HSF1 Is Essential for Myeloma Cell Survival and A Promising Therapeutic Target.

scientific article

HSF1 Is Essential for Myeloma Cell Survival and A Promising Therapeutic Target. is …
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scholarly articleQ13442814

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P356DOI10.1158/1078-0432.CCR-17-1594
P932PMC publication ID6420136
P698PubMed publication ID29391353

P50authorGareth J. MorganQ61996585
Jacqueline H L FokQ87669807
Keith JonesQ42289984
Christopher P WardellQ56422135
P2093author name stringLei Zhang
Faith E Davies
Suzanne A Eccles
Paul Workman
Jonathan J Keats
Carl S Rye
Charlotte Pawlyn
Michael D Bright
Somaieh Hedayat
Nicola E A Chessum
Emmanuel De Billy
Fabio Mirabella
Lauren I Aronson
P2860cites workHeat shock factor 1 is a powerful multifaceted modifier of carcinogenesisQ24655006
Analysis of phosphorylation of human heat shock factor 1 in cells experiencing a stressQ24792454
DangER: protein ovERload. Targeting protein degradation to treat myelomaQ26825417
Protein translation and folding are coupled by an endoplasmic-reticulum-resident kinaseQ28296183
Tanespimycin monotherapy in relapsed multiple myeloma: results of a phase 1 dose-escalation studyQ33390600
KRIBB11 Inhibits HSP70 Synthesis through Inhibition of Heat Shock Factor 1 Function by Impairing the Recruitment of Positive Transcription Elongation Factor b to the hsp70 PromoterQ33747276
High level of HSF1 associates with aggressive endometrial carcinoma and suggests potential for HSP90 inhibitorsQ33877440
Selective suppression of lymphomas by functional loss of Hsf1 in a p53-deficient mouse model for spontaneous tumorsQ79801045
Inhibiting the transcription factor HSF1 as an anticancer strategyQ83588880
Tanespimycin and bortezomib combination treatment in patients with relapsed or relapsed and refractory multiple myeloma: results of a phase 1/2 studyQ84013087
Guidelines for the welfare and use of animals in cancer researchQ33903753
Choose and Use Your Chemical Probe Wisely to Explore Cancer BiologyQ33906319
Heat-shock transcription factor HSF1 has a critical role in human epidermal growth factor receptor-2-induced cellular transformation and tumorigenesisQ34134476
HSF1 drives a transcriptional program distinct from heat shock to support highly malignant human cancersQ34292197
Antimyeloma Effects of the Heat Shock Protein 70 Molecular Chaperone Inhibitor MAL3-101Q35251058
High levels of nuclear heat-shock factor 1 (HSF1) are associated with poor prognosis in breast cancerQ35546764
Hsp90 molecular chaperone inhibitors: are we there yet?Q35655105
Heat shock transcription factor Hsf1 is involved in tumor progression via regulation of hypoxia-inducible factor 1 and RNA-binding protein HuRQ35807282
A novel association between the human heat shock transcription factor 1 (HSF1) and prostate adenocarcinomaQ35809875
Global cellular response to chemotherapy-induced apoptosisQ37255788
Intraclonal heterogeneity is a critical early event in the development of myeloma and precedes the development of clinical symptomsQ37564751
Bortezomib-induced heat shock response protects multiple myeloma cells and is activated by heat shock factor 1 serine 326 phosphorylationQ37644930
Recent advances and future directions in targeting the secretory apparatus in multiple myelomaQ38258197
Tight coordination of protein translation and HSF1 activation supports the anabolic malignant stateQ38361655
Hsp70 inhibition induces myeloma cell death via the intracellular accumulation of immunoglobulin and the generation of proteotoxic stressQ39120344
State of heat shock factor 1 expression as a putative diagnostic marker for oral squamous cell carcinomaQ39481890
Proteotoxic stress targeted therapy (PSTT): induction of protein misfolding enhances the antitumor effect of the proteasome inhibitor bortezomibQ39569161
Dual targeting of HSC70 and HSP72 inhibits HSP90 function and induces tumor-specific apoptosisQ39943208
A stressful life (or death): combinatorial proteotoxic approaches to cancer-selective therapeutic vulnerabilityQ40048204
Heat shock protein inhibition is associated with activation of the unfolded protein response pathway in myeloma plasma cellsQ40128062
Gene and protein expression profiling of human ovarian cancer cells treated with the heat shock protein 90 inhibitor 17-allylamino-17-demethoxygeldanamycin.Q40149301
Extensive immunoglobulin production sensitizes myeloma cells for proteasome inhibition.Q40169580
BIRB 796 enhances cytotoxicity triggered by bortezomib, heat shock protein (Hsp) 90 inhibitor, and dexamethasone via inhibition of p38 mitogen-activated protein kinase/Hsp27 pathway in multiple myeloma cell lines and inhibits paracrine tumour growthQ40195083
Proteasome inhibitors induce a terminal unfolded protein response in multiple myeloma cellsQ40310345
Antimyeloma activity of heat shock protein-90 inhibition.Q40380103
Discovery of 4,6-disubstituted pyrimidines as potent inhibitors of the heat shock factor 1 (HSF1) stress pathway and CDK9.Q41292799
Overexpression of EZH2 in multiple myeloma is associated with poor prognosis and dysregulation of cell cycle control.Q41760786
New inhibitor targeting human transcription factor HSF1: effects on the heat shock response and tumor cell survivalQ42237173
Induction of a heat shock factor 1-dependent stress response alters the cytotoxic activity of hsp90-binding agents.Q42492406
Heat shock factor 1 is a potent therapeutic target for enhancing the efficacy of treatments for multiple myeloma with adverse prognosis.Q42548885
Targeting heat shock protein 72 enhances Hsp90 inhibitor-induced apoptosis in myeloma.Q42940075
Progress and Paradigms in Multiple MyelomaQ44694137
Gene expression profiling and correlation with outcome in clinical trials of the proteasome inhibitor bortezomibQ44937333
The heat shock transcription factor 1 as a potential new therapeutic target in multiple myelomaQ46665629
Integration of Novel Agents into the Care of Patients with Multiple MyelomaQ46754093
Discovery of a Chemical Probe Bisamide (CCT251236): An Orally Bioavailable Efficacious Pirin Ligand from a Heat Shock Transcription Factor 1 (HSF1) Phenotypic ScreenQ48125728
Drugging the heat shock factor 1 pathway: exploitation of the critical cancer cell dependence on the guardian of the proteome.Q53361004
Heat shock factor 1 promotes invasion and metastasis of hepatocellular carcinoma in vitro and in vivo.Q54343391
P4510describes a project that usesImageJQ1659584
P433issue10
P407language of work or nameEnglishQ1860
P304page(s)2395-2407
P577publication date2018-02-01
P1433published inClinical Cancer ResearchQ332253
P1476titleHSF1 Is Essential for Myeloma Cell Survival and A Promising Therapeutic Target
P478volume24

Reverse relations

cites work (P2860)
Q96155632Actionable Strategies to Target Multiple Myeloma Plasma Cell Resistance/Resilience to Stress: Insights From "Omics" Research
Q58594721HSF1 as a Cancer Biomarker and Therapeutic Target
Q90172862Immunosurveillance of cancer cell stress
Q57793384Small Molecule Inhibitors of HSF1-Activated Pathways as Potential Next-Generation Anticancer Therapeutics
Q91906119The first Autumn School on Proteostasis: from molecular mechanisms to organismal consequences

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