Organoids with cancer stem cell-like properties secrete exosomes and HSP90 in a 3D nanoenvironment

scientific article published on 7 February 2018

Organoids with cancer stem cell-like properties secrete exosomes and HSP90 in a 3D nanoenvironment is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1371/JOURNAL.PONE.0191109
P8608Fatcat IDrelease_u2qg33nj7vd5bk32icq3vgokva
P932PMC publication ID5802492
P698PubMed publication ID29415026

P50authorTakanori EguchiQ88695175
P2093author name stringHirohiko Okamura
Masaharu Takigawa
Ken-Ichi Kozaki
Stuart K Calderwood
Tetsuya Nakatsura
Jun Murakami
Manami Shimomura
Kenta Uchibe
Chiharu Sogawa
Kuniaki Okamoto
Manabu Itoh
Kazumi Ohyama
Kazuya Arai
Keisuke Nakano
Kisho Ono
Ryosuke Iinuma
Toshifumi Fujiwara
Yoshiki Murata
Yuka Okusha
Yuri Namba
P2860cites workOverexpression of the zinc finger protein MZF1 inhibits hematopoietic development from embryonic stem cells: correlation with negative regulation of CD34 and c-myb promoter activityQ40017527
Prostate cancer antigen-1 contributes to cell survival and invasion though discoidin receptor 1 in human prostate cancerQ40059974
Expression profiling identifies altered expression of genes that contribute to the inhibition of transforming growth factor-beta signaling in ovarian cancerQ40236483
Identification of genes involved in tumor-like properties of embryonic stem cellsQ40254961
Induction of heat shock proteins in B-cell exosomes.Q40392853
Prostate cancer invasion is influenced more by expression of a CD44 isoform including variant 9 than by Muc18.Q40563114
STAT3 mediates IL-6-induced neuroendocrine differentiation in prostate cancer cells .Q40905638
γδ T Cells Support Pancreatic Oncogenesis by Restraining αβ T Cell ActivationQ41057828
Probing the Diversity of T Cell Dysfunction in CancerQ41098734
Establishment and characterization of high- and low-lung-metastatic cell lines derived from murine colon adenocarcinoma 26 tumor lineQ41253803
Targeting the hsp70 gene delays mammary tumor initiation and inhibits tumor cell metastasisQ42171605
Stress-response protein RBM3 attenuates the stem-like properties of prostate cancer cells by interfering with CD44 variant splicingQ42438370
De-novo expression of CD44 and survival in gastric cancerQ42483834
Active macropinocytosis induction by stimulation of epidermal growth factor receptor and oncogenic Ras expression potentiates cellular uptake efficacy of exosomesQ42755820
Breast cancer-associated antigen, DF3/MUC1, induces apoptosis of activated human T cellsQ42806657
Integrin signal masks growth-promotion activity of HB-EGF in monolayer cell culturesQ43249115
Cancer-related inflammation, the seventh hallmark of cancer: links to genetic instabilityQ22242922
Hallmarks of Cancer: The Next GenerationQ22252312
Small molecule inhibitors of aurora-a induce proteasomal degradation of N-myc in childhood neuroblastomaQ24296639
DACH1 is a cell fate determination factor that inhibits cyclin D1 and breast tumor growthQ24303568
CXCL8/IL-8 and CXCL12/SDF-1alpha co-operatively promote invasiveness and angiogenesis in pancreatic cancerQ24318416
ESRP1 and ESRP2 are epithelial cell-type-specific regulators of FGFR2 splicingQ24321530
The Hippo Signaling Pathway in Development and CancerQ24603986
miR-9, a MYC/MYCN-activated microRNA, regulates E-cadherin and cancer metastasisQ24613599
Human and mouse adipose-derived cells support feeder-independent induction of pluripotent stem cellsQ24624032
The role of PTEN/Akt/PI3K signaling in the maintenance and viability of prostate cancer stem-like cell populationsQ24646816
A reciprocal repression between ZEB1 and members of the miR-200 family promotes EMT and invasion in cancer cellsQ24649109
Cellular Reprogramming Using Defined Factors and MicroRNAsQ26744303
Extracellular HSPs: The Complicated Roles of Extracellular HSPs in ImmunityQ26747413
Extracellular vesicle transfer of cancer pathogenic componentsQ26770045
STING: infection, inflammation and cancerQ26776009
Therapeutic strategies targeting cancer stem cellsQ26781398
Extracellular Hsp90 (eHsp90) as the actual target in clinical trials: intentionally or unintentionallyQ26991472
Deconstructing the third dimension: how 3D culture microenvironments alter cellular cuesQ27023837
The two faces of Hippo: targeting the Hippo pathway for regenerative medicine and cancer treatmentQ27025661
HIF1α and HIF2α: sibling rivalry in hypoxic tumour growth and progressionQ27025886
A Novel High-Throughput 3D Screening System for EMT Inhibitors: A Pilot Screening Discovered the EMT Inhibitory Activity of CDK2 Inhibitor SU9516Q27323906
Exosomes secreted under hypoxia enhance invasiveness and stemness of prostate cancer cells by targeting adherens junction moleculesQ27333594
Angiogenic Mechanisms of Human CD34+ Stem Cell Exosomes in the Repair of Ischemic Hindlimb.Q50797309
Intracellular MMP3 Promotes HSP Gene Expression in Collaboration With Chromobox Proteins.Q53097440
The TAM family: phosphatidylserine sensing receptor tyrosine kinases gone awry in cancer.Q54298179
Expression of CD44R1 adhesion molecule in colon carcinomas and metastasesQ72213003
Cancer-associated MUC1 mucin inhibits human T-cell proliferation, which is reversible by IL-2Q74033284
Angiogenic effects of interleukin 8 (CXCL8) in human intestinal microvascular endothelial cells are mediated by CXCR2Q78701428
Identification of putative stem cell markers, CD133 and CXCR4, in hTERT-immortalized primary nonmalignant and malignant tumor-derived human prostate epithelial cell lines and in prostate cancer specimensQ80099843
The transcriptional repressor ZEB1 promotes metastasis and loss of cell polarity in cancerQ80502357
Association of multiple copies of the N-myc oncogene with rapid progression of neuroblastomasQ93621132
Tumor-derived spheroids: Relevance to cancer stem cells and clinical applicationsQ37735627
TGFbeta signalling: a complex web in cancer progressionQ37760038
Redox regulation in stem-like cancer cells by CD44 variant isoforms.Q38075424
The Hippo pathway and human cancer.Q38087215
Stress proteins in aging and life spanQ38112457
LIN28B fosters colon cancer migration, invasion and transformation through let-7-dependent and -independent mechanismsQ38281095
Cdc37 as a co-chaperone to Hsp90.Q38285298
The transcription factor ZEB1 (deltaEF1) promotes tumour cell dedifferentiation by repressing master regulators of epithelial polarityQ38301987
Identification of KLF17 as a novel epithelial to mesenchymal transition inducer via direct activation of TWIST1 in endometrioid endometrial cancer.Q38311270
The tumour microenvironment after radiotherapy: mechanisms of resistance and recurrenceQ38536374
HER2 and EGFR Overexpression Support Metastatic Progression of Prostate Cancer to Bone.Q38735527
Divergent clonal evolution of castration-resistant neuroendocrine prostate cancerQ38768101
Communication by Extracellular Vesicles: Where We Are and Where We Need to Go.Q38769897
Combined evaluation of a panel of protein and miRNA serum-exosome biomarkers for pancreatic cancer diagnosis increases sensitivity and specificity.Q38941237
Epithelial splicing regulatory proteins 1 (ESRP1) and 2 (ESRP2) suppress cancer cell motility via different mechanisms.Q38964131
ATP-binding cassette transporters in tumor endothelial cells and resistance to metronomic chemotherapyQ39143201
MicroRNA-9 enhances migration and invasion through KLF17 in hepatocellular carcinomaQ39150597
EMT, CSCs, and drug resistance: the mechanistic link and clinical implicationsQ39233875
Melanomas resist T-cell therapy through inflammation-induced reversible dedifferentiationQ39262830
Molecular characterization of neuroendocrine prostate cancer and identification of new drug targetsQ39385550
Direct signaling between platelets and cancer cells induces an epithelial-mesenchymal-like transition and promotes metastasisQ39441340
TGF-β drives epithelial-mesenchymal transition through δEF1-mediated downregulation of ESRP.Q39451094
The use of nanoimprinted scaffolds as 3D culture models to facilitate spontaneous tumor cell migration and well-regulated spheroid formationQ39530908
MCF7 side population cells with characteristics of cancer stem/progenitor cells express the tumor antigen MUC1.Q39996214
Stem cells, cancer, and cancer stem cellsQ27860878
Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factorsQ27860937
Possible functions of CD169-positive sinus macrophages in lymph nodes in anti-tumor immune responsesQ28068802
Concise Review: Stem Cells in Pancreatic Cancer: From Concept to TranslationQ28081553
Concise Review: NANOG in Cancer Stem Cells and Tumor Development: An Update and Outstanding QuestionsQ28088370
mTOR is essential for the proteotoxic stress response, HSF1 activation and heat shock protein synthesisQ28116279
Id1 and Id3 are required for neurogenesis, angiogenesis and vascularization of tumour xenograftsQ28146071
Identification and functional characterization of distinct critically important bone morphogenetic protein-specific response elements in the Id1 promoterQ28208212
Transitions between epithelial and mesenchymal states: acquisition of malignant and stem cell traitsQ28237197
The emerging role of EpCAM in cancer and stem cell signalingQ28251164
The cell fate determination factor DACH1 is expressed in estrogen receptor-alpha-positive breast cancer and represses estrogen receptor-alpha signalingQ28252084
Novel transcription-factor-like function of human matrix metalloproteinase 3 regulating the CTGF/CCN2 geneQ28263327
The clonal evolution of tumor cell populationsQ28271546
Heat shock proteins and heat shock factor 1 in carcinogenesis and tumor development: an updateQ28272905
Targeting the dynamic HSP90 complex in cancerQ28288602
Pharmacogenomic discovery using cell-based modelsQ28392982
KLF17 is a negative regulator of epithelial-mesenchymal transition and metastasis in breast cancerQ28594330
Clonal evolution in cancerQ29547696
Prospective identification of tumorigenic prostate cancer stem cellsQ29547859
Drug resistance and the solid tumor microenvironmentQ29614403
Clonal evolution in relapsed acute myeloid leukaemia revealed by whole-genome sequencingQ29614647
Extracellular vesicles: exosomes, microvesicles, and friendsQ29618137
Melanoma exosomes educate bone marrow progenitor cells toward a pro-metastatic phenotype through METQ29618139
Accessories to the crime: functions of cells recruited to the tumor microenvironmentQ29620161
NF-κB regulates mesenchymal transition for the induction of non-small cell lung cancer initiating cellsQ30417710
Dachshund inhibits oncogene-induced breast cancer cellular migration and invasion through suppression of interleukin-8.Q30481878
Collective cell migration requires suppression of actomyosin at cell-cell contacts mediated by DDR1 and the cell polarity regulators Par3 and Par6.Q30497855
CD44v/CD44s expression patterns are associated with the survival of pancreatic carcinoma patientsQ30584751
The role of CD133 in the identification and characterisation of tumour-initiating cells in non-small-cell lung cancerQ33451434
The Sca-1 cell surface marker enriches for a prostate-regenerating cell subpopulation that can initiate prostate tumorigenesisQ33769624
Comparison of defined culture systems for feeder cell free propagation of human embryonic stem cellsQ33794176
Characterization of cancer stem-like cells derived from mouse induced pluripotent stem cells transformed by tumor-derived extracellular vesiclesQ33935224
High aldehyde dehydrogenase activity identifies tumor-initiating and metastasis-initiating cells in human prostate cancerQ34118497
The plasminogen activator/plasmin systemQ34202297
Interactions between cancer stem cells and their niche govern metastatic colonizationQ34239769
miRNA-720 controls stem cell phenotype, proliferation and differentiation of human dental pulp cellsQ34395505
The EGFR family and its ligands in human cancer. signalling mechanisms and therapeutic opportunitiesQ34399306
Evolution of the cancer stem cell modelQ34408981
The many faces of metalloproteases: cell growth, invasion, angiogenesis and metastasisQ34421800
Hypoxia-inducible factors, stem cells, and cancerQ34625782
CD44 splice isoform switching in human and mouse epithelium is essential for epithelial-mesenchymal transition and breast cancer progressionQ34627193
OstemiR: a novel panel of microRNA biomarkers in osteoblastic and osteocytic differentiation from mesencymal stem cellsQ34637681
Exosomes as divine messengers: are they the Hermes of modern molecular oncology?Q34675263
HSF1 regulation of β-catenin in mammary cancer cells through control of HuR/elavL1 expressionQ34765945
Targeting tumor-associated macrophages as a novel strategy against breast cancerQ34803221
Spherical cancer models in tumor biologyQ35023931
Human ovarian carcinoma–associated mesenchymal stem cells regulate cancer stem cells and tumorigenesis via altered BMP productionQ35142842
Increased fucosylation has a pivotal role in invasive and metastatic properties of head and neck cancer stem cellsQ35238399
Terminal neuroendocrine differentiation of human prostate carcinoma cells in response to increased intracellular cyclic AMPQ35436566
The role of Notch in tumorigenesis: oncogene or tumour suppressor?Q35564593
β-catenin/TCF4 complex induces the epithelial-to-mesenchymal transition (EMT)-activator ZEB1 to regulate tumor invasiveness.Q35585837
Hsp90 molecular chaperone inhibitors: are we there yet?Q35655105
Osteopontin mediates an MZF1-TGF-β1-dependent transformation of mesenchymal stem cells into cancer-associated fibroblasts in breast cancerQ35768332
TGFβ1 secreted by cancer-associated fibroblasts induces epithelial-mesenchymal transition of bladder cancer cells through lncRNA-ZEB2NAT.Q35830257
Hsp90α and Hsp90β together operate a hypoxia and nutrient paucity stress-response mechanism during wound healingQ35898804
Anticancer drugs cause release of exosomes with heat shock proteins from human hepatocellular carcinoma cells that elicit effective natural killer cell antitumor responses in vitroQ35939788
Distinct neural stem cell populations give rise to disparate brain tumors in response to N-MYC.Q35989886
Epidermal Growth Factor Receptor in Prostate Cancer Derived ExosomesQ36010700
Transactivation of vascular endothelial growth factor receptor-2 by interleukin-8 (IL-8/CXCL8) is required for IL-8/CXCL8-induced endothelial permeabilityQ36173954
PC3 is a cell line characteristic of prostatic small cell carcinoma.Q36185201
Identification of a distinct population of CD133(+)CXCR4(+) cancer stem cells in ovarian cancerQ36293646
Epithelial-mesenchymal transition in development and cancer: role of phosphatidylinositol 3' kinase/AKT pathwaysQ36313178
Secreted Hsp90 is a novel regulator of the epithelial to mesenchymal transition (EMT) in prostate cancer.Q36368188
MacroH2A1 downregulation enhances the stem-like properties of bladder cancer cells by transactivation of Lin28BQ36686246
Unusual and underappreciated: small cell carcinoma of the prostate.Q36725653
MUC1-C oncoprotein as a target in breast cancer: activation of signaling pathways and therapeutic approachesQ36753508
TGF-β1 exposure induces epithelial to mesenchymal transition both in CSCs and non-CSCs of the A549 cell line, leading to an increase of migration ability in the CD133+ A549 cell fraction.Q36907085
SIRT6 Suppresses Pancreatic Cancer through Control of Lin28bQ36968417
Lin-Sca-1+CD49fhigh stem/progenitors are tumor-initiating cells in the Pten-null prostate cancer modelQ37438615
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P433issue2
P407language of work or nameEnglishQ1860
P921main subjectneoplastic stem cellsQ1638475
organoidQ11293125
P304page(s)e0191109
P577publication date2018-02-07
P1433published inPLOS OneQ564954
P1476titleOrganoids with cancer stem cell-like properties secrete exosomes and HSP90 in a 3D nanoenvironment
P478volume13

Reverse relations

cites work (P2860)
Q920895163D Cellular Architecture Affects MicroRNA and Protein Cargo of Extracellular Vesicles
Q900457373D cell culture stimulates the secretion of in vivo like extracellular vesicles
Q974220143D culture technologies of cancer stem cells: promising ex vivo tumor models
Q90162116A Novel Model of Cancer Drug Resistance: Oncosomal Release of Cytotoxic and Antibody-Based Drugs
Q92051086Advances in therapeutic applications of extracellular vesicles
Q90418846Alcohol Exposure Impacts the Composition of HeLa-Derived Extracellular Vesicles
Q89896564Antiparkinson Drug Benztropine Suppresses Tumor Growth, Circulating Tumor Cells, and Metastasis by Acting on SLC6A3/DAT and Reducing STAT3
Q90598634Cell Stress Induced Stressome Release Including Damaged Membrane Vesicles and Extracellular HSP90 by Prostate Cancer Cells
Q92154779Chaperoning STAT3/5 by Heat Shock Proteins: Interest of Their Targeting in Cancer Therapy
Q90270928Cockle Shell-Derived Aragonite CaCO3 Nanoparticles for Co-Delivery of Doxorubicin and Thymoquinone Eliminates Cancer Stem Cells
Q58576093Depletion of Lipid Efflux Pump ABCG1 Triggers the Intracellular Accumulation of Extracellular Vesicles and Reduces Aggregation and Tumorigenesis of Metastatic Cancer Cells
Q94553421Designer Self-Assembling Peptide Hydrogels to Engineer 3D Cell Microenvironments for Cell Constructs Formation and Precise Oncology Remodeling in Ovarian Cancer
Q102141394Exosomes and breast cancer drug resistance
Q94601218Exosomes in osteoarthritis and cartilage injury: advanced development and potential therapeutic strategies
Q104500575Extracellular heat shock proteins and cancer: New perspectives
Q64972659Extracellular vesicle release from intestinal organoids is modulated by Apc mutation and other colorectal cancer progression factors.
Q90080306Heat Shock Proteins Are Essential Components in Transformation and Tumor Progression: Cancer Cell Intrinsic Pathways and Beyond
Q93052187Immunological Outcomes Mediated Upon Binding of Heat Shock Proteins to Scavenger Receptors SCARF1 and LOX-1, and Endocytosis by Mononuclear Phagocytes
Q92127472Immunoregulatory Potential of Exosomes Derived from Cancer Stem Cells
Q92636704MZF1 and SCAND1 Reciprocally Regulate CDC37 Gene Expression in Prostate Cancer
Q99634882Organoids in Translational Oncology
Q90163791Roles of Extracellular HSPs as Biomarkers in Immune Surveillance and Immune Evasion
Q59806470The Crosstalk between Cancer Stem Cells and Microenvironment Is Critical for Solid Tumor Progression: The Significant Contribution of Extracellular Vesicles

Search more.