Targeting the hsp70 gene delays mammary tumor initiation and inhibits tumor cell metastasis

scientific article published on 9 February 2015

Targeting the hsp70 gene delays mammary tumor initiation and inhibits tumor cell metastasis is …
instance of (P31):
scholarly articleQ13442814

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P6179Dimensions Publication ID1049631772
P356DOI10.1038/ONC.2015.1
P932PMC publication ID7331470
P698PubMed publication ID25659585
P5875ResearchGate publication ID272100464

P2093author name stringM Y Sherman
J Gong
T Eguchi
B Song
S K Calderwood
A Murshid
D Weng
P2860cites workMetastasis is an early event in mouse mammary carcinomas and is associated with cells bearing stem cell markersQ21195203
Hallmarks of Cancer: The Next GenerationQ22252312
Links between metabolism and cancerQ24626229
Epithelial-mesenchymal transitions in tumour progressionQ27860487
mTOR is essential for the proteotoxic stress response, HSF1 activation and heat shock protein synthesisQ28116279
Met, metastasis, motility and moreQ28235183
Invasive growth: a MET-driven genetic programme for cancer and stem cellsQ28253680
Beyond tumorigenesis: cancer stem cells in metastasisQ28279788
Essential role for the c-met receptor in the migration of myogenic precursor cells into the limb budQ28506228
Genomic instability and enhanced radiosensitivity in Hsp70.1- and Hsp70.3-deficient miceQ28506379
The Hsp70 and Hsp60 chaperone machinesQ29547601
The heat-shock proteinsQ29617227
CoREST represses the heat shock response mediated by HSF1.Q39957026
Overexpression of the heat-shock protein 70 is associated to imatinib resistance in chronic myeloid leukemiaQ40207892
Using a xenograft model of human breast cancer metastasis to find genes associated with clinically aggressive diseaseQ40402325
Prognostic significance of co-expression of RON and MET receptors in node-negative breast cancer patients.Q40443024
Role of the major heat shock proteins as molecular chaperonesQ40800614
Transgenic mouse models of mammary tumorigenesisQ40856673
Members of the heat-shock protein 70 family promote cancer cell growth by distinct mechanismsQ41197754
Members of the 70-kilodalton heat shock protein family contain a highly conserved calmodulin-binding domainQ43183832
Mucin 1-specific immunotherapy in a mouse model of spontaneous breast cancerQ44270295
Heat-shock protein 70 as a prognostic marker in node-negative breast cancer.Q44486941
Targeted expression of HGF/SF in mouse mammary epithelium leads to metastatic adenosquamous carcinomas through the activation of multiple signal transduction pathways.Q44662285
C-Met overexpression in node-positive breast cancer identifies patients with poor clinical outcome independent of Her2/neuQ45083973
HSP90 inhibition is effective in breast cancer: a phase II trial of tanespimycin (17-AAG) plus trastuzumab in patients with HER2-positive metastatic breast cancer progressing on trastuzumab.Q45387477
Stimulation of mammary tumorigenesis by systemic tissue inhibitor of matrix metalloproteinase 4 gene delivery.Q45876182
c-MET expression level in primary colon cancer: a predictor of tumor invasion and lymph node metastases.Q46265281
Targeting HSP70 for cancer therapy.Q52295438
Activation of the c-Src tyrosine kinase is required for the induction of mammary tumors in transgenic miceQ71606712
The potential role of HSP70 as an indicator of response to radiation and hyperthermia treatments for recurrent breast cancerQ71794499
c-Met autocrine activation induces development of malignant melanoma and acquisition of the metastatic phenotypeQ77583076
Significant correlation between expression of heat shock proteins 27, 70 and lymphocyte infiltration in esophageal squamous cell carcinomaQ77648006
Prevention of spontaneous breast carcinoma by prophylactic vaccination with dendritic/tumor fusion cellsQ78946224
Correlation of heat shock protein (HSP70) expression with cell proliferation (MIB1), estrogen receptors (ER) and clinicopathological variables in invasive ductal breast carcinomasQ81563587
Hsp70: anti-apoptotic and tumorigenic proteinQ84904226
Wound repair and regenerationQ29617949
Induction of mammary tumors by expression of polyomavirus middle T oncogene: a transgenic mouse model for metastatic diseaseQ29619726
Hsp70-Bag3 interactions regulate cancer-related signaling networksQ30009385
How the cell copes with stress and the function of heat shock proteinsQ30419921
Combination of trastuzumab and tanespimycin (17-AAG, KOS-953) is safe and active in trastuzumab-refractory HER-2 overexpressing breast cancer: a phase I dose-escalation studyQ33377626
Identification of metastasis-related proteins and their clinical relevance to triple-negative human breast cancerQ33382317
Targeting HSP70: the second potentially druggable heat shock protein and molecular chaperone?Q33550062
Expression of heat shock proteins and heat shock protein messenger ribonucleic acid in human prostate carcinoma in vitro and in tumors in vivo.Q33736465
Immunotherapy of radioresistant mammary tumors with early metastasis using molecular chaperone vaccines combined with ionizing radiationQ33859251
Heat shock proteins in cancer: diagnostic, prognostic, predictive, and treatment implicationsQ33899708
Mechanisms of HGF/Met signaling to Brk and Sam68 in breast cancer progressionQ34085432
The turn motif is a phosphorylation switch that regulates the binding of Hsp70 to protein kinase C.Q34134869
Wound-healing assay.Q34373085
OstemiR: a novel panel of microRNA biomarkers in osteoblastic and osteocytic differentiation from mesencymal stem cellsQ34637681
Heat shock factor 1 represses estrogen-dependent transcription through association with MTA1.Q34699433
Matrix metalloproteinase genes are associated with breast cancer risk and survival: the Breast Cancer Health Disparities StudyQ34733697
A unique role for heat shock protein 70 and its binding partner tissue transglutaminase in cancer cell migrationQ35423309
High levels of nuclear heat-shock factor 1 (HSF1) are associated with poor prognosis in breast cancerQ35546764
Hsp90 molecular chaperone inhibitors: are we there yet?Q35655105
Molecular chaperones in mammary cancer growth and breast tumor therapyQ35843133
HSP90 and HSP70 proteins are essential for stabilization and activation of WASF3 metastasis-promoting proteinQ35880133
Heat shock protein Hsp72 plays an essential role in Her2-induced mammary tumorigenesisQ36208512
Scatter factor: molecular characteristics and effect on the invasiveness of epithelial cellsQ36223889
Hsp70 is a novel posttranscriptional regulator of gene expression that binds and stabilizes selected mRNAs containing AU-rich elementsQ36506606
Sca-1 identifies the tumor-initiating cells in mammary tumors of BALB-neuT transgenic miceQ36982130
Prognostic significance of heat shock protein 70 expression in early gastric carcinomaQ36983407
Hsp90, an unlikely ally in the war on cancerQ37274497
MET signalling: principles and functions in development, organ regeneration and cancerQ37811895
Inhibition of HSP70: a challenging anti-cancer strategyQ38023055
The heat shock responseQ38152771
Molecular cochaperones: tumor growth and cancer treatmentQ38166376
Expression of c-met is a strong independent prognostic factor in breast carcinomaQ38472256
Analysis of cellular migration using a two-chamber methodologyQ39478456
HSF1, a versatile factor in tumorogenesisQ39584867
c-Met is essential for wound healing in the skinQ39735911
P433issue43
P407language of work or nameEnglishQ1860
P921main subjecttumor initiationQ7852676
P304page(s)5460-5471
P577publication date2015-02-09
P1433published inOncogeneQ1568657
P1476titleTargeting the hsp70 gene delays mammary tumor initiation and inhibits tumor cell metastasis
P478volume34

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cites work (P2860)
Q90162116A Novel Model of Cancer Drug Resistance: Oncosomal Release of Cytotoxic and Antibody-Based Drugs
Q47362562A Workflow Guide to RNA-seq Analysis of Chaperone Function and Beyond
Q38752925Anticancer Effects of Targeting Hsp70 in Tumor Stromal Cells.
Q37535974Arresting the colonial destiny of metastatic seeds with DNA aptamers.
Q50354200Cancer cell responses to Hsp70 inhibitor JG-98: Comparison with Hsp90 inhibitors and finding synergistic drug combinations.
Q55311846Discovery and optimization of cardenolides inhibiting HSF1 activation in human colon HCT-116 cancer cells.
Q39122582Exosomes in cancer theranostic: Diamonds in the rough
Q92156072Extracellular Hsp70 Reduces the Pro-Tumor Capacity of Monocytes/Macrophages Co-Cultivated with Cancer Cells
Q90080306Heat Shock Proteins Are Essential Components in Transformation and Tumor Progression: Cancer Cell Intrinsic Pathways and Beyond
Q37013952Heat Shock Proteins Promote Cancer: It's a Protection Racket
Q50567847Heat shock proteins and cancer: intracellular chaperones or extracellular signalling ligands?
Q42498952Heat-shock protein 70 expression in the equine cornea
Q53097440Intracellular MMP3 Promotes HSP Gene Expression in Collaboration With Chromobox Proteins.
Q90248977Membrane-bound exosomal HSP70 as a biomarker for detection and monitoring of malignant solid tumours: a pilot study
Q39292455Molecular Chaperone Accumulation in Cancer and Decrease in Alzheimer's Disease: The Potential Roles of HSF1.
Q50133361Organoids with cancer stem cell-like properties secrete exosomes and HSP90 in a 3D nanoenvironment
Q47241645Regulation of Mammary Luminal Cell Fate and Tumorigenesis by p38α.
Q38745407miR-218 Inhibits Proliferation, Migration, and EMT of Gastric Cancer Cells by Targeting WASF3.

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