| scholarly article | Q13442814 |
| review article | Q7318358 |
| P2093 | author name string | Chou TC | |
| P433 | issue | 3 | |
| P407 | language of work or name | English | Q1860 |
| P304 | page(s) | 621-81 | |
| P577 | publication date | 2006-09-01 | |
| P1433 | published in | Pharmacological Reviews | Q2085079 |
| P1476 | title | Theoretical basis, experimental design, and computerized simulation of synergism and antagonism in drug combination studies | |
| P478 | volume | 58 |
| Q35230325 | (-)-Epigallocatechin-3-gallate and DZNep reduce polycomb protein level via a proteasome-dependent mechanism in skin cancer cells |
| Q42276515 | (Non-)translational medicine: targeting bacterial RNA |
| Q53701223 | 17-DMAG inhibits the multiplication of several Babesia species and Theileria equi on in vitro cultures, and Babesia microti in mice. |
| Q90706679 | 2-Deoxyglucose and Newcastle Disease Virus Synergize to Kill Breast Cancer Cells by Inhibition of Glycolysis Pathway Through Glyceraldehyde3-Phosphate Downregulation |
| Q35076698 | 2-amino-N-(2,6-dichloropyridin-3-yl)acetamide derivatives as a novel class of HBV capsid assembly inhibitor. |
| Q53688064 | 3-Bromopyruvate as an Alternative Option for the Treatment of Protothecosis. |
| Q47371537 | 6-shogaol induces apoptosis and enhances radiosensitivity in head and neck squamous cell carcinoma cell lines |
| Q38719143 | 6BIO Enhances Oligonucleotide Activity in Cells: A Potential Combinatorial Anti-androgen Receptor Therapy in Prostate Cancer Cells |
| Q30376631 | 6SLN-lipo PGA specifically catches (coats) human influenza virus and synergizes neuraminidase-targeting drugs for human influenza therapeutic potential. |
| Q37199458 | 90-kDa heat shock protein inhibition abrogates the topoisomerase I poison-induced G2/M checkpoint in p53-null tumor cells by depleting Chk1 and Wee1. |
| Q33904997 | A 219-mer CHO-expressing receptor-binding domain of SARS-CoV S protein induces potent immune responses and protective immunity |
| Q36976738 | A 3-in-1 polymeric micelle nanocontainer for poorly water-soluble drugs. |
| Q37173701 | A Bayesian approach to dose-response assessment and synergy and its application to in vitro dose-response studies |
| Q64880265 | A CARP-1 functional mimetic compound is synergistic with BRAF-targeting in non-small cell lung cancers. |
| Q98564727 | A CRISPR knockout negative screen reveals synergy between CDKs inhibitor and metformin in the treatment of human cancer in vitro and in vivo |
| Q52352234 | A DHODH inhibitor increases p53 synthesis and enhances tumor cell killing by p53 degradation blockage. |
| Q89597623 | A New Highlight of Ephedra alata Decne Properties as Potential Adjuvant in Combination with Cisplatin to Induce Cell Death of 4T1 Breast Cancer Cells In Vitro and In Vivo |
| Q90194898 | A Novel CXCR4 Targeting Protein SDF-1/54 as an HIV-1 Entry Inhibitor |
| Q40278524 | A Novel Inhibitor IDPP Interferes with Entry and Egress of HCV by Targeting Glycoprotein E1 in a Genotype-Specific Manner |
| Q64268720 | A Novel Mathematical Model for Studying Antimicrobial Interactions Against |
| Q58693121 | A Novel Nanobody Targeting Middle East Respiratory Syndrome Coronavirus (MERS-CoV) Receptor-Binding Domain Has Potent Cross-Neutralizing Activity and Protective Efficacy against MERS-CoV |
| Q28475468 | A Novel Small Molecule Inhibitor of Hepatitis C Virus Entry |
| Q64101889 | A PLK1 kinase inhibitor enhances the chemosensitivity of cisplatin by inducing pyroptosis in oesophageal squamous cell carcinoma |
| Q28552262 | A Platform for Rapid, Quantitative Assessment of Multiple Drug Combinations Simultaneously in Solid Tumors In Vivo |
| Q36823866 | A Potent Derivative of Indolizino[6,7-b]Indole for Treatment of Human Non-Small Cell Lung Cancer Cells. |
| Q28552295 | A Rapid Screening Assay Identifies Monotherapy with Interferon-ß and Combination Therapies with Nucleoside Analogs as Effective Inhibitors of Ebola Virus |
| Q92534513 | A STAT3-based gene signature stratifies glioma patients for targeted therapy |
| Q51746684 | A Smart Paclitaxel-Disulfiram Nanococrystals for Efficient MDR Reversal and Enhanced Apoptosis. |
| Q92028076 | A Strategy to Deliver Precise Oral Doses of the Glucosinolates or Isothiocyanates from Moringa oleifera Leaves for Use in Clinical Studies |
| Q36075829 | A Toll-Like Receptor 5 Agonist Improves the Efficacy of Antibiotics in Treatment of Primary and Influenza Virus-Associated Pneumococcal Mouse Infections. |
| Q50962785 | A central composite rotatable design (CCRD) approach to study the combined effect of antimicrobial agents against bacterial pathogens. |
| Q36182645 | A central role for RAF→MEK→ERK signaling in the genesis of pancreatic ductal adenocarcinoma. |
| Q35973103 | A chemical family-based strategy for uncovering hidden bioactive molecules and multicomponent interactions in herbal medicines. |
| Q38881802 | A combination of the telomerase inhibitor, BIBR1532, and paclitaxel synergistically inhibit cell proliferation in breast cancer cell lines |
| Q31100573 | A competitive stapled peptide screen identifies a selective small molecule that overcomes MCL-1-dependent leukemia cell survival |
| Q34548282 | A critical HA1 neutralizing domain of H5N1 influenza in an optimal conformation induces strong cross-protection |
| Q36369127 | A critical subset model provides a conceptual basis for the high antiviral activity of major HIV drugs |
| Q39681066 | A demonstration of the susceptibility of clinical isolates obtained from cystic fibrosis patients to manuka honey |
| Q36774468 | A dual drug regimen synergistically blocks human parainfluenza virus infection. |
| Q33563358 | A formal model for analyzing drug combination effects and its application in TNF-alpha-induced NFkappaB pathway |
| Q39559549 | A genome-wide RNAi screen identifies novel targets of neratinib sensitivity leading to neratinib and paclitaxel combination drug treatments. |
| Q59336242 | A high therapeutic efficacy of polymeric prodrug nano-assembly for a combination of photodynamic therapy and chemotherapy |
| Q33575946 | A high-throughput pharmaceutical screen identifies compounds with specific toxicity against BRCA2-deficient tumors |
| Q36159688 | A high-throughput screen of inactive X chromosome reactivation identifies the enhancement of DNA demethylation by 5-aza-2'-dC upon inhibition of ribonucleotide reductase |
| Q34618606 | A kinome screen identifies checkpoint kinase 1 (CHK1) as a sensitizer for RRM1-dependent gemcitabine efficacy |
| Q37603481 | A mechanism for overcoming P-glycoprotein-mediated drug resistance: novel combination therapy that releases stored doxorubicin from lysosomes via lysosomal permeabilization using Dp44mT or DpC. |
| Q38839041 | A mouse model of luciferase-transfected stromal cells of giant cell tumor of bone. |
| Q38705760 | A multi-functional PEGylated gold(iii) compound: potent anti-cancer properties and self-assembly into nanostructures for drug co-delivery |
| Q36387986 | A multi-scale mathematical modeling framework to investigate anti-viral therapeutic opportunities in targeting HIV-1 accessory proteins |
| Q28542823 | A multifunctional drug combination shows highly potent therapeutic efficacy against human cancer xenografts in athymic mice |
| Q37612692 | A novel HDAC inhibitor, CG200745, inhibits pancreatic cancer cell growth and overcomes gemcitabine resistance |
| Q37285560 | A novel Ras inhibitor (MDC-1016) reduces human pancreatic tumor growth in mice |
| Q64077348 | A novel anti-melanoma SRC-family kinase inhibitor |
| Q28817145 | A novel compound which sensitizes BRAF wild-type melanoma cells to vemurafenib in a TRIM16-dependent manner |
| Q38979471 | A novel copper(I) complex induces ER-stress-mediated apoptosis and sensitizes B-acute lymphoblastic leukemia cells to chemotherapeutic agents |
| Q35076966 | A novel inhibitor of gyrase B is a potent drug candidate for treatment of tuberculosis and nontuberculosis mycobacterial infections. |
| Q40061875 | A novel multi-CDK inhibitor P1446A-05 restricts melanoma growth and produces synergistic effects in combination with MAPK pathway inhibitors |
| Q86953265 | A novel nanoparticle formulation overcomes multiple types of membrane efflux pumps in human breast cancer cells |
| Q40170253 | A novel preventive strategy against HIV-1 infection: combinatorial use of inhibitors targeting the nucleocapsid and fusion proteins |
| Q63246151 | A pan-coronavirus fusion inhibitor targeting the HR1 domain of human coronavirus spike |
| Q91731356 | A pharmacodynamic model of clinical synergy in multiple myeloma |
| Q42196934 | A pharmacokinetic-viral kinetic model describes the effect of alisporivir as monotherapy or in combination with peg-IFN on hepatitis C virologic response |
| Q57784571 | A plug-and-play, drug-on-pillar platform for combination drug screening implemented by microfluidic adaptive printing |
| Q37560283 | A preclinical assay for chemosensitivity in multiple myeloma |
| Q35812907 | A quantitative basis for antiretroviral therapy for HIV-1 infection |
| Q28538813 | A quinoxaline derivative as a potent chemotherapeutic agent, alone or in combination with benznidazole, against Trypanosoma cruzi |
| Q39379856 | A rapid LC/MS/MS method for the analysis of nonvolatile antiinflammatory agents from Mentha spp |
| Q40503787 | A recombinant receptor-binding domain of MERS-CoV in trimeric form protects human dipeptidyl peptidase 4 (hDPP4) transgenic mice from MERS-CoV infection |
| Q33815195 | A recombinant vaccine of H5N1 HA1 fused with foldon and human IgG Fc induced complete cross-clade protection against divergent H5N1 viruses |
| Q92202321 | A self-assembled supramolecular natural product gel from liquidambaric acid in traditional Chinese medicine with inherent anti-inflammatory activity for drug delivery |
| Q35966272 | A sphingosine kinase inhibitor combined with temozolomide induces glioblastoma cell death through accumulation of dihydrosphingosine and dihydroceramide, endoplasmic reticulum stress and autophagy |
| Q30466831 | A stapled BIM peptide overcomes apoptotic resistance in hematologic cancers. |
| Q39632109 | A stapled p53 helix overcomes HDMX-mediated suppression of p53. |
| Q30658500 | A strategy for the identification of combinatorial bioactive compounds contributing to the holistic effect of herbal medicines. |
| Q35925179 | A synthetic-lethality RNAi screen reveals an ERK-mTOR co-targeting pro-apoptotic switch in PIK3CA+ oral cancers |
| Q36893507 | A systematic methodology for proteome-wide identification of peptides inhibiting the proliferation and migration of endothelial cells |
| Q33692329 | A systems biology approach to identify effective cocktail drugs |
| Q37712188 | ABT-737 Synergizes with Cisplatin Bypassing Aberration of Apoptotic Pathway in Non-small Cell Lung Cancer. |
| Q39280369 | ABT-737 synergizes with arsenic trioxide to induce apoptosis of gastric carcinoma cells in vitro and in vivo |
| Q53703893 | AKR1C enzymes sustain therapy resistance in paediatric T-ALL. |
| Q90167561 | ALDH1A1 Contributes to PARP Inhibitor Resistance via Enhancing DNA Repair in BRCA2-/- Ovarian Cancer Cells |
| Q35983805 | AML sensitivity to YM155 is modulated through AKT and Mcl-1. |
| Q39652396 | AMPK-induced activation of Akt by AICAR is mediated by IGF-1R dependent and independent mechanisms in acute lymphoblastic leukemia |
| Q28539135 | ASDCD: antifungal synergistic drug combination database |
| Q37274810 | AXL Is a Logical Molecular Target in Head and Neck Squamous Cell Carcinoma |
| Q64073169 | AXL degradation in combination with EGFR-TKI can delay and overcome acquired resistance in human non-small cell lung cancer cells |
| Q54108341 | AZD1775 Increases Sensitivity to Olaparib and Gemcitabine in Cancer Cells with p53 Mutations. |
| Q42465266 | AZDAST the new horizon in antimicrobial synergism detection |
| Q36268156 | Abacavir, an anti-HIV-1 drug, targets TDP1-deficient adult T cell leukemia |
| Q41134308 | Aberrant signalling by protein kinase CK2 in imatinib-resistant chronic myeloid leukaemia cells: biochemical evidence and therapeutic perspectives |
| Q37054272 | Ablation of MCL1 expression by virally induced microRNA-29 reverses chemoresistance in human osteosarcomas |
| Q36835733 | Ablation of PI3K blocks BCR-ABL leukemogenesis in mice, and a dual PI3K/mTOR inhibitor prevents expansion of human BCR-ABL+ leukemia cells |
| Q34229317 | Abrogating phosphorylation of eIF4B is required for EGFR and mTOR inhibitor synergy in triple-negative breast cancer. |
| Q36518353 | Acid Ceramidase in Melanoma: EXPRESSION, LOCALIZATION, AND EFFECTS OF PHARMACOLOGICAL INHIBITION |
| Q57192034 | Actinomycin-D and dimethylamino-parthenolide synergism in treating human pancreatic cancer cells |
| Q32177441 | Actions of sesquiterpene lactones isolated from Moquiniastrum polymorphum subsp. floccosum in MCF7 cell line and their potentiating action on doxorubicin |
| Q38971418 | Activated hedgehog pathway is a potential target for pharmacological intervention in biliary tract cancer. |
| Q49787526 | Activation of p53 and destabilization of androgen receptor by combinatorial inhibition of MDM2 and MDMX in prostate cancer cells |
| Q27308683 | Activation of protein phosphatase 2A tumor suppressor as potential treatment of pancreatic cancer. |
| Q28389729 | Activities of N,N'-Diarylurea MMV665852 analogs against Schistosoma mansoni |
| Q41855451 | Activity of BKM120 and BEZ235 against Lymphoma Cells. |
| Q55363491 | Activity of roniciclib in medullary thyroid cancer. |
| Q39352296 | Activity of the MEK inhibitor selumetinib (AZD6244; ARRY-142886) in nasopharyngeal cancer cell lines. |
| Q42361379 | Additivity and Interactions in Ecotoxicity of Pollutant Mixtures: Some Patterns, Conclusions, and Open Questions. |
| Q28484203 | Adenovirus-mediated sensitization to the cytotoxic drugs docetaxel and mitoxantrone is dependent on regulatory domains in the E1ACR1 gene-region |
| Q38687343 | Advances in computational approaches in identifying synergistic drug combinations |
| Q90394240 | Akt inhibition synergizes with polycomb repressive complex 2 inhibition in the treatment of multiple myeloma |
| Q37079752 | Akt2 and acid ceramidase cooperate to induce cell invasion and resistance to apoptosis |
| Q38795351 | Alisol F 24 Acetate Enhances Chemosensitivity and Apoptosis of MCF-7/DOX Cells by Inhibiting P-Glycoprotein-Mediated Drug Efflux. |
| Q37285551 | Allosteric MEK1/2 inhibitor refametinib (BAY 86-9766) in combination with sorafenib exhibits antitumor activity in preclinical murine and rat models of hepatocellular carcinoma |
| Q38529440 | Allosteric effects of erythromycin pretreatment on thioridazine block of hERG potassium channels |
| Q55175737 | Altered membrane rigidity via enhanced endogenous cholesterol synthesis drives cancer cell resistance to destruxins. |
| Q37394107 | Alternating electric fields (TTFields) in combination with paclitaxel are therapeutically effective against ovarian cancer cells in vitro and in vivo |
| Q53729565 | Amiloride Is Effective in the Management of Abiraterone-Induced Mineralocorticoid Excess Syndrome without Interfering with Its Antineoplastic Activity. |
| Q50497689 | Amyloid aggregation of lysozyme: the synergy study of red wine polyphenols. |
| Q99565937 | An ATF24 peptide-functionalized β-elemene-nanostructured lipid carrier combined with cisplatin for bladder cancer treatment |
| Q91143106 | An IRAK1-PIN1 signalling axis drives intrinsic tumour resistance to radiation therapy |
| Q33580906 | An Introduction to Terminology and Methodology of Chemical Synergy-Perspectives from Across Disciplines |
| Q36855729 | An antimetastatic role for decorin in breast cancer. |
| Q38983370 | An application of a Hill-based response surface model for a drug combination experiment on lung cancer |
| Q42288812 | An engineered HIV-1 gp41 trimeric coiled coil with increased stability and anti-HIV-1 activity: implication for developing anti-HIV microbicides |
| Q34028492 | An improved isoprenylcysteine carboxylmethyltransferase inhibitor induces cancer cell death and attenuates tumor growth in vivo |
| Q47697971 | An improved model for the analysis of combined antimicrobials: a replacement for the Chou-Talalay combination index method. |
| Q58417419 | An introduction to systems toxicology |
| Q39491356 | An oncolytic adenovirus defective in pRb-binding (dl922-947) can efficiently eliminate pancreatic cancer cells and tumors in vivo in combination with 5-FU or gemcitabine. |
| Q37091715 | Analyses of the combination of 6-MP and dasatinib in cell culture |
| Q28472663 | Analysis of compound synergy in high-throughput cellular screens by population-based lifetime modeling |
| Q38546567 | Analysis of drug combinations: current methodological landscape |
| Q36035896 | Analysis of the cytotoxic activity of carboplatin and gemcitabine combination |
| Q37306043 | Andrographolide promotes vincristine-induced SK-NEP-1 tumor cell death via PI3K-AKT-p53 signaling pathway |
| Q57821553 | Anetumab ravtansine inhibits tumor growth and shows additive effect in combination with targeted agents and chemotherapy in mesothelin-expressing human ovarian cancer models |
| Q55713061 | Angelica gigas Nakai and Decursin Downregulate Myc Expression to Promote Cell Death in B-cell Lymphoma. |
| Q38857169 | Angiotensin II receptor antagonist olmesartan and NF-kappaB inhibitor as cytotoxic and apoptotic agents in MCF-7 human cell line |
| Q92669556 | Antagonistic cooperativity between crystal growth modifiers |
| Q37369778 | Anti HSV-1 activity of halistanol sulfate and halistanol sulfate C isolated from Brazilian marine sponge Petromica citrina (Demospongiae). |
| Q36924097 | Anti proliferative activity of ELACY (CP-4055) in combination with cloretazine (VNP40101M), idarubicin, gemcitabine, irinotecan and topotecan in human leukemia and lymphoma cells |
| Q37687445 | Anti-EGFR monoclonal antibodies and EGFR tyrosine kinase inhibitors as combination therapy for triple-negative breast cancer. |
| Q38730179 | Anti-EGFR monoclonal antibodies enhance sensitivity to DNA-damaging agents in BRCA1-mutated and PTEN-wild-type triple-negative breast cancer cells |
| Q64080737 | Anti-Ehrlichia properties of the essential oil of Ageratum conyzoides L. and its interaction with doxycycline |
| Q28551486 | Anti-Tumor Activity of Yuanhuacine by Regulating AMPK/mTOR Signaling Pathway and Actin Cytoskeleton Organization in Non-Small Cell Lung Cancer Cells |
| Q36562253 | Anti-cancer efficacy of SREBP inhibitor, alone or in combination with docetaxel, in prostate cancer harboring p53 mutations |
| Q36222756 | Anti-malarial effect of semi-synthetic drug amitozyn |
| Q39993830 | Anti-proliferative and chemosensitizing effects of luteolin on human gastric cancer AGS cell line |
| Q38819264 | Anti-tumor activities of luteolin and silibinin in glioblastoma cells: overexpression of miR-7-1-3p augmented luteolin and silibinin to inhibit autophagy and induce apoptosis in glioblastoma in vivo |
| Q35143496 | Anti-tumor activity and signaling events triggered by the isothiocyanates, sulforaphane and phenethyl isothiocyanate, in multiple myeloma |
| Q41967128 | Anti-tumor activity of liposome encapsulated fluoroorotic acid as a single agent and in combination with liposome irinotecan |
| Q38572743 | Antiangiogenic and anticolorectal cancer effects of metronomic irinotecan chemotherapy alone and in combination with semaxinib |
| Q37145412 | Anticancer Activity of Novel Daphnane Diterpenoids from Daphne genkwa through Cell-Cycle Arrest and Suppression of Akt/STAT/Src Signalings in Human Lung Cancer Cells |
| Q38712653 | Antifungal drugs combinations: a patent review 2000-2015. |
| Q37361159 | Antigenicity and immunogenicity of SARS-CoV S protein receptor-binding domain stably expressed in CHO cells |
| Q40905434 | Antihyperglycemic, antihyperlipidemic and antioxidant activity of phenolic rich extract of Brassica oleraceae var gongylodes on streptozotocin induced Wistar rats |
| Q46430242 | Antileishmanial Efficacy and Pharmacokinetics of DB766-azole Combinations |
| Q53797062 | Antimicrobial potency of single and combined mupirocin and monoterpenes, thymol, menthol and 1,8-cineole against Staphylococcus aureus planktonic and biofilm growth. |
| Q50266190 | Antinociceptive and anti-exudative synergism between dexketoprofen and tramadol in a model of inflammatory pain in mice |
| Q36633461 | Antinociceptive interaction of (±)-CPP and propentofylline in monoarthritic rats |
| Q58207131 | Antioxidant activity and antimicrobial effect of tarragon (Artemisia dracunculus) extract and chemical composition of its essential oil |
| Q92854031 | Antiplatelet Drug Ticagrelor Enhances Chemotherapeutic Efficacy by Targeting the Novel P2Y12-AKT Pathway in Pancreatic Cancer Cells |
| Q93017580 | Antiproliferative Activity of Pt(IV) Conjugates Containing the Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) Ketoprofen and Naproxen † |
| Q90204539 | Antiproliferative Effects of Hop-derived Prenylflavonoids and Their Influence on the Efficacy of Oxaliplatine, 5-fluorouracil and Irinotecan in Human ColorectalC Cells |
| Q90400032 | Antipsychotic Drug Trifluoperazine Suppresses Colorectal Cancer by Inducing G0/G1 Arrest and Apoptosis |
| Q37502083 | Antitumor Activities of Rauwolfia vomitoria Extract and Potentiation of Carboplatin Effects Against Ovarian Cancer |
| Q89761673 | Antitumor Activity of Asperphenin A, a Lipopeptidyl Benzophenone from Marine-Derived Aspergillus sp. Fungus, by Inhibiting Tubulin Polymerization in Colon Cancer Cells |
| Q33747713 | Antitumor Effects and Biological Mechanism of Action of the Aqueous Extract of the Camptotheca acuminata Fruit in Human Endometrial Carcinoma Cells. |
| Q58786173 | Antitumor activity of arsenite in combination with tetrandrine against human breast cancer cell line MDA-MB-231 in vitro and in vivo |
| Q38836263 | Antitumor activity of fucoidan against diffuse large B cell lymphoma in vitro and in vivo. |
| Q37601058 | Antitumor activity of gemcitabine can be potentiated in pancreatic cancer through modulation of TLR4/NF-κB signaling by 6-shogaol |
| Q39004130 | Antitumor activity of the dietary diterpene carnosol against a panel of human cancer cell lines |
| Q99551805 | Antitumor effects of ribavirin in combination with TMZ and IFN-β in malignant glioma cells |
| Q36572251 | Antiviral Activity of Hatay Propolis Against Replication of Herpes Simplex Virus Type 1 and Type 2. |
| Q35840864 | Antiviral and cellular metabolism interactions between Dexelvucitabine and lamivudine |
| Q37345775 | Apigenin potentiates TRAIL therapy of non-small cell lung cancer via upregulating DR4/DR5 expression in a p53-dependent manner |
| Q60937807 | Apoptosis Induction via ATM Phosphorylation, Cell Cycle Arrest, and ER Stress by Goniothalamin and Chemodrugs Combined Effects on Breast Cancer-Derived MDA-MB-231 Cells |
| Q37718693 | Apoptosis is augmented in high-grade serous ovarian cancer by the combined inhibition of Bcl-2/Bcl-xL and PARP. |
| Q44448455 | Apoptosis sensitizers enhance cytotoxicity in hepatoblastoma cells |
| Q64078565 | Application of Antimicrobial Peptides of the Innate Immune System in Combination With Conventional Antibiotics-A Novel Way to Combat Antibiotic Resistance? |
| Q92580225 | Application of Box-Behnken Design in the Preparation, Optimization, and In Vitro Evaluation of Self-Assembly-Based Tamoxifen- and Doxorubicin-Loaded and Dual Drug-Loaded Niosomes for Combinatorial Breast Cancer Treatment |
| Q55283899 | Application of Feedback System Control Optimization Technique in Combined Use of Dual Antiplatelet Therapy and Herbal Medicines. |
| Q28534259 | Application of multiplexed kinase inhibitor beads to study kinome adaptations in drug-resistant leukemia |
| Q34372116 | Applying Emax model and bivariate thin plate splines to assess drug interactions |
| Q36477744 | Aqueous Extract of Solanum nigrum Leaf Activates Autophagic Cell Death and Enhances Docetaxel-Induced Cytotoxicity in Human Endometrial Carcinoma Cells. |
| Q36988394 | Aqueous Extract of Solanum nigrum Leaves Induces Autophagy and Enhances Cytotoxicity of Cisplatin, Doxorubicin, Docetaxel, and 5-Fluorouracil in Human Colorectal Carcinoma Cells |
| Q34497105 | Arginine starvation impairs mitochondrial respiratory function in ASS1-deficient breast cancer cells. |
| Q64101518 | Arsenic Trioxide and (-)-Gossypol Synergistically Target Glioma Stem-Like Cells via Inhibition of Hedgehog and Notch Signaling |
| Q28542497 | Arsenic trioxide and resveratrol show synergistic anti-leukemia activity and neutralized cardiotoxicity |
| Q41621238 | Arsenic trioxide potentiates sensitivity of multiple myeloma cells to lenalidomide by upregulating cereblon expression levels |
| Q37148048 | Arsenite-loaded nanoparticles inhibit PARP-1 to overcome multidrug resistance in hepatocellular carcinoma cells |
| Q36916456 | Artemisinin-derived dimer ART-838 potently inhibited human acute leukemias, persisted in vivo, and synergized with antileukemic drugs |
| Q39026832 | Artificial peptides conjugated with cholesterol and pocket-specific small molecules potently inhibit infection by laboratory-adapted and primary HIV-1 isolates and enfuvirtide-resistant HIV-1 strains |
| Q90176098 | Ascorbic Acid Sensitizes Colorectal Carcinoma to the Cytotoxicity of Arsenic Trioxide via Promoting Reactive Oxygen Species-Dependent Apoptosis and Pyroptosis |
| Q28533798 | Ascorbic acid and a cytostatic inhibitor of glycolysis synergistically induce apoptosis in non-small cell lung cancer cells |
| Q89977280 | Assessing the Effect of Mycotoxin Combinations: Which Mathematical Model Is (the Most) Appropriate? |
| Q51794100 | Assessment of dose-effect and therapeutic time window in preclinical studies of rhEGF and GHRP-6 coadministration for stroke therapy. |
| Q38957295 | Assessment of non-linear combination effect terms for drug-drug interactions |
| Q47191578 | Assessment of the antinociceptive and ulcerogenic activity of the tapentadol-diclofenac combination in rodents |
| Q36005028 | At therapeutic concentration bupivacaine causes neuromuscular blockade and enhances rocuronium-induced blockade |
| Q92815203 | Attenuation of UVB-Induced Photo-Aging by Polyphenolic-Rich Spatholobus Suberectus Stem Extract Via Modulation of MAPK/AP-1/MMPs Signaling in Human Keratinocytes |
| Q55478403 | Augmented antitumor activity by olaparib plus AZD1775 in gastric cancer through disrupting DNA damage repair pathways and DNA damage checkpoint. |
| Q39875482 | Augmented antitumor effects of combination therapy of cisplatin with ethaselen as a novel thioredoxin reductase inhibitor on human A549 cell in vivo |
| Q36807632 | Aurora kinase A mediates epithelial ovarian cancer cell migration and adhesion |
| Q38727281 | Axitinib induces senescence-associated cell death and necrosis in glioma cell lines: The proteasome inhibitor, bortezomib, potentiates axitinib-induced cytotoxicity in a p21(Waf/Cip1) dependent manner |
| Q39156125 | Azidothymidine hinders arsenic trioxide-induced apoptosis in acute promyelocytic leukemia cells by induction of p21 and attenuation of G2/M arrest |
| Q34316329 | BACPTDP: a water-soluble camptothecin pro-drug with enhanced activity in hypoxic/acidic tumors |
| Q91689214 | BCL6 Evolved to Enable Stress Tolerance in Vertebrates and Is Broadly Required by Cancer Cells to Adapt to Stress |
| Q91386174 | BET and Aurora Kinase A inhibitors synergize against MYCN-positive human glioblastoma cells |
| Q90299058 | BET inhibition in advanced cutaneous T cell lymphoma is synergistically potentiated by BCL2 inhibition or HDAC inhibition |
| Q57463137 | BGJ398, A Pan-FGFR Inhibitor, Overcomes Paclitaxel Resistance in Urothelial Carcinoma with FGFR1 Overexpression |
| Q36713338 | BMS-345541 sensitizes MCF-7 breast cancer cells to ionizing radiation by selective inhibition of homologous recombinational repair of DNA double-strand breaks |
| Q41244127 | BRAID: A Unifying Paradigm for the Analysis of Combined Drug Action. |
| Q48202788 | Bacterial Alkaloids Prevent Amoebal Predation |
| Q57563961 | Bacterial Alkaloids Prevent Amoebal Predation |
| Q37469105 | Bacterial pore-forming proteins as anthelmintics |
| Q35013101 | Bcl-2 inhibitor HA14-1 and genistein together adeptly down regulated survival factors and activated cysteine proteases for apoptosis in human malignant neuroblastoma SK-N-BE2 and SH-SY5Y cells |
| Q93016738 | Bcl-2-dependent synthetic lethal interaction of the IDF-11774 with the V0 subunit C of vacuolar ATPase (ATP6V0C) in colorectal cancer |
| Q55041230 | Beclomethasone dipropionate and formoterol fumarate synergistically interact in hyperresponsive medium bronchi and small airways. |
| Q37088706 | Bifurcation-based approach reveals synergism and optimal combinatorial perturbation |
| Q39531266 | Bilberry extract, its major polyphenolic compounds, and the soy isoflavone genistein antagonize the cytostatic drug erlotinib in human epithelial cells |
| Q41009977 | Binding of Released Bim to Mcl-1 is a Mechanism of Intrinsic Resistance to ABT-199 which can be Overcome by Combination with Daunorubicin or Cytarabine in AML Cells. |
| Q93377869 | Bioactive constituents isolated from Atractylodes lancea (Thunb.) DC. rhizome exhibit synergistic effect against cholangiocarcinoma cell |
| Q92704123 | Bioactivity of Farnesyltransferase Inhibitors Against Entamoeba histolytica and Schistosoma mansoni |
| Q52648791 | Biogenic nanosilver synthesized in Metarhizium robertsii waste mycelium extract - As a modulator of Candida albicans morphogenesis, membrane lipidome and biofilm. |
| Q89879470 | Biological Effects of Glucosinolate Degradation Products from Horseradish: A Horse that Wins the Race |
| Q36824455 | Biological evaluation of antibody-maytansinoid conjugates as a strategy of RON targeted drug delivery for treatment of non-small cell lung cancer |
| Q28077880 | Biomolecular Network-Based Synergistic Drug Combination Discovery |
| Q51096090 | Bishomoisoprenoid triazole bisphosphonates as inhibitors of geranylgeranyl diphosphate synthase. |
| Q98165145 | Boosting Replication and Penetration of Oncolytic Adenovirus by Paclitaxel Eradicate Peritoneal Metastasis of Gastric Cancer |
| Q34045104 | Bortezomib-induced unfolded protein response increases oncolytic HSV-1 replication resulting in synergistic antitumor effects |
| Q63884105 | Bosutinib Inhibits EGFR Activation in Head and Neck Cancer |
| Q51602035 | Brassinosteriod Insensitive 2 (BIN2) acts as a downstream effector of the Target of Rapamycin (TOR) signaling pathway to regulate photoautotrophic growth in Arabidopsis. |
| Q36202610 | Breaking resistance of pancreatic cancer cells to an attenuated vesicular stomatitis virus through a novel activity of IKK inhibitor TPCA-1 |
| Q92393132 | Breaking the selectivity-uptake trade-off of photoimmunoconjugates with nanoliposomal irinotecan for synergistic multi-tier cancer targeting |
| Q34657731 | Breast cancer as photodynamic therapy target: Enhanced therapeutic efficiency by overview of tumor complexity |
| Q47264095 | Broad Spectrum Inhibitor of Influenza A and B Viruses Targeting the Viral Nucleoprotein. |
| Q34181482 | Broad anti-HIV activity of the Oscillatoria agardhii agglutinin homologue lectin family |
| Q47878727 | By inhibiting PFKFB3, aspirin overcomes sorafenib resistance in hepatocellular carcinoma. |
| Q35284185 | Bypassing the EPR effect with a nanomedicine harboring a sustained-release function allows better tumor control |
| Q64260278 | CCDC6 and USP7 expression levels suggest novel treatment options in high-grade urothelial bladder cancer |
| Q64939563 | CD20 and CD37 antibodies synergize to activate complement by Fc-mediated clustering. |
| Q92922839 | CD44 Targeting Mediated by Polymeric Nanoparticles and Combination of Chlorine TPCS2a-PDT and Docetaxel-Chemotherapy for Efficient Killing of Breast Differentiated and Stem Cancer Cells In Vitro |
| Q92992525 | CDK5 Inhibitor Downregulates Mcl-1 and Sensitizes Pancreatic Cancer Cell Lines to Navitoclax |
| Q37168650 | CHK1 inhibition as a strategy for targeting Fanconi Anemia (FA) DNA repair pathway deficient tumors |
| Q52643927 | CISNE: An accurate description of dose-effect and synergism in combination therapies. |
| Q91899874 | COTI-2, A Novel Thiosemicarbazone Derivative, Exhibits Antitumor Activity in HNSCC through p53-dependent and -independent Mechanisms |
| Q89748843 | COX-2/sEH Dual Inhibitor PTUPB Potentiates the Antitumor Efficacy of Cisplatin |
| Q92861465 | CPX-351: a nanoscale liposomal co-formulation of daunorubicin and cytarabine with unique biodistribution and tumor cell uptake properties |
| Q99616867 | CRISPR/Cas9 genome-wide loss-of-function screening identifies druggable cellular factors involved in sunitinib resistance in renal cell carcinoma |
| Q47898008 | CX-4945, a selective inhibitor of casein kinase-2 (CK2), exhibits anti-tumor activity in hematologic malignancies including enhanced activity in chronic lymphocytic leukemia when combined with fludarabine and inhibitors of the B-cell receptor pathwa |
| Q39493687 | CYP1A1 is overexpressed upon incubation of breast cancer cells with a polyphenolic cocoa extract |
| Q36214091 | Calcium and P-glycoprotein independent synergism between schweinfurthins and verapamil |
| Q52583854 | Calmodulin antagonist enhances DR5-mediated apoptotic signaling in TRA-8 resistant triple negative breast cancer cells. |
| Q53806907 | Camellia sinensis Ameliorates the Efficacy of Last Line Antibiotics Against Carbapenem Resistant Escherichia coli. |
| Q24305602 | Cancer-selective targeting of the NF-κB survival pathway with GADD45β/MKK7 inhibitors |
| Q33590580 | Cannabidiol enhances the inhibitory effects of delta9-tetrahydrocannabinol on human glioblastoma cell proliferation and survival |
| Q37671286 | Cannabidiol inhibits paclitaxel-induced neuropathic pain through 5-HT(1A) receptors without diminishing nervous system function or chemotherapy efficacy |
| Q42314593 | Cannabinoids synergize with carfilzomib, reducing multiple myeloma cells viability and migration. |
| Q28546914 | Capsaicin Enhances the Drug Sensitivity of Cholangiocarcinoma through the Inhibition of Chemotherapeutic-Induced Autophagy |
| Q52677331 | Capsaicin and Piperine Can Overcome Multidrug Resistance in Cancer Cells to Doxorubicin. |
| Q48597130 | Capsaicin exerts synergistic antitumor effect with sorafenib in hepatocellular carcinoma cells through AMPK activation |
| Q41978951 | Carboplatin and oxaliplatin in sequenced combination with bortezomib in ovarian tumour models |
| Q38446206 | Carboplatin synergistically triggers the efficacy of photodynamic therapy via caspase 3-, 8-, and 12-dependent pathways in human anaplastic thyroid cancer cells |
| Q58764275 | Cariprazine, A Dopamine D₂/D₃ Receptor Partial Agonist, Modulates ABCG2-Mediated Multidrug Resistance in Cancer |
| Q35014803 | Catalytic inhibitors of topoisomerase II differently modulate the toxicity of anthracyclines in cardiac and cancer cells |
| Q39702755 | Cathepsin E enhances anticancer activity of doxorubicin on human prostate cancer cells showing resistance to TRAIL-mediated apoptosis |
| Q39012520 | Cationic membrane-active peptides - anticancer and antifungal activity as well as penetration into human skin |
| Q33714804 | Cellular responses to T-2 toxin and/or deoxynivalenol that induce cartilage damage are not specific to chondrocytes |
| Q48162924 | Central effect of crocin on penicillin-induced epileptiform activity in rats |
| Q91029095 | Cetylpyridinium chloride interaction with the hepatitis B virus core protein inhibits capsid assembly |
| Q26746257 | Challenges in Analyzing the Biological Effects of Resveratrol |
| Q41436013 | Challenging issues in molecular-targeted therapy |
| Q36114723 | Changes in the in vitro activity of platinum drugs when administered in two aliquots. |
| Q41143505 | Characterization of the aminopyridine derivative KRC-180 as a JAK2 inhibitor |
| Q90589863 | Characterization of the receptor-binding domain (RBD) of 2019 novel coronavirus: implication for development of RBD protein as a viral attachment inhibitor and vaccine |
| Q39620511 | Checkpoint kinase inhibitor synergizes with DNA-damaging agents in G1 checkpoint-defective neuroblastoma |
| Q54118223 | Chemical Genetic Screens Identify Kinase Inhibitor Combinations that Target Anti-Apoptotic Proteins for Cancer Therapy. |
| Q36328210 | Chemical conjugation of 2-hexadecynoic acid to C5-curcumin enhances its antibacterial activity against multi-drug resistant bacteria |
| Q98471319 | Chemogenomic screening identifies the Hsp70 co-chaperone DNAJA1 as a hub for anticancer drug resistance |
| Q33398646 | Chemotherapeutic treatment efficacy and sensitivity are increased by adjuvant alternating electric fields (TTFields). |
| Q36280164 | Chemotherapy induces adaptive drug resistance and metastatic potentials via phenotypic CXCR4-expressing cell state transition in ovarian cancer |
| Q28474893 | Chemotherapy synergizes with radioimmunotherapy targeting La autoantigen in tumors |
| Q98464599 | Chidamide increases the sensitivity of Non-small Cell Lung Cancer to Crizotinib by decreasing c-MET mRNA methylation |
| Q64072895 | Chidamide, a novel histone deacetylase inhibitor, inhibits multiple myeloma cells proliferation through succinate dehydrogenase subunit A |
| Q28396027 | Chk2 deficiency in Myc overexpressing lymphoma cells elicits a synergistic lethal response in combination with PARP inhibition |
| Q39430270 | Chk2 mediates RITA-induced apoptosis |
| Q39610375 | Chromatin structure predicts epigenetic therapy responsiveness in sarcoma |
| Q58751747 | Chronic myeloid leukaemia cells require the bone morphogenic protein pathway for cell cycle progression and self-renewal |
| Q48350344 | Cisplatin and valproate released from the bifunctional [Pt(IV)Cl2(NH3)2(valproato)2] antitumor prodrug or from liposome formulations: who does what? |
| Q38864663 | Cisplatin-, Doxorubicin-, and Docetaxel-Induced Cell Death Promoted by the Aqueous Extract of Solanum nigrum in Human Ovarian Carcinoma Cells. |
| Q34318452 | Class I and class II histone deacetylases are potential therapeutic targets for treating pancreatic cancer |
| Q38075544 | Clinical developments of chemotherapeutic nanomedicines: polymers and liposomes for delivery of camptothecins and platinum (II) drugs |
| Q33716011 | Co-delivery of cisplatin and rapamycin for enhanced anticancer therapy through synergistic effects and microenvironment modulation. |
| Q31146794 | Co-exposure to low doses of the food contaminants deoxynivalenol and nivalenol has a synergistic inflammatory effect on intestinal explants |
| Q91892950 | Co-targeting EGFR and mTOR with gefitinib and everolimus in triple-negative breast cancer cells |
| Q98891536 | Co-targeting PIM and PI3K/mTOR using multikinase inhibitor AUM302 and a combination of AZD-1208 and BEZ235 in prostate cancer |
| Q36805184 | Co-treatment by docetaxel and vinblastine breaks down P-glycoprotein mediated chemo-resistance |
| Q35884844 | Combination Effects of Antimicrobial Peptides |
| Q47852580 | Combination Therapy with Sulfasalazine and Valproic Acid Promotes Human Glioblastoma Cell Death Through Imbalance of the Intracellular Oxidative Response. |
| Q90246950 | Combination Treatment of Cervical Cancer Using Folate-Decorated, pH-Sensitive, Carboplatin and Paclitaxel Co-Loaded Lipid-Polymer Hybrid Nanoparticles |
| Q46642455 | Combination antifungal therapy involving amphotericin B, rapamycin and 5-fluorocytosine using PEG-phospholipid micelles. |
| Q38718627 | Combination antiretroviral therapy and cell-cell spread of wild-type and drug-resistant human immunodeficiency virus-1. |
| Q37107517 | Combination chemotherapy and photodynamic therapy with fab' fragment targeted HPMA copolymer conjugates in human ovarian carcinoma cells |
| Q33670961 | Combination cytotoxicity of backbone degradable HPMA copolymer gemcitabine and platinum conjugates toward human ovarian carcinoma cells |
| Q41853267 | Combination effects of docetaxel and Doxorubicin in hormone-refractory prostate cancer cells |
| Q34465240 | Combination erlotinib-cisplatin and Atg3-mediated autophagy in erlotinib resistant lung cancer |
| Q92295753 | Combination immunotherapy with IL-4 Pseudomonas exotoxin and IFN-α and IFN-γ mediate antitumor effects in vitro and in a mouse model of human ovarian cancer |
| Q39407582 | Combination of ATP-competitive mammalian target of rapamycin inhibitors with standard chemotherapy for colorectal cancer |
| Q53069361 | Combination of Garcinia cambogia Extract and Pear Pomace Extract Additively Suppresses Adipogenesis and Enhances Lipolysis in 3T3-L1 Cells. |
| Q39375125 | Combination of HDAC and topoisomerase inhibitors in small cell lung cancer |
| Q35175423 | Combination of N-(4-hydroxyphenyl) retinamide and apigenin suppressed starvation-induced autophagy and promoted apoptosis in malignant neuroblastoma cells |
| Q47845823 | Combination of a chemopreventive agent and paclitaxel in CD44-targeted hybrid nanoparticles for breast cancer treatment |
| Q39355339 | Combination of an allosteric Akt Inhibitor MK-2206 with etoposide or rapamycin enhances the antitumor growth effect in neuroblastoma. |
| Q37362758 | Combination of autophagy inducer rapamycin and oncolytic adenovirus improves antitumor effect in cancer cells |
| Q28395254 | Combination of bifunctional alkylating agent and arsenic trioxide synergistically suppresses the growth of drug-resistant tumor cells |
| Q35184278 | Combination of dasatinib and curcumin eliminates chemo-resistant colon cancer cells |
| Q52742986 | Combination of doxorubicin with harmine-loaded liposomes exerting synergistic antitumor efficacy. |
| Q64068564 | Combination of eribulin plus AKT inhibitor evokes synergistic cytotoxicity in soft tissue sarcoma cells |
| Q48360649 | Combination of etoposide and fisetin results in anti-cancer efficiency against osteosarcoma cell models. |
| Q36162351 | Combination of heat shock protein 90 and focal adhesion kinase inhibitors synergistically inhibits the growth of non-small cell lung cancer cells. |
| Q55004955 | Combination of interferon-expressing oncolytic adenovirus with chemotherapy and radiation is highly synergistic in hamster model of pancreatic cancer. |
| Q37007277 | Combination of low concentration of (-)-epigallocatechin gallate (EGCG) and curcumin strongly suppresses the growth of non-small cell lung cancer in vitro and in vivo through causing cell cycle arrest |
| Q39343246 | Combination of low doses of enzastaurin and lenalidomide has synergistic activity in B-non-Hodgkin lymphoma cell lines |
| Q36986471 | Combination of oxidative stress and FOXM1 inhibitors induces apoptosis in cancer cells and inhibits xenograft tumor growth |
| Q64113560 | Combination of the natural product capsaicin and docetaxel synergistically kills human prostate cancer cells through the metabolic regulator AMP-activated kinase |
| Q28076891 | Combination therapeutics in complex diseases |
| Q58714990 | Combination therapy of simvastatin and 5, 6-dimethylxanthenone-4-acetic acid synergistically suppresses the aggressiveness of B16.F10 melanoma cells |
| Q64284731 | Combination therapy with c-met inhibitor and TRAIL enhances apoptosis in dedifferentiated liposarcoma patient-derived cells |
| Q84136161 | Combination therapy with the albumin-binding prodrug of doxorubicin (INNO-206) and doxorubicin achieves complete remissions and improves tolerability in an ovarian A2780 xenograft model |
| Q47184289 | Combination treatment of RAD001 and BEZ235 exhibits synergistic antitumor activity via down-regulation of p-4E-BP1/Mcl-1 in small cell lung cancer. |
| Q42700746 | Combination treatment of ergosterol followed by amphotericin B induces necrotic cell death in human hepatocellular carcinoma cells |
| Q41916031 | Combination treatment with fasudil and clioquinol produces synergistic anti-tumor effects in U87 glioblastoma cells by activating apoptosis and autophagy |
| Q42378380 | Combination treatment with rucaparib (Rubraca) and MDM2 inhibitors, Nutlin-3 and RG7388, has synergistic and dose reduction potential in ovarian cancer |
| Q38921856 | Combination treatment with triptolide and hydroxycamptothecin synergistically enhances apoptosis in A549 lung adenocarcinoma cells through PP2A-regulated ERK, p38 MAPKs and Akt signaling pathways. |
| Q37679984 | Combinational therapy of crizotinib and afatinib for malignant pleural mesothelioma |
| Q27489596 | Combinations of 2'-C-methylcytidine analogues with interferon-alpha2b and triple combination with ribavirin in the hepatitis C virus replicon system |
| Q47118928 | Combinations of QTc-prolonging drugs: towards disentangling pharmacokinetic and pharmacodynamic effects in their potentially additive nature |
| Q38966159 | Combinations of alkaloids affecting different molecular targets with the saponin digitonin can synergistically enhance trypanocidal activity against Trypanosoma brucei brucei |
| Q39219026 | Combinations of lambda interferon with direct-acting antiviral agents are highly efficient in suppressing hepatitis C virus replication |
| Q39843204 | Combinations of the first and next generations of human immunodeficiency virus (HIV) fusion inhibitors exhibit a highly potent synergistic effect against enfuvirtide- sensitive and -resistant HIV type 1 strains |
| Q36189311 | Combinatorial Action of MicroRNAs let-7 and miR-34 Effectively Synergizes with Erlotinib to Suppress Non-small Cell Lung Cancer Cell Proliferation. |
| Q92731843 | Combinatorial Therapy of Zinc Metallochaperones with Mutant p53 Reactivation and Diminished Copper Binding |
| Q41516113 | Combinatorial bioactive botanicals re-sensitize tamoxifen treatment in ER-negative breast cancer via epigenetic reactivation of ERα expression |
| Q37007347 | Combinatorial effects of lapatinib and rapamycin in triple-negative breast cancer cells |
| Q41473798 | Combinatorial epigenetic mechanisms and efficacy of early breast cancer inhibition by nutritive botanicals |
| Q38741250 | Combinatory estrogenic effects between the isoflavone genistein and the mycotoxins zearalenone and alternariol in vitro |
| Q60908061 | Combined Cytotoxicity of the Phycotoxin Okadaic Acid and Mycotoxins on Intestinal and Neuroblastoma Human Cell Models |
| Q36638340 | Combined Effects of Lipophilic Phycotoxins (Okadaic Acid, Azapsiracid-1 and Yessotoxin) on Human Intestinal Cells Models |
| Q52615755 | Combined Inhibition of ATR and WEE1 as a Novel Therapeutic Strategy in Triple-Negative Breast Cancer. |
| Q33648582 | Combined MEK and Pi3'-kinase inhibition reveals synergy in targeting thyroid cancer in vitro and in vivo. |
| Q41057184 | Combined PI3K/Akt and Hsp90 targeting synergistically suppresses essential functions of alloreactive T cells and increases Tregs |
| Q89896759 | Combined Targeting of AKT and mTOR Inhibits Proliferation of Human NF1-Associated Malignant Peripheral Nerve Sheath Tumour Cells In Vitro but not in a Xenograft Mouse Model In Vivo |
| Q89314557 | Combined Treatments of Magnetic Intra-Lysosomal Hyperthermia with Doxorubicin Promotes Synergistic Anti-Tumoral Activity |
| Q53395371 | Combined and independent cytotoxicity of sodium hypochlorite, ethylenediaminetetraacetic acid and chlorhexidine. |
| Q61445534 | Combined antitumoral effects of pretubulysin and methotrexate |
| Q87407130 | Combined arsenic trioxide-cisplatin treatment enhances apoptosis in oral squamous cell carcinoma cells |
| Q97540425 | Combined blockade of EGFR and glutamine metabolism in preclinical models of colorectal cancer |
| Q49967937 | Combined effect of telmisartan and fluvastatin on arachidonic acid metabolism in human liver microsomes. |
| Q38885833 | Combined enzyme/prodrug treatment by genetically engineered AT-MSC exerts synergy and inhibits growth of MDA-MB-231 induced lung metastases |
| Q35323235 | Combined ginger extract & Gelam honey modulate Ras/ERK and PI3K/AKT pathway genes in colon cancer HT29 cells |
| Q37123636 | Combined inhibition of BET family proteins and histone deacetylases as a potential epigenetics-based therapy for pancreatic ductal adenocarcinoma |
| Q35657004 | Combined inhibition of the cell cycle related proteins Wee1 and Chk1/2 induces synergistic anti-cancer effect in melanoma. |
| Q39165973 | Combined targeting of AKT and mTOR using MK-2206 and RAD001 is synergistic in the treatment of cholangiocarcinoma |
| Q27852093 | Combined targeting of MEK and PI3K/mTOR effector pathways is necessary to effectively inhibit NRAS mutant melanoma in vitro and in vivo |
| Q47123785 | Combined targeting of Raf and Mek synergistically inhibits tumorigenesis in triple negative breast cancer model systems |
| Q36372763 | Combined therapy of oncolytic adenovirus and temozolomide enhances lung cancer virotherapy in vitro and in vivo. |
| Q88913621 | Combined toxicity of chlorantraniliprole, lambda-cyhalothrin, and imidacloprid to the silkworm Bombyx mori (Lepidoptera: Bombycidae) |
| Q92348262 | Combined treatment with N-acetylcysteine and gefitinib overcomes drug resistance to gefitinib in NSCLC cell line |
| Q58746764 | Combined use of CDK4/6 and mTOR inhibitors induce synergistic growth arrest of diffuse intrinsic pontine glioma cells via mutual downregulation of mTORC1 activity |
| Q39096429 | Combined γ-tocotrienol and Met inhibitor treatment suppresses mammary cancer cell proliferation, epithelial-to-mesenchymal transition and migration |
| Q34104025 | Combining AKT inhibition with chloroquine and gefitinib prevents compensatory autophagy and induces cell death in EGFR mutated NSCLC cells |
| Q59357014 | Combining New Non-Nucleoside Reverse Transcriptase Inhibitors (RTIs) with AZT Results in Strong Synergism against Multi-RTI-Resistant HIV-1 Strains |
| Q98565962 | Combining PARP inhibitors with platinum or ruthenium-based complexes for cancer therapy |
| Q61805218 | Combining a Fusion Inhibitory Peptide Targeting the MERS-CoV S2 Protein HR1 Domain and a Neutralizing Antibody Specific for the S1 Protein Receptor-Binding Domain (RBD) Showed Potent Synergism against Pseudotyped MERS-CoV with or without Mutations in |
| Q36139333 | Combining genomic and network characteristics for extended capability in predicting synergistic drugs for cancer. |
| Q37676300 | Combining metformin and nelfinavir exhibits synergistic effects against the growth of human cervical cancer cells and xenograft in nude mice |
| Q38793940 | Comparison of in vitro antileukemic activity of obatoclax and ABT-737. |
| Q38684463 | Complex interplay of kinetic factors governs the synergistic properties of HIV-1 entry inhibitors. |
| Q28541174 | Computational analyses of synergism in small molecular network motifs |
| Q37114045 | Concomitant inhibition of DNA methyltransferase and BCL-2 protein function synergistically induce mitochondrial apoptosis in acute myelogenous leukemia cells |
| Q39465147 | Concomitant treatment of F98 glioma cells with new liposomal platinum compounds and ionizing radiation |
| Q33551779 | Confidence Intervals of Interaction Index for Assessing Multiple Drug Interaction |
| Q35820046 | Convection enhanced delivery of carboplatin in combination with radiotherapy for the treatment of brain tumors |
| Q42633806 | Convergent and divergent pathways decoding hierarchical additive mechanisms in treating cerebral ischemia-reperfusion injury. |
| Q38749913 | Cooperative Dynamics of AR and ER Activity in Breast Cancer |
| Q39492343 | Cooperative enhancement of radiosensitivity after combined treatment of 17-(allylamino)-17-demethoxygeldanamycin and celecoxib in human lung and colon cancer cell lines |
| Q36949088 | Coordinate regulation of enzyme markers for inflammation and for protection against oxidants and electrophiles. |
| Q37593968 | Correlation of NEDD4-1 and PTEN expression with the invasive capacity of pituitary adenomas |
| Q40837147 | Could Caffeic Acid Phenethyl Ester Expand the Antitumor Effect of Tamoxifen in Breast Carcinoma? |
| Q39352663 | Cranberry proanthocyanidins act in synergy with licochalcone A to reduce Porphyromonas gingivalis growth and virulence properties, and to suppress cytokine secretion by macrophages |
| Q86895331 | Criteria for deviation from predictions by the concentration addition model |
| Q92133931 | Crizotinib and PARP inhibitors act synergistically by triggering apoptosis in high-grade serous ovarian cancer |
| Q42373819 | Crizotinib, a MET inhibitor, inhibits growth, migration, and invasion of breast cancer cells in vitro and synergizes with chemotherapeutic agents |
| Q33636430 | Crosstalk in inflammation: the interplay of glucocorticoid receptor-based mechanisms and kinases and phosphatases |
| Q47216231 | Crucial role of HO-1/IRF4-dependent apoptosis induced by panobinostat and lenalidomide in multiple myeloma |
| Q92802103 | Crystal violet structural analogues identified by in silico drug repositioning present anti-Trypanosoma cruzi activity through inhibition of proline transporter TcAAAP069 |
| Q47141971 | Cucurbitacin B and SCH772984 exhibit synergistic anti-pancreatic cancer activities by suppressing EGFR, PI3K/Akt/mTOR, STAT3 and ERK signaling |
| Q89688035 | Curcumin enhances chemotherapeutic effects and suppresses ANGPTL4 in anoikis-resistant cholangiocarcinoma cells |
| Q38777239 | Curcumin mediates oxaliplatin-acquired resistance reversion in colorectal cancer cell lines through modulation of CXC-Chemokine/NF-κB signalling pathway. |
| Q33906004 | Curcumin reduces expression of Bcl-2, leading to apoptosis in daunorubicin-insensitive CD34+ acute myeloid leukemia cell lines and primary sorted CD34+ acute myeloid leukemia cells |
| Q49470056 | Curcumol potentiates celecoxib-induced growth inhibition and apoptosis in human non-small cell lung cancer |
| Q89642153 | Current Methods for Quantifying Drug Synergism |
| Q39016850 | Current Trends in Multidrug Optimization |
| Q37610047 | Cyclooxygenase-2 inhibitor is a robust enhancer of anticancer agents against hepatocellular carcinoma multicellular spheroids |
| Q35129112 | CypA, a gene downstream of HIF-1α, promotes the development of PDAC |
| Q58609363 | Cytotoxic Effects of Some Flavonoids and Imatinib on K562 Chronic Myeloid Leukemia Cell Line: Data Analysis Using the Combination Index Method |
| Q37666991 | Cytotoxic effects of fascaplysin against small cell lung cancer cell lines |
| Q36078092 | Cytotoxicity enhancement in MDA-MB-231 cells by the combination treatment of tetrahydropalmatine and berberine derived from Corydalis yanhusuo W. T. Wang |
| Q92815979 | Cytotoxicity, Genotoxicity and Disturbance of Cell Cycle in HepG2 Cells Exposed to OTA and BEA: Single and Combined Actions |
| Q39608912 | Cytotoxicity, drug combinability, and biological correlates of ABT-737 against acute lymphoblastic leukemia cells with MLL rearrangement |
| Q37621452 | DAFODIL: A novel liposome-encapsulated synergistic combination of doxorubicin and 5FU for low dose chemotherapy |
| Q102210924 | DNA damage induced by KP372-1 hyperactivates PARP1 and enhances lethality of pancreatic cancer cells with PARP inhibition |
| Q34708878 | Dasatinib (BMS-35482) has synergistic activity with paclitaxel and carboplatin in ovarian cancer cells. |
| Q36929175 | Dasatinib (BMS-35482) potentiates the activity of gemcitabine and docetaxel in uterine leiomyosarcoma cell lines |
| Q34335004 | Dasatinib inhibits the growth of molecularly heterogeneous myeloid leukemias |
| Q36315850 | Dasatinib synergizes with both cytotoxic and signal transduction inhibitors in heterogeneous breast cancer cell lines--lessons for design of combination targeted therapy |
| Q51807216 | De Novo Lipid Synthesis Facilitates Gemcitabine Resistance through Endoplasmic Reticulum Stress in Pancreatic Cancer. |
| Q34075366 | Deciphering combinations of PI3K/AKT/mTOR pathway drugs augmenting anti-angiogenic efficacy in vivo |
| Q35109281 | Decitabine and suberoylanilide hydroxamic acid (SAHA) inhibit growth of ovarian cancer cell lines and xenografts while inducing expression of imprinted tumor suppressor genes, apoptosis, G2/M arrest, and autophagy |
| Q38410843 | Decursin in Angelica gigas Nakai (AGN) Enhances Doxorubicin Chemosensitivity in NCI/ADR-RES Ovarian Cancer Cells via Inhibition of P-glycoprotein Expression |
| Q47290651 | DeepSynergy: Predicting anti-cancer drug synergy with Deep Learning |
| Q38763826 | Deferasirox has strong anti-leukemia activity but may antagonize theanti-leukemia effect of doxorubicin |
| Q27305016 | Defining an additivity framework for mixture research in inducible whole-cell biosensors |
| Q38391007 | Delivering an Automated and Integrated Approach to Combination Screening Using Acoustic-Droplet Technology |
| Q37580222 | Desferal regulates hCtr1 and transferrin receptor expression through Sp1 and exhibits synergistic cytotoxicity with platinum drugs in oxaliplatin-resistant human cervical cancer cells in vitro and in vivo |
| Q93159845 | Design of Poly(lactic-co-glycolic Acid) (PLGA) Nanoparticles for Vaginal Co-Delivery of Griffithsin and Dapivirine and Their Synergistic Effect for HIV Prophylaxis |
| Q91625107 | Design of a Multicompartment Hydrogel that Facilitates Time-Resolved Delivery of Combination Therapy and Synergized Killing of Glioblastoma |
| Q52672649 | Design of a novel curcumin-soybean phosphatidylcholine complex-based targeted drug delivery systems. |
| Q34056295 | Design of phase I combination trials: recommendations of the Clinical Trial Design Task Force of the NCI Investigational Drug Steering Committee |
| Q47703909 | Design, Synthesis, and Cytotoxicity Evaluation of Novel Griseofulvin Analogues with Improved Water Solubility |
| Q39627994 | Design, synthesis, and biological evaluation of novel water-soluble N-mustards as potential anticancer agents |
| Q47965422 | Developing combination of artesunate with paclitaxel loaded into poly-d,l-lactic-co-glycolic acid nanoparticle for systemic delivery to exhibit synergic chemotherapeutic response |
| Q92343750 | Development of Liposomal Gemcitabine with High Drug Loading Capacity |
| Q33902627 | Development of a Novel Lead that Targets M. tuberculosis Polyketide Synthase 13. |
| Q90460813 | Development of a Novel Quinoline Derivative as a P-Glycoprotein Inhibitor to Reverse Multidrug Resistance in Cancer Cells |
| Q39682371 | Development of a safe and convenient neutralization assay for rapid screening of influenza HA-specific neutralizing monoclonal antibodies |
| Q59812030 | Development of dual-drug-loaded stealth nanocarriers for targeted and synergistic anti-lung cancer efficacy |
| Q39608885 | Development of stealth liposome coencapsulating doxorubicin and fluoxetine |
| Q41051936 | Development of water-soluble polyanionic carbosilane dendrimers as novel and highly potent topical anti-HIV-2 microbicides. |
| Q35065737 | Development, evaluation, and application of an in silico model for antimalarial drug treatment and failure. |
| Q60045827 | Dichloroacetate and Salinomycin Exert a Synergistic Cytotoxic Effect in Colorectal Cancer Cell Lines |
| Q55098336 | Dichloroacetate enhances the antitumor efficacy of chemotherapeutic agents via inhibiting autophagy in non-small-cell lung cancer. |
| Q90687221 | Dichloroacetic acid (DCA) synergizes with the SIRT2 inhibitor Sirtinol and AGK2 to enhance anti-tumor efficacy in non-small cell lung cancer |
| Q33812450 | Dietary mastic oil extracted from Pistacia lentiscus var. chia suppresses tumor growth in experimental colon cancer models. |
| Q47392008 | Different Inhibitory Potencies of Oseltamivir Carboxylate, Zanamivir, and Several Tannins on Bacterial and Viral Neuraminidases as Assessed in a Cell-Free Fluorescence-Based Enzyme Inhibition Assay. |
| Q57492122 | Different Response of Mutant and Wildtype Rhabdomyosarcoma Toward SMO and PI3K Inhibitors |
| Q52726488 | Differential sensitization of two human colon cancer cell lines to the antitumor effects of irinotecan combined with 5-aza-2'-deoxycytidine. |
| Q48808585 | Dihydrocelastrol inhibits multiple myeloma cell proliferation and promotes apoptosis through ERK1/2 and IL-6/STAT3 pathways in vitro and in vivo. |
| Q27335381 | Dioscin strengthens the efficiency of adriamycin in MCF-7 and MCF-7/ADR cells through autophagy induction: More than just down-regulation of MDR1. |
| Q38945222 | Direct binding of arsenic trioxide to AMPK and generation of inhibitory effects on acute myeloid leukemia precursors |
| Q33552261 | Direct control of mitochondrial function by mTOR. |
| Q93055781 | Direct targeting of oncogenic RAS mutants with a tumor-specific cytosol-penetrating antibody inhibits RAS mutant-driven tumor growth |
| Q42731763 | Discovering Molecular Targets in Cancer with Multiscale Modeling |
| Q28547862 | Discovery of Drug Synergies in Gastric Cancer Cells Predicted by Logical Modeling |
| Q97426477 | Discovery of Synergistic and Antagonistic Drug Combinations against SARS-CoV-2 In Vitro |
| Q49207324 | Discovery of a FLT3 inhibitor LDD1937 as an anti-leukemic agent for acute myeloid leukemia |
| Q33778375 | Discovery of a highly synergistic anthelmintic combination that shows mutual hypersusceptibility |
| Q47560158 | Discovery of a semi-synthesized cyclolignan as a potent HIV-1 non-nucleoside reverse transcriptase inhibitor |
| Q28536663 | Discovery of potent broad spectrum antivirals derived from marine actinobacteria |
| Q57120671 | Discovery of synergistic anti-inflammatory compound combination from herbal formula GuGe FengTong Tablet |
| Q33689527 | Disruption of SHH signaling cascade by SBE attenuates lung cancer progression and sensitizes DDP treatment |
| Q34038766 | Disruption of autophagy by the histone deacetylase inhibitor MGCD0103 and its therapeutic implication in B-cell chronic lymphocytic leukemia. |
| Q90211585 | Dissecting RAF Inhibitor Resistance by Structure-based Modeling Reveals Ways to Overcome Oncogenic RAS Signaling |
| Q92825104 | Disulfiram Overcomes Cisplatin Resistance in Human Embryonal Carcinoma Cells |
| Q28484538 | Diverse small molecule inhibitors of human apurinic/apyrimidinic endonuclease APE1 identified from a screen of a large public collection |
| Q36805956 | Do bupivacaine, clindamycin, and gentamicin at their clinical concentrations enhance rocuronium-induced neuromuscular block? |
| Q91829105 | Docosahexaenoic Acid Serving As Sensitizing Agents And Gefitinib Resistance Revertants In EGFR Targeting Treatment |
| Q38240591 | Does Synergy Exist in Nursing? A Concept Analysis. |
| Q47133357 | Dormant glioblastoma cells acquire stem cell characteristics and are differentially affected by Temozolomide and AT101 treatment |
| Q91393722 | Downregulating Notch counteracts KrasG12D-induced ERK activation and oxidative phosphorylation in myeloproliferative neoplasm |
| Q34715771 | Doxorubicin synergizes with 34.5ENVE to enhance antitumor efficacy against metastatic ovarian cancer |
| Q47687132 | Doxycycline synergizes with doxorubicin to inhibit the proliferation of castration-resistant prostate cancer cells |
| Q34683447 | Dramatic potentiation of the antiviral activity of HIV antibodies by cholesterol conjugation |
| Q51734368 | Drug Combination Synergy in Worm-like Polymeric Micelles Improves Treatment Outcome for Small Cell and Non-Small Cell Lung Cancer. |
| Q91743379 | Drug Combinations: Mathematical Modeling and Networking Methods |
| Q51504147 | Drug Synergism of Proteasome Inhibitors and Mitotane by Complementary Activation of ER Stress in Adrenocortical Carcinoma Cells. |
| Q36104367 | Drug combinatorics and side effect estimation on the signed human drug-target network |
| Q35609403 | Drug effectiveness explained: the mathematics of antiviral agents for HIV. |
| Q40907848 | Drug interaction: focusing on response surface models |
| Q34289180 | Drug repurposing identifies a synergistic combination therapy with imatinib mesylate for gastrointestinal stromal tumor |
| Q92133167 | Drug responses are conserved across patient-derived xenograft models of melanoma leading to identification of novel drug combination therapies |
| Q34762862 | Drug susceptibility profile and pathogenicity of H7N9 influenza virus (Anhui1 lineage) with R292K substitution. |
| Q28486428 | Drug synergy of tenofovir and nanoparticle-based antiretrovirals for HIV prophylaxis |
| Q37723910 | Drug synergy screen and network modeling in dedifferentiated liposarcoma identifies CDK4 and IGF1R as synergistic drug targets. |
| Q42120714 | Dual "mAb" HER family blockade in head and neck cancer human cell lines combined with photon therapy |
| Q37151091 | Dual CCNE1/PIK3CA targeting is synergistic in CCNE1-amplified/PIK3CA-mutated uterine serous carcinomas in vitro and in vivo |
| Q36258125 | Dual HER2/PIK3CA Targeting Overcomes Single-Agent Acquired Resistance in HER2-Amplified Uterine Serous Carcinoma Cell Lines In Vitro and In Vivo |
| Q57461985 | Dual Inhibition of DNA and Histone Methyltransferases Increases Viral Mimicry in Ovarian Cancer Cells |
| Q91754756 | Dual Kit/Aur Inhibitors as Chemosensitizing Agents for the Treatment of Melanoma: Design, Synthesis, Docking Studies and Functional Investigation |
| Q33767414 | Dual PI3K and Wnt pathway inhibition is a synergistic combination against triple negative breast cancer |
| Q91859360 | Dual Targeting of Aurora Kinases with AMG 900 Exhibits Potent Preclinical Activity Against Acute Myeloid Leukemia with Distinct Post-Mitotic Outcomes |
| Q37645301 | Dual agent loaded PLGA nanoparticles enhanced antitumor activity in a multidrug-resistant breast tumor eenograft model |
| Q50981985 | Dual blockade of PI3K/AKT/mTOR (NVP-BEZ235) and Ras/Raf/MEK (AZD6244) pathways synergistically inhibit growth of primary endometrioid endometrial carcinoma cultures, whereas NVP-BEZ235 reduces tumor growth in the corresponding xenograft models. |
| Q41368267 | Dual pharmacological inhibition of glutathione and thioredoxin systems synergizes to kill colorectal carcinoma stem cells |
| Q28304985 | Dual small-molecule targeting of procaspase-3 dramatically enhances zymogen activation and anticancer activity |
| Q33904684 | Dual targeting of EWS-FLI1 activity and the associated DNA damage response with trabectedin and SN38 synergistically inhibits Ewing sarcoma cell growth |
| Q38893052 | Dual targeting of acute myeloid leukemia progenitors by catalytic mTOR inhibition and blockade of the p110α subunit of PI3 kinase |
| Q38762779 | Dual-drug loaded nanoformulation with a galactosamine homing moiety for liver-targeted anticancer therapy |
| Q41078694 | Dual-targeted hybrid nanoparticles of synergistic drugs for treating lung metastases of triple negative breast cancer in mice |
| Q91958132 | Durable complete response in renal cell carcinoma clinical trials |
| Q92798829 | EGCG overcomes gefitinib resistance by inhibiting autophagy and augmenting cell death through targeting ERK phosphorylation in NSCLC |
| Q99728118 | EGFR activity addiction facilitates anti-ERBB based combination treatment of squamous bladder cancer |
| Q33276007 | EGFR inhibitors identified as a potential treatment for chordoma in a focused compound screen |
| Q37262805 | EGFR-targeted diphtheria toxin stimulates TRAIL killing of glioblastoma cells by depleting anti-apoptotic proteins |
| Q61570984 | EWS/FLI Confers Tumor Cell Synthetic Lethality to CDK12 Inhibition in Ewing Sarcoma |
| Q34460151 | EZH2 inhibition sensitizes BRG1 and EGFR mutant lung tumours to TopoII inhibitors |
| Q90855720 | Early polytherapy for benzodiazepine-refractory status epilepticus |
| Q41444506 | Ecdysteroids sensitize MDR and non-MDR cancer cell lines to doxorubicin, paclitaxel, and vincristine but tend to protect them from cisplatin |
| Q37450471 | Effect of Fusarium-Derived Metabolites on the Barrier Integrity of Differentiated Intestinal Porcine Epithelial Cells (IPEC-J2). |
| Q36423770 | Effect of low doses of actinomycin D on neuroblastoma cell lines |
| Q35669596 | Effect of sulfasalazine on human neuroblastoma: analysis of sepiapterin reductase (SPR) as a new therapeutic target |
| Q38921495 | Effect of the coffee ingredient cafestol on head and neck squamous cell carcinoma cell lines |
| Q52911914 | Effect of the histone deacetylase inhibitor resminostat on head and neck squamous cell carcinoma cell lines. |
| Q36276803 | Effect on hepatitis C virus replication of combinations of direct-acting antivirals, including NS5A inhibitor daclatasvir |
| Q38889577 | Effects of 5'-azacytidine and alendronate on a hepatocellular carcinoma cell line: a proteomics perspective. |
| Q91811000 | Effects of Synergistic Inhibition on α-glucosidase by Phytoalexins in Soybeans |
| Q37652650 | Effects of U0126 and MK2206 on cell growth and re-growth of endometriotic stromal cells grown on substrates of varying stiffness |
| Q57817674 | Effects of a single long-acting muscarinic antagonist agent and a long-acting muscarinic antagonist/long-acting β2-adrenoceptor agonist combination on lung function and symptoms in untreated COPD patients in Japan |
| Q35769651 | Effects of cytochalasin congeners, microtubule-directed agents, and doxorubicin alone or in combination against human ovarian carcinoma cell lines in vitro |
| Q39729652 | Effects of enzastaurin, alone or in combination, on signaling pathway controlling growth and survival of B-cell lymphoma cell lines |
| Q38826046 | Effects of mTOR inhibitors and cytoskeletal-directed agents alone and in combination against normal and neoplastic hematopoietic cells in vitro |
| Q42366591 | Effects of roniciclib in preclinical models of anaplastic thyroid cancer. |
| Q37457602 | Efficacy of the combination of MEK and CDK4/6 inhibitors in vitro and in vivo in KRAS mutant colorectal cancer models |
| Q42263053 | Efficient measurement and factorization of high-order drug interactions in Mycobacterium tuberculosis |
| Q53840409 | Efficient synthesis of novel 3-aryl-5-(4-chloro-2-morpholinothiazol-5-yl)-4,5-dihydro-1H-pyrazoles and their antifungal activity alone and in combination with commercial antifungal agents. |
| Q39660881 | Electrophysiological Study of the Antinociception Produced by the Coapplication of (±)-CPP and Propentofylline in Monoarthritic Rats |
| Q64287135 | Ellagic acid microspheres restrict the growth of Babesia and Theileria in vitro and Babesia microti in vivo |
| Q34282170 | Emax model and interaction index for assessing drug interaction in combination studies |
| Q48297063 | Encapsulating pH-Responsive Doxorubicin-Phthalocyanine Conjugates in Mesoporous Silica Nanoparticles for Combined Photodynamic Therapy and Controlled Chemotherapy. |
| Q41811207 | Endoplasmic reticulum protein ERp46 in prostate adenocarcinoma |
| Q35895730 | Endoplasmic reticulum stress in the peripheral nervous system is a significant driver of neuropathic pain |
| Q40141950 | Enfuvirtide (T20)-Based Lipopeptide Is a Potent HIV-1 Cell Fusion Inhibitor: Implications for Viral Entry and Inhibition |
| Q42835560 | Engineered Breast Cancer Cell Spheroids Reproduce Biologic Properties of Solid Tumors |
| Q35746919 | Engineering of lipid prodrug-based, hyaluronic acid-decorated nanostructured lipid carriers platform for 5-fluorouracil and cisplatin combination gastric cancer therapy |
| Q39125279 | Enhanced 5-fluorouracil cytotoxicity in high COX-2 expressing hepatocellular carcinoma cells by wogonin via the PI3K/Akt pathway |
| Q63246460 | Enhanced Ability of Oligomeric Nanobodies Targeting MERS Coronavirus Receptor-Binding Domain |
| Q36700778 | Enhanced Cytotoxic Effects of Combined Valproic Acid and the Aurora Kinase Inhibitor VE465 on Gynecologic Cancer Cells |
| Q64375045 | Enhanced Delivery of Oncolytic Adenovirus by Neural Stem Cells for Treatment of Metastatic Ovarian Cancer |
| Q39417166 | Enhanced anti-inflammatory effect of resveratrol and EPA in treated endotoxin-activated RAW 264.7 macrophages |
| Q36502354 | Enhanced antitumor activity of combinations of free and HPMA copolymer-bound drugs |
| Q36354776 | Enhanced antitumor effects by docetaxel/LL37-loaded thermosensitive hydrogel nanoparticles in peritoneal carcinomatosis of colorectal cancer. |
| Q37255356 | Enhanced delivery of cisplatin to intraperitoneal ovarian carcinomas mediated by the effects of bortezomib on the human copper transporter 1 |
| Q33727026 | Enhanced resistance to tamoxifen by the c-ABL proto-oncogene in breast cancer |
| Q34760255 | Enhancement of SMN protein levels in a mouse model of spinal muscular atrophy using novel drug-like compounds |
| Q39940476 | Enhancement of docetaxel-induced cytotoxicity and apoptosis by all-trans retinoic acid (ATRA) through downregulation of survivin (BIRC5), MCL-1 and LTbeta-R in hormone- and drug resistant prostate cancer cell line, DU-145. |
| Q36552134 | Enhancement of synthetic lethality via combinations of ABT-888, a PARP inhibitor, and carboplatin in vitro and in vivo using BRCA1 and BRCA2 isogenic models |
| Q42108356 | Enhancing Therapeutic Efficacy of Cisplatin by Blocking DNA Damage Repair |
| Q48893820 | Enhancing VSV oncolytic activity with an improved cytosine deaminase suicide gene strategy |
| Q89701219 | Enhancing neuronal chloride extrusion rescues α2/α3 GABAA-mediated analgesia in neuropathic pain |
| Q39963848 | Enhancing the in vitro cytotoxic activity of Delta9-tetrahydrocannabinol in leukemic cells through a combinatorial approach |
| Q51387581 | Environmental risk of combined emerging pollutants in terrestrial environments: chlorophyll a fluorescence analysis. |
| Q39776104 | Enzastaurin (LY317615), a protein kinase C beta selective inhibitor, enhances antiangiogenic effect of radiation |
| Q58744105 | Enzymatic chokepoints and synergistic drug targets in the sterol biosynthesis pathway of Naegleria fowleri |
| Q56769203 | Enzyme Prodrug Therapy Engineered into Biomaterials |
| Q90077905 | Enzyme-induced in vivo assembly of gold nanoparticles for imaging-guided synergistic chemo-photothermal therapy of tumor |
| Q39281746 | Epigenetic modifications and p21-cyclin B1 nexus in anticancer effect of histone deacetylase inhibitors in combination with silibinin on non-small cell lung cancer cells |
| Q35152542 | Erlotinib-cisplatin combination inhibits growth and angiogenesis through c-MYC and HIF-1α in EGFR-mutated lung cancer in vitro and in vivo |
| Q34623582 | Escin exerts synergistic anti-inflammatory effects with low doses of glucocorticoids in vivo and in vitro |
| Q38978135 | Establishment of novel cell lines recapitulating the genetic landscape of uveal melanoma and preclinical validation of mTOR as a therapeutic target |
| Q39256481 | Ethacrynic acid and a derivative enhance apoptosis in arsenic trioxide-treated myeloid leukemia and lymphoma cells: the role of glutathione S-transferase p1-1. |
| Q48121718 | Eugenol potentiates cisplatin anti-cancer activity through inhibition of ALDH-positive breast cancer stem cells and the NF-κB signaling pathway. |
| Q58555788 | Evaluation for Synergistic Effects by Combinations of Photodynamic Therapy (PDT) with Temoporfin (mTHPC) and Pt(II) Complexes Carboplatin, Cisplatin or Oxaliplatin in a Set of Five Human Cancer Cell Lines |
| Q35971203 | Evaluation of activity and combination strategies with the microtubule-targeting drug sagopilone in breast cancer cell lines. |
| Q40430947 | Evaluation of combined noxious effects of siduron and cadmium on the earthworm Eisenia fetida |
| Q92431265 | Evaluation of drug combination effect using a Bliss independence dose-response surface model |
| Q39277056 | Evaluation of single and combination therapies with tenofovir disoproxil fumarate and emtricitabine in vitro and in a robust mouse model supporting high levels of hepatitis B virus replication |
| Q91587335 | Evaluation of tamoxifen and simvastatin as the combination therapy for the treatment of hormonal dependent breast cancer cells |
| Q92135206 | Evaluation of the inhibitory effect of ivermectin on the growth of Babesia and Theileria parasites in vitro and in vivo |
| Q24297396 | Evidence that Aurora B is implicated in spindle checkpoint signalling independently of error correction |
| Q38979977 | Ewing sarcoma inhibition by disruption of EWSR1-FLI1 transcriptional activity and reactivation of p53. |
| Q35720063 | Ex vivo analysis identifies effective HIV-1 latency-reversing drug combinations. |
| Q38710842 | Examining the In-Vitro Efficacy of the IAP Antagonist Birinapant as a Single-Agent or in Combination with Dacarbazine to Induce Melanoma Cell Death |
| Q50099962 | Exceptional Potency and Structural Basis of a T1249-Derived Lipopeptide Fusion Inhibitor against HIV-1, HIV-2, and Simian Immunodeficiency Virus |
| Q91669693 | Exploiting Curcumin Synergy With Natural Products Using Quantitative Analysis of Dose-Effect Relationships in an Experimental In Vitro Model of Osteoarthritis |
| Q42163449 | Exploiting the 2-Amino-1,3,4-thiadiazole Scaffold To Inhibit Trypanosoma brucei Pteridine Reductase in Support of Early-Stage Drug Discovery. |
| Q46712164 | Exploring brusatol as a new anti-pancreatic cancer adjuvant: biological evaluation and mechanistic studies |
| Q35832805 | Exploring protein kinase inhibitors: potentiating gemcitabine efficacy in pancreatic cancer |
| Q36033055 | Exploring protein kinase inhibitors: unveiling gemcitabine resistance in pancreatic cancer |
| Q54264719 | F14512, a polyamine-vectorized anti-cancer drug, currently in clinical trials exhibits a marked preclinical anti-leukemic activity. |
| Q36094104 | FOXM1 is overexpressed in B-acute lymphoblastic leukemia (B-ALL) and its inhibition sensitizes B-ALL cells to chemotherapeutic drugs |
| Q38896592 | FOXM1: A novel drug target in gastroenteropancreatic neuroendocrine tumors |
| Q52344630 | Facilitating Anti-Cancer Combinatorial Drug Discovery by Targeting Epistatic Disease Genes. |
| Q35535689 | Farnesol decreases biofilms of Staphylococcus epidermidis and exhibits synergy with nafcillin and vancomycin |
| Q36275798 | Farnesylthiosalicylic acid sensitizes hepatocarcinoma cells to artemisinin derivatives |
| Q46312149 | Fatty acid synthase as a potential therapeutic target in feline oral squamous cell carcinoma. |
| Q61999392 | Feasibility of Exposure-Response Analyses for Clinical Dose-Ranging Studies of Drug Combinations |
| Q41852076 | Fermented wheat germ extract induced cell death and enhanced cytotoxicity of Cisplatin and 5-Fluorouracil on human hepatocellular carcinoma cells |
| Q93063358 | Ferroptosis Promotes Photodynamic Therapy: Supramolecular Photosensitizer-Inducer Nanodrug for Enhanced Cancer Treatment |
| Q38739235 | Fisetin Enhances Chemotherapeutic Effect of Cabazitaxel against Human Prostate Cancer Cells |
| Q39729044 | Flavonoid combinations cause synergistic inhibition of proinflammatory mediator secretion from lipopolysaccharide-induced RAW 264.7 cells. |
| Q37061029 | Flavopiridol synergizes with sorafenib to induce cytotoxicity and potentiate antitumorigenic activity in EGFR/HER-2 and mutant RAS/RAF breast cancer model systems |
| Q51618177 | Free Ca2+ as an early intracellular biomarker of exposure of cyanobacteria to environmental pollution. |
| Q37706527 | Frequent amplification of receptor tyrosine kinase genes in welldifferentiated/ dedifferentiated liposarcoma |
| Q37405583 | Fucose-containing fraction of Ling-Zhi enhances lipid rafts-dependent ubiquitination of TGFβ receptor degradation and attenuates breast cancer tumorigenesis |
| Q64097934 | Functional Characterization of Target of Rapamycin Signaling in |
| Q60304301 | Functional Genome-wide Screening Identifies Targets and Pathways Sensitizing Pancreatic Cancer Cells to Dasatinib |
| Q96640875 | Functional genomics identifies new synergistic therapies for retinoblastoma |
| Q92086528 | Functional genomics identifies predictive markers and clinically actionable resistance mechanisms to CDK4/6 inhibition in bladder cancer |
| Q36883651 | Functional mechanotransduction is required for cisplatin-induced hair cell death in the zebrafish lateral line. |
| Q57247628 | GPR55 signalling promotes proliferation of pancreatic cancer cells and tumour growth in mice, and its inhibition increases effects of gemcitabine |
| Q36069860 | GSK-3 directly regulates phospho-4EBP1 in renal cell carcinoma cell-line: an intrinsic subcellular mechanism for resistance to mTORC1 inhibition |
| Q28533696 | Gag-Pol processing during HIV-1 virion maturation: a systems biology approach |
| Q39320594 | Gambogic acid as a non-competitive inhibitor of ATP-binding cassette transporter B1 reverses the multidrug resistance of human epithelial cancers by promoting ATP-binding cassette transporter B1 protein degradation |
| Q36657315 | Ganoderma lucidum Combined with the EGFR Tyrosine Kinase Inhibitor, Erlotinib Synergize to Reduce Inflammatory Breast Cancer Progression |
| Q96134624 | Garcinol Alone and in Combination With Cisplatin Affect Cellular Behavior and PI3K/AKT Protein Phosphorylation in Human Ovarian Cancer Cells |
| Q93274532 | Gefitinib sensitization of cisplatin-resistant wild-type EGFR non-small cell lung cancer cells |
| Q91756033 | Gefitinib-mediated apoptosis is enhanced via inhibition of autophagy by chloroquine diphosphate in cutaneous squamous cell carcinoma cells |
| Q28385542 | General Sensitization of melanoma cells for TRAIL-induced apoptosis by the potassium channel inhibitor TRAM-34 depends on release of SMAC |
| Q41661754 | Genetic regulation of the RUNX transcription factor family has antitumor effects |
| Q30528894 | Genetically defined subsets of human pancreatic cancer show unique in vitro chemosensitivity |
| Q39390538 | Genistein and delphinidin antagonize the genotoxic effects of the mycotoxin alternariol in human colon carcinoma cells |
| Q61570969 | Genome-scale CRISPR-Cas9 screen identifies druggable dependencies in wild-type Ewing sarcoma |
| Q64104320 | Genome-wide prediction of synthetic rescue mediators of resistance to targeted and immunotherapy |
| Q33598112 | Genome-wide transcriptome profiling of homologous recombination DNA repair |
| Q37585821 | Ginger phytochemicals exhibit synergy to inhibit prostate cancer cell proliferation |
| Q47912248 | Ginsenosides synergize with mitomycin C in combating human non-small cell lung cancer by repressing Rad51-mediated DNA repair |
| Q89085390 | Glaucarubinone Combined with Gemcitabine Improves Pancreatic Cancer Survival in an Immunocompetent Orthotopic Murine Model |
| Q28307180 | Glaucarubinone and gemcitabine synergistically reduce pancreatic cancer growth via down-regulation of P21-activated kinases |
| Q28077040 | Glucocorticoid-independent modulation of GR activity: Implications for immunotherapy |
| Q55263355 | Glucocorticoids Inhibit Oncogenic RUNX1-ETO in Acute Myeloid Leukemia with Chromosome Translocation t(8;21). |
| Q38956735 | Glycolytic inhibitor 2-deoxy-d-glucose suppresses cell proliferation and enhances methylprednisolone sensitivity in non-Hodgkin lymphoma cells through down-regulation of HIF-1α and c-MYC. |
| Q50671078 | Gnaphaliin A and gnaphaliin B synergize the relaxant effect of salbutamol but not of ipratropium in guinea pig trachea. |
| Q39134027 | Gossypol and an HMT G9a inhibitor act in synergy to induce cell death in pancreatic cancer cells. |
| Q38854734 | Guadecitabine (SGI-110) priming sensitizes hepatocellular carcinoma cells to oxaliplatin |
| Q33903753 | Guidelines for the welfare and use of animals in cancer research |
| Q39527047 | HDAC inhibitor vorinostat enhances the antitumor effect of gefitinib in squamous cell carcinoma of head and neck by modulating ErbB receptor expression and reverting EMT. |
| Q37437368 | HDAC5, a potential therapeutic target and prognostic biomarker, promotes proliferation, invasion and migration in human breast cancer |
| Q40152011 | HIV-1 gp41-targeting fusion inhibitory peptides enhance the gp120-targeting protein-mediated inactivation of HIV-1 virions |
| Q42530771 | HSP90 Inhibitor Encapsulated Photo-Theranostic Nanoparticles for Synergistic Combination Cancer Therapy |
| Q28542855 | HSP90 inhibition enhances antimitotic drug-induced mitotic arrest and cell death in preclinical models of non-small cell lung cancer |
| Q39659709 | HZ08, a great regulator to reverse multidrug resistance via cycle arrest and apoptosis sensitization in MCF-7/ADM |
| Q33952689 | Hair cell toxicity in anti-cancer drugs: evaluating an anti-cancer drug library for independent and synergistic toxic effects on hair cells using the zebrafish lateral line |
| Q28468670 | Halofuginone and artemisinin synergistically arrest cancer cells at the G1/G0 phase by upregulating p21Cip1 and p27Kip1 |
| Q42548885 | Heat shock factor 1 is a potent therapeutic target for enhancing the efficacy of treatments for multiple myeloma with adverse prognosis. |
| Q36538227 | Herbal Formulation C168 Attenuates Proliferation and Induces Apoptosis in HCT 116 Human Colorectal Carcinoma Cells: Role of Oxidative Stress and DNA Damage |
| Q37057176 | Herbal compound triptolide synergistically enhanced antitumor activity of amino-terminal fragment of urokinase |
| Q92001906 | Heteromerization fingerprints between bradykinin B2 and thromboxane TP receptors in native cells |
| Q99605685 | High Sensitivity of Circulating Tumor Cells Derived from a Colorectal Cancer Patient for Dual Inhibition with AKT and mTOR Inhibitors |
| Q28818948 | High throughput chemical library screening identifies a novel p110-δ inhibitor that potentiates the anti-myeloma effect of bortezomib |
| Q39199511 | High-dose parenteral ascorbate enhanced chemosensitivity of ovarian cancer and reduced toxicity of chemotherapy |
| Q30402235 | High-throughput matrix screening identifies synergistic and antagonistic antimalarial drug combinations |
| Q28541862 | High-throughput screening for the identification of new therapeutic options for metastatic pheochromocytoma and paraganglioma |
| Q38827449 | Highly Stable Tetra-Phenolato Titanium(IV) Agent Formulated into Nanoparticles Demonstrates Anti-Tumoral Activity and Selectivity |
| Q98196708 | Highly synergistic drug combination prevents vaginal HIV infection in humanized mice |
| Q64237055 | Histamine H receptor antagonists enhance the efficacy of antibacterials against Escherichia coli |
| Q38300138 | Histone deacetylase 1 gene expression and sensitization of multidrug-resistant neuroblastoma cell lines to cytotoxic agents by depsipeptide |
| Q37378168 | Histone deacetylase inhibitor romidepsin enhances anti-tumor effect of erlotinib in non-small cell lung cancer (NSCLC) cell lines |
| Q39752287 | Histone deacetylase inhibitors induce FPGS mRNA expression and intracellular accumulation of long-chain methotrexate polyglutamates in childhood acute lymphoblastic leukemia: implications for combination therapy |
| Q51426321 | Homoharringtonine (omacetaxine mepesuccinate) as an adjunct for FLT3-ITD acute myeloid leukemia. |
| Q64979617 | Homoharringtonine, an approved anti-leukemia drug, suppresses triple negative breast cancer growth through a rapid reduction of anti-apoptotic protein abundance. |
| Q64056288 | Hsp90 Inhibitor SNX-2112 Enhances TRAIL-Induced Apoptosis of Human Cervical Cancer Cells via the ROS-Mediated JNK-p53-Autophagy-DR5 Pathway |
| Q92864486 | Hsp90B enhances MAST1-mediated cisplatin resistance by protecting MAST1 from proteosomal degradation |
| Q34228030 | Human broadly neutralizing antibodies to the envelope glycoprotein complex of hepatitis C virus |
| Q38834031 | Human melanoma cells resistant to MAPK inhibitors can be effectively targeted by inhibition of the p90 ribosomal S6 kinase |
| Q34920079 | Human monocytes in the presence of interferons alpha2a and gamma are potent killers of serous ovarian cancer cell lines in combination with paclitaxel and carboplatin |
| Q38750556 | Hyaluronic acid-coated, prodrug-based nanostructured lipid carriers for enhanced pancreatic cancer therapy |
| Q55299659 | Hybrid stochastic framework predicts efficacy of prophylaxis against HIV: An example with different dolutegravir prophylaxis schemes. |
| Q41169934 | Hyperosmotic stress enhances cytotoxicity of SMAC mimetics. |
| Q42322249 | IGF-1R inhibition sensitizes breast cancer cells to ATM-related kinase (ATR) inhibitor and cisplatin |
| Q58712237 | IGF1R upregulation confers resistance to isoform-specific inhibitors of PI3K in PIK3CA-driven ovarian cancer |
| Q42385508 | IKBKE Is a Substrate of EGFR and a Therapeutic Target in Non-Small Cell Lung Cancer with Activating Mutations of EGFR. |
| Q90468316 | Ibrutinib significantly inhibited Bruton's tyrosine kinase (BTK) phosphorylation,in-vitro proliferation and enhanced overall survival in a preclinical Burkitt lymphoma (BL) model |
| Q64098295 | Ibudilast sensitizes glioblastoma to temozolomide by targeting Macrophage Migration Inhibitory Factor (MIF) |
| Q36332525 | Identification and Mechanistic Investigation of Drug-Drug Interactions Associated With Myopathy: A Translational Approach |
| Q58098901 | Identification and antitumor activity of a novel inhibitor of the NIMA-related kinase NEK6 |
| Q30535722 | Identification and structural characterization of a broadly neutralizing antibody targeting a novel conserved epitope on the influenza virus H5N1 hemagglutinin |
| Q57186407 | Identification of Novel Cdc7 Kinase Inhibitors as Anti-Cancer Agents that Target the Interaction with Dbf4 by the Fragment Complementation and Drug Repositioning Approach |
| Q35165195 | Identification of Small Inhibitory Molecules Targeting the Bfl-1 Anti-Apoptotic Protein That Alleviates Resistance to ABT-737. |
| Q91995083 | Identification of Withaferin A as a Potential Candidate for Anti-Cancer Therapy in Non-Small Cell Lung Cancer |
| Q36092925 | Identification of a Dual Inhibitor of Janus Kinase 2 (JAK2) and p70 Ribosomal S6 Kinase1 (S6K1) Pathways |
| Q38856111 | Identification of a dibenzocyclooctadiene lignan as a HIV-1 non-nucleoside reverse transcriptase inhibitor |
| Q91897802 | Identification of a potent small-molecule inhibitor of bacterial DNA repair that potentiates quinolone antibiotic activity in methicillin-resistant Staphylococcus aureus |
| Q89454919 | Identification of synergistic drug combinations using breast cancer patient-derived xenografts |
| Q37013055 | Identification of unique synergistic drug combinations associated with downexpression of survivin in a preclinical breast cancer model system |
| Q59334918 | Identifying chondroprotective diet-derived bioactives and investigating their synergism |
| Q37376100 | Identifying genotype-dependent efficacy of single and combined PI3K- and MAPK-pathway inhibition in cancer |
| Q91722838 | IgG Fc-binding motif-conjugated HIV-1 fusion inhibitor exhibits improved potency and in vivo half-life: Potential application in combination with broad neutralizing antibodies |
| Q41349651 | Imidazoquinoxaline anticancer derivatives and imiquimod interact with tubulin: Characterization of molecular microtubule inhibiting mechanisms in correlation with cytotoxicity. |
| Q49847103 | Impact of RNA polymerase I inhibitor CX-5461 on viral kinase-dependent and -independent cytomegalovirus replication |
| Q33731278 | Improved prediction of PARP inhibitor response and identification of synergizing agents through use of a novel gene expression signature generation algorithm |
| Q35076711 | Improving neutralization potency and breadth by combining broadly reactive HIV-1 antibodies targeting major neutralization epitopes |
| Q28534701 | Improving pharmacokinetic-pharmacodynamic modeling to investigate anti-infective chemotherapy with application to the current generation of antimalarial drugs |
| Q51075204 | In Vitro Drug-Induced Liver Injury Prediction: Criteria Optimization of Efflux Transporter IC50 and Physicochemical Properties. |
| Q59813798 | In Vitro Evaluation of Sulforaphane and a Natural Analog as Potent Inducers of 5-Fluorouracil Anticancer Activity |
| Q50905634 | In Vitro Synergistic Enhancement of Newcastle Disease Virus to 5-Fluorouracil Cytotoxicity against Tumor Cells. |
| Q38955207 | In Vitro and In Vivo Drug Interaction Study of Two Lead Combinations, Oxantel Pamoate plus Albendazole and Albendazole plus Mebendazole, for the Treatment of Soil-Transmitted Helminthiasis |
| Q37706134 | In silico and in vitro drug screening identifies new therapeutic approaches for Ewing sarcoma |
| Q47838952 | In silico profiling of systemic effects of drugs to predict unexpected interactions |
| Q51525907 | In silico synergism and antagonism of an anti-tumour system intervened by coupling immunotherapy and chemotherapy: a mathematical modelling approach. |
| Q33853773 | In vitro additive interaction between ketoconazole and antimony against intramacrophage Leishmania (Leishmania) amazonensis amastigotes |
| Q49849111 | In vitro and in vivo effects of MK2206 and chloroquine combination therapy on endometriosis: Autophagy may be required for regrowth of endometriosis. |
| Q32184852 | In vitro and in vivo inhibition of tumor cell viability by combined dihydroartemisinin and doxorubicin treatment, and the underlying mechanism |
| Q92730930 | In vitro anticancer effect of tricyclic antidepressant nortriptyline on multiple myeloma |
| Q55429885 | In vitro antineoplastic effects of auranofin in canine lymphoma cells. |
| Q50499404 | In vitro antioxidant activities of three red wine polyphenols and their mixtures: an interaction study. |
| Q58113724 | In vitro antitumor activity of progesterone in human adrenocortical carcinoma |
| Q38898723 | In vitro drug combination studies of Letermovir (AIC246, MK-8228) with approved anti-human cytomegalovirus (HCMV) and anti-HIV compounds in inhibition of HCMV and HIV replication. |
| Q92669135 | In vitro effect of curcumin in combination with chemotherapy drugs in Ph+ acute lymphoblastic leukemia cells |
| Q38984590 | In vitro evaluation of combination of polyenes with EDTA against Aspergillus spp. by different methods (FICI and CI Model). |
| Q41929082 | In vitro genotoxicity and cytotoxicity of a particular combination of pemetrexed and cefixime in human peripheral blood lymphocytes. |
| Q39701114 | In vitro sequence-dependent synergism between paclitaxel and gefitinib in human lung cancer cell lines. |
| Q98906768 | In vitro study on aspects of molecular mechanisms underlying invasive aspergillosis caused by gliotoxin and fumagillin, alone and in combination |
| Q33665367 | In vitro study on the schedule-dependency of the interaction between pemetrexed, gemcitabine and irradiation in non-small cell lung cancer and head and neck cancer cells |
| Q90681764 | In vivo acute toxicity evaluation and in vitro molecular mechanism study of antiproliferative activity of a novel indole Schiff base β-diiminato manganeseIII complex in hormone-dependent and triple negative breast cancer cells |
| Q34290075 | In vivo and in vitro sensitivity of Fasciola hepatica to triclabendazole combined with artesunate, artemether, or OZ78 |
| Q54157122 | In vivo and in vitro studies of Cry5B and nicotinic acetylcholine receptor agonist anthelmintics reveal a powerful and unique combination therapy against intestinal nematode parasites |
| Q89315057 | In-Vitro Activity of Silybin and Related Flavonolignans against Leishmania infantum and L. donovani |
| Q41684504 | In-vitro antiviral efficacy of ribavirin and interferon-alpha against canine distemper virus. |
| Q38976616 | Increase of MET gene copy number confers resistance to a monovalent MET antibody and establishes drug dependence |
| Q38744308 | Increased Expression of System xc- in Glioblastoma Confers an Altered Metabolic State and Temozolomide Resistance |
| Q37727935 | Individual and Combined Cytotoxic Effects of Co-Occurring Deoxynivalenol Family Mycotoxins on Human Gastric Epithelial Cells |
| Q37244398 | Indole-3- carbinol enhances sorafenib cytotoxicity in hepatocellular carcinoma cells: A mechanistic study |
| Q37653919 | Induction of Early Autophagic Process on Leishmania amazonensis by Synergistic Effect of Miltefosine and Innovative Semi-synthetic Thiosemicarbazone |
| Q36808210 | Induction of autophagy by valproic acid enhanced lymphoma cell chemosensitivity through HDAC-independent and IP3-mediated PRKAA activation |
| Q35845241 | Induction of brain tumor stem cell apoptosis by FTY720: a potential therapeutic agent for glioblastoma |
| Q90575995 | Induction of programmed cell death in Trypanosoma cruzi by Lippia alba essential oils and their major and synergistic terpenes (citral, limonene and caryophyllene oxide) |
| Q34768518 | Inference of synergy/antagonism between anticancer drugs from the pooled analysis of clinical trials |
| Q37564392 | Inhibiting cytoplasmic accumulation of HuR synergizes genotoxic agents in urothelial carcinoma of the bladder. |
| Q35696221 | Inhibition of Bcl-xL overcomes polyploidy resistance and leads to apoptotic cell death in acute myeloid leukemia cells |
| Q94527333 | Inhibition of CDK2 reduces EZH2 phosphorylation and reactivates ERα expression in high-grade serous ovarian carcinoma |
| Q90093681 | Inhibition of CDK9 by voruciclib synergistically enhances cell death induced by the Bcl-2 selective inhibitor venetoclax in preclinical models of acute myeloid leukemia |
| Q37376388 | Inhibition of CHK1 enhances cell death induced by the Bcl-2-selective inhibitor ABT-199 in acute myeloid leukemia cells |
| Q92648102 | Inhibition of DOT1L and PRMT5 promote synergistic anti-tumor activity in a human MLL leukemia model induced by CRISPR/Cas9 |
| Q38996766 | Inhibition of ER stress-associated IRE-1/XBP-1 pathway reduces leukemic cell survival |
| Q36070321 | Inhibition of JNK Sensitizes Hypoxic Colon Cancer Cells to DNA-Damaging Agents |
| Q89700494 | Inhibition of Mcl-1 enhances cell death induced by the Bcl-2-selective inhibitor ABT-199 in acute myeloid leukemia cells |
| Q37636705 | Inhibition of Mnk enhances apoptotic activity of cytarabine in acute myeloid leukemia cells |
| Q37737877 | Inhibition of Pyruvate Kinase M2 Markedly Reduces Chemoresistance of Advanced Bladder Cancer to Cisplatin. |
| Q55347904 | Inhibition of Wnt/beta-catenin signaling downregulates expression of aldehyde dehydrogenase isoform 3A1 (ALDH3A1) to reduce resistance against temozolomide in glioblastoma in vitro. |
| Q39003793 | Inhibition of Wnt/β-catenin pathway by niclosamide: a therapeutic target for ovarian cancer. |
| Q64924808 | Inhibition of XPO1 enhances cell death induced by ABT-199 in acute myeloid leukaemia via Mcl-1. |
| Q46576204 | Inhibition of bile salt transport by drugs associated with liver injury in primary hepatocytes from human, monkey, dog, rat, and mouse |
| Q39091219 | Inhibition of cellular STAT3 synergizes with the cytomegalovirus kinase inhibitor maribavir to disrupt infection |
| Q48021721 | Inhibition of histone deacetylases sensitizes EGF receptor-TK inhibitor-resistant non-small-cell lung cancer cells to erlotinib in vitro and in vivo |
| Q38987856 | Inhibition of mTOR with everolimus and silencing by vascular endothelial cell growth factor-specific siRNA induces synergistic antitumor activity in multiple myeloma cells |
| Q36899877 | Inhibition of mTORC2 Induces Cell-Cycle Arrest and Enhances the Cytotoxicity of Doxorubicin by Suppressing MDR1 Expression in HCC Cells |
| Q36047831 | Inhibition of nasopharyngeal carcinoma cell proliferation and synergism of cisplatin with silvestrol and episilvestrol isolated from Aglaia stellatopilosa |
| Q100503057 | Inhibition of poly(ADP-ribose) polymerase induces synthetic lethality in BRIP1 deficient ovarian epithelial cells |
| Q42412981 | Inhibition of protein kinase CK2 by CX-5011 counteracts imatinib-resistance preventing rpS6 phosphorylation in chronic myeloid leukaemia cells: new combined therapeutic strategies. |
| Q39053372 | Inhibition of protein kinase CK2 with the clinical-grade small ATP-competitive compound CX-4945 or by RNA interference unveils its role in acute myeloid leukemia cell survival, p53-dependent apoptosis and daunorubicin-induced cytotoxicity |
| Q49787961 | Inhibition of the NEDD8 conjugation pathway induces calcium-dependent compensatory activation of the pro-survival MEK/ERK pathway in acute lymphoblastic leukemia |
| Q37294562 | Inhibition of the PI3K/AKT pathway potentiates cytotoxicity of EGFR kinase inhibitors in triple-negative breast cancer cells. |
| Q47703632 | Inhibition of the oncogenic fusion protein EWS-FLI1 causes G2-M cell cycle arrest and enhanced vincristine sensitivity in Ewing's sarcoma. |
| Q92965686 | Inhibition of the transcriptional kinase CDK7 overcomes therapeutic resistance in HER2-positive breast cancers |
| Q41866064 | Inhibitor of H3K27 demethylase JMJD3/UTX GSK-J4 is a potential therapeutic option for castration resistant prostate cancer |
| Q35746524 | Inhibitors of pan-PI3K Signaling Synergize with BRAF or MEK Inhibitors to Prevent BRAF-Mutant Melanoma Cell Growth |
| Q36164329 | Inhibitory Effect of the Noncamptothecin Topoisomerase I Inhibitor LMP-400 on Female Mice Models and Human Pheochromocytoma Cells |
| Q42120055 | Inhibitory effects of Cinnamomum burmannii Blume stem bark extract and trans-cinnamaldehyde on nasopharyngeal carcinoma cells; synergism with cisplatin. |
| Q92123389 | Inhibitory effects of Syzygium aromaticum and Camellia sinensis methanolic extracts on the growth of Babesia and Theileria parasites |
| Q41838603 | Inhibitory effects of salviae miltiorrhizae radix (danshen) and puerariae lobatae radix (gegen) in carbachol-induced rat detrusor smooth muscle contractility |
| Q38983891 | Injectable poly(organophosphazene) hydrogel system for effective paclitaxel and doxorubicin combination therapy |
| Q36117479 | Innate immune agonist, dsRNA, induces apoptosis in ovarian cancer cells and enhances the potency of cytotoxic chemotherapeutics |
| Q51347228 | Insecticidal activity of individual and mixed monoterpenoids of geranium essential oil against Pediculus humanus capitis (Phthiraptera: Pediculidae). |
| Q35099031 | Interaction network among functional drug groups |
| Q88764097 | Interaction of Bacterial Phenazines with Colistimethate in Bronchial Epithelial Cells |
| Q39752399 | Interactions at human ether-à-go-go-related gene channels |
| Q35787743 | Interactions between different generation HIV-1 fusion inhibitors and the putative mechanism underlying the synergistic anti-HIV-1 effect resulting from their combination |
| Q38791590 | Interactions between phytochemicals from fruits and vegetables: Effects on bioactivities and bioavailability. |
| Q40926668 | Interactions of cyclin-dependent kinase inhibitors AT-7519, flavopiridol and SNS-032 with ABCB1, ABCG2 and ABCC1 transporters and their potential to overcome multidrug resistance in vitro. |
| Q41950579 | Interactions of propofol and remifentanil on bispectral index under 66% N(2)O: analysis by dose-effect curve, isobologram, and combination index |
| Q64265909 | Interactive anticancer effect of nanomicellar curcumin and galbanic acid combination therapy with some common chemotherapeutics in colon carcinoma cells |
| Q46655968 | Interference of heavy metals on the photosynthetic response from a Cr(VI)-resistant Dictyosphaerium chlorelloides strain |
| Q49952133 | Interferon-alpha enhances the antitumour activity of EGFR-targeted therapies by upregulating RIG-I in head and neck squamous cell carcinoma |
| Q38599063 | Interleukin-6-dependent growth in a newly established plasmablastic lymphoma cell line and its therapeutic targets |
| Q39245263 | Intrinsic properties of tumour cells have a key impact on the bystander effect mediated by genetically engineered mesenchymal stromal cells |
| Q36296803 | Investigating antimalarial drug interactions of emetine dihydrochloride hydrate using CalcuSyn-based interactivity calculations |
| Q56339655 | Investigating the efficacy of triple artemisinin-based combination therapies (TACTs) for treating malaria patients using mathematical modelling |
| Q38759275 | Investigation of the cytotoxic implications of metal chelators against melanoma and approaches to improve the cytotoxicity profiles of metal coordinating agents. |
| Q34636091 | Involvement of p53 in cell death following cell cycle arrest and mitotic catastrophe induced by rotenone. |
| Q41383019 | Irinotecan and 5-fluorouracil-co-loaded, hyaluronic acid-modified layer-by-layer nanoparticles for targeted gastric carcinoma therapy |
| Q41872813 | Irinotecan synergistically enhances the antiproliferative and proapoptotic effects of axitinib in vitro and improves its anticancer activity in vivo |
| Q41439828 | Iron Chelators and Exogenic Photosensitizers. Synergy through Oxidative Stress Gene Expression. |
| Q33636546 | Iron chelators in photodynamic therapy revisited: synergistic effect by novel highly active thiosemicarbazones |
| Q90661538 | Irreversible JNK1-JUN inhibition by JNK-IN-8 sensitizes pancreatic cancer to 5-FU/FOLFOX chemotherapy |
| Q38778339 | Isatin Derived Spirocyclic Analogues with α-Methylene-γ-butyrolactone as Anticancer Agents: A Structure-Activity Relationship Study |
| Q37107598 | JAK2 inhibition sensitizes resistant EGFR-mutant lung adenocarcinoma to tyrosine kinase inhibitors |
| Q37168132 | JAK2-V617F-induced MAPK activity is regulated by PI3K and acts synergistically with PI3K on the proliferation of JAK2-V617F-positive cells |
| Q50975399 | Joint toxicity of chlorpyrifos, atrazine, and cadmium at lethal concentrations to the earthworm Eisenia fetida. |
| Q34547607 | KLF4 overexpression and apigenin treatment down regulated anti-apoptotic Bcl-2 proteins and matrix metalloproteinases to control growth of human malignant neuroblastoma SK-N-DZ and IMR-32 cells |
| Q40379755 | Kaempferol and Chrysin Synergies to Improve Septic Mice Survival. |
| Q61798864 | Kinase inhibitor library screening identifies synergistic drug combinations effective in sensitive and resistant melanoma cells |
| Q47715440 | Kinome expression profiling of human neuroblastoma tumors identifies potential drug targets for ultra high-risk patients |
| Q39652400 | Kinome profiling of myxoid liposarcoma reveals NF-kappaB-pathway kinase activity and casein kinase II inhibition as a potential treatment option. |
| Q33917578 | Kinome profiling reveals breast cancer heterogeneity and identifies targeted therapeutic opportunities for triple negative breast cancer |
| Q51116483 | Kinome-Wide RNA Interference Screen Reveals a Role for PDK1 in Acquired Resistance to CDK4/6 Inhibition in ER-Positive Breast Cancer. |
| Q42153101 | L-Canavanine potentiates the cytotoxicity of doxorubicin and cisplatin in arginine deprived human cancer cells |
| Q55359747 | LAB Bacteriocins Controlling the Food Isolated (Drug-Resistant) Staphylococci. |
| Q36629339 | LIM kinase inhibitors disrupt mitotic microtubule organization and impair tumor cell proliferation |
| Q38998207 | LOX/COX inhibitors enhance the antineoplastic effects of all-trans retinoic acid in osteosarcoma cell lines |
| Q35141879 | Lactaptin induces p53-independent cell death associated with features of apoptosis and autophagy and delays growth of breast cancer cells in mouse xenografts |
| Q42212236 | Lapatinib potentiates cytotoxicity of YM155 in neuroblastoma via inhibition of the ABCB1 efflux transporter |
| Q96304093 | Leonurine Promotes Cisplatin Sensitivity in Human Cervical Cancer Cells Through Increasing Apoptosis and Inhibiting Drug-Resistant Proteins |
| Q51016311 | Lethal activity of individual and mixed monoterpenoids of geranium essential oil on Musca domestica. |
| Q64944731 | Leveraging Mathematical Modeling to Quantify Pharmacokinetic and Pharmacodynamic Pathways: Equivalent Dose Metric. |
| Q37076592 | Linifanib (ABT-869) Potentiates the Efficacy of Chemotherapeutic Agents through the Suppression of Receptor Tyrosine Kinase-Mediated AKT/mTOR Signaling Pathways in Gastric Cancer. |
| Q39273308 | Linker for activation of T-cell family member2 (LAT2) a lipid raft adaptor protein for AKT signaling, is an early mediator of alkylphospholipid anti-leukemic activity |
| Q92316046 | Lipoic Acid Synergizes with Antineoplastic Drugs in Colorectal Cancer by Targeting p53 for Proteasomal Degradation |
| Q38958186 | Liposomes loaded with a dirhenium compound and cisplatin: preparation, properties and improved in vivo anticancer activity. |
| Q35107625 | Local anesthetics induce apoptosis in human thyroid cancer cells through the mitogen-activated protein kinase pathway |
| Q36194410 | Long-lasting reduction in clonogenic potential of colorectal cancer cells by sequential treatments with 5-azanucleosides and topoisomerase inhibitors. |
| Q88802600 | Loss of EGFR confers acquired resistance to AZD9291 in an EGFR-mutant non-small cell lung cancer cell line with an epithelial-mesenchymal transition phenotype |
| Q37627650 | Loss of HSulf-1: The Missing Link between Autophagy and Lipid Droplets in Ovarian Cancer |
| Q37708984 | Loss of phosphodiesterase 4D mediates acquired triapine resistance via Epac-Rap1-Integrin signaling. |
| Q36608713 | Low-dose anisomycin sensitizes melanoma cells to TRAIL induced apoptosis |
| Q38778245 | Low-molecular-weight polymer-drug conjugates for synergistic anticancer activity of camptothecin and doxorubicin combinations |
| Q37545395 | Lurbinectedin induces depletion of tumor-associated macrophages, an essential component of its in vivo synergism with gemcitabine, in pancreatic adenocarcinoma mouse models. |
| Q37469859 | Lycorine Downregulates HMGB1 to Inhibit Autophagy and Enhances Bortezomib Activity in Multiple Myeloma. |
| Q33915624 | MDM2 antagonist Nutlin-3a potentiates antitumour activity of cytotoxic drugs in sarcoma cell lines |
| Q33860877 | MDM2 antagonist nutlin-3a reverses mitoxantrone resistance by inhibiting breast cancer resistance protein mediated drug transport |
| Q37381179 | MEK plus PI3K/mTORC1/2 Therapeutic Efficacy Is Impacted by TP53 Mutation in Preclinical Models of Colorectal Cancer. |
| Q34182679 | MET and PI3K/mTOR as a potential combinatorial therapeutic target in malignant pleural mesothelioma |
| Q40081674 | MIV-150 and zinc acetate combination provides potent and broad activity against HIV-1. |
| Q39447204 | MK-2206, a novel allosteric inhibitor of Akt, synergizes with gefitinib against malignant glioma via modulating both autophagy and apoptosis |
| Q36305476 | MLN4924 Synergistically Enhances Cisplatin-induced Cytotoxicity via JNK and Bcl-xL Pathways in Human Urothelial Carcinoma |
| Q33758880 | MTI-101 treatment inducing activation of Stim1 and TRPC1 expression is a determinant of response in multiple myeloma |
| Q36644774 | Maduramicin Rapidly Eliminates Malaria Parasites and Potentiates the Gametocytocidal Activity of the Pyrazoleamide PA21A050. |
| Q39093841 | Mahanine synergistically enhances cytotoxicity of 5-fluorouracil through ROS-mediated activation of PTEN and p53/p73 in colon carcinoma |
| Q37100095 | Manganoporphyrins increase ascorbate-induced cytotoxicity by enhancing H2O2 generation |
| Q35753931 | Mannan-modified adenovirus targeting TERT and VEGFR-2: A universal tumour vaccine |
| Q98237656 | Marine alkaloid monanchoxymycalin C: a new specific activator of JNK1/2 kinase with anticancer properties |
| Q50050690 | Marine-derived Fungi Extracts Enhance the Cytotoxic Activity of Doxorubicin in Nonsmall Cell Lung Cancer Cells A459. |
| Q41727459 | Mathematical modeling of multi-drugs therapy: a challenge for determining the optimal combinations of antiviral drugs |
| Q38987653 | Measuring and Statistically Testing the Size of the Effect of a Chemical Compound on a Continuous In-Vitro Pharmacological Response Through a New Statistical Model of Response Detection Limit |
| Q37309889 | Mechanism-Based Drug Combinations with the DNA Strand-Breaking Nucleoside Analog CNDAC. |
| Q37164915 | Mechanism-based epigenetic chemosensitization therapy of diffuse large B-cell lymphoma |
| Q49788115 | Mechanism-informed Repurposing of Minocycline Overcomes Resistance to Topoisomerase Inhibition for Peritoneal Carcinomatosis. |
| Q83265745 | Mechanisms of drug combinations: interaction and network perspectives |
| Q28385690 | Mechanisms of synergistic antileukemic interactions between valproic acid and cytarabine in pediatric acute myeloid leukemia |
| Q37630747 | Mechanisms responsible for the synergistic antileukemic interactions between ATR inhibition and cytarabine in acute myeloid leukemia cells |
| Q24607424 | Mechanistic evaluation of the novel HSP90 inhibitor NVP-AUY922 in adult and pediatric glioblastoma |
| Q64235564 | Mechanistic framework predicts drug-class specific utility of antiretrovirals for HIV prophylaxis |
| Q34423557 | Medicines, shaken and stirred: a critical review on the ecotoxicology of pharmaceutical mixtures |
| Q48269310 | Melanocortin Receptor-4 and Glioblastoma Cells: Effects of the Selective Antagonist ML00253764 Alone and in Combination with Temozolomide In Vitro and In Vivo. |
| Q47135125 | Melatonin Attenuates Potato Late Blight by Disrupting Cell Growth, Stress Tolerance, Fungicide Susceptibility and Homeostasis of Gene Expression in Phytophthora infestans |
| Q92703570 | Mentha Rhizomes as an Alternative Source of Natural Antioxidants |
| Q58700158 | Metformin and its sulphonamide derivative simultaneously potentiateanti-cholinesterase activity of donepezil and inhibit beta-amyloid aggregation |
| Q37583668 | Metformin and salicylate synergistically activate liver AMPK, inhibit lipogenesis and improve insulin sensitivity |
| Q27853104 | Metformin and trametinib have synergistic effects on cell viability and tumor growth in NRAS mutant cancer. |
| Q51748677 | Metformin exerts multitarget antileukemia activity in JAK2V617F-positive myeloproliferative neoplasms. |
| Q48191745 | Metformin incombination with curcumin inhibits the growth, metastasis, and angiogenesis of hepatocellular carcinoma in vitro and in vivo. |
| Q34979869 | Metformin induces apoptosis through AMPK-dependent inhibition of UPR signaling in ALL lymphoblasts |
| Q37671148 | Metformin potentiates the effect of arsenic trioxide suppressing intrahepatic cholangiocarcinoma: roles of p38 MAPK, ERK3, and mTORC1. |
| Q33824268 | Metformin synergistically enhances antiproliferative effects of cisplatin and etoposide in NCI-H460 human lung cancer cells |
| Q92880101 | Methanol Extract of Aerial Parts of Pavetta indica L. Enhances the Cytotoxic Effect of Doxorubicin and Induces Radiation Sensitization in MDA-MB-231 Triple-Negative Breast Cancer Cells |
| Q37238341 | Methionine depletion with recombinant methioninase: in vitro and in vivo efficacy against neuroblastoma and its synergism with chemotherapeutic drugs |
| Q47561424 | Methods for High-throughput Drug Combination Screening and Synergy Scoring. |
| Q28540634 | Methylseleninic acid sensitizes Notch3-activated OVCA429 ovarian cancer cells to carboplatin |
| Q55292678 | Metronomic combination of Vinorelbine and 5Fluorouracil is able to inhibit triple-negative breast cancer cells. Results from the proof-of-concept VICTOR-0 study. |
| Q35247727 | Metronomic gemcitabine in combination with sunitinib inhibits multisite metastasis and increases survival in an orthotopic model of pancreatic cancer |
| Q49788086 | MiR-205-5p and miR-342-3p cooperate in the repression of the E2F1 transcription factor in the context of anticancer chemotherapy resistance. |
| Q34285363 | Mifepristone prevents repopulation of ovarian cancer cells escaping cisplatin-paclitaxel therapy. |
| Q47607986 | Mixed Liposome Approach for Ratiometric and Sequential Delivery of Paclitaxel and Gemcitabine |
| Q89612847 | Mixture toxicity of copper and nonylphenol on the embryo-larval development of Rhinella arenarum |
| Q48134336 | Mixtures of Lipophilic Phycotoxins: Exposure Data and Toxicological Assessment |
| Q40994676 | Modeling Suggests a Mechanism of Synergy Between Hepatitis C Virus Entry Inhibitors and Drugs of Other Classes |
| Q40599449 | Modeling drug resistance in a conjoint normal-tumor setting |
| Q46811191 | Modeling the mitotic regulatory network identifies highly efficient anti-cancer drug combinations. |
| Q26781613 | Modelling of compound combination effects and applications to efficacy and toxicity: state-of-the-art, challenges and perspectives |
| Q36930517 | Models from experiments: combinatorial drug perturbations of cancer cells |
| Q36366991 | Modulation of Tamoxifen Cytotoxicity by Caffeic Acid Phenethyl Ester in MCF-7 Breast Cancer Cells |
| Q46380198 | Modulation of imatinib cytotoxicity by selenite in HCT116 colorectal cancer cells. |
| Q41859467 | Modulation of the Ribonucleotide Reductase‐Antimetabolite Drug Interaction in Cancer Cell Lines |
| Q64076854 | Molecular Profiling of Druggable Targets in Clear Cell Renal Cell Carcinoma Through Targeted RNA Sequencing |
| Q39132772 | Molecular changes in the phosphatidylinositide 3-kinase (PI3K) pathway are common in gastric cancer. |
| Q52689272 | Molecular characterization of breast cancer cell response to metabolic drugs. |
| Q39300788 | Molecular evidence for increased antitumor activity of gemcitabine in combination with a cyclin-dependent kinase inhibitor, P276-00 in pancreatic cancers |
| Q34560236 | Molecular mechanism of the schedule-dependent synergistic interaction in EGFR-mutant non-small cell lung cancer cell lines treated with paclitaxel and gefitinib |
| Q38636162 | Molecularly targeted drug combinations demonstrate selective effectiveness for myeloid- and lymphoid-derived hematologic malignancies. |
| Q60301842 | Monensin inhibits cell proliferation and tumor growth of chemo-resistant pancreatic cancer cells by targeting the EGFR signaling pathway |
| Q36544108 | Monocarboxylate transporters (MCTs) in gliomas: expression and exploitation as therapeutic targets |
| Q108127200 | MuSyC is a consensus framework that unifies multi-drug synergy metrics for combinatorial drug discovery |
| Q91260347 | Mucoadhesive effect of Curcuma longa extract and curcumin decreases the ranitidine effect, but not bismuth subsalicylate on ethanol-induced ulcer model |
| Q34135640 | Multi-layered nanoparticles for combination gene and drug delivery to tumors. |
| Q38848214 | Multicomponent 5-fluorouracil loaded PAMAM stabilized-silver nanocomposites synergistically induce apoptosis in human cancer cells |
| Q39360651 | Multidrug-resistant cells overexpressing P-glycoprotein are susceptible to DNA crosslinking agents due to attenuated Src/nuclear EGFR cascade-activated DNA repair activity |
| Q35180706 | Multifaceted cytoprotection by synthetic polyacetylenes inspired by the ginseng-derived natural product, panaxytriol |
| Q59189913 | Multifunctional microspherical magnetic and pH responsive carriers for combination anticancer therapy engineered by droplet-based microfluidics |
| Q51129504 | Multikinase inhibitors sorafenib and sunitinib as radiosensitizers in head and neck cancer cell lines. |
| Q41335784 | Multimodal delivery of irinotecan from microparticles with two distinct compartments |
| Q57455290 | Multiple circulating saponins from intravenous ShenMai inhibit OATP1Bs in vitro: potential joint precipitants of drug interactions |
| Q34365949 | Mutant NRASQ61 shares signaling similarities across various cancer types--potential implications for future therapies. |
| Q91937502 | Mutant p53 improves cancer cells' resistance to endoplasmic reticulum stress by sustaining activation of the UPR regulator ATF6 |
| Q91564632 | Myc targeted CDK18 promotes ATR and homologous recombination to mediate PARP inhibitor resistance in glioblastoma |
| Q38751338 | Mycotoxins co-contamination: Methodological aspects and biological relevance of combined toxicity studies. |
| Q37536566 | NEAT1 upregulates EGCG-induced CTR1 to enhance cisplatin sensitivity in lung cancer cells |
| Q40937224 | NFATc1 as a therapeutic target in FLT3-ITD-positive AML. |
| Q28552626 | NLLSS: Predicting Synergistic Drug Combinations Based on Semi-supervised Learning |
| Q91970526 | NT157 has antineoplastic effects and inhibits IRS1/2 and STAT3/5 in JAK2V617F-positive myeloproliferative neoplasm cells |
| Q39291545 | NVP-BEZ235 alone and in combination in mantle cell lymphoma: an effective therapeutic strategy. |
| Q95840240 | Nanoparticle delivery of a pH-sensitive prodrug of doxorubicin and a mitochondrial targeting VES-H8R8 synergistically kill multi-drug resistant breast cancer cells |
| Q42562347 | Nanotherapy for Cancer: Targeting and Multifunctionality in the Future of Cancer Therapies. |
| Q98288425 | Napabucasin overcomes cisplatin resistance in ovarian germ cell tumor-derived cell line by inhibiting cancer stemness |
| Q92558863 | Naproxen and Its Phototransformation Products: Persistence and Ecotoxicity to Toad Tadpoles (Anaxyrus terrestris), Individually and in Mixtures |
| Q55262002 | Narrow line between benefit and harm: Additivity of hyperthermia to cisplatin cytotoxicity in different gastrointestinal cancer cells. |
| Q26749598 | Natural Co-Occurrence of Mycotoxins in Foods and Feeds and Their in vitro Combined Toxicological Effects |
| Q36736534 | Nelfinavir augments proteasome inhibition by bortezomib in myeloma cells and overcomes bortezomib and carfilzomib resistance |
| Q42230712 | Network Analysis of Drug-target Interactions: A Study on FDA-approved New Molecular Entities Between 2000 to 2015 |
| Q37185385 | Network analysis identifies an HSP90-central hub susceptible in ovarian cancer |
| Q60301502 | Network spectra for drug-target identification in complex diseases: new guns against old foes |
| Q97541998 | Network-principled deep generative models for designing drug combinations as graph sets |
| Q48464373 | Neuroprotective effect of epidermal growth factor plus growth hormone-releasing peptide-6 resembles hypothermia in experimental stroke |
| Q90287106 | Neutralization Synergy between HIV-1 Attachment Inhibitor Fostemsavir and Anti-CD4 Binding Site Broadly Neutralizing Antibodies against HIV |
| Q33920494 | New potential anti-cancer agents synergize with bortezomib and ABT-737 against prostate cancer |
| Q40600575 | Newcastle disease virus, rituximab, and doxorubicin combination as anti-hematological malignancy therapy |
| Q33672978 | Newly identified CHO ERCC3/XPB mutations and phenotype characterization |
| Q30275354 | Niclosamide and its analogs are potent inhibitors of Wnt/β-catenin, mTOR and STAT3 signaling in ovarian cancer |
| Q33372690 | Nifuroxazide inhibits survival of multiple myeloma cells by directly inhibiting STAT3. |
| Q37678601 | Nitazoxanide: nematicidal mode of action and drug combination studies |
| Q43198017 | Nitrous oxide and isoflurane are synergistic with respect to amplitude and latency effects on sensory evoked potentials |
| Q34248336 | Non-specific chemical inhibition of the Fanconi anemia pathway sensitizes cancer cells to cisplatin |
| Q33559623 | Non-thermal plasma with 2-deoxy-D-glucose synergistically induces cell death by targeting glycolysis in blood cancer cells |
| Q35745350 | Nonneutralizing Antibodies Induced by the HIV-1 gp41 NHR Domain Gain Neutralizing Activity in the Presence of the HIV Fusion Inhibitor Enfuvirtide: a Potential Therapeutic Vaccine Strategy. |
| Q39298317 | Norcantharidin enhances bortezomib-antimyeloma activity in multiple myeloma cells in vitro and in nude mouse xenografts |
| Q30650188 | Not Just a Sum? Identifying Different Types of Interplay between Constituents in Combined Interventions |
| Q39548307 | Novel 2-substituted quinolin-4-yl-benzenesulfonate derivatives: synthesis, antiproliferative activity, and inhibition of cellular tubulin polymerization |
| Q36239589 | Novel 3-Substituted 7-Phenylpyrrolo[3,2-f]quinolin-9(6H)-ones as Single Entities with Multitarget Antiproliferative Activity |
| Q40052683 | Novel Cell-Killing Mechanisms of Hydroxyurea and the Implication Towards Combination Therapy for the Treatment of Fungal Infections |
| Q91706081 | Novel Hsp90 Inhibitor C086 Potently Inhibits Non-Small Cell Lung Cancer Cells As A Single Agent Or In Combination With Gefitinib |
| Q21245491 | Novel anti-glioblastoma agents and therapeutic combinations identified from a collection of FDA approved drugs |
| Q39840520 | Novel benzylidene-thiazolidine-2,4-diones inhibit Pim protein kinase activity and induce cell cycle arrest in leukemia and prostate cancer cells |
| Q46330183 | Novel combination of salinomycin and resveratrol synergistically enhances the anti-proliferative and pro-apoptotic effects on human breast cancer cells |
| Q35828072 | Novel human anti-claudin 1 mAbs inhibit hepatitis C virus infection and may synergize with anti-SRB1 mAb. |
| Q34261735 | Novel indole-2-carboxamide compounds are potent broad-spectrum antivirals active against western equine encephalitis virus in vivo. |
| Q92798590 | Novel purine thioglycoside analogs: synthesis, nanoformulation and biological evaluation in in vitro human liver and breast cancer models |
| Q38599086 | Novel quinolone chalcones targeting colchicine-binding pocket kill multidrug-resistant cancer cells by inhibiting tubulin activity and MRP1 function |
| Q91661010 | Novel renal medullary carcinoma cell lines, UOK353 and UOK360, provide preclinical tools to identify new therapeutic treatments |
| Q38966954 | Novel resveratrol and 5-fluorouracil coencapsulated in PEGylated nanoliposomes improve chemotherapeutic efficacy of combination against head and neck squamous cell carcinoma |
| Q28828711 | Novel small molecules potentiate premature termination codon readthrough by aminoglycosides |
| Q39657784 | Nuclear Phospho-Akt Increase Predicts Synergy of PI3K Inhibition and Doxorubicin in Breast and Ovarian Cancer |
| Q36413415 | OSI-027 inhibits pancreatic ductal adenocarcinoma cell proliferation and enhances the therapeutic effect of gemcitabine both in vitro and in vivo |
| Q38759279 | OTX015 (MK-8628), a novel BET inhibitor, displays in vitro and in vivo antitumor effects alone and in combination with conventional therapies in glioblastoma models |
| Q35007971 | Obatoclax potentiates the cytotoxic effect of cytarabine on acute myeloid leukemia cells by enhancing DNA damage |
| Q37642537 | Oblongifolin C and guttiferone K extracted from Garcinia yunnanensis fruit synergistically induce apoptosis in human colorectal cancer cells in vitro |
| Q49788126 | Octopod PtCu Nanoframe for Dual-Modal Imaging-Guided Synergistic Photothermal Radiotherapy |
| Q38822225 | Octreotide in combination with AT-101 induces cytotoxicity and apoptosis through up-regulation of somatostatin receptors 2 and 5 in DU-145 prostate cancer cells |
| Q91863948 | Oleandrin synergizes with cisplatin in human osteosarcoma cells by enhancing cell apoptosis through activation of the p38 MAPK signaling pathway |
| Q33995471 | Oncolytic herpes simplex virus vectors and chemotherapy: are combinatorial strategies more effective for cancer? |
| Q37031896 | Oncolytic herpes viruses, chemotherapeutics, and other cancer drugs |
| Q92191255 | Opportunities and Limitations for Untargeted Mass Spectrometry Metabolomics to Identify Biologically Active Constituents in Complex Natural Product Mixtures |
| Q35887626 | Optimization of antigen dose for a receptor-binding domain-based subunit vaccine against MERS coronavirus |
| Q40811119 | Optimizing combinations of flavonoids deriving from astragali radix in activating the regulatory element of erythropoietin by a feedback system control scheme |
| Q38836010 | Organic nanoparticle systems for spatiotemporal control of multimodal chemotherapy |
| Q39229950 | Organometallic anticancer agents that interfere with cellular energy processes: a subtle approach to inducing cancer cell death |
| Q61813617 | Organoselenium Compounds as Novel Adjuvants of Chemotherapy Drugs-A Promising Approach to Fight Cancer Drug Resistance |
| Q93048430 | Oridonin Sensitizes Cisplatin-Induced Apoptosis via AMPK/Akt/mTOR-Dependent Autophagosome Accumulation in A549 Cells |
| Q53270194 | Oroxylin A improves the sensitivity of HT-29 human colon cancer cells to 5-FU through modulation of the COX-2 signaling pathway. |
| Q93007127 | Overcoming Resistance to Platinum-Based Drugs in Ovarian Cancer by Salinomycin and Its Derivatives-An In Vitro Study |
| Q53700817 | Overcoming chemoresistance in pancreatic cancer cells: role of the bitter taste receptor T2R10. |
| Q39561017 | Overcoming resistance to fulvestrant (ICI182,780) by downregulating the c-ABL proto-oncogene in breast cancer |
| Q92717407 | Overcoming the Intrinsic Gefitinib-resistance via Downregulation of AXL in Non-small Cell Lung Cancer |
| Q33688298 | Overexpression of pyruvate dehydrogenase kinase 1 in retinoblastoma: A potential therapeutic opportunity for targeting vitreous seeds and hypoxic regions. |
| Q41233146 | P-glycoprotein attenuates DNA repair activity in multidrug-resistant cells by acting through the Cbp-Csk-Src cascade |
| Q57930706 | PARP inhibitors synergize with gemcitabine by potentiating DNA damage in non-small-cell lung cancer |
| Q91866529 | PARP-1 inhibitor modulate β-catenin signaling to enhance cisplatin sensitivity in cancer cervix |
| Q57476483 | PDE3 Inhibitors Repurposed as Treatments for Age-Related Cognitive Impairment |
| Q35470322 | PG545 enhances anti-cancer activity of chemotherapy in ovarian models and increases surrogate biomarkers such as VEGF in preclinical and clinical plasma samples |
| Q37252398 | PI3 Kinase Pathway and MET Inhibition is Efficacious in Malignant Pleural Mesothelioma |
| Q33912340 | PI3K Inhibition Augments the Therapeutic Efficacy of a 3a-aza-Cyclopenta[α]indene Derivative in Lung Cancer Cells |
| Q35955221 | PI3K inhibition synergizes with glucocorticoids but antagonizes with methotrexate in T-cell acute lymphoblastic leukemia |
| Q53055574 | PI3K-dependent multiple myeloma cell survival is mediated by the PIK3CA isoform. |
| Q35948581 | PI3K/AKT/mTOR inhibition in combination with doxorubicin is an effective therapy for leiomyosarcoma. |
| Q38653998 | PK/PD studies on non-selective PDE inhibitors in rats using cAMP as a marker of pharmacological response. |
| Q56972352 | PPARγ and RXR ligands disrupt the inflammatory cross-talk in the hypoxic breast cancer stem cells niche |
| Q38895818 | PRIMA-1Met induces apoptosis in Waldenström's Macroglobulinemia cells independent of p53. |
| Q34540884 | PTH1 receptor is involved in mediating cellular response to long-chain polyunsaturated fatty acids |
| Q36807492 | Paclitaxel Enhances Carboplatin-DNA Adduct Formation and Cytotoxicity |
| Q39265679 | Paclitaxel and CYC3, an aurora kinase A inhibitor, synergise in pancreatic cancer cells but not bone marrow precursor cells |
| Q36583648 | Paclitaxel and the dietary flavonoid fisetin: a synergistic combination that induces mitotic catastrophe and autophagic cell death in A549 non-small cell lung cancer cells |
| Q37037268 | Palbociclib treatment of FLT3-ITD+ AML cells uncovers a kinase-dependent transcriptional regulation of FLT3 and PIM1 by CDK6. |
| Q48237975 | Parametric modeling and optimal experimental designs for estimating isobolograms for drug interactions in toxicology |
| Q58605682 | Participation of ATP-sensitive K+ channels and μ-opioid receptors in the antinociceptive synergism of the paracetamol-tapentadol co-administration in the formalin-induced pain assay in mice |
| Q34072134 | Pentoxifylline sensitizes human cervical tumor cells to cisplatin-induced apoptosis by suppressing NF-kappa B and decreased cell senescence. |
| Q50131822 | Peptide-Based Membrane Fusion Inhibitors Targeting HCoV-229E Spike Protein HR1 and HR2 Domains. |
| Q38878195 | Peptides derived from the dependence receptor ALK are proapoptotic for ALK-positive tumors |
| Q36782342 | Periostin in tumor microenvironment is associated with poor prognosis and platinum resistance in epithelial ovarian carcinoma. |
| Q46787080 | Personal care product preservatives: risk assessment and mixture toxicities with an industrial wastewater. |
| Q39386461 | Perturbing pro-survival proteins using quinoxaline derivatives: a structure-activity relationship study |
| Q36351453 | Pharmacologic ascorbate synergizes with gemcitabine in preclinical models of pancreatic cancer |
| Q36599638 | Pharmacological characterization of the opioid inactive isomers (+)-naltrexone and (+)-naloxone as antagonists of toll-like receptor 4 |
| Q37685088 | Pharmacological considerations in the design of anti-malarial drug combination therapies - is matching half-lives enough? |
| Q38786793 | Pharmacological inhibition of LSD1 for the treatment of MLL-rearranged leukemia |
| Q38846668 | Pharmacological inhibition of fatty-acid oxidation synergistically enhances the effect of l-asparaginase in childhood ALL cells. |
| Q93162823 | Pharmacological mTOR targeting enhances the antineoplastic effects of selective PI3Kα inhibition in medulloblastoma |
| Q26777927 | Pharmacology of novel treatments for COPD: are fixed dose combination LABA/LAMA synergistic? |
| Q38718552 | Phenformin Enhances the Efficacy of ERK Inhibition in NF1-Mutant Melanoma. |
| Q41994485 | Phenyl Propionate and Sex Pheromone for Monitoring Navel Orangeworm (Lepidoptera: Pyralidae) in the Presence of Mating Disruption |
| Q38705667 | Phosphodiesterase 3A: a new player in development of interstitial cells of Cajal and a prospective target in gastrointestinal stromal tumors (GIST). |
| Q89895702 | Phytochemical Characterization and Chemotherapeutic Potential of Cinnamomum verum Extracts on the Multiplication of Protozoan Parasites In Vitro and In Vivo |
| Q89509844 | Phytochemical Screening and Antiprotozoal Effects of the Methanolic Berberis vulgaris and Acetonic Rhus coriaria Extracts |
| Q42228206 | Piper betle leaf extract enhances the cytotoxicity effect of 5-fluorouracil in inhibiting the growth of HT29 and HCT116 colon cancer cells |
| Q46306697 | Piperlongumine induces G2/M phase arrest and apoptosis in cholangiocarcinoma cells through the ROS-JNK-ERK signaling pathway. |
| Q36956674 | Polymer-drug conjugates as modulators of cellular apoptosis |
| Q30372383 | Polymeric Nanostructures for Imaging and Therapy |
| Q34780483 | Polyoxygenated steroids from the octocoral Leptogorgia punicea and in vitro evaluation of their cytotoxic activity. |
| Q58766168 | Polypharmacological Profiles Underlying the Antitumor Property of Root (Danshen) Interfering with NOX-Dependent Neutrophil Extracellular Traps |
| Q37157480 | Polyphenol-rich strawberry extract (PRSE) shows in vitro and in vivo biological activity against invasive breast cancer cells. |
| Q37570886 | Polysaccharide from Sepia esculenta ink and cisplatin inhibit synergistically proliferation and metastasis of triple-negative breast cancer MDA-MB-231 cells |
| Q34788066 | Polytherapy with a combination of three repurposed drugs (PXT3003) down-regulates Pmp22 over-expression and improves myelination, axonal and functional parameters in models of CMT1A neuropathy |
| Q35935794 | Pomalidomide in combination with dexamethasone results in synergistic anti-tumour responses in pre-clinical models of lenalidomide-resistant multiple myeloma |
| Q52720471 | Pomalidomide promotes chemosensitization of pancreatic cancer by inhibition of NF-κB. |
| Q21285102 | Pomegranate Juice Metabolites, Ellagic Acid and Urolithin A, Synergistically Inhibit Androgen-Independent Prostate Cancer Cell Growth via Distinct Effects on Cell Cycle Control and Apoptosis |
| Q44988870 | Potent Dual BET Bromodomain-Kinase Inhibitors as Value-Added Multitargeted Chemical Probes and Cancer Therapeutics |
| Q61818479 | Potent MERS-CoV Fusion Inhibitory Peptides Identified from HR2 Domain in Spike Protein of Bat Coronavirus HKU4 |
| Q64055650 | Potent and Highly Selective Aldo-Keto Reductase 1C3 (AKR1C3) Inhibitors Act as Chemotherapeutic Potentiators in Acute Myeloid Leukemia and T-Cell Acute Lymphoblastic Leukemia |
| Q89080700 | Potent effects of roniciclib alone and with sorafenib against well-differentiated thyroid cancer |
| Q37687119 | Potent in vitro and in vivo effects of polyclonal anti-human-myeloma globulins |
| Q93012453 | Potent inhibition of HIV replication in primary human cells by novel synthetic polyketides inspired by Aureothin |
| Q34559882 | Potentiation of in vitro and in vivo antitumor efficacy of doxorubicin by cyclin-dependent kinase inhibitor P276-00 in human non-small cell lung cancer cells |
| Q34146866 | Potentiation of temozolomide cytotoxicity by inhibition of DNA polymerase beta is accentuated by BRCA2 mutation |
| Q35934137 | Poxvirus-Based Active Immunotherapy with PD-1 and LAG-3 Dual Immune Checkpoint Inhibition Overcomes Compensatory Immune Regulation, Yielding Complete Tumor Regression in Mice |
| Q36823732 | Poxvirus-based active immunotherapy synergizes with CTLA-4 blockade to increase survival in a murine tumor model by improving the magnitude and quality of cytotoxic T cells |
| Q38686509 | Pre-clinical drug screen reveals topotecan, actinomycin D and volasertib as potential new therapeutic candidates for ETMR brain tumor patients |
| Q37457809 | Pre-clinical efficacy and synergistic potential of the MDM2-p53 antagonists, Nutlin-3 and RG7388, as single agents and in combined treatment with cisplatin in ovarian cancer. |
| Q28078909 | Pre-clinical evaluation of a novel class of anti-cancer agents, the Pyrrolo-1, 5-benzoxazepines |
| Q39658512 | Preclinical Characterization of BI 201335, a C-Terminal Carboxylic Acid Inhibitor of the Hepatitis C Virus NS3-NS4A Protease |
| Q36276835 | Preclinical Profile and Characterization of the Hepatitis C Virus NS3 Protease Inhibitor Asunaprevir (BMS-650032). |
| Q59794233 | Preclinical Studies Support Combined Inhibition of BET Family Proteins and Histone Deacetylases as Epigenetic Therapy for Cutaneous T-Cell Lymphoma |
| Q33798031 | Preclinical characterization of BMS-791325, an allosteric inhibitor of hepatitis C Virus NS5B polymerase |
| Q37816960 | Preclinical development of molecular-targeted agents for cancer |
| Q35178056 | Preclinical evaluation on the tumor suppression efficiency and combination drug effects of fermented wheat germ extract in human ovarian carcinoma cells |
| Q33578960 | Preclinical pharmacological evaluation of a novel multiple kinase inhibitor, ON123300, in brain tumor models |
| Q37330186 | Preclinical versus clinical drug combination studies |
| Q37593264 | Predicting Drug Combination Index and Simulating the Network-Regulation Dynamics by Mathematical Modeling of Drug-Targeted EGFR-ERK Signaling Pathway |
| Q34397561 | Predicting and characterizing selective multiple drug treatments for metabolic diseases and cancer. |
| Q94528697 | Prediction of drug combination effects with a minimal set of experiments |
| Q37264069 | Prediction of multidimensional drug dose responses based on measurements of drug pairs. |
| Q64235544 | Prediction of ultra-high-order antibiotic combinations based on pairwise interactions |
| Q42425463 | Preferential targeting of cancer stem cells in the radiosensitizing effect of ABT-737 on HNSCC. |
| Q58769710 | Prevalence and patterns of higher-order drug interactions in |
| Q40062702 | Prevention of vaginal and rectal HIV transmission by antiretroviral combinations in humanized mice |
| Q48534871 | Prexasertib, a cell cycle checkpoint kinases 1 and 2 inhibitor, increases in vitro toxicity of PARP inhibition by preventing Rad51 foci formation in BRCA wild type high-grade serous ovarian cancer |
| Q92962871 | Prim-O-glucosylcimifugin enhances the antitumour effect of PD-1 inhibition by targeting myeloid-derived suppressor cells |
| Q47163733 | Primary and Immortalized Human Respiratory Cells Display Different Patterns of Cytotoxicity and Cytokine Release upon Exposure to Deoxynivalenol, Nivalenol and Fusarenon-X. |
| Q27853295 | Primary cross-resistance to BRAFV600E-, MEK1/2- and PI3K/mTOR-specific inhibitors in BRAF-mutant melanoma cells counteracted by dual pathway blockade |
| Q92819977 | Probabilistic modeling of personalized drug combinations from integrated chemical screen and molecular data in sarcoma |
| Q42120404 | Probing the PI3K/Akt/mTor pathway using (31)P-NMR spectroscopy: routes to glycogen synthase kinase 3. |
| Q36624591 | Probing the catalytic functions of Bub1 kinase using the small molecule inhibitors BAY-320 and BAY-524. |
| Q36850849 | Prognostic impact and targeting of CRM1 in acute myeloid leukemia |
| Q38937979 | Prognostic relevance of carbonic anhydrase IX expression is distinct in various subtypes of breast cancer and its silencing suppresses self-renewal capacity of breast cancer cells. |
| Q28388403 | Prophylactic and therapeutic functions of drug combinations against noise-induced hearing loss |
| Q53837345 | Protection Efficacy of C5A Against Vaginal and Rectal HIV Challenges in Humanized Mice. |
| Q36306931 | Protective Effect of Intranasal Regimens Containing Peptidic Middle East Respiratory Syndrome Coronavirus Fusion Inhibitor Against MERS-CoV Infection |
| Q33607616 | Protein kinase A inhibition facilitates the antitumor activity of xanthohumol, a valosin-containing protein inhibitor. |
| Q53684285 | Proteomic profiling identifies key coactivators utilized by mutant ERα proteins as potential new therapeutic targets. |
| Q54224174 | Pulsatilla Saponin D Inhibits Autophagic Flux and Synergistically Enhances the Anticancer Activity of Chemotherapeutic Agents Against HeLa Cells. |
| Q34001266 | Purine Nucleoside Phosphorylase mediated molecular chemotherapy and conventional chemotherapy: a tangible union against chemoresistant cancer |
| Q28537944 | Purvalanol A, olomoucine II and roscovitine inhibit ABCB1 transporter and synergistically potentiate cytotoxic effects of daunorubicin in vitro |
| Q37277114 | QLT0267, a small molecule inhibitor targeting integrin-linked kinase (ILK), and docetaxel can combine to produce synergistic interactions linked to enhanced cytotoxicity, reductions in P-AKT levels, altered F-actin architecture and improved treatmen |
| Q40341184 | Quantifying antiviral activity optimizes drug combinations against hepatitis C virus infection |
| Q37504253 | Quantitative Characterization of the Toxicities of Cd-Ni and Cd-Cr Binary Mixtures Using Combination Index Method |
| Q28539989 | Quantitative analysis of the anti-proliferative activity of combinations of selected iron-chelating agents and clinically used anti-neoplastic drugs |
| Q38022020 | Quantitative methods for assessing drug synergism |
| Q27902294 | Quantitative modeling of dose–response and drug combination based on pathway network |
| Q42560502 | Quercetin-induced inhibition and synergistic activity with cisplatin - a chemotherapeutic strategy for nasopharyngeal carcinoma cells |
| Q99556255 | Quetiapine and novel PDE10A inhibitors potentiate the anti-BuChE activity of donepezil |
| Q38702241 | Quinacrine in endometrial cancer: Repurposing an old antimalarial drug |
| Q36546665 | Quinacrine promotes autophagic cell death and chemosensitivity in ovarian cancer and attenuates tumor growth |
| Q34974049 | RNA interference screening identifies lenalidomide sensitizers in multiple myeloma, including RSK2. |
| Q92016630 | ROS as a novel indicator to predict anticancer drug efficacy |
| Q37372829 | RUNX1 regulates phosphoinositide 3-kinase/AKT pathway: role in chemotherapy sensitivity in acute megakaryocytic leukemia. |
| Q40258666 | Rad51 Degradation: Role in Oncolytic Virus-Poly(ADP-Ribose) Polymerase Inhibitor Combination Therapy in Glioblastoma |
| Q39486602 | Radiosensitization of head and neck cancer cells by the phytochemical agent sulforaphane. |
| Q54626064 | Rakicidin A effectively induces apoptosis in hypoxia adapted Bcr-Abl positive leukemic cells. |
| Q33572258 | Rapamycin downregulates thymidylate synthase and potentiates the activity of pemetrexed in non-small cell lung cancer |
| Q92565739 | Rapamycin enhanced the antitumor effects of doxorubicin in myelogenous leukemia K562 cells by downregulating the mTOR/p70S6K pathway |
| Q39143241 | Rapamycin interacts synergistically with idarubicin to induce T-leukemia cell apoptosis in vitro and in a mesenchymal stem cell simulated drug-resistant microenvironment via Akt/mammalian target of rapamycin and extracellular signal-related kinase s |
| Q44236729 | Rapamycin sensitizes cancer cells to growth inhibition by the PARP inhibitor olaparib |
| Q47762519 | Rapid Screening of Active Components with an Osteoclastic Inhibitory Effect in Herba epimedii Using Quantitative Pattern-Activity Relationships Based on Joint-Action Models. |
| Q46438080 | Rational Design of Selective Allosteric Inhibitors of PHGDH and Serine Synthesis with Anti-tumor Activity. |
| Q92689707 | Rational Design of Zika Virus Subunit Vaccine with Enhanced Efficacy |
| Q33603605 | Rationale for poly(ADP-ribose) polymerase (PARP) inhibitors in combination therapy with camptothecins or temozolomide based on PARP trapping versus catalytic inhibition |
| Q34994744 | Reactivation of estrogen receptor α by vorinostat sensitizes mesenchymal-like triple-negative breast cancer to aminoflavone, a ligand of the aryl hydrocarbon receptor |
| Q38874339 | Reactive Oxygen Species Synergize To Potently and Selectively Induce Cancer Cell Death |
| Q58790081 | Recent advances in combinatorial drug screening and synergy scoring |
| Q37206908 | Recent advances of cocktail chemotherapy by combination drug delivery systems. |
| Q47429067 | Receptor kinase profiles identify a rationale for multitarget kinase inhibition in immature T-ALL. |
| Q30399700 | Receptor-binding domain of MERS-CoV with optimal immunogen dosage and immunization interval protects human transgenic mice from MERS-CoV infection |
| Q37512915 | Recombinant Receptor-Binding Domains of Multiple Middle East Respiratory Syndrome Coronaviruses (MERS-CoVs) Induce Cross-Neutralizing Antibodies against Divergent Human and Camel MERS-CoVs and Antibody Escape Mutants |
| Q37366744 | Recombinant receptor-binding domain of SARS-CoV spike protein expressed in mammalian, insect and E. coli cells elicits potent neutralizing antibody and protective immunity |
| Q35708197 | Recombinant viral protein promotes apoptosis and suppresses invasion of ovarian adenocarcinoma cells by targeting α5β1 integrin to down-regulate Akt and MMP-2 |
| Q64983648 | Red American ginseng enhances the effect of fluorouracil on human colon cancer cells via both paraptosis and apoptosis pathways. |
| Q36035473 | Redox-Triggered Release of Moxifloxacin from Mesoporous Silica Nanoparticles Functionalized with Disulfide Snap-Tops Enhances Efficacy Against Pneumonic Tularemia in Mice |
| Q39035366 | Regulation of Mdm2 protein stability and the p53 response by NEDD4-1 E3 ligase |
| Q37340750 | Relevance of anti-inflammatory and antioxidant activities of exemestane and synergism with sulforaphane for disease prevention |
| Q48698494 | Replication Stress Leading to Apoptosis within the S-phase Contributes to Synergism between Vorinostat and AZD1775 in HNSCC Harboring High-Risk TP53 Mutation. |
| Q40198772 | Reply to Padmanabhan and Dixit: Hepatitis C virus entry inhibitors for optimally boosting direct-acting antiviral-based treatments |
| Q54967719 | Repression of Septin9 and Septin2 suppresses tumor growth of human glioblastoma cells. |
| Q35563726 | Reprogramming epigenetic silencing: artificial transcription factors synergize with chromatin remodeling drugs to reactivate the tumor suppressor mammary serine protease inhibitor. |
| Q54976863 | Repurposing sertraline sensitizes non-small cell lung cancer cells to erlotinib by inducing autophagy. |
| Q90407446 | Resistance to Epigenetic-Targeted Therapy Engenders Tumor Cell Vulnerabilities Associated with Enhancer Remodeling |
| Q37684589 | Resistance to PARP inhibitors by SLFN11 inactivation can be overcome by ATR inhibition |
| Q34820199 | Resveratrol analogs: promising chemopreventive agents |
| Q36346111 | Resveratrol overcomes gefitinib resistance by increasing the intracellular gefitinib concentration and triggering apoptosis, autophagy and senescence in PC9/G NSCLC cells |
| Q28831178 | Resveratrol synergistically augments anti-tumor effect of 5-FU in vitro and in vivo by increasing S-phase arrest and tumor apoptosis |
| Q91959541 | Retinoic acid synergizes with the unfolded protein response and oxidative stress to induce cell death in FLT3-ITD+ AML |
| Q60228349 | Reversal of Multidrug Resistance in Human Colon Cancer and Human Leukemia Cells by Three Plant Extracts and Their Major Secondary Metabolites |
| Q42701542 | Reverse chemomodulatory effects of the SIRT1 activators resveratrol and SRT1720 in Ewing's sarcoma cells: resveratrol suppresses and SRT1720 enhances etoposide- and vincristine-induced anticancer activity |
| Q36057956 | Revisiting the isobole and related quantitative methods for assessing drug synergism |
| Q38896751 | Ricolinostat, a selective HDAC6 inhibitor, shows anti-lymphoma cell activity alone and in combination with bendamustine |
| Q38985441 | Role of MAPK in oncolytic herpes viral therapy in triple-negative breast cancer. |
| Q64997623 | Role of synergy and immunostimulation in design of chemotherapy combinations: An analysis of doxorubicin and camptothecin. |
| Q41595578 | Role of zoledronic acid in oncolytic virotherapy: Promotion of antitumor effect and prevention of bone destruction |
| Q61443408 | Rosemary (Rosmarinus officinalis) extract causes ROS-induced necrotic cell death and inhibits tumor growth in vivo |
| Q47140442 | Ruxolitinib combined with vorinostat suppresses tumor growth and alters metabolic phenotype in hematological diseases |
| Q64074909 | Ruxolitinib in combination with prednisone and nilotinib exhibit synergistic effects in human cells lines and primary cells from myeloproliferative neoplasms |
| Q38776511 | S-1 plus nab-paclitaxel is a promising regimen for pancreatic cancer in a preclinical model |
| Q36907129 | SIRT1 activation enhances HDAC inhibition-mediated upregulation of GADD45G by repressing the binding of NF-κB/STAT3 complex to its promoter in malignant lymphoid cells |
| Q36545758 | SMAC mimetic Debio 1143 synergizes with taxanes, topoisomerase inhibitors and bromodomain inhibitors to impede growth of lung adenocarcinoma cells. |
| Q92715575 | SRC and MEK Co-inhibition Synergistically Enhances the Anti-tumor Effect in Both Non-small-cell Lung Cancer (NSCLC) and Erlotinib-Resistant NSCLC |
| Q39562657 | SU5416 and EGCG work synergistically and inhibit angiogenic and survival factors and induce cell cycle arrest to promote apoptosis in human malignant neuroblastoma SH-SY5Y and SK-N-BE2 cells |
| Q46309523 | Salidroside, a Chemopreventive Glycoside, Diminishes Cytotoxic Effect of Cisplatin in Vitro |
| Q35833001 | Salinomycin decreases doxorubicin resistance in hepatocellular carcinoma cells by inhibiting the β-catenin/TCF complex association via FOXO3a activation |
| Q55437664 | Salvianolic Acid B and Ginsenoside Re Synergistically Protect Against Ox-LDL-Induced Endothelial Apoptosis Through the Antioxidative and Antiinflammatory Mechanisms. |
| Q37285595 | Sanguisorba officinalis L synergistically enhanced 5-fluorouracil cytotoxicity in colorectal cancer cells by promoting a reactive oxygen species-mediated, mitochondria-caspase-dependent apoptotic pathway |
| Q54978341 | Saracatinib Inhibits Middle East Respiratory Syndrome-Coronavirus Replication In Vitro. |
| Q53465288 | Schedule dependent synergy of gemcitabine and doxorubicin: Improvement of in vitro efficacy and lack of in vitro-in vivo correlation. |
| Q34877852 | Schedule-dependent antitumor effects of 5-fluorouracil combined with sorafenib in hepatocellular carcinoma |
| Q53058056 | Schedule-dependent synergistic interaction between docetaxel and gefitinib in NSCLC cell lines regardless of the mutation status of EGFR and KRAS and its molecular mechanisms. |
| Q91910582 | Screening drug target combinations in disease-related molecular networks |
| Q93122076 | Screening the Medicines for Malaria Venture Pathogen Box against piroplasm parasites |
| Q61807559 | Screening-based approach to discover effective platinum-based chemotherapies for cancers with poor prognosis |
| Q55453526 | Scutellarin Enhances Antitumor Effects and Attenuates the Toxicity of Bleomycin in H22 Ascites Tumor-Bearing Mice. |
| Q55031258 | Searching Synergistic Dose Combinations for Anticancer Drugs. |
| Q38551269 | Searching for Drug Synergy in Complex Dose-Response Landscapes Using an Interaction Potency Model |
| Q41872280 | Selective AKR1C3 Inhibitors Potentiate Chemotherapeutic Activity in Multiple Acute Myeloid Leukemia (AML) Cell Lines |
| Q36078830 | Selective cytotoxicity of a Vietnamese traditional formula, Nam Dia long, against MCF-7 cells by synergistic effects |
| Q34104084 | Selective inhibition of unfolded protein response induces apoptosis in pancreatic cancer cells. |
| Q96304555 | Self-assembled small molecule natural product gel for drug delivery: a breakthrough in new application of small molecule natural products |
| Q44336883 | Semi-mechanistic pharmacokinetic/pharmacodynamic modelling of the antinociceptive response in the presence of competitive antagonism: the interaction between tramadol and its active metabolite on micro-opioid agonism and monoamine reuptake inhibitio |
| Q58782876 | Sensitivity of Colorectal Cancer to Arginine Deprivation Therapy is Shaped by Differential Expression of Urea Cycle Enzymes |
| Q37366251 | Sensitivity of imatinib-resistant T315I BCR-ABL CML to a synergistic combination of ponatinib and forskolin treatment |
| Q38366458 | Sepantronium is a DNA damaging agent that synergizes with PLK1 inhibitor volasertib |
| Q34633719 | Sequence-dependent antiproliferative effects of gefitinib and docetaxel on non-small cell lung cancer (NSCLC) cells and the possible mechanism |
| Q48030096 | Sequential Therapy of Breast Cancer Cell Lines with Vitamin C and Quercetin Improves the Efficacy of Chemotherapeutic Drugs |
| Q93018744 | Sequential combination of cisplatin with eugenol targets ovarian cancer stem cells through the Notch-Hes1 signalling pathway |
| Q93060574 | Short and Long-Term Effects of the Exposure of Breast Cancer Cell Lines to Different Ratios of Free or Co-Encapsulated Liposomal Paclitaxel and Doxorubicin |
| Q35956555 | Signals in APOBEC3F N-terminal and C-terminal deaminase domains each contribute to encapsidation in HIV-1 virions and are both required for HIV-1 restriction |
| Q50941709 | Simultaneous, But Not Consecutive, Combination With Folinate Salts Potentiates 5-Fluorouracil Antitumor Activity In Vitro and In Vivo. |
| Q91830288 | Simvastatin Evokes An Unpredicted Antagonism For Tamoxifen In MCF-7 Breast Cancer Cells |
| Q28547300 | Simvastatin and Benznidazole-Mediated Prevention of Trypanosoma cruzi-Induced Endothelial Activation: Role of 15-epi-lipoxin A4 in the Action of Simvastatin |
| Q38952701 | Simvastatin interacts synergistically with tipifarnib to induce apoptosis in leukemia cells through the disruption of RAS membrane localization and ERK pathway inhibition |
| Q37209050 | Site-specific Isopeptide Bridge Tethering of Chimeric gp41 N-terminal Heptad Repeat Helical Trimers for the Treatment of HIV-1 Infection. |
| Q97086542 | Skp2 Depletion Reduces Tumor-Initiating Properties and Promotes Apoptosis in Synovial Sarcoma |
| Q41840140 | Smac mimetic LCL161 supports neuroblastoma chemotherapy in a drug class-dependent manner and synergistically interacts with ALK inhibitor TAE684 in cells with ALK mutation F1174L. |
| Q42371593 | Small molecule CP-31398 induces reactive oxygen species-dependent apoptosis in human multiple myeloma |
| Q94069602 | Small molecule inhibition of lysine-specific demethylase 1 (LSD1) and histone deacetylase (HDAC) alone and in combination in Ewing sarcoma cell lines |
| Q35740455 | Small molecule inhibitor screen identifies synergistic activity of the bromodomain inhibitor CPI203 and bortezomib in drug resistant myeloma |
| Q36880450 | Small molecule tolfenamic acid and dietary spice curcumin treatment enhances antiproliferative effect in pancreatic cancer cells via suppressing Sp1, disrupting NF-kB translocation to nucleus and cell cycle phase distribution |
| Q92948950 | Small-Molecule Poly(ADP-ribose) Polymerase and PD-L1 Inhibitor Conjugates as Dual-Action Anticancer Agents |
| Q47435439 | Smart Combinations of Bioactive Compounds in Fruits and Vegetables May Guide New Strategies for Personalized Prevention of Chronic Diseases |
| Q37545171 | Solanesyl diphosphate synthase, an enzyme of the ubiquinone synthetic pathway, is required throughout the life cycle of Trypanosoma brucei |
| Q35828564 | Sorafenib and DE605, a novel c-Met inhibitor, synergistically suppress hepatocellular carcinoma |
| Q39679973 | Sorafenib and Quinacrine Target Anti-Apoptotic Protein MCL1: A Poor Prognostic Marker in Anaplastic Thyroid Cancer (ATC). |
| Q41770394 | Sorafenib induces cathepsin B-mediated apoptosis of bladder cancer cells by regulating the Akt/PTEN pathway. The Akt inhibitor, perifosine, enhances the sorafenib-induced cytotoxicity against bladder cancer cells. |
| Q38730830 | Standardized Extract from Caesalpinia spinosa is Cytotoxic Over Cancer Stem Cells and Enhance Anticancer Activity of Doxorubicin. |
| Q57359361 | Star-Graft Quarterpolymer-Based Polymersomes as Nanocarriers for Co-Delivery of Hydrophilic/Hydrophobic Chemotherapeutic Agents |
| Q64101992 | Statins may have double-edged effects in patients with lung adenocarcinoma after lung resection |
| Q27689029 | Structure-based discovery of Middle East respiratory syndrome coronavirus fusion inhibitor |
| Q38733984 | Strychnos pseudoquina A. St. Hil.: a Brazilian medicinal plant with promising in vitro antiherpes activity |
| Q52935211 | Suberoylanilide hydroxamic acid enhances chemosensitivity to 5-fluorouracil in hepatocellular carcinoma via inhibition of thymidylate synthase. |
| Q35075792 | Suberoylanilide hydroxamic acid induces hypersensitivity to radiation therapy in acute myelogenous leukemia cells expressing constitutively active FLT3 mutants |
| Q90633154 | Subpopulation targeting of pyruvate dehydrogenase and GLUT1 decouples metabolic heterogeneity during collective cancer cell invasion |
| Q41517478 | Sulphated polysaccharides from Ulva clathrata and Cladosiphon okamuranus seaweeds both inhibit viral attachment/entry and cell-cell fusion, in NDV infection |
| Q39493416 | Supercritical CO2 decaffeination of unroasted coffee beans produces melanoidins with distinct NF-κB inhibitory activity. |
| Q28833740 | Suppression of KRas-mutant cancer through the combined inhibition of KRAS with PLK1 and ROCK |
| Q90430639 | Suppression of stress induction of the 78-kilodalton glucose regulated protein (GRP78) in cancer by IT-139, an anti-tumor ruthenium small molecule inhibitor |
| Q38408268 | Susceptibility of Broiler Chickens to Coccidiosis When Fed Subclinical Doses of Deoxynivalenol and Fumonisins-Special Emphasis on the Immunological Response and the Mycotoxin Interaction. |
| Q38788594 | Synergetic effects of aqueous extracts of Fuzi (Radix Aconiti Lateralis Preparata) and Tubeimu (Rhizoma Bolbostemmatis) on MDA-MB-231 and SKBR3 cells |
| Q46863380 | Synergic effects of artemisinin and resveratrol in cancer cells |
| Q43176371 | Synergism between COX-3 inhibitors in two animal models of pain |
| Q44350855 | Synergism between dexketoprofen and meloxicam in an orofacial formalin test was not modified by opioid antagonists |
| Q87271736 | Synergism between tramadol and parecoxib in the orofacial formalin test |
| Q64072873 | Synergism of PARP inhibitor fluzoparib (HS10160) and MET inhibitor HS10241 in breast and ovarian cancer cells |
| Q40016074 | Synergism of perampanel and zonisamide in the rat amygdala kindling model of temporal lobe epilepsy |
| Q46496580 | Synergism of the IGRs Methoprene and Pyriproxyfen Against Larval Cat Fleas (Siphonaptera: Pulicidae). |
| Q46469595 | Synergism of thymol, carvacrol and eugenol in larvae of the cattle tick, Rhipicephalus microplus, and brown dog tick, Rhipicephalus sanguineus |
| Q58604428 | Synergistic Action of 1,2-Epoxy-3 (3- (3,4-dimethoxyphenyl)- 4H-1-benzopiyran-4-on) Propane with Doxorubicin and Cisplatin through Increasing of p53, TIMP-3, and MicroRNA-34a in Cervical Cancer Cell Line (HeLa) |
| Q36275685 | Synergistic Activation of Latent HIV-1 Expression by Novel Histone Deacetylase Inhibitors and Bryostatin-1. |
| Q39178137 | Synergistic Activity between Statins and Bisphosphonates against Acute Experimental Toxoplasmosis. |
| Q50440802 | Synergistic Activity for Natural and Synthetic Inhibitors of Angiogenesis Induced by Murine Sarcoma L-1 and Human Kidney Cancer Cells. |
| Q27312452 | Synergistic Activity of Deguelin and Fludarabine in Cells from Chronic Lymphocytic Leukemia Patients and in the New Zealand Black Murine Model |
| Q51362699 | Synergistic Anticancer Effect of Peptide-Docetaxel Nanoassembly Targeted to Tubulin: Toward Development of Dual Warhead Containing Nanomedicine. |
| Q35147292 | Synergistic Apoptosis-Inducing Antileukemic Effects of Arsenic Trioxide and Mucuna macrocarpa Stem Extract in Human Leukemic Cells via a Reactive Oxygen Species-Dependent Mechanism. |
| Q90133167 | Synergistic Cytotoxicity of Renieramycin M and Doxorubicin in MCF-7 Breast Cancer Cells |
| Q50285730 | Synergistic Drug Combinations with a CDK4/6 Inhibitor in T-cell Acute Lymphoblastic Leukemia |
| Q89984716 | Synergistic Effect of 1,3,6-Trihydroxy-4,5,7-Trichloroxanthone in Combination with Doxorubicin on B-Cell Lymphoma Cells and Its Mechanism of Action Through Molecular Docking |
| Q38733649 | Synergistic Effect of SH003 and Doxorubicin in Triple-negative Breast Cancer |
| Q90749068 | Synergistic Effect of a HER2 Targeted Thorium-227 Conjugate in Combination with Olaparib in a BRCA2 Deficient Xenograft Model |
| Q64387609 | Synergistic Effect of a Mesothelin Targeted Thorium-227 Conjugate in Combination with DNA Damage Response Inhibitors in Ovarian Cancer Xenograft Models |
| Q26741422 | Synergistic Effects of Chinese Herbal Medicine: A Comprehensive Review of Methodology and Current Research |
| Q42178099 | Synergistic Effects of Danshen (Salvia Miltiorrhiza Radix et Rhizoma) and Sanqi (Notoginseng Radix et Rhizoma) Combination in Inhibiting Inflammation Mediators in RAW264.7 Cells. |
| Q40612557 | Synergistic Effects of Sulfated Polysaccharides from Mexican Seaweeds against Measles Virus |
| Q47378920 | Synergistic Induction of Apoptosis by Quercetin and Curcumin in Chronic Myeloid Leukemia (K562) Cells. |
| Q38726548 | Synergistic Interactions between Hepatitis B Virus RNase H Antagonists and Other Inhibitors |
| Q37284697 | Synergistic Neuroprotective Effects of Two Herbal Ingredients via CREB-Dependent Pathway |
| Q48310652 | Synergistic Promotion on Tyrosinase Inhibition by Antioxidants. |
| Q28546901 | Synergistic Reactivation of Latent HIV Expression by Ingenol-3-Angelate, PEP005, Targeted NF-kB Signaling in Combination with JQ1 Induced p-TEFb Activation |
| Q37680216 | Synergistic action by multi-targeting compounds produces a potent compound combination for human NSCLC both in vitro and in vivo |
| Q38847744 | Synergistic action of 5Z-7-oxozeaenol and bortezomib in inducing apoptosis of Burkitt lymphoma cell line Daudi |
| Q37687313 | Synergistic activity of ALK and mTOR inhibitors for the treatment of NPM-ALK positive lymphoma |
| Q37259527 | Synergistic activity of the SRC family kinase inhibitor dasatinib and oxaliplatin in colon carcinoma cells is mediated by oxidative stress |
| Q43072801 | Synergistic activity of the Src/Abl inhibitor bosutinib in combination with imatinib |
| Q104492782 | Synergistic and Antagonistic Drug Combinations against SARS-CoV-2 |
| Q36452158 | Synergistic and Antagonistic Mutation Responses of Human MCL-5 Cells to Mixtures of Benzo[a]pyrene and 2-Amino-1-Methyl-6-Phenylimidazo[4,5-b]pyridine: Dose-Related Variation in the Joint Effects of Common Dietary Carcinogens |
| Q42155591 | Synergistic and Selective Cancer Cell Killing Mediated by the Oncolytic Adenoviral Mutant AdΔΔ and Dietary Phytochemicals in Prostate Cancer Models |
| Q47236942 | Synergistic anti-HCV broadly neutralizing human monoclonal antibodies with independent mechanisms. |
| Q34400208 | Synergistic anti-cancer effect of phenformin and oxamate |
| Q52097904 | Synergistic anti-cancer effects of epigenetic drugs on medulloblastoma cells. |
| Q37293167 | Synergistic anti-leukemic interactions between ABT-199 and panobinostat in acute myeloid leukemia ex vivo |
| Q36843733 | Synergistic anti-leukemic interactions between panobinostat and MK-1775 in acute myeloid leukemia ex vivo |
| Q93013199 | Synergistic anti-methicillin-resistant Staphylococcus aureus (MRSA) activity and absolute stereochemistry of 7,8-dideoxygriseorhodin C |
| Q54985966 | Synergistic anti-proliferative effects of combination of ABT-263 and MCL-1 selective inhibitor A-1210477 on cervical cancer cell lines. |
| Q36291134 | Synergistic anti-tumor activity and inhibition of angiogenesis by cotargeting of oncogenic and death receptor pathways in human melanoma |
| Q28484167 | Synergistic anti-tumor effects of combination of photodynamic therapy and arsenic compound in cervical cancer cells: in vivo and in vitro studies |
| Q35484306 | Synergistic anti-tumour effects of tetrandrine and chloroquine combination therapy in human cancer: a potential antagonistic role for p21. |
| Q51026097 | Synergistic antibacterial activity of the combination of the alkaloid sanguinarine with EDTA and the antibiotic streptomycin against multidrug resistant bacteria. |
| Q39018558 | Synergistic anticancer activity of valproate combined with nicotinamide enhances anti-proliferation response and apoptosis in MIAPaca2 cells |
| Q34468514 | Synergistic anticancer effects of a bioactive subfraction of Strobilanthes crispus and tamoxifen on MCF-7 and MDA-MB-231 human breast cancer cell lines |
| Q39281476 | Synergistic anticancer effects of arsenic trioxide with bortezomib in mantle cell lymphoma |
| Q50047764 | Synergistic anticancer effects of ruxolitinib and calcitriol in estrogen receptor‑positive, human epidermal growth factor receptor 2‑positive breast cancer cells |
| Q28476828 | Synergistic anticancer effects of the 9.2.27PE immunotoxin and ABT-737 in melanoma |
| Q55096310 | Synergistic antifungal effect of chitosan-stabilized selenium nanoparticles synthesized by pulsed laser ablation in liquids against Candida albicans biofilms. |
| Q42051272 | Synergistic antileukemic therapies in NOTCH1-induced T-ALL. |
| Q53902709 | Synergistic antioxidant action of Phikud Navakot ameliorates hydrogen peroxide-induced stress in human endothelial cells. |
| Q55317203 | Synergistic antitumor activity by combining trastuzumab with retinoic acid in HER2 positive human breast cancer cells. |
| Q35751958 | Synergistic antitumor activity of camptothecin-doxorubicin combinations and their conjugates with hyaluronic acid. |
| Q38815692 | Synergistic antitumor activity of pro-apoptotic agent PAC-1 with cisplatinum by the activation of CASP3 in pulmonary adenocarcinoma cell line H1299. |
| Q51284365 | Synergistic antitumor effect of Doxorubicin and tacrolimus (FK506) on hepatocellular carcinoma cell lines. |
| Q91597632 | Synergistic antitumour activity of HDAC inhibitor SAHA and EGFR inhibitor gefitinib in head and neck cancer: a key role for ΔNp63α |
| Q41096219 | Synergistic apoptotic effects of apigenin TPGS liposomes and tyroservatide: implications for effective treatment of lung cancer |
| Q36970257 | Synergistic chemopreventive effects of curcumin and berberine on human breast cancer cells through induction of apoptosis and autophagic cell death. |
| Q31075768 | Synergistic combination of microtubule targeting anticancer fludelone with cytoprotective panaxytriol derived from panax ginseng against MX-1 cells in vitro: experimental design and data analysis using the combination index method |
| Q36501393 | Synergistic combinations of multiple chemotherapeutic agents in high capacity poly(2-oxazoline) micelles |
| Q34597465 | Synergistic combinations of the CCR5 inhibitor VCH-286 with other classes of HIV-1 inhibitors |
| Q39257622 | Synergistic cytotoxicity of irinotecan and cisplatin in dual-drug targeted polymeric nanoparticles |
| Q38726658 | Synergistic disruption of ERα/HER2 crosstalk by endoxifen and lapatinib in breast cancer cells. |
| Q64235722 | Synergistic drug combinations prediction by integrating pharmacological data |
| Q33660974 | Synergistic effect of MiR-146a mimic and cetuximab on hepatocellular carcinoma cells. |
| Q90427395 | Synergistic effect of a retinoid X receptor-selective ligand bexarotene and docetaxel in prostate cancer |
| Q34635475 | Synergistic effect of afatinib with su11274 in non-small cell lung cancer cells resistant to gefitinib or erlotinib |
| Q39931462 | Synergistic effect of combination of phenethyl isothiocyanate and sulforaphane or curcumin and sulforaphane in the inhibition of inflammation |
| Q34358790 | Synergistic effect of combinatorial treatment with curcumin and mitomycin C on the induction of apoptosis of breast cancer cells: a cDNA microarray analysis |
| Q36078490 | Synergistic effect of curcumin on epigallocatechin gallate-induced anticancer action in PC3 prostate cancer cells |
| Q50971812 | Synergistic effect of docosahexaenoic acid on anticonvulsant activity of valproic acid and lamotrigine in animal seizure models. |
| Q46592179 | Synergistic effect of eribulin and CDK inhibition for the treatment of triple negative breast cancer. |
| Q38770836 | Synergistic effect of pacritinib with erlotinib on JAK2-mediated resistance in epidermal gowth factor receptor mutation-positive non-small cell lung Cancer |
| Q38856978 | Synergistic effect of targeting the epidermal growth factor receptor and hyaluronan synthesis in oesophageal squamous cell carcinoma cells. |
| Q61808037 | Synergistic effects of SHP2 and PI3K pathway inhibitors in GAB2-overexpressing ovarian cancer |
| Q35191181 | Synergistic effects of acyclovir and 3, 19-isopropylideneandrographolide on herpes simplex virus wild types and drug-resistant strains |
| Q39463690 | Synergistic effects of arsenic trioxide and silibinin on apoptosis and invasion in human glioblastoma U87MG cell line. |
| Q36901967 | Synergistic effects of ascorbate and sorafenib in hepatocellular carcinoma: New insights into ascorbate cytotoxicity |
| Q39397750 | Synergistic effects of combination treatment with bortezomib and doxorubicin in human neuroblastoma cell lines |
| Q28485464 | Synergistic effects of combined Wnt/KRAS inhibition in colorectal cancer cells |
| Q39138948 | Synergistic effects of curcumin with emodin against the proliferation and invasion of breast cancer cells through upregulation of miR-34a. |
| Q28828233 | Synergistic effects of melphalan and Pinus kesiya Royle ex Gordon (Simaosong) extracts on apoptosis induction in human cancer cells |
| Q36121745 | Synergistic effects of nelfinavir and bortezomib on proteotoxic death of NSCLC and multiple myeloma cells |
| Q41614789 | Synergistic effects of phenylhexyl isothiocyanate and LY294002 on the PI3K/Akt signaling pathway in HL-60 cells |
| Q35577785 | Synergistic efficacy of a novel combination therapy controls growth of Bcl-x(L) bountiful neuroblastoma cells by increasing differentiation and apoptosis |
| Q37225141 | Synergistic efficacy of combination of enfuvirtide and sifuvirtide, the first- and next-generation HIV-fusion inhibitors |
| Q37684044 | Synergistic enhancement of cancer therapy using a combination of ceramide and docetaxel |
| Q38758785 | Synergistic estrogenic effects of Fusarium and Alternaria mycotoxins in vitro |
| Q39505317 | Synergistic growth inhibition based on small-molecule p53 activation as treatment for intraocular melanoma |
| Q52726251 | Synergistic growth inhibition of cancer cells harboring the RET/PTC1 oncogene by staurosporine and rotenone involves enhanced cell death. |
| Q35066769 | Synergistic induction of apoptosis in A549 cells by dihydroartemisinin and gemcitabine |
| Q28477256 | Synergistic inhibition of endothelial cell proliferation, tube formation, and sprouting by cyclosporin A and itraconazole |
| Q42933747 | Synergistic inhibition of glycinergic transmission in vitro and in vivo by flavonoids and strychnine |
| Q34124618 | Synergistic inhibitory effect of berberine and d-limonene on human gastric carcinoma cell line MGC803. |
| Q36407635 | Synergistic interaction between lipid-loading and doxorubicin exposure in Huh7 hepatoma cells results in enhanced cytotoxicity and cellular oxidative stress: implications for acute and chronic care of obese cancer patients |
| Q33931616 | Synergistic interaction between oncolytic viruses augments tumor killing |
| Q34837850 | Synergistic interaction between the HDAC inhibitor, MPT0E028, and sorafenib in liver cancer cells in vitro and in vivo |
| Q64080841 | Synergistic interaction of gemcitabine and paclitaxel by modulating acetylation and polymerization of tubulin in non-small cell lung cancer cell lines |
| Q38403037 | Synergistic interaction of ten essential oils against Haemonchus contortus in vitro. |
| Q34265716 | Synergistic interactions of the anti-casein kinase 2 CIGB-300 peptide and chemotherapeutic agents in lung and cervical preclinical cancer models |
| Q90387894 | Synergistic lethal mutagenesis of hepatitis C virus |
| Q36607965 | Synergistic lethality of mifepristone and LY294002 in ovarian cancer cells |
| Q36984507 | Synergistic potentiation of (-)-lomaiviticin A cytotoxicity by the ATR inhibitor VE-821. |
| Q39938201 | Synergistic protection of N-acetylcysteine and ascorbic acid 2-phosphate on human mesenchymal stem cells against mitoptosis, necroptosis and apoptosis. |
| Q46798093 | Synergistic radiation protective effect of purified Auricularia auricular-judae polysaccharide (AAP IV) with grape seed procyanidins. |
| Q34289164 | Synergistic simvastatin and metformin combination chemotherapy for osseous metastatic castration-resistant prostate cancer. |
| Q38916167 | Synergistic suppression of dengue virus replication using a combination of nucleoside analogs and nucleoside synthesis inhibitors |
| Q37728530 | Synergistic suppression of noscapine and conventional chemotherapeutics on human glioblastoma cell growth |
| Q92677555 | Synergy and antagonism in natural product extracts: when 1 + 1 does not equal 2 |
| Q33919240 | Synergy between dinotefuran and fipronil against the cat flea (Ctenocephalides felis): improved onset of action and residual speed of kill in adult cats |
| Q40188819 | Synergy evaluation by a pathway-pathway interaction network: a new way to predict drug combination |
| Q34762224 | Synergy in monoclonal antibody neutralization of HIV-1 pseudoviruses and infectious molecular clones |
| Q47567993 | Synergy of BCL2 and histone deacetylase inhibition against leukemic cells from cutaneous T-cell lymphoma patients. |
| Q37286038 | Synergy of a herpes oncolytic virus and paclitaxel for anaplastic thyroid cancer. |
| Q37240176 | Synergy: a concept in search of a definition |
| Q39043729 | Synthesis and structure-activity relationships of novel ecdysteroid dioxolanes as MDR modulators in cancer. |
| Q37243049 | Synthesis of bisethylnorspermine lipid prodrug as gene delivery vector targeting polyamine metabolism in breast cancer |
| Q34561602 | System-level study on synergism and antagonism of active ingredients in traditional Chinese medicine by using molecular imprinting technology |
| Q30422333 | Systematic identification of synergistic drug pairs targeting HIV |
| Q42050971 | Systematic prediction of drug combinations based on clinical side-effects |
| Q35777950 | Systematic synergy modeling: understanding drug synergy from a systems biology perspective |
| Q30423829 | Systems pharmacology uncovers Janus functions of botanical drugs: activation of host defense system and inhibition of influenza virus replication. |
| Q96022617 | TGF-β1-mediated repression of SLC7A11 drives vulnerability to GPX4 inhibition in hepatocellular carcinoma cells |
| Q37622508 | THZ1 targeting CDK7 suppresses STAT transcriptional activity and sensitizes T-cell lymphomas to BCL2 inhibitors |
| Q37672563 | TORC1 and class I HDAC inhibitors synergize to suppress mature B cell neoplasms |
| Q33584376 | TTFields alone and in combination with chemotherapeutic agents effectively reduce the viability of MDR cell sub-lines that over-express ABC transporters |
| Q41834213 | TW-37, a small-molecule inhibitor of Bcl-2, mediates S-phase cell cycle arrest and suppresses head and neck tumor angiogenesis |
| Q36584655 | Tacrolimus enhances the potency of posaconazole against Rhizopus oryzae in vitro and in an experimental model of mucormycosis |
| Q36198145 | Tanshinone IIA combined with adriamycin inhibited malignant biological behaviors of NSCLC A549 cell line in a synergistic way. |
| Q90480275 | Target of Rapamycin Regulates Genome Methylation Reprogramming to Control Plant Growth in Arabidopsis |
| Q41942526 | Targeted disruption of the EZH2-EED complex inhibits EZH2-dependent cancer |
| Q38788994 | Targeted hepatocellular carcinoma therapy: transferrin modified, self-assembled polymeric nanomedicine for co-delivery of cisplatin and doxorubicin |
| Q52716625 | Targeting AKT with oridonin inhibits growth of esophageal squamous cell carcinoma in vitro and patient derived xenografts in vivo. |
| Q47164935 | Targeting Anaplastic Lymphoma Kinase (ALK) in Rhabdomyosarcoma (RMS) with the Second-Generation ALK Inhibitor Ceritinib. |
| Q52927960 | Targeting Aurora kinase A and JAK2 prevents GVHD while maintaining Treg and antitumor CTL function. |
| Q48211870 | Targeting BRCA1/2 deficient ovarian cancer with CNDAC-based drug combinations |
| Q92434462 | Targeting CDK9 and MCL-1 by a new CDK9/p-TEFb inhibitor with and without 5-fluorouracil in esophageal adenocarcinoma |
| Q41616680 | Targeting Chromatin Regulators Inhibits Leukemogenic Gene Expression in NPM1 Mutant Leukemia. |
| Q38748709 | Targeting ERK enhances the cytotoxic effect of the novel PI3K and mTOR dual inhibitor VS-5584 in preclinical models of pancreatic cancer |
| Q39248620 | Targeting FLIP and Mcl-1 using a combination of aspirin and sorafenib sensitizes colon cancer cells to TRAIL. |
| Q55388853 | Targeting LMW-PTP to sensitize melanoma cancer cells toward chemo- and radiotherapy. |
| Q54977358 | Targeting Nicotinamide N-Methyltransferase and miR-449a in EGFR-TKI-Resistant Non-Small-Cell Lung Cancer Cells. |
| Q42317485 | Targeting Notch signaling as a novel therapy for retinoblastoma |
| Q48168156 | Targeting P-glycoprotein and SORCIN: Dihydromyricetin strengthens anti-proliferative efficiency of adriamycin via MAPK/ERK and Ca2+ -mediated apoptosis pathways in MCF-7/ADR and K562/ADR. |
| Q63447350 | Targeting PKCδ as a Therapeutic Strategy against Heterogeneous Mechanisms of EGFR Inhibitor Resistance in EGFR-Mutant Lung Cancer |
| Q55504441 | Targeting Polo-like kinase 1 and TRAIL enhances apoptosis in non-small cell lung cancer. |
| Q36557523 | Targeting autophagy enhances the anti-tumoral action of crizotinib in ALK-positive anaplastic large cell lymphoma |
| Q100750176 | Targeting interleukin-17 receptor B enhances gemcitabine sensitivity through downregulation of mucins in pancreatic cancer |
| Q55155565 | Targeting mTORC1/2 Complexes Inhibit Tumorigenesis and Enhance Sensitivity to 5-Flourouracil (5-FU) in Hepatocellular Carcinoma: A Preclinical Study of mTORC1/2-Targeted Therapy in Hepatocellular Carcinoma (HCC). |
| Q90469311 | Targeting of CD38 by the tumor suppressor miR-26a serves as a novel potential therapeutic agent in multiple myeloma |
| Q55015828 | Targeting of colony-stimulating factor 1 receptor (CSF1R) in the CLL microenvironment yields antineoplastic activity in primary patient samples. |
| Q37362875 | Targeting of glioblastoma cell lines and glioma stem cells by combined PIM kinase and PI3K-p110α inhibition |
| Q36748786 | Targeting of tubulin polymerization and induction of mitotic blockage by Methyl 2-(5-fluoro-2-hydroxyphenyl)-1H-benzo[d]imidazole-5-carboxylate (MBIC) in human cervical cancer HeLa cell |
| Q33607412 | Targeting of tumor growth and angiogenesis underlies the enhanced antitumor activity of lenvatinib in combination with everolimus |
| Q40150859 | Targeting polo-like kinase 1 suppresses essential functions of alloreactive T cells |
| Q37235682 | Targeting the Hsp90-associated viral oncoproteome in gammaherpesvirus-associated malignancies |
| Q89469502 | Targeting the IκB Kinase Enhancer and Its Feedback Circuit in Pancreatic Cancer |
| Q28547158 | Targeting the NF-κB Pathway as a Combination Therapy for Advanced Thyroid Cancer |
| Q36845783 | Targeting the apoptotic pathway with BCL-2 inhibitors sensitizes primary chronic lymphocytic leukemia cells to vesicular stomatitis virus-induced oncolysis |
| Q35832938 | Targeting the degradation of AXL receptor tyrosine kinase to overcome resistance in gefitinib-resistant non-small cell lung cancer |
| Q34205052 | Targeting the epidermal growth factor receptor in non-small cell lung cancer cells: the effect of combining RNA interference with tyrosine kinase inhibitors or cetuximab. |
| Q38925161 | Targeting the metabolic plasticity of multiple myeloma with FDA-approved ritonavir and metformin |
| Q34352858 | Targeting the wee1 kinase for treatment of pediatric Down syndrome acute myeloid leukemia |
| Q35032561 | Telodendrimer nanocarrier for co-delivery of paclitaxel and cisplatin: A synergistic combination nanotherapy for ovarian cancer treatment |
| Q92082943 | Terpene Derivatives as a Potential Agent against Antimicrobial Resistance (AMR) Pathogens |
| Q44206243 | Testing an application of a biotic ligand model to predict acute toxicity of metal mixtures to rainbow trout |
| Q36259408 | Text mining for drug-drug interaction |
| Q34649075 | The Akt inhibitor ISC-4 synergizes with cetuximab in 5-FU-resistant colon cancer |
| Q27340125 | The BMI1 inhibitor PTC-209 is a potential compound to halt cellular growth in biliary tract cancer cells |
| Q39466656 | The Bcl-2/Bcl-XL inhibitor ABT-737 promotes death of retinoblastoma cancer cells |
| Q35856790 | The Bone Marrow-Mediated Protection of Myeloproliferative Neoplastic Cells to Vorinostat and Ruxolitinib Relies on the Activation of JNK and PI3K Signalling Pathways |
| Q48169849 | The CDK4/6 inhibitor palbociclib synergizes with irinotecan to promote colorectal cancer cell death under hypoxia |
| Q42006192 | The CXCR4 antagonist plerixafor enhances the effect of rituximab in diffuse large B-cell lymphoma cell lines |
| Q59791937 | The Combination of Omega-3 Stearidonic Acid and Docetaxel Enhances Cell Death over Docetaxel Alone in Human Prostate Cancer Cells |
| Q38764663 | The Combination of Vemurafenib and Procaspase-3 Activation Is Synergistic in Mutant BRAF Melanomas |
| Q92997886 | The Cytotoxicity and Synergistic Potential of Aspirin and Aspirin Analogues Towards Oesophageal and Colorectal Cancer |
| Q39245345 | The DNA methyltransferase inhibitor zebularine exerts antitumor effects and reveals BATF2 as a poor prognostic marker for childhood medulloblastoma |
| Q89125034 | The Emerging Potential for Network Analysis to Inform Precision Cancer Medicine |
| Q36236520 | The Ethanolic Extract of Taiwanofungus camphoratus (Antrodia camphorata) Induces Cell Cycle Arrest and Enhances Cytotoxicity of Cisplatin and Doxorubicin on Human Hepatocellular Carcinoma Cells |
| Q91719737 | The Fusarium metabolite culmorin suppresses the in vitro glucuronidation of deoxynivalenol |
| Q59132751 | The HDAC Inhibitor Quisinostat (JNJ-26481585) Supresses Hepatocellular Carcinoma alone and Synergistically in Combination with Sorafenib by G0/G1 phase arrest and Apoptosis induction |
| Q48303460 | The Histone Deacetylase Inhibitor Valproic Acid Exerts a Synergistic Cytotoxicity with the DNA-Damaging Drug Ellipticine in Neuroblastoma Cells |
| Q57072895 | The Hop Polyphenols Xanthohumol and 8-Prenyl-Naringenin Antagonize the Estrogenic Effects of Mycotoxins in Human Endometrial Cancer Cells |
| Q92601023 | The Indenoisoquinoline TOP1 Inhibitors Selectively Target Homologous Recombination-Deficient and Schlafen 11-Positive Cancer Cells and Synergize with Olaparib |
| Q89944186 | The Landscape of the Anti-Kinase Activity of the IDH1 Inhibitors |
| Q42130801 | The Novel PIM1 Inhibitor NMS-P645 Reverses PIM1-Dependent Effects on TMPRSS2/ERG Positive Prostate Cancer Cells And Shows Anti-Proliferative Activity in Combination with PI3K Inhibition |
| Q64070965 | The PI3K inhibitor copanlisib synergizes with sorafenib to induce cell death in hepatocellular carcinoma |
| Q41470772 | The PI3K/Akt signaling pathway regulates the expression of Hsp70, which critically contributes to Hsp90-chaperone function and tumor cell survival in multiple myeloma |
| Q38694934 | The Phosphatidylinositol 3-kinase Pathway as a Potential Therapeutic Target in Bladder Cancer. |
| Q90474658 | The RUNX1/IL-34/CSF-1R axis is an autocrinally regulated modulator of resistance to BRAF-V600E inhibition in melanoma |
| Q92421507 | The SRC Inhibitor Dasatinib Induces Stem Cell-Like Properties in Head and Neck Cancer Cells that are Effectively Counteracted by the Mithralog EC-8042 |
| Q34754412 | The STAT5 inhibitor pimozide decreases survival of chronic myelogenous leukemia cells resistant to kinase inhibitors |
| Q40052441 | The Synergistic Antimicrobial Effects of Novel Bombinin and Bombinin H Peptides from the Skin Secretion of Bombina orientalis. |
| Q90656197 | The Synergistic Combination of Everolimus and Paroxetine Exerts Post-ischemic Neuroprotection In Vitro |
| Q33665411 | The TOR Pathway Is Involved in Adventitious Root Formation in Arabidopsis and Potato |
| Q92157178 | The Thrombopoietin Receptor Agonist Eltrombopag Inhibits Human Cytomegalovirus Replication Via Iron Chelation |
| Q64098099 | The Utility of Efavirenz-based Prophylaxis Against HIV Infection. A Systems Pharmacological Analysis |
| Q41098254 | The addition of calcitriol or its synthetic analog EB1089 to lapatinib and neratinib treatment inhibits cell growth and promotes apoptosis in breast cancer cells |
| Q35560628 | The antagonistic effect of neostigmine on rocuronium-, clindamycin-, or both-induced neuromuscular blocking in the rat phrenic nerve-hemidiaphragm |
| Q35943432 | The anti-fibrotic agent pirfenidone synergizes with cisplatin in killing tumor cells and cancer-associated fibroblasts |
| Q50130156 | The antitumor natural product tanshinone IIA inhibits protein kinase C and acts synergistically with 17-AAG. |
| Q34541532 | The bromodomain and extra-terminal inhibitor CPI203 enhances the antiproliferative effects of rapamycin on human neuroendocrine tumors |
| Q37702577 | The bromodomain inhibitor OTX015 (MK-8628) exerts anti-tumor activity in triple-negative breast cancer models as single agent and in combination with everolimus |
| Q38793446 | The combination effects of bendamustine with antimetabolites against childhood acute lymphoblastic leukemia cells |
| Q50623837 | The combination of agomelatine and ritanserin exerts a synergistic interaction in passive avoidance task. |
| Q33556388 | The combination of baicalin and baicalein enhances apoptosis via the ERK/p38 MAPK pathway in human breast cancer cells |
| Q38940707 | The combination of bortezomib with enzastaurin or lenalidomide enhances cytotoxicity in follicular and mantle cell lymphoma cell lines. |
| Q35541834 | The combination of thioxodihydroquinazolinones and platinum drugs reverses platinum resistance in tumor cells by inducing mitochondrial apoptosis independent of Bax and Bak |
| Q37736495 | The crosstalk between Target of Rapamycin (TOR) and Jasmonic Acid (JA) signaling existing in Arabidopsis and cotton |
| Q42434225 | The cytotoxic effects of regorafenib in combination with protein kinase D inhibition in human colorectal cancer cells |
| Q64280124 | The discovery and characterization of K-563, a novel inhibitor of the Keap1/Nrf2 pathway produced by Streptomyces sp |
| Q102379405 | The disubstituted adamantyl derivative LW1564 inhibits the growth of cancer cells by targeting mitochondrial respiration and reducing hypoxia-inducible factor (HIF)-1α accumulation |
| Q48118221 | The effects of dexketoprofen on duration of analgesia to a thermal stimulus when compared with a systemic control in a rat sciatic nerve block with levobupivacaine |
| Q56911719 | The effects of nitidine chloride and camptothecin on the growth of Babesia and Theileria parasites |
| Q64880768 | The effects of trans-chalcone and chalcone 4 hydrate on the growth of Babesia and Theileria. |
| Q35076888 | The efflux pump inhibitor timcodar improves the potency of antimycobacterial agents |
| Q35598535 | The ellagic acid-derived gut microbiota metabolite, urolithin A, potentiates the anticancer effects of 5-fluorouracil chemotherapy on human colon cancer cells |
| Q39155383 | The emerging mycotoxin, enniatin B1, down-modulates the gastrointestinal toxicity of T-2 toxin in vitro on intestinal epithelial cells and ex vivo on intestinal explants. |
| Q35671261 | The green tea catechin epigallocatechin gallate induces cell cycle arrest and shows potential synergism with cisplatin in biliary tract cancer cells. |
| Q42150240 | The highly synergistic, broad spectrum, antibacterial activity of organic acids and transition metals |
| Q39695495 | The histone deacetylase inhibitor panobinostat demonstrates marked synergy with conventional chemotherapeutic agents in human ovarian cancer cell lines |
| Q41573605 | The histone deacetylase inhibitor romidepsin synergizes with lenalidomide and enhances tumor cell death in T-cell lymphoma cell lines |
| Q39656219 | The histone deacetylase inhibitor suberoylanilide hydroxamic acid induces growth inhibition and enhances taxol-induced cell death in breast cancer |
| Q45853066 | The interaction of botanicals and AMPK signaling in the inhibition of castrate-resistant prostate cancer |
| Q28533345 | The lantibiotic peptide labyrinthopeptin A1 demonstrates broad anti-HIV and anti-HSV activity with potential for microbicidal applications |
| Q90142501 | The macrolide drug erythromycin does not protect the hERG channel from inhibition by thioridazine and terfenadine |
| Q34226169 | The mass-action law based algorithm for cost-effective approach for cancer drug discovery and development. |
| Q50525060 | The mass-action law based algorithms for quantitative econo-green bio-research. |
| Q35867431 | The natural antimicrobial peptide subtilosin acts synergistically with glycerol monolaurate, lauric arginate, and ε-poly-L-lysine against bacterial vaginosis-associated pathogens but not human lactobacilli. |
| Q35996498 | The natural compound forskolin synergizes with dexamethasone to induce cell death in myeloma cells via BIM |
| Q35232168 | The naturally born fusariotoxin enniatin B and sorafenib exert synergistic activity against cervical cancer in vitro and in vivo. |
| Q35551777 | The novel JAK inhibitor AZD1480 blocks STAT3 and FGFR3 signaling, resulting in suppression of human myeloma cell growth and survival |
| Q41825014 | The novel compound STK405759 is a microtubule-targeting agent with potent and selective cytotoxicity against multiple myeloma in vitro and in vivo. |
| Q39302268 | The novel tyrosine kinase inhibitor AKN-028 has significant antileukemic activity in cell lines and primary cultures of acute myeloid leukemia |
| Q35889653 | The novel β2-selective proteasome inhibitor LU-102 decreases phosphorylation of I kappa B and induces highly synergistic cytotoxicity in combination with ibrutinib in multiple myeloma cells |
| Q36115692 | The novel β2-selective proteasome inhibitor LU-102 synergizes with bortezomib and carfilzomib to overcome proteasome inhibitor resistance of myeloma cells |
| Q38699970 | The olive oil phenolic (-)-oleocanthal modulates estrogen receptor expression in luminal breast cancer in vitro and in vivo and synergizes with tamoxifen treatment |
| Q39986126 | The oral protein-kinase C beta inhibitor enzastaurin (LY317615) suppresses signalling through the AKT pathway, inhibits proliferation and induces apoptosis in multiple myeloma cell lines. |
| Q37636616 | The photosensitizer verteporfin has light-independent anti-leukemic activity for Ph-positive acute lymphoblastic leukemia and synergistically works with dasatinib |
| Q38768467 | The prognostic significance of specific HOX gene expression patterns in ovarian cancer. |
| Q41519431 | The promiscuous and synergic molecular interaction of polyphenols in bactericidal activity: an opportunity to improve the performance of antibiotics? |
| Q55364601 | The proton pump inhibitor pantoprazole disrupts protein degradation systems and sensitizes cancer cells to death under various stresses. |
| Q36851569 | The retinoic acid derivative, ABPN, inhibits pancreatic cancer through induction of Nrdp1 |
| Q52861555 | The role of hERG1 ion channels in epithelial-mesenchymal transition and the capacity of riluzole to reduce cisplatin resistance in colorectal cancer cells. |
| Q58731959 | The role of miRNAs 34a, 146a, 320a and 542 in the synergistic anticancer effects of methyl 2-(5-fluoro-2-hydroxyphenyl)-1H- benzo[d]imidazole-5-carboxylate (MBIC) with doxorubicin in breast cancer cells |
| Q33598372 | The role of quercetin and vitamin C in Nrf2-dependent oxidative stress production in breast cancer cells |
| Q57238244 | The scientific assessment of combined effects of risk factors: different approaches in experimental biosciences and epidemiology |
| Q35856765 | The synergic effect of vincristine and vorinostat in leukemia in vitro and in vivo |
| Q90106978 | The synergism of Clinacanthus nutans Lindau extracts with gemcitabine: downregulation of anti-apoptotic markers in squamous pancreatic ductal adenocarcinoma |
| Q59798559 | The synergistic effect of 2,3,5,4′-Tetrahydroxystilbene-2-O-β-D-glucoside combined with Adriamycin on MCF-7 breast cancer cells |
| Q55408644 | The synergistic effects of Apatinib combined with cytotoxic chemotherapeutic agents on gastric cancer cells and in a fluorescence imaging gastric cancer xenograft model. |
| Q28538702 | The synergistic in vitro and in vivo antitumor effect of combination therapy with salinomycin and 5-fluorouracil against hepatocellular carcinoma |
| Q35546455 | The synergistic inhibition of breast cancer proliferation by combined treatment with 4EGI-1 and MK2206 |
| Q47214772 | The synergistic role of ATP-dependent drug efflux pump and focal adhesion signaling pathways in vinorelbine resistance in lung cancer. |
| Q41226219 | Theory of synergistic effects: Hill-type response surfaces as 'null-interaction' models for mixtures |
| Q89099948 | Therapeutic efficacy of hydrogen‑rich saline alone and in combination with PI3K inhibitor in non‑small cell lung cancer |
| Q36958365 | Therapeutic evaluation of monoclonal antibody-maytansinoid conjugate as a model of RON-targeted drug delivery for pancreatic cancer treatment |
| Q34970050 | Therapeutic potential and molecular mechanism of a novel, potent, nonpeptide, Smac mimetic SM-164 in combination with TRAIL for cancer treatment |
| Q35631111 | Therapeutic target database update 2012: a resource for facilitating target-oriented drug discovery. |
| Q46062200 | Therapeutic targeting of PGBD5-induced DNA repair dependency in pediatric solid tumors |
| Q39733462 | Thioredoxin reductase inhibitor ethaselen increases the drug sensitivity of the colon cancer cell line LoVo towards cisplatin via regulation of G1 phase and reversal of G2/M phase arrest. |
| Q38876333 | Thymosin-β4 is a determinant of drug sensitivity for Fenretinide and Vorinostat combination therapy in neuroblastoma. |
| Q92315958 | Thyroid Peroxidase Activity is Inhibited by Phenolic Compounds-Impact of Interaction |
| Q34265547 | Time and dose relationships between schisandrin B- and schisandrae fructus oil-induced hepatotoxicity and the associated elevations in hepatic and serum triglyceride levels in mice |
| Q90724875 | Topical 2'-Hydroxyflavanone for Cutaneous Melanoma |
| Q50484112 | Toxicity of five antibiotics and their mixtures towards photosynthetic aquatic organisms: implications for environmental risk assessment. |
| Q88794958 | Toxicity of individual pharmaceuticals and their mixtures to Aliivibrio fischeri: Evidence of toxicological interactions in binary combinations |
| Q45776117 | Toxicological interactions between the mycotoxins deoxynivalenol, nivalenol and their acetylated derivatives in intestinal epithelial cells. |
| Q33649056 | Trabectedin and Campthotecin Synergistically Eliminate Cancer Stem Cells in Cell-of-Origin Sarcoma Models |
| Q35753103 | Tramadol and Tramadol+Caffeine Synergism in the Rat Formalin Test Are Mediated by Central Opioid and Serotonergic Mechanisms |
| Q90633546 | Transcriptional Modulation by Idelalisib Synergizes with Bendamustine in Chronic Lymphocytic Leukemia |
| Q37038076 | Transcriptional plasticity promotes primary and acquired resistance to BET inhibition |
| Q36429931 | Transforming growth factor beta receptor I inhibitor sensitizes drug-resistant pancreatic cancer cells to gemcitabine |
| Q99207519 | Treatment of MRSA-infected osteomyelitis using bacterial capturing, magnetically targeted composites with microwave-assisted bacterial killing |
| Q34693012 | Treatment of colorectal cancer using a combination of liposomal irinotecan (Irinophore C™) and 5-fluorouracil |
| Q46171794 | Treatment of experimental status epilepticus with synergistic drug combinations |
| Q49578235 | Treatment with docetaxel in combination with Aneustat leads to potent inhibition of metastasis in a patient-derived xenograft model of advanced prostate cancer |
| Q41339468 | Triple combination of carbosilane dendrimers, tenofovir and maraviroc as potential microbicide to prevent HIV-1 sexual transmission |
| Q37401564 | Triple combination of siRNAs targeting TGFβ1, TGFβR2, and CTGF enhances reduction of collagen I and smooth muscle actin in corneal fibroblasts. |
| Q33821011 | Triptolide Inhibits the AR Signaling Pathway to Suppress the Proliferation of Enzalutamide Resistant Prostate Cancer Cells |
| Q42378350 | Triterpenoids from Aglaia abbreviata exert cytotoxicity and multidrug resistant reversal effect in MCF-7/ADM cells via reactive oxygen species induction and P-glycoprotein inhibition |
| Q58759696 | Trojan Horse nanotheranostics with dual transformability and multifunctionality for highly effective cancer treatment |
| Q36303474 | Tumor-targeted polymeric nanostructured lipid carriers with precise ratiometric control over dual-drug loading for combination therapy in non-small-cell lung cancer |
| Q90397579 | Tuning the surface coating of IONs toward efficient sonochemical tethering and sustained liberation of topoisomerase II poisons |
| Q92705301 | Two Natural Alkaloids Synergistically Induce Apoptosis in Breast Cancer Cells by Inhibiting STAT3 Activation |
| Q26770477 | Two drugs are better than one. A short history of combined therapy of ovarian cancer |
| Q47818563 | Tyrosine kinase inhibition increases the cell surface localization of FLT3-ITD and enhances FLT3-directed immunotherapy of acute myeloid leukemia. |
| Q24632317 | Ubiquitin-dependent regulation of phospho-AKT dynamics by the ubiquitin E3 ligase, NEDD4-1, in the insulin-like growth factor-1 response |
| Q46153896 | Uncovering emergent interactions in three-way combinations of stressors. |
| Q34674537 | Underexpression of miR-34a in hepatocellular carcinoma and its contribution towards enhancement of proliferating inhibitory effects of agents targeting c-MET |
| Q58698984 | Understanding Synergistic Toxicity of Terpenes as Insecticides: Contribution of Metabolic Detoxification in |
| Q38065010 | Understanding synergy |
| Q58547208 | Unique Photochemo-Immuno-Nanoplatform against Orthotopic Xenograft Oral Cancer and Metastatic Syngeneic Breast Cancer |
| Q42365250 | Unique synergistic formulation of curcumin, epicatechin gallate and resveratrol, tricurin, suppresses HPV E6, eliminates HPV+ cancer cells, and inhibits tumor progression. |
| Q92435732 | Up-regulation of glycolipid transfer protein by bicyclol causes spontaneous restriction of hepatitis C virus replication |
| Q37022420 | Ursolic acid inhibits the growth of human pancreatic cancer and enhances the antitumor potential of gemcitabine in an orthotopic mouse model through suppression of the inflammatory microenvironment |
| Q37165886 | Ursolic acid synergistically enhances the therapeutic effects of oxaliplatin in colorectal cancer |
| Q96576715 | Urupocidin C: a new marine guanidine alkaloid which selectively kills prostate cancer cells via mitochondria targeting |
| Q37813687 | Use of nanoscale delivery systems to maintain synergistic drug ratios in vivo |
| Q37695696 | Using Delaunay triangulation and Voronoi tessellation to predict the toxicities of binary mixtures containing hormetic compound |
| Q40552307 | Using carbapenems for carbapenem-resistant Klebsiella pneumoniae-Are we flogging a dead (work)horse antibiotic? |
| Q34450398 | Utility of a PI3K/mTOR inhibitor (NVP-BEZ235) for thyroid cancer therapy. |
| Q35025521 | Utility of a histone deacetylase inhibitor (PXD101) for thyroid cancer treatment |
| Q47107700 | VS-5584 mediates potent anti-myeloma activity via the upregulation of a class II tumor suppressor gene, RARRES3 and the activation of Bim. |
| Q36094977 | Valproic acid synergistically enhances the cytotoxicity of clofarabine in pediatric acute myeloid leukemia cells |
| Q64974176 | Variable Responses of MYC Translocation Positive Lymphoma Cell Lines To Different Combinations of Novel Agents: Impact of BCL2 Family Protein Expression. |
| Q39132883 | Viability inhibition effect of gambogic acid combined with cisplatin on osteosarcoma cells via mitochondria-independent apoptotic pathway |
| Q37207653 | Viral reservoirs, residual viremia, and the potential of highly active antiretroviral therapy to eradicate HIV infection. |
| Q92081573 | Virucidal activity of ginger essential oil against caprine alphaherpesvirus-1 |
| Q28539539 | Visualization of network target crosstalk optimizes drug synergism in myocardial ischemia |
| Q28542814 | Vitamin C effect on mitoxantrone-induced cytotoxicity in human breast cancer cell lines |
| Q37264298 | Vitamin C increases viral mimicry induced by 5-aza-2'-deoxycytidine |
| Q55004046 | Vitamin C preferentially kills cancer stem cells in hepatocellular carcinoma via SVCT-2. |
| Q34063560 | Voreloxin, a first-in-class anticancer quinolone derivative, acts synergistically with cytarabine in vitro and induces bone marrow aplasia in vivo |
| Q38431434 | Vorinostat and Mithramycin A in combination therapy as an interesting strategy for the treatment of Sézary T lymphoma: a transcriptomic approach |
| Q48119543 | Vorinostat enhances the anticancer effect of oxaliplatin on hepatocellular carcinoma cells. |
| Q39527860 | Vorinostat induced cellular stress disrupts the p38 mitogen activated protein kinase and extracellular signal regulated kinase pathways leading to apoptosis in Waldenström macroglobulinemia cells. |
| Q34587139 | Vorinostat synergizes with ridaforolimus and abrogates the ridaforolimus-induced activation of AKT in synovial sarcoma cells |
| Q35058327 | WIP1 phosphatase as a potential therapeutic target in neuroblastoma |
| Q36244669 | Wee-1 Kinase Inhibition Sensitizes High-Risk HPV+ HNSCC to Apoptosis Accompanied by Downregulation of MCl-1 and XIAP Antiapoptotic Proteins |
| Q36020559 | Wee-1 kinase inhibition overcomes cisplatin resistance associated with high-risk TP53 mutations in head and neck cancer through mitotic arrest followed by senescence |
| Q28485360 | What does it take to synergistically combine sub-potent natural products into drug-level potent combinations? |
| Q26782977 | What is synergy? The Saariselkä agreement revisited |
| Q38466630 | Wnt/β-catenin signaling and AXIN1 regulate apoptosis triggered by inhibition of the mutant kinase BRAFV600E in human melanoma. |
| Q33523404 | XIAP is not required for human tumor cell survival in the absence of an exogenous death signal |
| Q36292020 | XIAP-targeting drugs re-sensitize PIK3CA-mutated colorectal cancer cells for death receptor-induced apoptosis |
| Q37706137 | YAP1 regulates ABCG2 and cancer cell side population in human lung cancer cells |
| Q35666495 | Zinc acetate/carrageenan gels exhibit potent activity in vivo against high-dose herpes simplex virus 2 vaginal and rectal challenge. |
| Q38949883 | Zoledronic acid increases cytotoxicity by inducing apoptosis in hormone and docetaxel-resistant prostate cancer cell lines |
| Q91861733 | [Bortezomib and obatoclax for dual blockade of protein degradation pathways show synergistic anti-tumor effect in human acute T lymphoblastic leukemia cells] |
| Q33643125 | c-Jun N-terminal kinase in synergistic neurite outgrowth in PC12 cells mediated through P90RSK. |
| Q90575286 | d-a-Tocopheryl Polyethylene Glycol 1000 Succinate and a small-molecule Survivin suppressant synergistically induce apoptosis in SKBR3 breast cancer cells |
| Q36962884 | eIF4B is a convergent target and critical effector of oncogenic Pim and PI3K/Akt/mTOR signaling pathways in Abl transformants. |
| Q37492231 | hvTRA, a novel TRAIL receptor agonist, induces apoptosis and sustained growth retardation in melanoma |
| Q36874139 | mTOR Inhibitors Suppress Homologous Recombination Repair and Synergize with PARP Inhibitors via Regulating SUV39H1 in BRCA-Proficient Triple-Negative Breast Cancer |
| Q35809470 | mTORC1 and DNA-PKcs as novel molecular determinants of sensitivity to Chk1 inhibition |
| Q42051478 | miR-129 promotes apoptosis and enhances chemosensitivity to 5-fluorouracil in colorectal cancer |
| Q34653749 | miR-146a inhibits cell growth, cell migration and induces apoptosis in non-small cell lung cancer cells |
| Q89574008 | miR-196b target screen reveals mechanisms maintaining leukemia stemness with therapeutic potential |
| Q92094478 | miR-486-3p mediates hepatocellular carcinoma sorafenib resistance by targeting FGFR4 and EGFR |
| Q34547830 | p53-Reactivating small molecules induce apoptosis and enhance chemotherapeutic cytotoxicity in head and neck squamous cell carcinoma |
| Q39631491 | p53-mediated transcriptional regulation and activation of the actin cytoskeleton regulatory RhoC to LIMK2 signaling pathway promotes cell survival |
| Q41099486 | pH-Responsive Isoniazid-Loaded Nanoparticles Markedly Improve Tuberculosis Treatment in Mice |
| Q39644504 | siRNA Knockdown of Ribonucleotide Reductase Inhibits Melanoma Cell Line Proliferation Alone or Synergistically with Temozolomide |
| Q88978644 | α- Tocopherol succinate loaded nano-structed lipid carriers improves antitumor activity of doxorubicin in breast cancer models in vivo |
| Q47285607 | α-Methylation enhances the potency of isoprenoid triazole bisphosphonates as geranylgeranyl diphosphate synthase inhibitors |
| Q38749027 | γ-Tocotrienol suppresses growth and sensitises human colorectal tumours to capecitabine in a nude mouse xenograft model by down-regulating multiple molecules |
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