Regulatory T cells constrain the TCR repertoire of antigen-stimulated conventional CD4 T cells

scientific article published on 20 December 2017

Regulatory T cells constrain the TCR repertoire of antigen-stimulated conventional CD4 T cells is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.15252/EMBJ.201796881
P932PMC publication ID5793804
P698PubMed publication ID29263148

P50authorOberdan LeoQ95947194
Muriel MoserQ106196377
Isabel VogelQ57561216
P2093author name stringGeorge Kassiotis
Christine Decaestecker
Adrien Galuppo
Martina Fontaine
Yousra Ajouaou
Yves-Rémi Van Eycke
P2860cites workClonally diverse CTL response to a dominant viral epitope recognizes potential epitope variantsQ74844467
Lower Affinity T Cells are Critical Components and Active Participants of the Immune ResponseQ26781296
Regulation of immune reactivity by intercellular transferQ26851618
The role of naive T cell precursor frequency and recruitment in dictating immune response magnitudeQ26998750
How TCRs bind MHCs, peptides, and coreceptorsQ29619572
T-cell antigen receptor genes and T-cell recognitionQ29619721
T cell exhaustionQ29620463
Regulatory T cells prevent catastrophic autoimmunity throughout the lifespan of miceQ29622850
Estimating the diversity, completeness, and cross-reactivity of the T cell repertoireQ33357547
CTLA4 blockade broadens the peripheral T-cell receptor repertoireQ33560753
Implication of gammadelta T cells in the human immune response to cytomegalovirusQ33854964
A direct estimate of the human alphabeta T cell receptor diversityQ33878476
T-cell-receptor-dependent signal intensity dominantly controls CD4(+) T cell polarization In VivoQ33964858
An estimation of the number of cells in the human bodyQ34037445
Revisiting thymic positive selection and the mature T cell repertoire for antigenQ34125011
Regulation of antigen receptor gene assembly in lymphocytesQ34303115
The Galaxy platform for accessible, reproducible and collaborative biomedical analyses: 2016 updateQ34524689
Narrowed TCR repertoire and viral escape as a consequence of heterologous immunityQ34537506
The TCR's sensitivity to self peptide-MHC dictates the ability of naive CD8(+) T cells to respond to foreign antigensQ34734561
Overlap and Effective Size of the Human CD8 + T Cell Receptor RepertoireQ35539339
The many important facets of T-cell repertoire diversityQ35709655
Thymus-derived regulatory T cells restrain pro-inflammatory Th1 responses by downregulating CD70 on dendritic cellsQ35819655
Improved survival with T cell clonotype stability after anti-CTLA-4 treatment in cancer patientsQ36020800
Statistical inference of the generation probability of T-cell receptors from sequence repertoiresQ36342895
CD4+ CD25+ regulatory T cells control T helper cell type 1 responses to foreign antigens induced by mature dendritic cells in vivoQ36371316
Most alpha/beta T cell receptor diversity is due to terminal deoxynucleotidyl transferaseQ36376375
Naive CD4(+) T cell frequency varies for different epitopes and predicts repertoire diversity and response magnitude.Q36383089
Multiplicity of virus-encoded helper T-cell epitopes expressed on FBL-3 tumor cellsQ36650857
T cell receptor αβ diversity inversely correlates with pathogen-specific antibody levels in human cytomegalovirus infectionQ36672239
Retrovirus-specificity of regulatory T cells is neither present nor required in preventing retrovirus-induced bone marrow immune pathologyQ37074537
IMGT/HighV QUEST paradigm for T cell receptor IMGT clonotype diversity and next generation repertoire immunoprofilingQ37187165
T cell-positive selection uses self-ligand binding strength to optimize repertoire recognition of foreign antigensQ37202148
The function of follicular helper T cells is regulated by the strength of T cell antigen receptor bindingQ37266009
Intrinsic CD4+ T cell sensitivity and response to a pathogen are set and sustained by avidity for thymic and peripheral complexes of self peptide and MHC.Q37620444
TCR signal quantity and quality in CD4(+) T cell differentiation.Q38279985
Mechanisms of Surveillance of Dendritic Cells by Regulatory T LymphocytesQ38651640
The Contained Self-Reactive Peripheral T Cell Repertoire: Size, Diversity, and Cellular CompositionQ38850915
Direct measurement of T cell receptor affinity and sequence from naïve antiviral T cellsQ39978090
Suppression of lethal autoimmunity by regulatory T cells with a single TCR specificityQ40355426
The outline structure of the T-cell alpha beta receptor.Q41094902
Mice lacking terminal deoxynucleotidyl transferase: adult mice with a fetal antigen receptor repertoireQ41126132
Cutting edge: lack of high affinity competition for peptide in polyclonal CD4+ responses unmasks IL-4 productionQ41862779
Adjuvant effect of diphtheria toxin after mucosal administration in both wild type and diphtheria toxin receptor engineered mouse strainsQ41991355
Peptide dose, affinity, and time of differentiation can contribute to the Th1/Th2 cytokine balance.Q42058318
Anti-CTLA-4 therapy broadens the melanoma-reactive CD8+ T cell response.Q42186944
Why must T cells be cross-reactive?Q44666822
Size estimate of the alpha beta TCR repertoire of naive mouse splenocytesQ47238652
Regulatory T cells increase the avidity of primary CD8+ T cell responses and promote memory.Q50930669
A Shannon entropy analysis of immunoglobulin and T cell receptor.Q52901409
The major histocompatibility complex-restricted antigen receptor on T cells in mouse and man: Identification of constant and variable peptidesQ56889076
T Cell Receptor Recognition Motifs Govern Immune Escape Patterns in Acute SIV InfectionQ57075654
Efficient immune responses in mice lacking N-region diversityQ63952511
P433issue3
P407language of work or nameEnglishQ1860
P921main subjectTCR repertoireQ106577188
P304page(s)398-412
P577publication date2017-12-20
P1433published inThe EMBO JournalQ1278554
P1476titleRegulatory T cells constrain the TCR repertoire of antigen-stimulated conventional CD4 T cells
P478volume37

Reverse relations

cites work (P2860)
Q90950138Dormant pathogenic CD4+ T cells are prevalent in the peripheral repertoire of healthy mice
Q64123898FUS(1-359) transgenic mice as a model of ALS: pathophysiological and molecular aspects of the proteinopathy
Q92005460Friend retrovirus studies reveal complex interactions between intrinsic, innate and adaptive immunity
Q88489714The opposing roles of CD4+ T cells in anti-tumour immunity