"Inverse Drug Discovery" Strategy To Identify Proteins That Are Targeted by Latent Electrophiles As Exemplified by Aryl Fluorosulfates

scientific article published on 21 December 2017

"Inverse Drug Discovery" Strategy To Identify Proteins That Are Targeted by Latent Electrophiles As Exemplified by Aryl Fluorosulfates is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1021/JACS.7B08366
P932PMC publication ID5762408
P698PubMed publication ID29265822

P50authorIan Andrew WilsonQ5983280
Jeffery W. KellyQ6175781
Karl Barry SharplessQ110925
Benjamin CravattQ4888433
Stefano ForliQ63385497
Hua WangQ63385706
Lars PlateQ42410251
P2093author name stringDavid E Mortenson
Suhua Li
Evan T Powers
Wentao Chen
Gabriel J Brighty
Grant Bare
P2860cites workThe Protein Data BankQ24515306
Comparison of apo- and heme-bound crystal structures of a truncated human heme oxygenase-2Q24621015
Modulation of intracellular ROS levels by TIGAR controls autophagyQ24644257
Mechanism of Action and Clinical Application of Tafamidis in Hereditary Transthyretin AmyloidosisQ26764754
Identification, characterization, and crystal structure of the Omega class glutathione transferasesQ27622324
Rational design of an organometallic glutathione transferase inhibitorQ27655297
On Terminal Alkynes That Can React with Active-Site Cysteine Nucleophiles in ProteasesQ27676208
The structures of human glutathione transferase P1-1 in complex with glutathione and various inhibitors at high resolutionQ27748324
Profiling the specific reactivity of the proteome with non-directed activity-based probesQ28200208
A stepwise huisgen cycloaddition process: copper(I)-catalyzed regioselective "ligation" of azides and terminal alkynesQ28219495
Structure-function relationships of cellular retinoic acid-binding proteins. Quantitative analysis of the ligand binding properties of the wild-type proteins and site-directed mutantsQ28301476
Chemical Proteomic Profiling of Human MethyltransferasesQ28821490
Proteome-wide covalent ligand discovery in native biological systemsQ28829116
Potent and selective inhibitors of glutathione S-transferase omega 1 that impair cancer drug resistanceQ31030253
Proteomic profiling of mechanistically distinct enzyme classes using a common chemotypeQ31090816
Substrate profiling of cysteine proteases using a combinatorial peptide library identifies functionally unique specificitiesQ33235638
Fatty acid-binding proteins: role in metabolic diseases and potential as drug targetsQ33649348
The resurgence of covalent drugsQ34174891
The role of glutathione-S-transferase in anti-cancer drug resistanceQ34272162
Tp53-induced glycolysis and apoptosis regulator (TIGAR) protects glioma cells from starvation-induced cell death by up-regulating respiration and improving cellular redox homeostasisQ34293667
The retinoic acid binding protein CRABP2 is increased in murine models of degenerative joint diseaseQ43120812
Bioconjugation by copper(I)-catalyzed azide-alkyne [3 + 2] cycloadditionQ44358246
Activity-based protein profiling in vivo using a copper(i)-catalyzed azide-alkyne [3 + 2] cycloadditionQ44404296
Expression of nm23‐H1 is associated with poor prognosis in peripheral T‐cell lymphomaQ44655400
Sulfur(VI) fluoride exchange (SuFEx): another good reaction for click chemistry.Q46005837
On the nature of organic catalysis "on water".Q46333766
Chemical proteomics with sulfonyl fluoride probes reveals selective labeling of functional tyrosines in glutathione transferasesQ46771140
Covalent Enzyme Inhibition through Fluorosulfate Modification of a Noncatalytic Serine ResidueQ48109970
Competition-based, quantitative chemical proteomics in breast cancer cells identifies new target profiles for sulforaphaneQ48237312
Beta-lactams as selective chemical probes for the in vivo labeling of bacterial enzymes involved in cell wall biosynthesis, antibiotic resistance, and virulence.Q50777469
Selective Inhibitors of Glutathione Transferase P1 with Trioxane Structure as Anticancer AgentsQ59613491
Efficient and highly selective covalent labeling of the estrogen receptor with [3H]tamoxifen aziridineQ71687809
Serum nm23-H1 protein as a prognostic factor in aggressive non-Hodgkin lymphomaQ73549780
Nm23-h1 indirectly promotes the survival of acute myeloid leukemia blast cells by binding to more mature components of the leukemic cloneQ82948471
Sulfonyl fluoride analogues as activity-based probes for serine proteasesQ87371817
Ibrutinib (PCI-32765), the first BTK (Bruton's tyrosine kinase) inhibitor in clinical trialsQ34321304
Extreme electric fields power catalysis in the active site of ketosteroid isomeraseQ34454777
"On water": unique reactivity of organic compounds in aqueous suspensionQ34556981
Structural basis of perturbed pKa values of catalytic groups in enzyme active sitesQ34670783
Relative quantification of proteins in human cerebrospinal fluids by MS/MS using 6-plex isobaric tagsQ34756963
MS3 eliminates ratio distortion in isobaric multiplexed quantitative proteomicsQ35491186
Chemical strategies for activity-based proteomicsQ35616321
Selective N-Hydroxyhydantoin Carbamate Inhibitors of Mammalian Serine HydrolasesQ35676731
A fluorogenic aryl fluorosulfate for intraorganellar transthyretin imaging in living cells and in Caenorhabditis elegansQ35756357
Catalysis of DNA cleavage and nucleoside triphosphate synthesis by NM23-H2/NDP kinase share an active site that implies a DNA repair functionQ35838174
Blockade of extracellular NM23 or its endothelial target slows breast cancer growth and metastasis.Q36086478
Chemoproteomic profiling of host and pathogen enzymes active in choleraQ36614194
Activity-based protein profiling: the serine hydrolasesQ36773877
N(6)-Methyladenosine: a conformational marker that regulates the substrate specificity of human demethylases FTO and ALKBH5.Q36881797
Evaluation of serum nucleoside diphosphate kinase A for the detection of colorectal cancerQ36934087
Retinoic acid in the development, regeneration and maintenance of the nervous systemQ36946560
Arylfluorosulfates Inactivate Intracellular Lipid Binding Protein(s) through Chemoselective SuFEx Reaction with a Binding Site Tyr ResidueQ37008862
A coupled protein and probe engineering approach for selective inhibition and activity-based probe labeling of the caspasesQ37043619
Purinergic regulation of vascular endothelial growth factor signaling in angiogenesisQ37222633
Proteome-wide reactivity profiling identifies diverse carbamate chemotypes tuned for serine hydrolase inhibitionQ37251595
Mechanistic evaluation and transcriptional signature of a glutathione S-transferase omega 1 inhibitorQ37329941
Design of Selective Substrates and Activity-Based Probes for Hydrolase Important for Pathogenesis 1 (HIP1) from Mycobacterium tuberculosis.Q37414141
A chemoproteomic platform to quantitatively map targets of lipid-derived electrophilesQ37513287
Targeted covalent drugs of the kinase familyQ37770660
Current developments in activity-based protein profilingQ38221616
The case for extracellular Nm23-H1 as a driver of acute myeloid leukaemia (AML) progression.Q38239598
Covalent protein modification: the current landscape of residue-specific electrophilesQ38280788
Covalent inhibitors in drug discovery: from accidental discoveries to avoided liabilities and designed therapiesQ38499073
Lentivirus-mediated silencing of HSDL2 suppresses cell proliferation in human gliomasQ38818624
Broad-Spectrum Kinase Profiling in Live Cells with Lysine-Targeted Sulfonyl Fluoride Probes.Q39041277
Investigating the proteome reactivity and selectivity of aryl halidesQ39248781
Selective Covalent Protein Modification by 4-Halopyridines through Catalysis.Q40226850
Serum nm23-H1 protein as a prognostic factor in hematological malignanciesQ40713872
A tyrosine-reactive irreversible inhibitor for glutathione S-transferase Pi (GSTP1).Q41859046
P433issue1
P407language of work or nameEnglishQ1860
P921main subjectdrug discoveryQ1418791
P304page(s)200-210
P577publication date2017-12-21
P1433published inJournal of the American Chemical SocietyQ898902
P1476title"Inverse Drug Discovery" Strategy To Identify Proteins That Are Targeted by Latent Electrophiles As Exemplified by Aryl Fluorosulfates
P478volume140

Reverse relations

cites work (P2860)
Q92757150A rapid access to aliphatic sulfonyl fluorides
Q90665895Activity-Based Sensing: A Synthetic Methods Approach for Selective Molecular Imaging and Beyond
Q90254510Aryl-fluorosulfate-based Lysine Covalent Pan-Inhibitors of Apoptosis Protein (IAP) Antagonists with Cellular Efficacy
Q64968466Arylfluorosulfate-Based Electrophiles for Covalent Protein Labeling: A New Addition to the Arsenal.
Q93178340Biocompatible SuFEx Click Chemistry: Thionyl Tetrafluoride (SOF4 )-Derived Connective Hubs for Bioconjugation to DNA and Proteins
Q83232453Ceapins block the unfolded protein response sensor ATF6α by inducing a neomorphic inter-organelle tether
Q90402827Emerging Utility of Fluorosulfate Chemical Probes
Q52619354Genetically Encoding Fluorosulfate-l-tyrosine To React with Lysine, Histidine, and Tyrosine via SuFEx in Proteins in Vivo.
Q91452567Global targeting of functional tyrosines using sulfur-triazole exchange chemistry
Q92997375Installation of -SO2F groups onto primary amides
Q56530196Pharmacologic ATF6 activating compounds are metabolically activated to selectively modify endoplasmic reticulum proteins
Q99728291Protein targeting with SAF(er) electrophiles
Q90371179Small-molecule covalent bond formation at tyrosine creates a binding site and inhibits activation of Ral GTPases
Q98459819Stability and cell permeability of sulfonyl fluorides in the design  of Lys-covalent antagonists of protein-protein interactions
Q93105246SuFEx-enabled, agnostic discovery of covalent inhibitors of human neutrophil elastase
Q64027818Sulfonyl Fluorides (SFs): More Than Click Reagents?
Q99637234Using sulfuramidimidoyl fluorides that undergo sulfur(VI) fluoride exchange for inverse drug discovery

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