Effects of Histone Deacetylase Inhibitor Panobinostat (LBH589) on Bone Marrow Mononuclear Cells of Relapsed or Refractory Multiple Myeloma Patients and Its Mechanisms

scientific article published on 29 October 2017

Effects of Histone Deacetylase Inhibitor Panobinostat (LBH589) on Bone Marrow Mononuclear Cells of Relapsed or Refractory Multiple Myeloma Patients and Its Mechanisms is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.12659/MSM.904232
P932PMC publication ID5674922
P698PubMed publication ID29080899

P2093author name stringLing Zhang
Wenhua Liu
Yanping Ma
Gu Jia
P2860cites workThe histone deacetylase inhibitor LBH589 is a potent antimyeloma agent that overcomes drug resistance.Q40272775
Combination of the histone deacetylase inhibitor LBH589 and the hsp90 inhibitor 17-AAG is highly active against human CML-BC cells and AML cells with activating mutation of FLT-3.Q40498632
The histone deacetylase inhibitor NVP-LAQ824 inhibits angiogenesis and has a greater antitumor effect in combination with the vascular endothelial growth factor receptor tyrosine kinase inhibitor PTK787/ZK222584.Q40514693
Analysis of histone deacetylase inhibitor, depsipeptide (FR901228), effect on multiple myelomaQ40520464
Synergistic induction of oxidative injury and apoptosis in human multiple myeloma cells by the proteasome inhibitor bortezomib and histone deacetylase inhibitorsQ40550020
Histone deacetylase inhibitor LAQ824 down-regulates Her-2 and sensitizes human breast cancer cells to trastuzumab, taxotere, gemcitabine, and epothilone BQ40623032
Aggresome induction by proteasome inhibitor bortezomib and alpha-tubulin hyperacetylation by tubulin deacetylase (TDAC) inhibitor LBH589 are synergistic in myeloma cellsQ42156460
Molecular sequelae of histone deacetylase inhibition in human malignant B cellsQ44280918
Histone deacetylase inhibitor LAQ824 both lowers expression and promotes proteasomal degradation of Bcr-Abl and induces apoptosis of imatinib mesylate-sensitive or -refractory chronic myelogenous leukemia-blast crisis cells.Q44564135
Panobinostat induces apoptosis via production of reactive oxygen species and synergizes with topoisomerase inhibitors in cervical cancer cellsQ46466046
HDAC1 regulates fear extinction in mice.Q47913817
A histone deacetylase inhibitor enhances expression of genes inhibiting Wnt pathway and augments activity of DNA demethylation reagent against nonsmall-cell lung cancerQ48199426
Histone Deacetylase InhibitorsQ55952250
Inhibitors of histone deacetylases induce tumor-selective apoptosis through activation of the death receptor pathwayQ58862256
Toso, a cell surface, specific regulator of Fas-induced apoptosis in T cellsQ24316070
Chromatin modifications and their functionQ27861067
Cell death: critical control pointsQ28240722
Clinical development of histone deacetylase inhibitors as anticancer agentsQ28244438
The mouse cell surface protein TOSO regulates Fas/Fas ligand-induced apoptosis through its binding to Fas-associated death domainQ28512719
Anticancer activities of histone deacetylase inhibitorsQ29616624
Phase I Study of Panobinostat (LBH589) and Letrozole in Postmenopausal Metastatic Breast Cancer PatientsQ33429255
Molecular sequelae of proteasome inhibition in human multiple myeloma cellsQ34393832
Caspase-independent cell deathQ34433759
HDAC inhibitor L-carnitine and proteasome inhibitor bortezomib synergistically exert anti-tumor activity in vitro and in vivoQ34534191
Activation of p21 by HDAC inhibitors requires acetylation of H2A.Z.Q34562595
Histone deacetylases and cancer: causes and therapiesQ34570082
Transcriptional signature of histone deacetylase inhibition in multiple myeloma: biological and clinical implicationsQ35734509
The pan-HDAC inhibitor panobinostat acts as a sensitizer for erlotinib activity in EGFR-mutated and -wildtype non-small cell lung cancer cellsQ35870933
Multidrug resistance: retrospect and prospects in anti-cancer drug treatment.Q36536479
HDAC inhibitors in kidney development and diseaseQ37115414
Histone deacetylase inhibitors: mechanism of action and therapeutic use in cancer.Q37217007
Efficacy and Safety of Danshen Compound Tablets in Preventing Thalidomide-Associated Thromboembolism in Patients with Multiple Myeloma: A Multicenter Retrospective Study.Q37362054
Fluorodeoxyglucose Positron Emission Tomography-Computed Tomography (FDG PET/CT) Findings in an Unusual Case of Multiple Myeloma Presenting with a Large Extra-Axial Intracranial MassQ37523926
A novel HDAC inhibitor, CG200745, inhibits pancreatic cancer cell growth and overcomes gemcitabine resistanceQ37612692
PARP-1 cleavage fragments: signatures of cell-death proteases in neurodegenerationQ37822920
Pulmonary Nocardiosis in a Multiple Myeloma Patient Treated with Proteasome Inhibitors.Q38388852
Panobinostat: A Review in Relapsed or Refractory Multiple MyelomaQ38716460
Panobinostat for the management of multiple myelomaQ38806260
Ricolinostat, the First Selective Histone Deacetylase 6 Inhibitor, in Combination with Bortezomib and Dexamethasone for Relapsed or Refractory Multiple MyelomaQ39040044
The pan-histone deacetylase inhibitor LBH589 (panobinostat) alters the invasive breast cancer cell phenotype.Q39040551
Histone deacetylase inhibitors induce human renal cell carcinoma cell apoptosis through p-JNK activationQ39075781
The HDAC inhibitor, panobinostat, induces apoptosis by suppressing the expresssion of specificity protein 1 in oral squamous cell carcinoma.Q39121802
P304page(s)5150-5157
P577publication date2017-10-29
P1433published inMedical Science MonitorQ15756323
P1476titleEffects of Histone Deacetylase Inhibitor Panobinostat (LBH589) on Bone Marrow Mononuclear Cells of Relapsed or Refractory Multiple Myeloma Patients and Its Mechanisms
P478volume23

Reverse relations

Q58749971The Expression of Actin-Related Protein 2/3 Complex Subunit 5 (ARPC5) Expression in Multiple Myeloma and its Prognostic Significancecites workP2860

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