| scholarly article | Q13442814 |
| P356 | DOI | 10.1007/S00232-017-0008-5 |
| P698 | PubMed publication ID | 29260282 |
| P50 | author | Lisa M Munter | Q57637372 |
| P2093 | author name string | Sandra Paschkowsky | |
| Felix Oestereich | |||
| P2860 | cites work | Lipid Rafts: Linking Alzheimer's Amyloid-β Production, Aggregation, and Toxicity at Neuronal Membranes | Q41604924 |
| The intramembrane protease SPPL2a promotes B cell development and controls endosomal traffic by cleavage of the invariant chain | Q41881169 | ||
| iRHOM2 is a critical pathogenic mediator of inflammatory arthritis | Q42056708 | ||
| The intramembrane protease Sppl2a is required for B cell and DC development and survival via cleavage of the invariant chain | Q42132797 | ||
| Generation of Alzheimer disease-associated amyloid β42/43 peptide by γ-secretase can be inhibited directly by modulation of membrane thickness | Q42202065 | ||
| Direct and potent regulation of gamma-secretase by its lipid microenvironment | Q42347726 | ||
| Genetic interaction implicates iRhom2 in the regulation of EGF receptor signalling in mice. | Q42615354 | ||
| Influence of hydrophobic mismatch on the catalytic activity of Escherichia coli GlpG rhomboid protease. | Q42659401 | ||
| Inhibition of intracellular cholesterol transport alters presenilin localization and amyloid precursor protein processing in neuronal cells. | Q43906981 | ||
| Statin therapy for Alzheimer's disease: will it work? | Q44125950 | ||
| Increased amyloid- levels in APPSWE transgenic mice treated chronically with a physiological high-fat high-cholesterol diet | Q44243543 | ||
| Reconstitution of gamma-secretase activity | Q44393107 | ||
| Gamma-secretase activity is present in rafts but is not cholesterol-dependent | Q44667739 | ||
| Gamma-secretase: proteasome of the membrane? | Q44918417 | ||
| Immature nicastrin stabilizes APH-1 independent of PEN-2 and presenilin: identification of nicastrin mutants that selectively interact with APH-1. | Q44930736 | ||
| The lipidome associated with the γ-secretase complex is required for its integrity and activity | Q46604869 | ||
| The Mitochondrial Rhomboid Protease PARL Is Regulated by PDK2 to Integrate Mitochondrial Quality Control and Metabolism. | Q47828445 | ||
| The 1985 Nobel Prize in physiology or medicine | Q48411373 | ||
| Cholesterol modulation as an emerging strategy for the treatment of Alzheimer's disease | Q48761995 | ||
| Mutation analyses and association studies to assess the role of the presenilin-associated rhomboid-like gene in Parkinson's disease | Q48972691 | ||
| Regulated intramembrane proteolysis: emergent role in cell signalling pathways | Q50100385 | ||
| Exploring the chemical space of gamma-secretase modulators. | Q51683912 | ||
| gamma-Secretase: successive tripeptide and tetrapeptide release from the transmembrane domain of beta-carboxyl terminal fragment. | Q51776761 | ||
| Potential Link between Amyloid β-Protein 42 and C-terminal Fragment γ 49–99 of β-Amyloid Precursor Protein | Q51837859 | ||
| Neural membrane phospholipids in Alzheimer disease. | Q53213229 | ||
| Crystal structure of a rhomboid family intramembrane protease. | Q54453416 | ||
| The PARLance of Parkinson disease. | Q54598226 | ||
| Peptidomimetic probes and molecular modeling suggest that Alzheimer's gamma-secretase is an intramembrane-cleaving aspartyl protease | Q77314168 | ||
| Ubiquitin-dependent intramembrane rhomboid protease promotes ERAD of membrane proteins | Q24293182 | ||
| Functional alteration of PARL contributes to mitochondrial dysregulation in Parkinson's disease | Q24294218 | ||
| The mitochondrial intramembrane protease PARL cleaves human Pink1 to regulate Pink1 trafficking | Q24297960 | ||
| The α-helical content of the transmembrane domain of the British dementia protein-2 (Bri2) determines its processing by signal peptide peptidase-like 2b (SPPL2b) | Q24300479 | ||
| Association of gamma-secretase with lipid rafts in post-Golgi and endosome membranes | Q24532064 | ||
| Membrane lipids: where they are and how they behave | Q24653084 | ||
| Functional and evolutionary implications of enhanced genomic analysis of rhomboid intramembrane proteases | Q24672054 | ||
| The site-2 protease | Q26851197 | ||
| Protease regulation: the Yin and Yang of neural development and disease | Q27000161 | ||
| Structural basis for intramembrane proteolysis by rhomboid serine proteases | Q27640962 | ||
| The crystal structure of the rhomboid peptidase from Haemophilus influenzae provides insight into intramembrane proteolysis | Q27641079 | ||
| The Amyloid Precursor Protein Has a Flexible Transmembrane Domain and Binds Cholesterol | Q27679405 | ||
| Mechanism of farnesylated CAAX protein processing by the intramembrane protease Rce1 | Q27680718 | ||
| Proteolysis inside the Membrane Is a Rate-Governed Reaction Not Driven by Substrate Affinity | Q27680807 | ||
| Domain swapping in the cytoplasmic domain of the Escherichia coli rhomboid protease | Q27683841 | ||
| Functional rafts in cell membranes | Q27860768 | ||
| Mitochondrial membrane remodelling regulated by a conserved rhomboid protease | Q27935531 | ||
| Rhomboid protease inhibitors: Emerging tools and future therapeutics | Q28070218 | ||
| Regulated intramembrane proteolysis: a control mechanism conserved from bacteria to humans | Q28145545 | ||
| Alzheimer's disease: the cholesterol connection | Q28186482 | ||
| Signal peptidases | Q28217085 | ||
| Assembly, trafficking and function of gamma-secretase | Q28268951 | ||
| Identification of distinct gamma-secretase complexes with different APH-1 variants | Q28274942 | ||
| Mitochondrial membrane potential regulates PINK1 import and proteolytic destabilization by PARL | Q29615624 | ||
| Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and gamma-secretase activity | Q29616491 | ||
| An internal water-retention site in the rhomboid intramembrane protease GlpG ensures catalytic efficiency | Q30535607 | ||
| Control of lipid organization and actin assembly during clathrin-mediated endocytosis by the cytoplasmic tail of the rhomboid protein Rbd2 | Q30638815 | ||
| A family of rhomboid-like genes: Drosophila rhomboid-1 and roughoid/rhomboid-3 cooperate to activate EGF receptor signaling. | Q33334741 | ||
| Identification of Rbd2 as a candidate protease for sterol regulatory element binding protein (SREBP) cleavage in fission yeast. | Q33361873 | ||
| Deregulation of sphingolipid metabolism in Alzheimer's disease | Q33693061 | ||
| Monocyclic β-lactams are selective, mechanism-based inhibitors of rhomboid intramembrane proteases | Q33777125 | ||
| Cleavage by signal peptide peptidase is required for the degradation of selected tail-anchored proteins | Q33797023 | ||
| Differential contribution of the three Aph1 genes to gamma-secretase activity in vivo | Q33810588 | ||
| Reconstitution of intramembrane proteolysis in vitro reveals that pure rhomboid is sufficient for catalysis and specificity | Q33836549 | ||
| Three pools of plasma membrane cholesterol and their relation to cholesterol homeostasis | Q33861421 | ||
| Cell surface presenilin-1 participates in the gamma-secretase-like proteolysis of Notch | Q33883369 | ||
| Presenilin proteins and their function during embryonic development and Alzheimer's disease | Q34003636 | ||
| Roles for dysfunctional sphingolipid metabolism in Alzheimer's disease neuropathogenesis | Q34007818 | ||
| Compartmentalization of beta-secretase (Asp2) into low-buoyant density, noncaveolar lipid rafts | Q34088442 | ||
| Sequence-specific intramembrane proteolysis: identification of a recognition motif in rhomboid substrates | Q34092101 | ||
| A cholesterol-lowering drug reduces beta-amyloid pathology in a transgenic mouse model of Alzheimer's disease | Q34094305 | ||
| Drosophila rhomboid-1 defines a family of putative intramembrane serine proteases | Q34098885 | ||
| Tumor necrosis factor signaling requires iRhom2 to promote trafficking and activation of TACE | Q34247194 | ||
| iRhom2 regulation of TACE controls TNF-mediated protection against Listeria and responses to LPS | Q34247201 | ||
| Structure, mechanism and inhibition of gamma-secretase and presenilin-like proteases | Q34382868 | ||
| Characterization of intermediate steps in amyloid beta (Aβ) production under near-native conditions | Q34384785 | ||
| The mitochondrial rhomboid protease PSARL is a new candidate gene for type 2 diabetes | Q34397407 | ||
| Substrate binding and specificity of rhomboid intramembrane protease revealed by substrate-peptide complex structures | Q34438267 | ||
| Structural analysis of a rhomboid family intramembrane protease reveals a gating mechanism for substrate entry | Q34581109 | ||
| Cholesterol depletion inhibits the generation of beta-amyloid in hippocampal neurons | Q34663462 | ||
| Central nervous system: cholesterol turnover, brain development and neurodegeneration | Q34732190 | ||
| Shedding of glycan-modifying enzymes by signal peptide peptidase-like 3 (SPPL3) regulates cellular N-glycosylation | Q34807554 | ||
| Alzheimer disease gamma-secretase: a complex story of GxGD-type presenilin proteases | Q35032054 | ||
| A subset of membrane-altering agents and γ-secretase modulators provoke nonsubstrate cleavage by rhomboid proteases | Q35054154 | ||
| Membrane organization and lipid rafts | Q35230032 | ||
| The role of cholesterol and statins in Alzheimer's disease | Q35638053 | ||
| γ-Secretase directly sheds the survival receptor BCMA from plasma cells | Q35814239 | ||
| Cholestenoic acid, an endogenous cholesterol metabolite, is a potent γ-secretase modulator. | Q35848336 | ||
| Mitochondrial processing peptidase regulates PINK1 processing, import and Parkin recruitment | Q35874914 | ||
| A fluid connection: cholesterol and Abeta | Q35906228 | ||
| Effects of membrane lipids on the activity and processivity of purified γ-secretase | Q35944806 | ||
| Substrate determinants of signal peptide peptidase-like 2a (SPPL2a)-mediated intramembrane proteolysis of the invariant chain CD74. | Q35961531 | ||
| Identification and Characterization of a Novel Aspergillus fumigatus Rhomboid Family Putative Protease, RbdA, Involved in Hypoxia Sensing and Virulence. | Q35986516 | ||
| Latest emerging functions of SPP/SPPL intramembrane proteases | Q36331190 | ||
| Membrane immersion allows rhomboid proteases to achieve specificity by reading transmembrane segment dynamics. | Q36386421 | ||
| B cell survival, surface BCR and BAFFR expression, CD74 metabolism, and CD8- dendritic cells require the intramembrane endopeptidase SPPL2A. | Q36547677 | ||
| Phospholipids and Alzheimer's disease: alterations, mechanisms and potential biomarkers | Q36590043 | ||
| RbdB, a Rhomboid Protease Critical for SREBP Activation and Virulence in Aspergillus fumigatus | Q36891197 | ||
| Structural studies of the transmembrane C-terminal domain of the amyloid precursor protein (APP): does APP function as a cholesterol sensor? | Q36948254 | ||
| Steroids as γ-secretase modulators | Q37118735 | ||
| Alterations in cerebrospinal fluid glycerophospholipids and phospholipase A2 activity in Alzheimer's disease. | Q37163086 | ||
| Rhomboid protease dynamics and lipid interactions | Q37186369 | ||
| Cholesterol retention in Alzheimer's brain is responsible for high beta- and gamma-secretase activities and Abeta production | Q37288781 | ||
| Signature amyloid β profiles are produced by different γ-secretase complexes | Q37583567 | ||
| Regulated intramembrane proteolysis--lessons from amyloid precursor protein processing | Q37854085 | ||
| Stressed out about obesity: IRE1α-XBP1 in metabolic disorders | Q37894253 | ||
| Sphingolipids: critical players in Alzheimer's disease | Q38029867 | ||
| Emerging role of rhomboid family proteins in mammalian biology and disease | Q38096675 | ||
| Learning by failing: ideas and concepts to tackle γ-secretases in Alzheimer's disease and beyond | Q38257864 | ||
| Understanding intramembrane proteolysis: from protein dynamics to reaction kinetics | Q38459056 | ||
| Lipid composition influences the release of Alzheimer's amyloid β-peptide from membranes. | Q38666447 | ||
| Rhomboid proteases in human disease: Mechanisms and future prospects. | Q38688867 | ||
| Protein prenylation: unique fats make their mark on biology | Q38704283 | ||
| Alternative Processing of the Amyloid Precursor Protein Family by Rhomboid Protease RHBDL4. | Q38749991 | ||
| Intramembrane proteases as drug targets | Q38790377 | ||
| Notch Antagonists: Potential Modulators of Cancer and Inflammatory Diseases. | Q38798513 | ||
| Signal peptide peptidase-mediated nuclear localization of heme oxygenase-1 promotes cancer cell proliferation and invasion independent of its enzymatic activity | Q38984568 | ||
| New role of signal peptide peptidase to liberate C-terminal peptides for MHC class I presentation | Q39094244 | ||
| Substitution of membrane cholesterol with β-sitosterol promotes nonamyloidogenic cleavage of endogenous amyloid precursor protein | Q39147498 | ||
| Signal peptide peptidase and SPP-like proteases - Possible therapeutic targets? | Q39380083 | ||
| Cryo-EM structures of human γ-secretase | Q39383228 | ||
| Trans fatty acids enhance amyloidogenic processing of the Alzheimer amyloid precursor protein (APP). | Q39419718 | ||
| Docosahexaenoic acid reduces amyloid beta production via multiple pleiotropic mechanisms | Q39591498 | ||
| In vivo analysis reveals substrate-gating mutants of a rhomboid intramembrane protease display increased activity in living cells | Q39861099 | ||
| Active gamma-secretase is localized to detergent-resistant membranes in human brain | Q40014328 | ||
| A Golgi rhomboid protease Rbd2 recruits Cdc48 to cleave yeast SREBP. | Q40407039 | ||
| SnapShot: Cartography of Intramembrane Proteolysis | Q40429007 | ||
| Association of active gamma-secretase complex with lipid rafts. | Q40457156 | ||
| P577 | publication date | 2017-12-19 | |
| P1433 | published in | Journal of Membrane Biology | Q6295550 |
| P1476 | title | Embedded in the Membrane: How Lipids Confer Activity and Specificity to Intramembrane Proteases |
| Q89357217 | Lipid Membranes and Reactions at Lipid Interfaces: Theory, Experiments, and Applications |
| Q92192134 | Lipid class composition of membrane and raft fractions from brains of individuals with Alzheimer's disease |
| Q57021974 | Membrane cholesterol as regulator of human rhomboid protease RHBDL4 |
| Q57818227 | Single-Molecule Analyses Reveal Rhomboid Proteins Are Strict and Functional Monomers in the Membrane |
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