ42717496
Concurrent expression of Oct4 and Nanog maintains mesenchymal stem-like property of human dental pulp cellsQ42997318
Glucose-regulated protein 78 silencing down-regulates vascular endothelial growth factor/vascular endothelial growth factor receptor 2 pathway to suppress human colon cancer tumor growth.Q44205082
Isoliquiritigenin, a flavonoid from licorice, plays a dual role in regulating gastrointestinal motility in vitro and in vivoQ46207931
P433issue55
P407language of work or nameEnglishQ1860
P921main subjectlip and oral cavity carcinomaQ55790434
P304page(s)93912-93923
P577publication date2017-09-28
P1433published inOncotargetQ1573155
P1476titleTargeting oral cancer stemness and chemoresistance by isoliquiritigenin-mediated GRP78 regulation
P478volume8

Reverse relations

cites work (P2860)
Q98721099GRP78 targeting: Hitting two birds with a stone
Q101136375HPV+ve/-ve oral-tongue cancer stem cells: A potential target for relapse-free therapy
Q92259555Heat Shock Proteins: Agents of Cancer Development and Therapeutic Targets in Anti-Cancer Therapy
Q91981304Simultaneous Determination and Pharmacokinetic Characterization of Glycyrrhizin, Isoliquiritigenin, Liquiritigenin, and Liquiritin in Rat Plasma Following Oral Administration of Glycyrrhizae Radix Extract

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