Targeting the epidermal growth factor receptor in non-small cell lung cancer cells: the effect of combining RNA interference with tyrosine kinase inhibitors or cetuximab.

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Targeting the epidermal growth factor receptor in non-small cell lung cancer cells: the effect of combining RNA interference with tyrosine kinase inhibitors or cetuximab. is …
instance of (P31):
scholarly articleQ13442814

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P6179Dimensions Publication ID1025124406
P356DOI10.1186/1741-7015-10-28
P932PMC publication ID3334713
P698PubMed publication ID22436374
P5875ResearchGate publication ID221902972

P50authorJacques De GreveQ58132858
Ijeoma Adaku UmeloQ59705430
P2093author name stringGang Chen
Erik Teugels
Peter Kronenberger
P2860cites workKRAS mutations and primary resistance of lung adenocarcinomas to gefitinib or erlotinibQ21563446
BIBW2992, an irreversible EGFR/HER2 inhibitor highly effective in preclinical lung cancer modelsQ24649935
A phase I dose escalation study of BIBW 2992, an irreversible dual inhibitor of epidermal growth factor receptor 1 (EGFR) and 2 (HER2) tyrosine kinase in a 2-week on, 2-week off schedule in patients with advanced solid tumoursQ24653999
Acquired resistance of lung adenocarcinomas to gefitinib or erlotinib is associated with a second mutation in the EGFR kinase domainQ24794765
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Structures of Lung Cancer-Derived EGFR Mutants and Inhibitor Complexes: Mechanism of Activation and Insights into Differential Inhibitor SensitivityQ27644014
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A phase I/II study of weekly high-dose erlotinib in previously treated patients with nonsmall cell lung cancerQ44290350
Dual-agent molecular targeting of the epidermal growth factor receptor (EGFR): combining anti-EGFR antibody with tyrosine kinase inhibitor.Q45004003
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Cetuximab plus chemotherapy in patients with advanced non-small-cell lung cancer (FLEX): an open-label randomised phase III trial.Q46027726
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siRNA targeting against EGFR, a promising candidate for a novel therapeutic application to lung adenocarcinomaQ46707269
Dual inhibition of the epidermal growth factor receptor with cetuximab, an IgG1 monoclonal antibody, and gefitinib, a tyrosine kinase inhibitor, in patients with refractory non-small cell lung cancer (NSCLC): a phase I studyQ46720863
Phase II trial of cetuximab in patients with previously treated non-small-cell lung cancer.Q51776233
Zero interaction response surfaces for combined-action assessment.Q64948214
Allelic dilution obscures detection of a biologically significant resistance mutation in EGFR-amplified lung cancerQ27851396
Gefitinib or carboplatin-paclitaxel in pulmonary adenocarcinomaQ27860881
PTEN loss contributes to erlotinib resistance in EGFR-mutant lung cancer by activation of Akt and EGFRQ28240702
Gefitinib-sensitizing EGFR mutations in lung cancer activate anti-apoptotic pathwaysQ28274882
Erlotinib in previously treated non-small-cell lung cancerQ29547546
Evidence of RNAi in humans from systemically administered siRNA via targeted nanoparticlesQ29615957
Theoretical basis, experimental design, and computerized simulation of synergism and antagonism in drug combination studiesQ29616780
Radiotherapy plus cetuximab for squamous-cell carcinoma of the head and neckQ29619277
The cell line secretome, a suitable tool for investigating proteins released in vivo by tumors: application to the study of p53-modulated proteins secreted in lung cancer cells.Q30871179
Amphiregulin promotes BAX inhibition and resistance to gefitinib in non-small-cell lung cancers.Q33731181
BIBW-2992, a dual receptor tyrosine kinase inhibitor for the treatment of solid tumors.Q34014866
Influence of RT-qPCR primer position on EGFR interference efficacy in lung cancer cells.Q34618082
Knockdown of oncogenic KRAS in non-small cell lung cancers suppresses tumor growth and sensitizes tumor cells to targeted therapyQ34701196
Strategies for overcoming resistance to EGFR family tyrosine kinase inhibitorsQ35116206
Status of epidermal growth factor receptor antagonists in the biology and treatment of cancerQ35177848
American Society of Clinical Oncology treatment of unresectable non-small-cell lung cancer guideline: update 2003.Q35613883
Current progress of siRNA/shRNA therapeutics in clinical trialsQ36071638
Clinical implications of the mechanism of epidermal growth factor receptor inhibitorsQ36565941
Modeling oncogene addiction using RNA interference.Q36840172
Dual MET-EGFR combinatorial inhibition against T790M-EGFR-mediated erlotinib-resistant lung cancer.Q36882696
Biology of interactions: antiepidermal growth factor receptor agentsQ36935078
Dual targeting of EGFR can overcome a major drug resistance mutation in mouse models of EGFR mutant lung cancerQ37363050
Cetuximab plus radiotherapy for the treatment of locally advanced squamous cell carcinoma of the head and neckQ37536418
EGFR inhibitors in non-small cell lung cancer (NSCLC): the emerging role of the dual irreversible EGFR/HER2 inhibitor BIBW 2992.Q37767383
KRAS mutation is an important predictor of resistance to therapy with epidermal growth factor receptor tyrosine kinase inhibitors in non-small-cell lung cancerQ38432430
Enhanced anticancer effect of the combination of BIBW2992 and thymidylate synthase-targeted agents in non-small cell lung cancer with the T790M mutation of epidermal growth factor receptorQ39695840
Quantification of epidermal growth factor receptor T790M mutant transcripts in lung cancer cells by real-time reverse transcriptase-quantitative polymerase chain reactionQ39766892
Combined inhibition of IGFR enhances the effects of gefitinib in H1650: a lung cancer cell line with EGFR mutation and primary resistance to EGFR-TK inhibitorsQ39773474
Double EGFR mutants containing rare EGFR mutant types show reduced in vitro response to gefitinib compared with common activating missense mutationsQ39813855
A gene expression signature associated with "K-Ras addiction" reveals regulators of EMT and tumor cell survivalQ39845869
Genistein enhances the effect of epidermal growth factor receptor tyrosine kinase inhibitors and inhibits nuclear factor kappa B in nonsmall cell lung cancer cell linesQ39872383
Cetuximab administered once every second week to patients with metastatic colorectal cancer: a two-part pharmacokinetic/pharmacodynamic phase I dose-escalation study.Q39925893
Molecular mechanisms underlying the synergistic interaction of erlotinib, an epidermal growth factor receptor tyrosine kinase inhibitor, with the multitargeted antifolate pemetrexed in non-small-cell lung cancer cells.Q40026514
Erlotinib exhibits antineoplastic off-target effects in AML and MDS: a preclinical studyQ40070060
Combination of EGFR/HER2 tyrosine kinase inhibition by BIBW 2992 and BIBW 2669 with irradiation in FaDu human squamous cell carcinoma.Q40133869
An alternative inhibitor overcomes resistance caused by a mutation of the epidermal growth factor receptor.Q40384809
Epidermal growth factor receptors harboring kinase domain mutations associate with the heat shock protein 90 chaperone and are destabilized following exposure to geldanamycinsQ40396742
Enhanced cytotoxicity induced by gefitinib and specific inhibitors of the Ras or phosphatidyl inositol-3 kinase pathways in non-small cell lung cancer cells.Q40400258
Combined epidermal growth factor receptor targeting with the tyrosine kinase inhibitor gefitinib (ZD1839) and the monoclonal antibody cetuximab (IMC-C225): superiority over single-agent receptor targeting.Q40505812
Modulation of Janus kinase 2 by p53 in ovarian cancer cellsQ40517172
Growth inhibitory effect of anti-K-ras adenovirus on lung cancer cells.Q41170117
Phase I trial of the irreversible EGFR and HER2 kinase inhibitor BIBW 2992 in patients with advanced solid tumorsQ42948964
P407language of work or nameEnglishQ1860
P921main subjectRNA interferenceQ201993
cetuximabQ420296
non-small-cell lung carcinomaQ3658562
P304page(s)28
P577publication date2012-03-21
P1433published inBMC MedicineQ4835947
P1476titleTargeting the epidermal growth factor receptor in non-small cell lung cancer cells: the effect of combining RNA interference with tyrosine kinase inhibitors or cetuximab
P478volume10

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