Discovery and optimization of cardenolides inhibiting HSF1 activation in human colon HCT-116 cancer cells.

scientific article

Discovery and optimization of cardenolides inhibiting HSF1 activation in human colon HCT-116 cancer cells. is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.18632/ONCOTARGET.25545
P932PMC publication ID6007471
P698PubMed publication ID29930764

P2093author name stringAlina D Nikotina
Boris A Margulis
Elena R Mikhaylova
Irina V Guzhova
Elena Y Komarova
Nikolay D Aksenov
Roman Suezov
Lidia Koludarova
Viktor G Kartzev
P2860cites workPrimary cultures of human colon cancer as a model to study cancer stem cells.Q38736903
Heat shock factor 1 is required for migration and invasion of human melanoma in vitro and in vivo.Q38959226
Targeting heat shock proteins by phenethyl isothiocyanate results in cell-cycle arrest and apoptosis of human breast cancer cellsQ39175428
Toxicity of triptolide and the molecular mechanisms involvedQ39237694
Molecular Chaperone Accumulation in Cancer and Decrease in Alzheimer's Disease: The Potential Roles of HSF1.Q39292455
Silencing HSF1 by short hairpin RNA decreases cell proliferation and enhances sensitivity to hyperthermia in human melanoma cell linesQ39636649
Therapeutic and toxic effects of digitalis: William Withering, 1785.Q39754968
Triptolide therapy for neuroblastoma decreases cell viability in vitro and inhibits tumor growth in vivoQ39821586
Targeting the hsp70 gene delays mammary tumor initiation and inhibits tumor cell metastasisQ42171605
New inhibitor targeting human transcription factor HSF1: effects on the heat shock response and tumor cell survivalQ42237173
Accumulation of major stress protein 70kDa protects myeloid and lymphoid cells from death by apoptosisQ42453548
Triptolide, an inhibitor of the human heat shock response that enhances stress-induced cell deathQ46937309
Regulation of heat shock transcription factors and their roles in physiology and diseaseQ47885818
A regulatory upstream promoter element in the Drosophila hsp 70 heat-shock gene.Q52527826
Real time monitoring of the cell viability during treatment with tumor-targeted toxins and saponins using impedance measurement.Q54517629
Heat shock factor 1 is a powerful multifaceted modifier of carcinogenesisQ24655006
Inhibition of inducible heat shock protein-70 (hsp72) enhances bortezomib-induced cell death in human bladder cancer cellsQ28534720
KRIBB11 Inhibits HSP70 Synthesis through Inhibition of Heat Shock Factor 1 Function by Impairing the Recruitment of Positive Transcription Elongation Factor b to the hsp70 PromoterQ33747276
Cisplatin in cancer therapy: molecular mechanisms of actionQ34098163
HSF1 drives a transcriptional program distinct from heat shock to support highly malignant human cancersQ34292197
Clonogenic assay of cells in vitro.Q34615431
Minnelide reduces tumor burden in preclinical models of osteosarcomaQ35282721
Heat shock factors: integrators of cell stress, development and lifespan.Q36109403
Targeting HSF1 disrupts HSP90 chaperone function in chronic lymphocytic leukemia.Q36544683
Synergistic anticancer effects of triptolide and celastrol, two main compounds from thunder god vine.Q36544979
Hsp70 chaperone as a survival factor in cell pathologyQ36674471
Knock-down of Hdj2/DNAJA1 co-chaperone results in an unexpected burst of tumorigenicity of C6 glioblastoma cells.Q37225473
Triptolide has anticancer and chemosensitization effects by down-regulating Akt activation through the MDM2/REST pathway in human breast cancerQ37269178
Cardiac glycosides in cancer therapy: from preclinical investigations towards clinical trials.Q38113122
HSP27, 70 and 90, anti-apoptotic proteins, in clinical cancer therapy (Review).Q38208761
Heat shock transcription factor 1 promotes the proliferation, migration and invasion of osteosarcoma cells.Q38709198
P4510describes a project that usesRTCAQ114077291
P433issue43
P407language of work or nameEnglishQ1860
P304page(s)27268-27279
P577publication date2018-06-05
P1433published inOncotargetQ1573155
P1476titleDiscovery and optimization of cardenolides inhibiting HSF1 activation in human colon HCT-116 cancer cells.
P478volume9

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cites work (P2860)
Q56973741Etoposide-Induced Apoptosis in Cancer Cells Can Be Reinforced by an Uncoupled Link between Hsp70 and Caspase-3
Q90381124Radiosensitization of HSF-1 Knockdown Lung Cancer Cells by Low Concentrations of Hsp90 Inhibitor NVP-AUY922
Q57793384Small Molecule Inhibitors of HSF1-Activated Pathways as Potential Next-Generation Anticancer Therapeutics

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