Discovering a Reliable Heat-Shock Factor-1 Inhibitor to Treat Human Cancers: Potential Opportunity for Phytochemists.

scientific article published on 6 April 2018

Discovering a Reliable Heat-Shock Factor-1 Inhibitor to Treat Human Cancers: Potential Opportunity for Phytochemists. is …
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scholarly articleQ13442814

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P356DOI10.3389/FONC.2018.00097
P932PMC publication ID5897429
P698PubMed publication ID29682483

P2093author name stringZhenguo Liu
Govindasamy Ilangovan
Arturo J Cardounel
Murugesan Velayutham
P2860cites workHeat shock factor 1 is a powerful multifaceted modifier of carcinogenesisQ24655006
Immunosuppressive, anti-inflammatory and anti-cancer properties of triptolide: A mini reviewQ26746015
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Modulation of Akt and ERK1/2 pathways by resveratrol in chronic myelogenous leukemia (CML) cells results in the downregulation of Hsp70Q28472533
Transportable, Chemical Genetic Methodology for the Small Molecule-Mediated Inhibition of Heat Shock Factor 1Q28829297
Regulation of the heat shock transcriptional response: cross talk between a family of heat shock factors, molecular chaperones, and negative regulatorsQ29618401
Tanespimycin as antitumor therapy.Q34026384
HSF1 drives a transcriptional program distinct from heat shock to support highly malignant human cancersQ34292197
The reprogramming of tumor stroma by HSF1 is a potent enabler of malignancyQ34599918
The natural compound cantharidin induces cancer cell death through inhibition of heat shock protein 70 (HSP70) and Bcl-2-associated athanogene domain 3 (BAG3) expression by blocking heat shock factor 1 (HSF1) binding to promotersQ34975398
Ginkgo biloba extract decreases non-small cell lung cancer cell migration by downregulating metastasis-associated factor heat-shock protein 27.Q35117661
Forced expression of heat shock protein 27 (Hsp27) reverses P-glycoprotein (ABCB1)-mediated drug efflux and MDR1 gene expression in Adriamycin-resistant human breast cancer cellsQ35312427
Inhibiting the transcription factor HSF1 as an anticancer strategyQ83588880
Heat shock transcription factor 1 is a key determinant of HCC development by regulating hepatic steatosis and metabolic syndromeQ35545513
High levels of nuclear heat-shock factor 1 (HSF1) are associated with poor prognosis in breast cancerQ35546764
Heat shock transcription factor Hsf1 is involved in tumor progression via regulation of hypoxia-inducible factor 1 and RNA-binding protein HuRQ35807282
Dominant-positive and dominant-negative heat shock factorsQ36009069
Role of GRP78 in promoting therapeutic-resistant breast cancerQ36143861
Prognostic value of peritumoral heat-shock factor-1 in patients receiving resection of hepatocellular carcinomaQ37182260
Elevated levels of HSF1 indicate a poor prognosis in breast cancerQ37528514
Xenohormesis: health benefits from an eon of plant stress response evolution.Q37762762
HSP27, 70 and 90, anti-apoptotic proteins, in clinical cancer therapy (Review).Q38208761
Molecular mechanisms and anti-cancer aspects of the medicinal phytochemicals rocaglamides (=flavaglines).Q38217477
Regulating the master regulator: Controlling heat shock factor 1 as a chemotherapy approachQ38545309
Involvement of GRP78 in the Resistance of Ovarian Carcinoma Cells to PaclitaxelQ38881257
Immediate and transient phosphorylation of the heat shock protein 27 initiates chemoresistance in prostate cancer cellsQ38955574
Nucleoside analog inhibits microRNA-214 through targeting heat-shock factor 1 in human epithelial ovarian cancer.Q39096424
Extract from mistletoe, Viscum album L., reduces Hsp27 and 14-3-3 protein expression and induces apoptosis in C6 rat glioma cellsQ39272299
Silencing HSF1 by short hairpin RNA decreases cell proliferation and enhances sensitivity to hyperthermia in human melanoma cell linesQ39636649
Hsp27 Protects Adenocarcinoma Cells from UV-Induced Apoptosis by Akt and p21-Dependent Pathways of SurvivalQ39653078
A novel HSP90 modulator with selective activity against thyroid cancers in vitroQ39767321
Non-oncogene addiction and the stress phenotype of cancer cellsQ40077390
Discovery of 4,6-disubstituted pyrimidines as potent inhibitors of the heat shock factor 1 (HSF1) stress pathway and CDK9.Q41292799
Regulation of heat shock factor trimer formation: role of a conserved leucine zipperQ41578892
New inhibitor targeting human transcription factor HSF1: effects on the heat shock response and tumor cell survivalQ42237173
p53 inhibitor pifithrin alpha can suppress heat shock and glucocorticoid signaling pathways.Q44362161
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P304page(s)97
P577publication date2018-04-06
P1433published inFrontiers in OncologyQ26839986
P1476titleDiscovering a Reliable Heat-Shock Factor-1 Inhibitor to Treat Human Cancers: Potential Opportunity for Phytochemists.
P478volume8

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Q89943442Schizandrin A exhibits potent anticancer activity in colorectal cancer cells by inhibiting heat shock factor 1cites workP2860

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