Heat Shock Proteins: Agents of Cancer Development and Therapeutic Targets in Anti-Cancer Therapy

scientific article published on 24 December 2019

Heat Shock Proteins: Agents of Cancer Development and Therapeutic Targets in Anti-Cancer Therapy is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

External links are
P356DOI10.3390/CELLS9010060
P932PMC publication ID7017199
P698PubMed publication ID31878360

P2093author name stringSang Hun Lee
Hyung Joo Kim
Chul Won Yun
Ji Ho Lim
P2860cites workNVP-AUY922: a small molecule HSP90 inhibitor with potent antitumor activity in preclinical breast cancer modelsQ21195221
Hallmarks of Cancer: The Next GenerationQ22252312
Injectable self-assembling peptide nanofibers create intramyocardial microenvironments for endothelial cellsQ24644294
Guidelines for the nomenclature of the human heat shock proteinsQ24653946
Use of mesenchymal stem cells and darbepoetin improve ischemia-induced acute kidney injury outcomesQ84266495
Heat shock protein 27 mediates the effect of 1,3,5-trihydroxy-13,13-dimethyl-2H-pyran [7,6-b] xanthone on mitochondrial apoptosis in hepatocellular carcinomaQ84324178
RP101 (brivudine) binds to heat shock protein HSP27 (HSPB1) and enhances survival in animals and pancreatic cancer patientsQ84744537
2,4-Bis(4-hydroxybenzyl)phenol inhibits heat shock transcription factor 1 and sensitizes lung cancer cells to conventional anticancer modalitiesQ87710008
Heat Shock Factor 1 Epigenetically Stimulates Glutaminase-1-Dependent mTOR Activation to Promote Colorectal CarcinogenesisQ88579091
Colorectal cancerQ89218269
Part I of GANNET53: A European Multicenter Phase I/II Trial of the Hsp90 Inhibitor Ganetespib Combined With Weekly Paclitaxel in Women With High-Grade, Platinum-Resistant Epithelial Ovarian Cancer-A Study of the GANNET53 ConsortiumQ90266870
Subcellular Hsp70 Inhibitors Promote Cancer Cell Death via Different MechanismsQ90597906
Increased Expression of DNAJC12 is Associated with Aggressive Phenotype of Gastric CancerQ90931867
A study on the biological function of heat shock factor 1 proteins in breast cancerQ91051090
C-terminal HSP90 inhibitor L80 elicits anti-metastatic effects in triple-negative breast cancer via STAT3 inhibitionQ91291421
Mortalin is a distinct bio-marker and prognostic factor in serous ovarian carcinomaQ91678689
Inhibition of HSP90 overcomes resistance to chemotherapy and radiotherapy in pancreatic cancerQ91884254
Overexpression of Hsc70 promotes proliferation, migration, and invasion of human glioma cellsQ91999252
Induction of HSP27 and HSP70 by constitutive overexpression of Redd1 confers resistance of lung cancer cells to ionizing radiationQ92322953
Keys to unlock androgen receptor translocationQ92451439
Phosphorylation of HSF1 by PIM2 Induces PD-L1 Expression and Promotes Tumor Growth in Breast CancerQ92601225
Targeting Heat Shock Protein 27 in Cancer: A Druggable Target for Cancer Treatment?Q92702650
Pifithrin-μ induces necroptosis through oxidative mitochondrial damage but accompanies epithelial-mesenchymal transition-like phenomenon in malignant mesothelioma cells under lactic acidosisQ92718267
Ganetespib in Epidermal Growth Factor Receptor-Tyrosine Kinase Inhibitor-resistant Non-small Cell Lung CancerQ92884962
Metabolic enzyme PDK3 forms a positive feedback loop with transcription factor HSF1 to drive chemoresistanceQ93063248
HSP60-regulated Mitochondrial Proteostasis and Protein Translation Promote Tumor Growth of Ovarian CancerQ93064128
KNK437 restricts the growth and metastasis of colorectal cancer via targeting DNAJA1/CDC45 axisQ93064615
High serum Hsp70 level predicts poor survival in colorectal cancer: Results obtained in an independent validation cohortQ93210769
HSP90 interacts with HMGCR and promotes the progression of hepatocellular carcinomaQ93357111
Down-regulation of HSP60 Suppresses the Proliferation of Glioblastoma Cells via the ROS/AMPK/mTOR PathwayQ42578957
5-Fluorouracil incorporation into RNA and DNA in relation to thymidylate synthase inhibition of human colorectal cancersQ44942609
Injectable fibrin scaffold improves cell transplant survival, reduces infarct expansion, and induces neovasculature formation in ischemic myocardiumQ45206400
GRP78 Regulates Apoptosis, Cell Survival and Proliferation in 5-Fluorouracil-resistant SNUC5 Colon Cancer CellsQ46312287
Dietary compound isoliquiritigenin targets GRP78 to chemosensitize breast cancer stem cells via β-catenin/ABCG2 signalingQ46475690
Stem cell extracellular vesicles and kidney injury.Q47099701
A J-Protein Co-chaperone Recruits BiP to Monomerize IRE1 and Repress the Unfolded Protein ResponseQ47111339
Targeting oral cancer stemness and chemoresistance by isoliquiritigenin-mediated GRP78 regulationQ47129799
HSP27-mediated Extracellular and Intracellular Signaling Pathways Synergistically Confer Chemo-Resistance in Squamous Cell Carcinoma of TongueQ47287671
HSP90 inhibitor (NVP-AUY922) enhances the anti-cancer effect of BCL-2 inhibitor (ABT-737) in small cell lung cancer expressing BCL-2.Q47592605
DNAJB1/HSP40 Suppresses Melanoma Differentiation-Associated Gene 5-Mitochondrial Antiviral Signaling Protein Function in Conjunction with HSP70.Q47600620
Panaxynol, a natural Hsp90 inhibitor, effectively targets both lung cancer stem and non-stem cellsQ47614665
Rethinking HSF1 in Stress, Development, and Organismal Health.Q47826063
HSF1 upregulates ATG4B expression and enhances epirubicin-induced protective autophagy in hepatocellular carcinoma cells.Q47827810
Cellular Prion Protein Enhances Drug Resistance of Colorectal Cancer Cells via Regulation of a Survival Signal PathwayQ47931139
The HSP90 inhibitor NVP-AUY922 inhibits growth of HER2 positive and trastuzumab-resistant breast cancer cells.Q49357108
miR-223/Hsp70/JNK/JUN/miR-223 feedback loop modulates the chemoresistance of osteosarcoma to cisplatinQ50060953
Pharmacologic resistance in colorectal cancer: a reviewQ26769850
Heat Shock Protein 70 (Hsp70) Peptide Activated Natural Killer (NK) Cells for the Treatment of Patients with Non-Small Cell Lung Cancer (NSCLC) after Radiochemotherapy (RCTx) - From Preclinical Studies to a Clinical Phase II TrialQ26858884
Mechanisms of Cisplatin nephrotoxicityQ26996320
The role of heat shock protein 70 (Hsp70) in radiation-induced immunomodulationQ28086922
Targeting heat shock proteins in cancerQ28298397
Quercetin sensitizes glioblastoma to t-AUCB by dual inhibition of Hsp27 and COX-2 in vitro and in vivoQ28391138
Quercetin suppresses drug-resistant spheres via the p38 MAPK-Hsp27 apoptotic pathway in oral cancer cellsQ28485142
Inhibition of inducible heat shock protein-70 (hsp72) enhances bortezomib-induced cell death in human bladder cancer cellsQ28534720
Geldanamycin-induced osteosarcoma cell death is associated with hyperacetylation and loss of mitochondrial pool of heat shock protein 60 (hsp60)Q28535817
Targeting Mortalin by Embelin Causes Activation of Tumor Suppressor p53 and Deactivation of Metastatic Signaling in Human Breast Cancer CellsQ28548067
Cancer drug resistance: an evolving paradigmQ29616694
Ex vivo pretreatment with melatonin improves survival, proangiogenic/mitogenic activity, and efficiency of mesenchymal stem cells injected into ischemic kidneyQ33333234
Identification of 5-fluorouracil response proteins in colorectal carcinoma cell line SW480 by two-dimensional electrophoresis and MALDI-TOF mass spectrometry.Q33346330
Bone marrow vascular niche: home for hematopoietic stem cellsQ33562455
Microvesicles derived from human Wharton's Jelly mesenchymal stromal cells ameliorate renal ischemia-reperfusion injury in rats by suppressing CX3CL1.Q33746472
HSP90 inhibitor AUY922 can reverse Fulvestrant induced feedback reaction in human breast cancer cellsQ33823200
Heat shock protein 70-2 (HSP70-2) a novel cancer testis antigen that promotes growth of ovarian cancerQ33850034
Silencing heat shock protein 27 decreases metastatic behavior of human head and neck squamous cell cancer cells in vitroQ34037168
Human heat shock protein-specific cytotoxic T lymphocytes display potent antitumour immunity in multiple myelomaQ34052565
Heat shock proteins in cancer: chaperones of tumorigenesisQ34495261
Molecular mechanism of mutant p53 stabilization: the role of HSP70 and MDM2.Q34516626
Hospital-acquired renal insufficiencyQ34522737
Heat shock protein 70 is acute phase reactant: response elicited by tumor treatment with photodynamic therapyQ34690871
Preclinical pharmacologic evaluation of geldanamycin as an antitumor agentQ34720809
Identification of an allosteric small-molecule inhibitor selective for the inducible form of heat shock protein 70.Q34747269
Heat shock protein DNAJB8 is a novel target for immunotherapy of colon cancer-initiating cellsQ35051440
Mesenchymal stem cells modulate albumin-induced renal tubular inflammation and fibrosis.Q35124912
Drug-induced renal failure: update on new medications and unique mechanisms of nephrotoxicityQ35156442
Stromal expression of heat-shock protein 27 is associated with worse clinical outcome in patients with colorectal cancer lung metastasesQ35202991
TRAIL-induced apoptosis is enhanced by heat shock protein 70 expressionQ35239558
Heat shock protein-90 inhibitors enhance antigen expression on melanomas and increase T cell recognition of tumor cellsQ35517613
The Effects of HSP27 on Gemcitabine-Resistant Pancreatic Cancer Cell Line Through SnailQ38837076
DNAJB1 negatively regulates MIG6 to promote epidermal growth factor receptor signaling.Q38846684
Reversing drug resistance of cisplatin by hsp90 inhibitors in human ovarian cancer cells.Q38848341
Heat Shock Protein 90 Is a Potential Therapeutic Target in CholangiocarcinomaQ38856791
Fisetin, a dietary flavonoid, induces apoptosis of cancer cells by inhibiting HSF1 activity through blocking its binding to the hsp70 promoterQ38891118
Sensitizing tumor cells to radiation by targeting the heat shock response.Q38905705
Global patterns and trends in colorectal cancer incidence and mortality.Q38915351
Melatonin as an antioxidant: under promises but over deliversQ38921589
Immediate and transient phosphorylation of the heat shock protein 27 initiates chemoresistance in prostate cancer cellsQ38955574
Hsp27 regulates EGF/β-catenin mediated epithelial to mesenchymal transition in prostate cancer.Q38965263
Overexpression of DNAJB6 promotes colorectal cancer cell invasion through an IQGAP1/ERK-dependent signaling pathwayQ38973613
Heat shock protein 90 promotes epithelial to mesenchymal transition, invasion, and migration in colorectal cancer.Q38991602
Cantharidin induces DNA damage and inhibits DNA repair-associated protein levels in NCI-H460 human lung cancer cellsQ39014471
Ibuprofen enhances the anticancer activity of cisplatin in lung cancer cells by inhibiting the heat shock protein 70.Q39028807
Heat Shock Proteins and Cancer.Q39052679
Heat shock proteins and cancer: How can nanomedicine be harnessed?Q39088929
Inhibition of mortalin expression reverses cisplatin resistance and attenuates growth of ovarian cancer cellsQ39153321
Hsp27 regulates epithelial mesenchymal transition, metastasis, and circulating tumor cells in prostate cancerQ39181122
Hsp27: a novel therapeutic target for pediatric M4/M5 acute myeloid leukemiaQ39195392
AKT/PKB Signaling: Navigating the NetworkQ39255027
Immune mechanism of the antitumor effects generated by bortezomibQ39296759
Proteomic investigation of anti-tumor activities exerted by sinularin against A2058 melanoma cellsQ39357652
Hsp70 promotes chemoresistance by blocking Bax mitochondrial translocation in ovarian cancer cellsQ39405662
Antitumor activity of NVP-AUY922, a novel heat shock protein 90 inhibitor, in human gastric cancer cells is mediated through proteasomal degradation of client proteinsQ39567800
Chemoresistance of lung cancer stemlike cells depends on activation of Hsp27.Q39572536
Quercetin blocks t-AUCB-induced autophagy by Hsp27 and Atg7 inhibition in glioblastoma cells in vitroQ39770367
Relationship between heat shock protein 60 (HSP60) mRNA expression and resistance to platinum analogues in human ovarian and bladder carcinoma cell lines.Q39997575
A novel epidermal growth factor receptor inhibitor promotes apoptosis in non-small cell lung cancer cells resistant to erlotinibQ40110275
Overexpression of human 27 kDa heat shock protein in laryngeal cancer cells confers chemoresistance associated with cell growth delayQ40244035
Loss of expression of a new member of the DNAJ protein family confers resistance to chemotherapeutic agents used in the treatment of ovarian cancer.Q40805152
Risks for mortality and renal replacement therapy in atherosclerotic renovascular disease compared to other causes of chronic kidney diseaseQ40955437
Overexpression of DNAJC12 predicts poor response to neoadjuvant concurrent chemoradiotherapy in patients with rectal cancerQ41168987
Drug-induced renal disordersQ41300677
Ganetespib induces G2/M cell cycle arrest and apoptosis in gastric cancer cells through targeting of receptor tyrosine kinase signalingQ41470003
HSP90 inhibition enhances cancer immunotherapy by upregulating interferon response genesQ41633092
Targeting Heat Shock Proteins in Cancer: A Promising Therapeutic ApproachQ41660505
Anti-Heat Shock Protein-27 Antibody Levels in Women with Breast Cancer: Association with Disease Complications and Two-Year Disease-Free SurvivalQ41807101
IGF-1 C Domain-Modified Hydrogel Enhances Cell Therapy for AKI.Q41815870
Molecular cloning and characterization of Hsp27.6: the first reported small heat shock protein from Apis cerana ceranaQ41844626
Loss of AMPK activation promotes the invasion and metastasis of pancreatic cancer through an HSF1-dependent pathwayQ41917874
Suppression of HSP27 increases the anti‑tumor effects of quercetin in human leukemia U937 cellsQ42068149
New inhibitor targeting human transcription factor HSF1: effects on the heat shock response and tumor cell survivalQ42237173
Safety and tolerability of autologous bone marrow mesenchymal stromal cells in ADPKD patients.Q42247916
Dendritic-tumor fusion cells derived heat shock protein70-peptide complex has enhanced immunogenicityQ35592959
Advances in the discovery and development of heat-shock protein 90 inhibitors for cancer treatmentQ35800838
Role of membrane Hsp70 in radiation sensitivity of tumor cellsQ35879762
Dnajb8, a Member of the Heat Shock Protein 40 Family Has a Role in the Tumor Initiation and Resistance to Docetaxel but Is Dispensable for Stress ResponseQ35889884
14S,21R-dihydroxy-docosahexaenoic acid treatment enhances mesenchymal stem cell amelioration of renal ischemia/reperfusion injuryQ35895293
Heat shock protein 70 promotes cancer cell viability by safeguarding lysosomal integrity.Q35946766
Combination therapy with HSP90 inhibitor 17-DMAG reconditions the tumor microenvironment to improve recruitment of therapeutic T cells.Q36074307
AKI Recovery Induced by Mesenchymal Stromal Cell-Derived Extracellular Vesicles Carrying MicroRNAsQ36104826
Selective killing of cancer cells by small molecules targeting heat shock stress responseQ36110701
Single-cell analysis reveals a stem-cell program in human metastatic breast cancer cellsQ36288896
Pre-conditioned mesenchymal stem cells ameliorate renal ischemic injury in rats by augmented survival and engraftmentQ36527237
Acquired resistance to 5-fluorouracil via HSP90/Src-mediated increase in thymidylate synthase expression in colon cancerQ36544923
GRP78 confers the resistance to 5-FU by activating the c-Src/LSF/TS axis in hepatocellular carcinomaQ36545246
Tyrosine phosphorylation of HSC70 and its interaction with RFC mediates methotrexate resistance in murine L1210 leukemia cellsQ36672242
Heat shock factor 1 (HSF1) controls chemoresistance and autophagy through transcriptional regulation of autophagy-related protein 7 (ATG7)Q36725008
Peptide aptamers: tools to negatively or positively modulate HSPB1(27) functionQ36801204
The HSP70 family and cancerQ36895403
Exosomes released by human umbilical cord mesenchymal stem cells protect against cisplatin-induced renal oxidative stress and apoptosis in vivo and in vitroQ36998694
Heat Shock Proteins Promote Cancer: It's a Protection RacketQ37013952
Association of hsp90 to the hTERT promoter is necessary for hTERT expression in human oral cancer cellsQ37090677
Identification and validation of multiple cell surface markers of clinical-grade adipose-derived mesenchymal stromal cells as novel release criteria for good manufacturing practice-compliant productionQ37170068
Silencing of heat shock protein 70 expression enhances radiotherapy efficacy and inhibits cell invasion in endometrial cancer cell lineQ37189369
Molecular chaperone Hsp27 regulates the Hippo tumor suppressor pathway in cancerQ37198879
Heat shock protein 70-2 (HSP70-2) overexpression in breast cancerQ37278498
PU-H71, a novel Hsp90 inhibitor, as a potential cancer-specific sensitizer to carbon-ion beam therapyQ37301093
Oncogenic role of mortalin contributes to ovarian tumorigenesis by activating the MAPK-ERK pathway.Q37370759
Downregulation of HSP60 disrupts mitochondrial proteostasis to promote tumorigenesis and progression in clear cell renal cell carcinomaQ37437672
Hsp90 Inhibitor Ganetespib Sensitizes Non-Small Cell Lung Cancer to Radiation but Has Variable Effects with ChemoradiationQ37470072
Novel targeted radiosensitisers in cancer treatmentQ37515552
A novel HSP90 inhibitor with reduced hepatotoxicity synergizes with radiotherapy to induce apoptosis, abrogate clonogenic survival, and improve tumor control in models of colorectal cancerQ37536525
Current concepts in clinical radiation oncologyQ37603804
HSP90 inhibition sensitizes head and neck cancer to platin-based chemoradiotherapy by modulation of the DNA damage response resulting in chromosomal fragmentationQ37615630
Relevance of mortalin to cancer cell stemness and cancer therapy.Q37625726
Heat shock proteins, cell survival and drug resistance: the mitochondrial chaperone TRAP1, a potential novel target for ovarian cancer therapyQ37639711
Identification of protein biomarkers and signaling pathways associated with prostate cancer radioresistance using label-free LC-MS/MS proteomic approachQ37657753
Hsp60 exerts a tumor suppressor function by inducing cell differentiation and inhibiting invasion in hepatocellular carcinomaQ37708885
Dual role of heat shock proteins as regulators of apoptosis and innate immunityQ37726692
Hsp90β promoted endothelial cell-dependent tumor angiogenesis in hepatocellular carcinomaQ37731561
Pre-incubation with hucMSC-exosomes prevents cisplatin-induced nephrotoxicity by activating autophagyQ37742360
Major heat shock protein Hsp72 controls oncogene-induced senescenceQ37764054
A review of the molecular aspects of melatonin's anti-inflammatory actions: recent insights and new perspectives.Q38020932
DNA repair dysregulation from cancer driver to therapeutic targetQ38061847
Mitochondrial dysfunction in cancer chemoresistanceQ38238332
Heat shock protein 90 (HSP90) is overexpressed in p16-negative oropharyngeal squamous cell carcinoma, and its inhibition in vitro potentiates the effects of chemoradiationQ38247880
Hsp70 in cancer: back to the futureQ38263003
SUMOylation of HSP27 by small ubiquitin-like modifier 2/3 promotes proliferation and invasion of hepatocellular carcinoma cellsQ38373448
The effects inhibiting the proliferation of cancer cells by far-infrared radiation (FIR) are controlled by the basal expression level of heat shock protein (HSP) 70A.Q38530494
Multifaceted roles of HSF1 in cancerQ38537301
Melatonin and endoplasmic reticulum stress: relation to autophagy and apoptosisQ38552126
Heat Shock Protein 27, a Novel Regulator of Transforming Growth Factor β Induced Resistance to Cisplatin in A549 CellQ38605077
Clinical, Prognostic and Therapeutic Significance of Heat Shock Proteins in Cancer.Q38638429
Low co-expression of epidermal growth factor receptor and its chaperone heat shock protein 90 is associated with worse prognosis in primary glioblastoma, IDH-wild-typeQ38647689
Role of HSPA1L as a cellular prion protein stabilizer in tumor progression via HIF-1α/GP78 axisQ38696076
Efficacy of an HSP90 inhibitor, ganetespib, in preclinical thyroid cancer modelsQ38704670
TAS-116, a Novel Hsp90 Inhibitor, Selectively Enhances Radiosensitivity of Human Cancer Cells to X-rays and Carbon Ion RadiationQ38722571
Pifithrin-μ is efficacious against non-small cell lung cancer via inhibition of heat shock protein 70.Q38724832
HSP90 is a promising target in gemcitabine and 5-fluorouracil resistant pancreatic cancer.Q38729418
Geldanamycin, an inhibitor of Hsp90, increases paclitaxel-mediated toxicity in ovarian cancer cells through sustained activation of the p38/H2AX axisQ38746293
Protection of stromal cell-derived factor 2 by heat shock protein 72 prevents oxaliplatin-induced cell death in oxaliplatin-resistant human gastric cancer cellsQ38772328
HSP27 Knockdown Increases Cytoplasmic p21 and Cisplatin Sensitivity in Ovarian Carcinoma CellsQ38789830
Mortalin expression in pancreatic cancer and its clinical and prognostic significanceQ38835653
Hsp72 and Nek6 Cooperate to Cluster Amplified Centrosomes in Cancer Cells.Q50883432
The Hsp40 J-domain modulates Hsp70 conformation and ATPase activity with a semi-elliptical spring.Q50903423
Inhibition of Hsp90 Suppresses PI3K/AKT/mTOR Signaling and Has Antitumor Activity in Burkitt Lymphoma.Q50942188
Mitochondrial Chaperonin HSP60 Is the Apoptosis-Related Target for Myrtucommulone.Q51027126
The HSP90 chaperone machinery.Q51042630
HSP90 inhibitor NVP-AUY922 induces cell apoptosis by disruption of the survivin in papillary thyroid carcinoma cells.Q51056375
Mortalin overexpression predicts poor prognosis in early stage of non-small cell lung cancer.Q51083082
HSP90 stabilizes B-cell receptor kinases in a multi-client interactome: PU-H71 induces CLL apoptosis in a cytoprotective microenvironment.Q51173647
EGFR-TKI-induced HSP70 degradation and BER suppression facilitate the occurrence of the EGFR T790 M resistant mutation in lung cancer cells.Q51741893
Cantharidin-encapsulated thermal-sensitive liposomes coated with gold nanoparticles for enhanced photothermal therapy on A431 cells.Q52564735
Glucose-Related Protein 78 Expression and Its Effects on Cisplatin-Resistance in Cervical Cancer.Q52590996
Fucoidan Rescues p-Cresol-Induced Cellular Senescence in Mesenchymal Stem Cells via FAK-Akt-TWIST Axis.Q52593726
Heat shock protein 70 is involved in malignant behaviors and chemosensitivities to cisplatin in cervical squamous cell carcinoma cells.Q53059742
Mitochondria and Cancer.Q53198693
Stress chaperone mortalin contributes to epithelial-mesenchymal transition and cancer metastasis.Q53205003
Inhibition of heat shock protein 27 (HspB1) tumorigenic functions by peptide aptamers.Q53260080
Epigenetic inactivation of MCJ (DNAJD1) in malignant paediatric brain tumours.Q53849621
Novel inhibitors of heat shock protein Hsp70-mediated luciferase refolding that bind to DnaJ.Q54337465
1,3,5-Trihydroxy-13,13-dimethyl-2H-pyran [7,6-b] xanthone directly targets heat shock protein 27 in hepatocellular carcinoma.Q54765314
Effective immunotherapy of rat glioblastoma with prolonged intratumoral delivery of exogenous heat shock protein Hsp70.Q55461040
Sensitization of prostate cancer to radiation therapy: Molecules and pathways to targetQ57108917
Increased expression of heat shock factor 1 (HSF1) is associated with poor survival in gastric cancer patientsQ57453051
Heat Shock Factor 1 Predicts Poor Prognosis of Gastric CancerQ57456602
Melatonin protects chronic kidney disease mesenchymal stem cells against senescence via PrP dependent enhancement of the mitochondrial functionQ58104822
Heat Shock Proteins as ImmunomodulantsQ58568805
HSF1 as a Cancer Biomarker and Therapeutic TargetQ58594721
HSP90AA1-mediated autophagy promotes drug resistance in osteosarcomaQ58698951
UBXN2A enhances CHIP-mediated proteasomal degradation of oncoprotein mortalin-2 in cancer cellsQ58766271
Cancer theory faces doubtsQ59053954
Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countriesQ60142201
HSP90 inhibitor, AUY922, debilitates intrinsic and acquired lapatinib-resistant HER2-positive gastric cancer cellsQ60923414
Silencing Heat Shock Protein 27 Inhibits the Progression and Metastasis of Colorectal Cancer (CRC) by Maintaining the Stability of Stromal Interaction Molecule 1 (STIM1) ProteinsQ60960823
Overcoming acquired resistance to HSP90 inhibition by targeting JAK-STAT signalling in triple-negative breast cancerQ61443854
Hsp70-Activated NK Cells in Combination With PD-1 Inhibition Significantly Increase Overall Survival in Preclinical Models of Glioblastoma and Lung CancerQ64060964
FAM3C-YY1 axis is essential for TGFβ-promoted proliferation and migration of human breast cancer MDA-MB-231 cells via the activation of HSF1Q64076406
Benzylidene lactam compound, KNK437, a novel inhibitor of acquisition of thermotolerance and heat shock protein induction in human colon carcinoma cellsQ73886924
ATP and ADP modulate a cation channel formed by Hsc70 in acidic phospholipid membranesQ74014525
Radioresistance is associated to increased Hsp70 content in human glioblastoma cell linesQ80409163
The protective effect of royal jelly against cisplatin-induced renal oxidative stress in ratsQ84006189
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P433issue1
P577publication date2019-12-24
P1433published inCellsQ27724621
P1476titleHeat Shock Proteins: Agents of Cancer Development and Therapeutic Targets in Anti-Cancer Therapy
P478volume9

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cites work (P2860)
Q99567271Effect of ultra‑wide‑band electromagnetic pulses on blood‑brain barrier permeability in rats
Q99709080HSPA1L Enhances Cancer Stem Cell-Like Properties by Activating IGF1Rβ and Regulating β-Catenin Transcription

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