New inhibitor targeting human transcription factor HSF1: effects on the heat shock response and tumor cell survival

scientific article published on 21 March 2017

New inhibitor targeting human transcription factor HSF1: effects on the heat shock response and tumor cell survival is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1093/NAR/GKX194
P932PMC publication ID5449623
P698PubMed publication ID28369544

P2093author name stringRichard Voellmy
Stuart Firth-Clark
Nuria Vilaboa
Natalie Winfield
Stewart B Kirton
Melanie Bayford
Alba Boré
Francisco Martin-Saavedra
P2860cites workChromatin Landscape Dictates HSF Binding to Target DNA ElementsQ21092435
Inhibiting heat shock factor 1 in human cancer cells with a potent RNA aptamerQ21132046
Negative regulation of the heat shock transcriptional response by HSBP1Q24310850
Molecular chaperones as HSF1-specific transcriptional repressorsQ24606489
Heat shock factor 1 is a powerful multifaceted modifier of carcinogenesisQ24655006
Phosphorylation of serine 303 is a prerequisite for the stress-inducible SUMO modification of heat shock factor 1Q24685095
Analysis of phosphorylation of human heat shock factor 1 in cells experiencing a stressQ24792454
Structure of human heat-shock transcription factor 1 in complex with DNAQ27703282
Systematic and integrative analysis of large gene lists using DAVID bioinformatics resourcesQ27860739
The genetics of the p53 pathway, apoptosis and cancer therapyQ27863460
Requirement for Hsp90 and a CyP-40-type cyclophilin in negative regulation of the heat shock responseQ27929962
DAXX interacts with heat shock factor 1 during stress activation and enhances its transcriptional activityQ28114898
HDAC6 controls major cell response pathways to cytotoxic accumulation of protein aggregatesQ28114913
mTOR is essential for the proteotoxic stress response, HSF1 activation and heat shock protein synthesisQ28116279
Activation of the DNA-binding ability of human heat shock transcription factor 1 may involve the transition from an intramolecular to an intermolecular triple-stranded coiled-coil structureQ28116875
Repression of heat shock transcription factor HSF1 activation by HSP90 (HSP90 complex) that forms a stress-sensitive complex with HSF1Q28118304
Evidence for a mechanism of repression of heat shock factor 1 transcriptional activity by a multichaperone complexQ28118708
Elevated expression of heat shock factor (HSF) 2A stimulates HSF1-induced transcription during stressQ28179990
Heat shock proteins and heat shock factor 1 in carcinogenesis and tumor development: an updateQ28272905
Molecular chaperones in protein folding and proteostasisQ29547715
limma powers differential expression analyses for RNA-sequencing and microarray studiesQ29617988
KRIBB11 Inhibits HSP70 Synthesis through Inhibition of Heat Shock Factor 1 Function by Impairing the Recruitment of Positive Transcription Elongation Factor b to the hsp70 PromoterQ33747276
HSP90 interacts with and regulates the activity of heat shock factor 1 in Xenopus oocytesQ33776598
Heat-shock transcription factor HSF1 has a critical role in human epidermal growth factor receptor-2-induced cellular transformation and tumorigenesisQ34134476
Targeted disruption of heat shock transcription factor 1 abolishes thermotolerance and protection against heat-inducible apoptosis.Q52529692
Induction of heat shock proteins by heregulin beta1 leads to protection from apoptosis and anchorage-independent growth.Q53851410
Interplay of Acetyltransferase EP300 and the Proteasome System in Regulating Heat Shock Transcription Factor 1Q58007306
Heat Shock Factor 2 (HSF2) Contributes to Inducible Expression ofhspGenes through Interplay with HSF1Q59572058
Purified human factor activates heat shock promoter in a HeLa cell-free transcription systemQ67980873
Modified His-tag fusion vector for enhanced protein purification by immobilized metal affinity chromatographyQ79824262
Novel gene switches for targeted and timed expression of proteins of interestQ81798921
HSF1 drives a transcriptional program distinct from heat shock to support highly malignant human cancersQ34292197
RPA assists HSF1 access to nucleosomal DNA by recruiting histone chaperone FACT.Q34400850
The proteasome inhibitor PS-341 inhibits growth, induces apoptosis, and overcomes drug resistance in human multiple myeloma cells.Q34514717
HDAC6-ubiquitin interaction controls the duration of HSF1 activation after heat shock.Q34680425
Transcription factors as targets for cancer therapyQ34932264
Promotion of heat shock factor Hsf1 degradation via adaptor protein filamin A-interacting protein 1-like (FILIP-1L).Q35213186
High levels of nuclear heat-shock factor 1 (HSF1) are associated with poor prognosis in breast cancerQ35546764
Heat shock transcription factor Hsf1 is involved in tumor progression via regulation of hypoxia-inducible factor 1 and RNA-binding protein HuRQ35807282
Heat shock factors: integrators of cell stress, development and lifespan.Q36109403
Stress-inducible regulation of heat shock factor 1 by the deacetylase SIRT1Q36194366
CHIP activates HSF1 and confers protection against apoptosis and cellular stressQ36266926
Multiple layers of regulation of human heat shock transcription factor 1.Q36553698
Chaperone regulation of the heat shock protein responseQ36700315
Mammalian Heat Shock Response and Mechanisms Underlying Its Genome-wide Transcriptional RegulationQ36782793
Heterotrimerization of heat-shock factors 1 and 2 provides a transcriptional switch in response to distinct stimuli.Q37112625
Structures of HSF2 reveal mechanisms for differential regulation of human heat-shock factors.Q37151770
Transcriptional response to stress in the dynamic chromatin environment of cycling and mitotic cellsQ37157244
The heat shock response: life on the verge of deathQ37802041
cAMP increasing agents prevent the stimulation of heat-shock protein 70 (HSP70) gene expression by cadmium chloride in human myeloid cell linesQ38293074
Genome-wide analysis of human HSF1 signaling reveals a transcriptional program linked to cellular adaptation and survivalQ38305894
Synthesis of rigidified eIF4E/eIF4G inhibitor-1 (4EGI-1) mimetic and their in vitro characterization as inhibitors of protein-protein interactionQ38995037
Silencing HSF1 by short hairpin RNA decreases cell proliferation and enhances sensitivity to hyperthermia in human melanoma cell linesQ39636649
Upregulation of lactate dehydrogenase A by ErbB2 through heat shock factor 1 promotes breast cancer cell glycolysis and growth.Q39814340
Heat shock factor-1 modulates p53 activity in the transcriptional response to DNA damageQ39871502
Interactions between extracellular signal-regulated protein kinase 1, 14-3-3epsilon, and heat shock factor 1 during stressQ40516132
The role of heat shock transcription factor 1 in the genome-wide regulation of the mammalian heat shock responseQ40648546
Regulation of heat shock factor trimer formation: role of a conserved leucine zipperQ41578892
ATF1 modulates the heat shock response by regulating the stress-inducible heat shock factor 1 transcription complexQ41926014
Cultured animal cells exposed to amino acid analogues or puromycin rapidly synthesize several polypeptidesQ42465867
Molecular recognition of receptor sites using a genetic algorithm with a description of desolvationQ43987901
Stress-induced oligomerization and chromosomal relocalization of heat-shock factorQ45295086
Abnormal proteins serve as eukaryotic stress signals and trigger the activation of heat shock genesQ46123618
P275copyright licenseCreative Commons Attribution-NonCommercial 4.0 InternationalQ34179348
P6216copyright statuscopyrightedQ50423863
P4510describes a project that useslimmaQ112236343
P433issue10
P304page(s)5797-5817
P577publication date2017-03-21
P1433published inNucleic Acids ResearchQ135122
P1476titleNew inhibitor targeting human transcription factor HSF1: effects on the heat shock response and tumor cell survival
P478volume45

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cites work (P2860)
Q89876909Chemical Biology Framework to Illuminate Proteostasis
Q55258376Discovering a Reliable Heat-Shock Factor-1 Inhibitor to Treat Human Cancers: Potential Opportunity for Phytochemists.
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Q90088002Dorsomorphin induces cancer cell apoptosis and sensitizes cancer cells to HSP90 and proteasome inhibitors by reducing nuclear heat shock factor 1 levels
Q57629429Dropping in on lipid droplets: insights into cellular stress and cancer
Q49390568HSF1 Is Essential for Myeloma Cell Survival and A Promising Therapeutic Target.
Q58594721HSF1 as a Cancer Biomarker and Therapeutic Target
Q92259555Heat Shock Proteins: Agents of Cancer Development and Therapeutic Targets in Anti-Cancer Therapy
Q39361672MUC1 induces tamoxifen resistance in estrogen receptor-positive breast cancer
Q92517775Nuclear orphan receptor NR2F6 confers cisplatin resistance in epithelial ovarian cancer cells by activating the Notch3 signaling pathway
Q89943442Schizandrin A exhibits potent anticancer activity in colorectal cancer cells by inhibiting heat shock factor 1
Q57793384Small Molecule Inhibitors of HSF1-Activated Pathways as Potential Next-Generation Anticancer Therapeutics
Q41660505Targeting Heat Shock Proteins in Cancer: A Promising Therapeutic Approach
Q89157968Targeting Transcription Factors for Cancer Treatment

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