Targeting ERK enhances the cytotoxic effect of the novel PI3K and mTOR dual inhibitor VS-5584 in preclinical models of pancreatic cancer

scientific article published on 15 May 2017

Targeting ERK enhances the cytotoxic effect of the novel PI3K and mTOR dual inhibitor VS-5584 in preclinical models of pancreatic cancer is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.18632/ONCOTARGET.17869
P932PMC publication ID5546481
P698PubMed publication ID28574828

P50authorAsfar S AzmiQ37368661
Yubin GeQ61731570
P2093author name stringMin Liang
Shuang Liu
Yang Xia
Guan Wang
Jeffrey W Taub
Holly Edwards
Ramzi M Mohammad
Gregory Dyson
Lijing Zhao
Lisa Polin
Changwen Ning
P2860cites workLong-Term ERK Inhibition in KRAS-Mutant Pancreatic Cancer Is Associated with MYC Degradation and Senescence-like Growth SuppressionQ27853310
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Phosphorylation and functional inactivation of TSC2 by Erk implications for tuberous sclerosis and cancer pathogenesisQ28246808
Random-effects models for longitudinal dataQ28279619
Mechanisms of synergistic antileukemic interactions between valproic acid and cytarabine in pediatric acute myeloid leukemiaQ28385690
Cancer statistics, 2016Q29547383
Improvements in survival and clinical benefit with gemcitabine as first-line therapy for patients with advanced pancreas cancer: a randomized trialQ29547565
mTOR inhibition induces upstream receptor tyrosine kinase signaling and activates AktQ29547767
PI3K pathway alterations in cancer: variations on a themeQ29615530
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Inhibition of mTORC1 leads to MAPK pathway activation through a PI3K-dependent feedback loop in human cancerQ29618030
PI3K and cancer: lessons, challenges and opportunitiesQ30080017
Inhibition of histone deacetylases 1 and 6 enhances cytarabine-induced apoptosis in pediatric acute myeloid leukemia cellsQ33831971
Class I and class II histone deacetylases are potential therapeutic targets for treating pancreatic cancerQ34318452
Suppression of feedback loops mediated by PI3K/mTOR induces multiple overactivation of compensatory pathways: an unintended consequence leading to drug resistanceQ34466060
Different patterns of Akt and ERK feedback activation in response to rapamycin, active-site mTOR inhibitors and metformin in pancreatic cancer cellsQ34600369
Synergistic antitumor interactions between MK-1775 and panobinostat in preclinical models of pancreatic cancerQ34808616
Dual PI3K/mTOR Inhibitors Induce Rapid Overactivation of the MEK/ERK Pathway in Human Pancreatic Cancer Cells through Suppression of mTORC2.Q35374899
Differential gene expression, GATA1 target genes, and the chemotherapy sensitivity of Down syndrome megakaryocytic leukemia.Q35848677
Inhibition of CHK1 enhances cell death induced by the Bcl-2-selective inhibitor ABT-199 in acute myeloid leukemia cellsQ37376388
Roles of the Ras/Raf/MEK/ERK pathway in leukemia therapy.Q37865381
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Targeting RAS-ERK signalling in cancer: promises and challengesQ38272894
Progress in the treatment of metastatic pancreatic cancer and the search for next opportunitiesQ38445723
Improving Prospects for Targeting RAS.Q38586951
MEK1 and MEK2 inhibitors and cancer therapy: the long and winding roadQ38591835
Targeting KRAS for diagnosis, prognosis, and treatment of pancreatic cancer: Hopes and realities.Q38688079
Combination of AZD2281 (Olaparib) and GX15-070 (Obatoclax) results in synergistic antitumor activities in preclinical models of pancreatic cancerQ39023247
Projecting cancer incidence and deaths to 2030: the unexpected burden of thyroid, liver, and pancreas cancers in the United StatesQ39190004
In vivo antitumor activity of MEK and phosphatidylinositol 3-kinase inhibitors in basal-like breast cancer models.Q39830937
GATA1, cytidine deaminase, and the high cure rate of Down syndrome children with acute megakaryocytic leukemia.Q40462682
ERK negatively regulates the epidermal growth factor-mediated interaction of Gab1 and the phosphatidylinositol 3-kinaseQ40744542
PI3K/mTOR dual inhibitor VS-5584 preferentially targets cancer stem cells.Q46229463
Identification of S664 TSC2 phosphorylation as a marker for extracellular signal-regulated kinase mediated mTOR activation in tuberous sclerosis and human cancerQ48087617
Detection of mycoplasma contaminations.Q54702212
P433issue27
P407language of work or nameEnglishQ1860
P921main subjectpancreatic cancerQ212961
P304page(s)44295-44311
P577publication date2017-05-15
P1433published inOncotargetQ1573155
P1476titleTargeting ERK enhances the cytotoxic effect of the novel PI3K and mTOR dual inhibitor VS-5584 in preclinical models of pancreatic cancer
P478volume8

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cites work (P2860)
Q92845161Alkannin represses growth of pancreatic cancer cells based on the down regulation of miR-199a
Q43991475Co-targeting PI3K, mTOR, and IGF1R with small molecule inhibitors for treating undifferentiated pleomorphic sarcoma.
Q91997192Combination Therapy with a PI3K/mTOR Dual Inhibitor and Chloroquine Enhances Synergistic Apoptotic Cell Death in Epstein-Barr Virus-Infected Gastric Cancer Cells
Q91811281Combined inhibition of the PI3K/mTOR/MEK pathway induces Bim/Mcl-1-regulated apoptosis in pancreatic cancer cells
Q57263190Integrative landscape of dysregulated signaling pathways of clinically distinct pancreatic cancer subtypes
Q92978701Machine Learning and Network Analyses Reveal Disease Subtypes of Pancreatic Cancer and their Molecular Characteristics
Q91388651Metabolic gene alterations impact the clinical aggressiveness and drug responses of 32 human cancers
Q52310328PP242 Counteracts Glioblastoma Cell Proliferation, Migration, Invasiveness and Stemness Properties by Inhibiting mTORC2/AKT.
Q89475388Role of oncogenic KRAS in the diagnosis, prognosis and treatment of pancreatic cancer
Q47281250Targeting PI3K, mTOR, ERK, and Bcl-2 signaling network shows superior antileukemic activity against AML ex vivo.

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