Frequent and Yet Unreported GNAQ and GNA11 Mutations are Found in Uveal Melanomas.

scientific article published on 5 December 2017

Frequent and Yet Unreported GNAQ and GNA11 Mutations are Found in Uveal Melanomas. is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1007/S12253-017-0371-7
P698PubMed publication ID29209985

P50authorBjoern SchneiderQ89496385
P2093author name stringAnselm Jünemann
Andreas Erbersdobler
Andrey Zhivov
Rudolf F Guthoff
Annette Zimpfer
Maja Huehns
Heike Zettl
Katrin Riedel
P2860cites workMutant Gq/11 promote uveal melanoma tumorigenesis by activating YAPQ24298571
Mutations in GNA11 in uveal melanomaQ24625723
Frequent somatic mutations of GNAQ in uveal melanoma and blue naeviQ24646052
Oncogenic mutations in GNAQ occur early in uveal melanomaQ24658558
Recent developments in prognostic and predictive testing in uveal melanomaQ26824096
The T1799A BRAF mutation is present in iris melanomaQ28254902
Distinct sets of genetic alterations in melanomaQ29614965
American joint committee on cancer staging of uveal melanomaQ30448877
Concomitant loss of chromosome 3 and whole arm losses and gains of chromosome 1, 6, or 8 in metastasizing primary uveal melanomaQ30649682
The emerging mutational landscape of G proteins and G-protein-coupled receptors in cancer.Q33799070
Hippo-independent activation of YAP by the GNAQ uveal melanoma oncogene through a trio-regulated rho GTPase signaling circuitry.Q33819083
Does ocular treatment of uveal melanoma influence survival?Q34059687
The genetics of uveal melanoma: an emerging framework for targeted therapyQ34249080
High throughput mass spectrometry-based mutation profiling of primary uveal melanomaQ34414476
Activation of the MAPK pathway is a common event in uveal melanomas although it rarely occurs through mutation of BRAF or RAS.Q36615986
Genomic Correlates of Immune-Cell Infiltrates in Colorectal CarcinomaQ36850230
Patient survival in uveal melanoma is not affected by oncogenic mutations in GNAQ and GNA11Q37040664
Oncogenic GNAQ mutations are not correlated with disease-free survival in uveal melanoma.Q37330725
Absence of BRAF gene mutations in uveal melanomas in contrast to cutaneous melanomas.Q37340405
A study of PCR inhibition mechanisms using real time PCR.Q38347942
Selumetinib for the treatment of metastatic uveal melanoma: past and future perspectivesQ38798084
Mutation frequencies of GNAQ, GNA11, BAP1, SF3B1, EIF1AX and TERT in uveal melanoma: detection of an activating mutation in the TERT gene promoter in a single case of uveal melanomaQ41881966
YAP inhibition blocks uveal melanogenesis driven by GNAQ or GNA11 mutationsQ41957475
Absence of mutations of the BRAF gene and constitutive activation of extracellular-regulated kinase in malignant melanomas of the uveaQ43998617
Lack of BRAF mutations in uveal melanomaQ44605105
The RAS-BRAF kinase pathway is not involved in uveal melanomaQ47390207
Lack of BRAF mutation in primary uveal melanoma.Q47807462
Genetic and clinico-pathologic analysis of metastatic uveal melanomaQ47932446
Analysis of GNAQ mutations, proliferation and MAPK pathway activation in uveal melanomasQ60527002
Independent regulation of hair and skin color by two G protein-coupled pathwaysQ62661037
Absence of BRAF and NRAS mutations in uveal melanomaQ79107430
Uveal melanoma: current insights into clinical relevance of genetic testingQ87133830
P433issue4
P304page(s)1319-1325
P577publication date2017-12-05
P1433published inPathology and Oncology ResearchQ26842743
P1476titleFrequent and Yet Unreported GNAQ and GNA11 Mutations are Found in Uveal Melanomas
P478volume25

Reverse relations

cites work (P2860)
Q103826156Functional characterization of uveal melanoma oncogenes
Q58760393GNA14 silencing suppresses the proliferation of endometrial carcinoma cells through inducing apoptosis and G/M cell cycle arrest
Q92073717LncRNAs in ocular neovascularizations
Q90263983[New treatment options for iridociliary tumors]
Q64269226γ-Propoxy-Sulfo-Lichenan Induces In Vitro Cell Differentiation of Human Keratinocytes