MicroRNA-21 promotes glioma cell proliferation and inhibits senescence and apoptosis by targeting SPRY1 via the PTEN/PI3K/AKT signaling pathway.

scientific article published on 5 January 2018

MicroRNA-21 promotes glioma cell proliferation and inhibits senescence and apoptosis by targeting SPRY1 via the PTEN/PI3K/AKT signaling pathway. is …
instance of (P31):
scholarly articleQ13442814
retracted paperQ45182324

External links are
P356DOI10.1111/CNS.12785
P932PMC publication ID6489721
P698PubMed publication ID29316313

P50authorMing LiQ94340482
P2093author name stringShuang-Yin Han
Xi-Qing Li
Lai-Jun Song
Chang Chai
P2860cites workPI3K/PTEN/AKT signaling regulates prostate tumor angiogenesisQ23914949
Identification and expression analysis of a novel splice variant of human Sprouty1 geneQ30821537
Overexpression of RASD1 inhibits glioma cell migration/invasion and inactivates the AKT/mTOR signaling pathwayQ33784380
Radiotherapy plus nimotuzumab or placebo in the treatment of high grade glioma patients: results from a randomized, double blind trialQ34778047
MicroRNA-21 targets a network of key tumor-suppressive pathways in glioblastoma cellsQ34842477
The oncogenic microRNA-21 inhibits the tumor suppressive activity of FBXO11 to promote tumorigenesisQ35172895
Increased signalling of EGFR and IGF1R, and deregulation of PTEN/PI3K/Akt pathway are related with trastuzumab resistance in HER2 breast carcinomas.Q35889941
Spry1 as a novel regulator of erythropoiesis, EPO/EPOR target, and suppressor of JAK2.Q36015223
GSK-3β regulates tumor growth and angiogenesis in human glioma cellsQ36544729
MicroRNA-519a promotes tumor growth by targeting PTEN/PI3K/AKT signaling in hepatocellular carcinomaQ36571466
MicroRNA-205 functions as a tumor suppressor in human glioblastoma cells by targeting VEGF-AQ36642299
microRNA-21 promotes tumor proliferation and invasion in gastric cancer by targeting PTENQ36642781
MicroRNA miR-451 downregulates the PI3K/AKT pathway through CAB39 in human gliomaQ36645527
Spry1 and Spry2 are necessary for eyelid closureQ37378046
PTEN regulation of the proliferation and differentiation of auditory progenitors through the PTEN/PI3K/Akt-signaling pathway in miceQ37530158
Role of the AKT pathway in microRNA expression of human U251 glioblastoma cellsQ38346740
MicroRNA-21 down-regulates the expression of tumor suppressor PDCD4 in human glioblastoma cell T98G.Q38358928
Integrated analysis using methylation and gene expression microarrays reveals PDE4C as a prognostic biomarker in human gliomaQ38476799
Honokiol induces autophagic cell death in malignant glioma through reactive oxygen species-mediated regulation of the p53/PI3K/Akt/mTOR signaling pathwayQ38767810
MicroRNA-21 activation of ERK signaling via PTEN is involved in arsenite-induced autophagy in human hepatic L-02 cellsQ38776012
MicroRNA-214 acts as a potential oncogene in breast cancer by targeting the PTEN-PI3K/Akt signaling pathwayQ38788151
Long non-coding RNA CASC2 suppresses malignancy in human gliomas by miR-21.Q38935662
A novel chemotherapeutic arene ruthenium(II) drug Rawq01 altered the effect of microRNA-21 on PTEN/AKT signaling pathway in esophageal cancer cellsQ39044915
SIRT1 promotes proliferation and inhibits apoptosis of human malignant glioma cell linesQ39301696
MiR-21 protected human glioblastoma U87MG cells from chemotherapeutic drug temozolomide induced apoptosis by decreasing Bax/Bcl-2 ratio and caspase-3 activityQ39679824
MicroRNA-21 (miR-21) represses tumor suppressor PTEN and promotes growth and invasion in non-small cell lung cancer (NSCLC).Q39728869
Downregulation of survivin and activation of caspase-3 through the PI3K/Akt pathway in ursolic acid-induced HepG2 cell apoptosis.Q39890141
Nerve growth factor improves visual loss in childhood optic gliomas: a randomized, double-blind, phase II clinical trialQ40976967
The MicroRNA-21 signaling pathway is involved in prorenin receptor (PRR) -induced VEGF expression in ARPE-19 cells under a hyperglycemic conditionQ42290908
Glioma, glutamate (SLC7A11) and seizures-a commentaryQ42344453
Roles of PI3K/AKT/GSK3/mTOR Pathway in Cell Signaling of Mental IllnessesQ42527577
Effects of MicroRNA-19b on the Proliferation, Apoptosis, and Migration of Wilms' Tumor Cells Via the PTEN/PI3K/AKT Signaling PathwayQ48098841
Human glioma tumors express high levels of the chemokine receptor CX3CR1.Q48312751
SIRT1 promotes tumorigenesis of hepatocellular carcinoma through PI3K/PTEN/AKT signaling.Q53171301
Non-invasive grading of oligodendrogliomas: correlation between in vivo metabolic pattern and histopathology.Q55475268
[The 2007 World Health Organisation classification of tumours of the central nervous system, comparison with 2000 classification]Q82084605
P433issue5
P921main subjectmicroRNAQ310899
P304page(s)369-380
P577publication date2018-01-05
P1433published inCNS Neuroscience & TherapeuticsQ5013184
P1476titleMicroRNA-21 promotes glioma cell proliferation and inhibits senescence and apoptosis by targeting SPRY1 via the PTEN/PI3K/AKT signaling pathway
P478volume24

Reverse relations

cites work (P2860)
Q112296973A Survival-Related Competitive Endogenous RNA Network of Prognostic lncRNAs, miRNAs, and mRNAs in Wilms Tumor
Q90113968A novel SCNN1G mutation in a PHA I infant patient correlates with nephropathy
Q92389924Activation of the Hedgehog Pathway Promotes Recovery of Neurological Function After Traumatic Brain Injury by Protecting the Neurovascular Unit
Q89446408Aspects of the immune system that impact brain function
Q92139608CDKL5 promotes proliferation, migration, and chemotherapeutic drug resistance of glioma cells via activation of the PI3K/AKT signaling pathway
Q90578644Cellular Senescence and Anti-Cancer Therapy
Q104575265EZH2-Inhibited MicroRNA-454-3p Promotes M2 Macrophage Polarization in Glioma
Q97530293Exosomal noncoding RNAs and tumor drug resistance
Q101227782Exosome-Encapsulated MicroRNA-21 from Esophageal Squamous Cell Carcinoma Cells Enhances Angiogenesis of Human Umbilical Venous Endothelial Cells by Targeting SPRY1
Q97683069Expression profiling of circular RNAs and their potential role in early‑stage diabetic cardiomyopathy
Q89909391Hyperhomocysteinemia inhibits tibial fracture healing in rats through PI3K/AKT signaling pathway
Q112338055Inhibition of EMMPRIN by microRNA-124 suppresses the growth, invasion and tumorigenicity of gliomas
Q93059559Low Expression of MicroRNA335-5p Is Associated with Malignant Behavior of Gallbladder Cancer: A Clinicopathological Study
Q90778203M2 bone marrow-derived macrophage-derived exosomes shuffle microRNA-21 to accelerate immune escape of glioma by modulating PEG3
Q59813119Mechanism research on a bioactive resveratrol- PLA-gelatin porous nano-scaffold in promoting the repair of cartilage defect
Q90003809Mesenchymal stem cell-derived exosomes protect beta cells against hypoxia-induced apoptosis via miR-21 by alleviating ER stress and inhibiting p38 MAPK phosphorylation
Q92166073MicroRNA-21-5p participates in IgA nephropathy by driving T helper cell polarization
Q92619701MicroRNA-26b-3p/ANTXR1 signaling modulates proliferation, migration, and apoptosis of glioma
Q60941141MicroRNA-562 negatively regulated c-MET/AKT pathway in the growth of glioblastoma cells
Q104504476MicroRNAs involved in the EGFR pathway in glioblastoma
Q96683433Overexpression of GATA4 enhances the antiapoptotic effect of exosomes secreted from cardiac colony-forming unit fibroblasts via miRNA221-mediated targeting of the PTEN/PI3K/AKT signaling pathway
Q97590835Overexpression of miR-217-5p protects against oxygen-glucose deprivation/reperfusion-induced neuronal injury via inhibition of PTEN
Q93088944Potential Therapeutic Effects of Exosomes Packed With a miR-21-Sponge Construct in a Rat Model of Glioblastoma
Q102066449Recent Advances in Immune Cell Therapy for Glioblastoma
Q104481410Reversed Senescence of Retinal Pigment Epithelial Cell by Coculture With Embryonic Stem Cell via the TGFβ and PI3K Pathways
Q98195525Role of exosomes in malignant glioma: microRNAs and proteins in pathogenesis and diagnosis
Q91271743Simultaneous miRNA and mRNA transcriptome profiling of glioblastoma samples reveals a novel set of OncomiR candidates and their target genes
Q89951810Super-enhancers: A new frontier for glioma treatment
Q104515522Targeting Akt-associated microRNAs for cancer therapeutics
Q92472354The Natural Product Butylcycloheptyl Prodiginine Binds Pre-miR-21, Inhibits Dicer-Mediated Processing of Pre-miR-21, and Blocks Cellular Proliferation
Q91437017The relationship of MicroRNA-21 and plaque stability in acute coronary syndrome
Q91540976lncRNA GAS5/miR-223/NAMPT axis modulates the cell proliferation and senescence of endothelial progenitor cells through PI3K/AKT signaling
Q93022424miR-1254 inhibits progression of glioma in vivo and in vitro by targeting CSF-1
Q91610547miRNA-26a-5p Accelerates Healing via Downregulation of PTEN in Fracture Patients with Traumatic Brain Injury
Q92142260miR‑21 inhibits autophagy and promotes malignant development in the bladder cancer T24 cell line

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