Enhancement of antibody-dependent cellular cytotoxicity of cetuximab by a chimeric protein encompassing interleukin-15.

scientific article published on 13 November 2017

Enhancement of antibody-dependent cellular cytotoxicity of cetuximab by a chimeric protein encompassing interleukin-15. is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1080/2162402X.2017.1393597
P932PMC publication ID5749662
P698PubMed publication ID29308327

P50authorMaria C. OchoaQ40724836
Elísabeth Pérez RuizQ42887426
Ignacio Melero, MD-PhDQ60525568
Iñaki EtxeberriaQ87724593
Pedro BerraondoQ88084891
P2093author name stringInmaculada Rodriguez
Luna Minute
Marcos Vasquez
Peter Wirtz
Saray Garasa
Celia Gomar
Susana Inoges
Ascensión López
Jan-Peter Andreas Mayer
P2860cites workSoluble interleukin-15 receptor alpha (IL-15R alpha)-sushi as a selective and potent agonist of IL-15 action through IL-15R beta/gamma. Hyperagonist IL-15 x IL-15R alpha fusion proteinsQ24294612
Mapping of the C1q binding site on rituxan, a chimeric antibody with a human IgG1 FcQ27622123
Cetuximab for the treatment of colorectal cancer.Q27851419
IL-15Ralpha recycles and presents IL-15 In trans to neighboring cellsQ28214975
High-dose recombinant interleukin 2 therapy for patients with metastatic melanoma: analysis of 270 patients treated between 1985 and 1993Q29619885
Redistribution, hyperproliferation, activation of natural killer cells and CD8 T cells, and cytokine production during first-in-human clinical trial of recombinant human interleukin-15 in patients with cancerQ33418729
Adoptive cell transfer as personalized immunotherapy for human cancerQ34043643
Targeting the epidermal growth factor receptor in non-small cell lung cancer cells: the effect of combining RNA interference with tyrosine kinase inhibitors or cetuximab.Q34205052
Liver gene transfer of interkeukin-15 constructs that become part of circulating high density lipoproteins for immunotherapyQ34533728
Dendritic cells prime natural killer cells by trans-presenting interleukin 15Q36157184
Interleukin (IL) 15 is a novel cytokine that activates human natural killer cells via components of the IL-2 receptorQ36363861
Differential requirement for IL-2 and IL-15 during bifurcated development of thymic regulatory T cellsQ36838267
Interleukin-2 toxicityQ37776348
Scavenger receptor class B, type I: a promising immunotherapy target.Q37851971
Interleukin-15 in gene therapy of cancer.Q38060229
Expression of GnTIII in a recombinant anti-CD20 CHO production cell line: Expression of antibodies with altered glycoforms leads to an increase in ADCC through higher affinity for FC gamma RIII.Q38299799
Fucose depletion from human IgG1 oligosaccharide enhances binding enthalpy and association rate between IgG1 and FcgammaRIIIaQ38343329
The IL-15-Based ALT-803 Complex Enhances FcγRIIIa-Triggered NK Cell Responses and In Vivo Clearance of B Cell LymphomasQ38831202
Antibody-dependent cell cytotoxicity: immunotherapy strategies enhancing effector NK cells.Q39110347
Tumor targeting of the IL-15 superagonist RLI by an anti-GD2 antibody strongly enhances its antitumor potencyQ39203683
Exploiting scavenger receptors in cancer immunotherapy: Lessons from CD5 and SR-B1.Q39306589
NK cells stimulated with IL-15 or CpG ODN enhance rituximab-dependent cellular cytotoxicity against B-cell lymphoma.Q40062910
FCGR2A and FCGR3A polymorphisms associated with clinical outcome of epidermal growth factor receptor expressing metastatic colorectal cancer patients treated with single-agent cetuximab.Q45949257
Antitumor immunotherapeutic and toxic properties of an HDL-conjugated chimeric IL-15 fusion protein.Q46748932
Experience with the use of high-dose interleukin-2 in the treatment of 652 cancer patientsQ69548004
The long signal peptide isoform and its alternative processing direct the intracellular trafficking of interleukin-15Q73929921
P433issue2
P921main subjectcetuximabQ420296
P304page(s)e1393597
P577publication date2017-11-13
P1433published inOncoImmunologyQ18026500
P1476titleEnhancement of antibody-dependent cellular cytotoxicity of cetuximab by a chimeric protein encompassing interleukin-15.
P478volume7

Reverse relations

cites work (P2860)
Q89997716Cetuximab, irinotecan and fluorouracile in fiRst-line treatment of immunologically-selected advanced colorectal cancer patients: the CIFRA study protocol
Q58561585Cytokines in clinical cancer immunotherapy
Q92594689Natural Killer Cells: Diverse Functions in Tumor Immunity and Defects in Pre-neoplastic and Neoplastic Stages of Tumorigenesis

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