| Q24627296 | (-)-Epigallocatechin gallate, a major constituent of green tea, poisons human type II topoisomerases |
| Q36740126 | 3D visualization software to analyze topological outcomes of topoisomerase reactions |
| Q54548355 | A GyrB-GyrA fusion protein expressed in yeast cells is able to remove DNA supercoils but cannot substitute eukaryotic topoisomerase II. |
| Q44541814 | A dual mechanism of action of the anticancer agent F 11782 on human topoisomerase II alpha |
| Q24675025 | A model for the mechanism of strand passage by DNA gyrase |
| Q30448695 | A mutation in Escherichia coli DNA gyrase conferring quinolone resistance results in sensitivity to drugs targeting eukaryotic topoisomerase II |
| Q38343316 | A mutation in human topoisomerase II alpha whose expression is lethal in DNA repair-deficient yeast cells |
| Q54486067 | A superhelical spiral in the Escherichia coli DNA gyrase A C-terminal domain imparts unidirectional supercoiling bias. |
| Q38359958 | A two-drug model for etoposide action against human topoisomerase IIalpha |
| Q43890632 | ATPase domain of eukaryotic DNA topoisomerase II. Inhibition of ATPase activity by the anti-cancer drug bisdioxopiperazine and ATP/ADP-induced dimerization |
| Q36839647 | Ability of viral topoisomerase II to discern the handedness of supercoiled DNA: bimodal recognition of DNA geometry by type II enzymes |
| Q37108432 | Analysis of the eukaryotic topoisomerase II DNA gate: a single-molecule FRET and structural perspective |
| Q28486816 | Application of a novel microtitre plate-based assay for the discovery of new inhibitors of DNA gyrase and DNA topoisomerase VI |
| Q38295973 | Base excision repair intermediates as topoisomerase II poisons |
| Q37069535 | Bimodal recognition of DNA geometry by human topoisomerase II alpha: preferential relaxation of positively supercoiled DNA requires elements in the C-terminal domain |
| Q24627367 | Bioflavonoids as poisons of human topoisomerase II alpha and II beta |
| Q27303056 | Breakage-reunion domain of Streptococcus pneumoniae topoisomerase IV: crystal structure of a gram-positive quinolone target |
| Q78037760 | Catalysis of ATP hydrolysis by two NH(2)-terminal fragments of yeast DNA topoisomerase II |
| Q22121990 | Cellular roles of dna topoisomerases: a molecular perspective |
| Q24307037 | Characterization of magnesium requirement of human 5'-tyrosyl DNA phosphodiesterase mediated reaction |
| Q42007501 | Chromatin regulates DNA torsional energy via topoisomerase II-mediated relaxation of positive supercoils |
| Q30539075 | Comparison of DNA decatenation by Escherichia coli topoisomerase IV and topoisomerase III: implications for non-equilibrium topology simplification |
| Q34187632 | Computational analysis of DNA gyrase action |
| Q74343232 | Computational analysis of the chiral action of type II DNA topoisomerases |
| Q34134771 | Control of the flow properties of DNA by topoisomerase II and its targeting inhibitor. |
| Q36719248 | Coupling between ATP binding and DNA cleavage by DNA topoisomerase II: A unifying kinetic and structural mechanism. |
| Q38091483 | Crossing-sign discrimination and knot-reduction for a lattice model of strand passage |
| Q40442144 | Crystallization and initial crystallographic analysis of covalent DNA-cleavage complexes of Staphyloccocus aureus DNA gyrase with QPT-1, moxifloxacin and etoposide |
| Q41853001 | Crystallization and preliminary X-ray diffraction analysis of two N-terminal fragments of the DNA-cleavage domain of topoisomerase IV from Staphylococcus aureus |
| Q37098901 | DNA Topology and Topoisomerases: Teaching a "Knotty" Subject |
| Q41962734 | DNA gyrase with a single catalytic tyrosine can catalyze DNA supercoiling by a nicking-closing mechanism |
| Q49621361 | DNA knots occur in intracellular chromatin. |
| Q33753277 | DNA supercoiling helps to unlink sister duplexes after replication |
| Q37313703 | DNA topoisomerase II and its growing repertoire of biological functions. |
| Q34718447 | DNA topoisomerase II as a target for cancer chemotherapy. |
| Q27437620 | DNA topoisomerase II modulates insulator function in Drosophila |
| Q36903197 | DNA topoisomerase II, genotoxicity, and cancer |
| Q43696114 | DNA topoisomerase VI generates ATP-dependent double-strand breaks with two-nucleotide overhangs |
| Q39320242 | DNA topoisomerase-targeting chemotherapeutics: what's new? |
| Q37255381 | DNA topoisomerases: harnessing and constraining energy to govern chromosome topology |
| Q30886598 | DNA-AP sites generation by etoposide in whole blood cells. |
| Q35180865 | DNA-induced narrowing of the gyrase N-gate coordinates T-segment capture and strand passage |
| Q35074614 | Development of a novel assay for human tyrosyl DNA phosphodiesterase 2 |
| Q24642324 | Dietary polyphenols as topoisomerase II poisons: B ring and C ring substituents determine the mechanism of enzyme-mediated DNA cleavage enhancement |
| Q27304824 | Direct observation of strand passage by DNA-topoisomerase and its limited processivity |
| Q41894707 | Dissection of the bacteriophage Mu strong gyrase site (SGS): significance of the SGS right arm in Mu biology and DNA gyrase mechanism |
| Q34142238 | Dual targeting of DNA gyrase and topoisomerase IV: target interactions of garenoxacin (BMS-284756, T-3811ME), a new desfluoroquinolone |
| Q45761550 | Enzymes that keep DNA under control: Meeting: DNA enzymes: structures and mechanisms |
| Q42814349 | Evidence for repressional role of an inverted CCAAT box in cell cycle-dependent transcription of the human DNA topoisomerase IIalpha gene |
| Q40663211 | Evidence from studies with intact mammalian cells that merbarone and bis(dioxopiperazine)s are topoisomerase II poisons |
| Q99634120 | FAM122A maintains DNA stability possibly through the regulation of topoisomerase IIα expression |
| Q39922598 | Functional dissection of the C-terminal domain of type II DNA topoisomerase from the kinetoplastid hemoflagellate Leishmania donovani |
| Q24809586 | Genomic transcriptional response to loss of chromosomal supercoiling in Escherichia coli |
| Q24674283 | Glutamate racemase from Mycobacterium tuberculosis inhibits DNA gyrase by affecting its DNA-binding |
| Q42724331 | GyrI: a counter-defensive strategy against proteinaceous inhibitors of DNA gyrase |
| Q64389460 | Gyrase containing a single C-terminal domain catalyzes negative supercoiling of DNA by decreasing the linking number in steps of two |
| Q27646509 | Holoenzyme assembly and ATP-mediated conformational dynamics of topoisomerase VI |
| Q41859520 | Hot-spot consensus of fluoroquinolone-mediated DNA cleavage by Gram-negative and Gram-positive type II DNA topoisomerases |
| Q44014803 | Human small cell lung cancer NYH cells resistant to the bisdioxopiperazine ICRF-187 exhibit a functional dominant Tyr165Ser mutation in the Walker A ATP binding site of topoisomerase II alpha. |
| Q38288542 | Human topoisomerase IIalpha possesses an intrinsic nucleic acid specificity for DNA ligation. Use of 5' covalently activated oligonucleotide substrates to study enzyme mechanism |
| Q46724322 | Human topoisomerase IIalpha rapidly relaxes positively supercoiled DNA: implications for enzyme action ahead of replication forks |
| Q36859298 | Human topoisomerase IIalpha uses a two-metal-ion mechanism for DNA cleavage |
| Q51616635 | ICRF-193, an anticancer topoisomerase II inhibitor, induces arched telophase spindles that snap, leading to a ploidy increase in fission yeast. |
| Q37184017 | Impact of the C-terminal domain of topoisomerase IIalpha on the DNA cleavage activity of the human enzyme |
| Q30453068 | Importance of the fourth alpha-helix within the CAP homology domain of type II topoisomerase for DNA cleavage site recognition and quinolone action |
| Q44542029 | Inhibition of DNA topoisomerases I and II, and growth inhibition of human cancer cell lines by a marine microalgal polysaccharide |
| Q33556397 | Interaction of the plasmid-encoded quinolone resistance protein Qnr with Escherichia coli DNA gyrase |
| Q40314755 | Interdomain communication in DNA topoisomerase II. DNA binding and enzyme activation. |
| Q42114704 | Isolation and characterization of mAMSA-hypersensitive mutants. Cytotoxicity of Top2 covalent complexes containing DNA single strand breaks |
| Q73212873 | Isoleucine 10 is essential for DNA gyrase B function in Escherichia coli |
| Q38329009 | Kinetic and thermodynamic analysis of mutant type II DNA topoisomerases that cannot covalently cleave DNA. |
| Q60948772 | Kinetic pathways of topology simplification by Type-II topoisomerases in knotted supercoiled DNA |
| Q73771194 | Kinetic proofreading can explain the supression of supercoiling of circular DNA molecules by type-II topoisomerases |
| Q40354649 | Leptosins isolated from marine fungus Leptoshaeria species inhibit DNA topoisomerases I and/or II and induce apoptosis by inactivation of Akt/protein kinase B. |
| Q45045135 | Linking topology of tethered polymer rings with applications to chromosome segregation and estimation of the knotting length |
| Q58057075 | Mechanism of action of and resistance to quinolones |
| Q34695074 | Mechanism of topology simplification by type II DNA topoisomerases |
| Q30486957 | Mechanisms of chiral discrimination by topoisomerase IV |
| Q24791392 | Mms22p protects Saccharomyces cerevisiae from DNA damage induced by topoisomerase II |
| Q30042495 | Molecular cloning of apicoplast-targeted Plasmodium falciparum DNA gyrase genes: unique intrinsic ATPase activity and ATP-independent dimerization of PfGyrB subunit |
| Q46492608 | Multiple modes of Escherichia coli DNA gyrase activity revealed by force and torque |
| Q33944673 | Mutation of cysteine residue 455 to alanine in human topoisomerase IIalpha confers hypersensitivity to quinones: enhancing DNA scission by closing the N-terminal protein gate |
| Q36619820 | Mycobacterium fluoroquinolone resistance protein B, a novel small GTPase, is involved in the regulation of DNA gyrase and drug resistance |
| Q45265133 | N-terminal region of the large subunit of Leishmania donovani bisubunit topoisomerase I is involved in DNA relaxation and interaction with the smaller subunit |
| Q45230495 | Novel symmetric and asymmetric DNA scission determinants for Streptococcus pneumoniae topoisomerase IV and gyrase are clustered at the DNA breakage site. |
| Q46650258 | Nucleotide-dependent domain movement in the ATPase domain of a human type IIA DNA topoisomerase. |
| Q36389184 | PARP inhibition potentiates the cytotoxic activity of C-1305, a selective inhibitor of topoisomerase II, in human BRCA1-positive breast cancer cells |
| Q28210906 | Phylogenomics of type II DNA topoisomerases |
| Q36492418 | Polyomavirus-associated nephropathy: update on antiviral strategies |
| Q38300639 | Positioning the 3'-DNA terminus for topoisomerase II-mediated religation |
| Q40445428 | Preferential relaxation of positively supercoiled DNA by E. coli topoisomerase IV in single-molecule and ensemble measurements. |
| Q36332400 | Protein footprinting at cysteines: probing ATP-modulated contacts in cysteine-substitution mutants of yeast DNA topoisomerase II. |
| Q38357316 | Quinolone-DNA interaction: sequence-dependent binding to single-stranded DNA reflects the interaction within the gyrase-DNA complex |
| Q33957966 | Quinone-induced enhancement of DNA cleavage by human topoisomerase IIalpha: adduction of cysteine residues 392 and 405. |
| Q42154507 | Radicicol confers mid-schizont arrest by inhibiting mitochondrial replication in Plasmodium falciparum |
| Q43829848 | Regulation of heat shock protein 90 ATPase activity by sequences in the carboxyl terminus |
| Q39469210 | Repositioning of Endonuclear Receptors Binders as Potential Antibacterial and Antifungal Agents. Eptyloxìm: A Potential and Novel Gyrase B and Cytochrome Cyp51 Inhibitor. |
| Q28534955 | Role of minor groove width and hydration pattern on amsacrine interaction with DNA |
| Q37207512 | SUMO modification of DNA topoisomerase II: trying to get a CENse of it all |
| Q42757723 | Scaling of Linking and Writhing Numbers for Spherically Confined and Topologically Equilibrated Flexible Polymers |
| Q34930322 | Similarity in the catalysis of DNA breakage and rejoining by type IA and IIA DNA topoisomerases |
| Q33752506 | Simulation of DNA catenanes |
| Q47070583 | Single-molecule analysis of DNA uncoiling by a type II topoisomerase. |
| Q33911168 | Single-molecule measurements of DNA topology and topoisomerases. |
| Q35690955 | Single-molecule measurements of the opening and closing of the DNA gate by eukaryotic topoisomerase II |
| Q35813703 | Single-molecule study of DNA unlinking by eukaryotic and prokaryotic type-II topoisomerases. |
| Q35100607 | Structural basis for topoisomerase VI inhibition by the anti-Hsp90 drug radicicol |
| Q58799715 | Structural insights into the gating of DNA passage by the topoisomerase II DNA-gate |
| Q47209084 | Structure and Chromosomal Organization of Yeast Genes Regulated by Topoisomerase II. |
| Q27641998 | Structure of the topoisomerase II ATPase region and its mechanism of inhibition by the chemotherapeutic agent ICRF-187 |
| Q37332317 | Substituents on etoposide that interact with human topoisomerase IIalpha in the binary enzyme-drug complex: contributions to etoposide binding and activity. |
| Q39154670 | Synthesis and biological evaluation of benzo[a]phenazine derivatives as a dual inhibitor of topoisomerase I and II. |
| Q24300110 | The ATP-operated clamp of human DNA topoisomerase IIalpha: hyperstimulation of ATPase by "piggy-back" binding |
| Q28189142 | The ATPase reaction cycle of yeast DNA topoisomerase II. Slow rates of ATP resynthesis and P(i) release |
| Q33904609 | The C-terminal domain of DNA gyrase A adopts a DNA-bending beta-pinwheel fold |
| Q37108461 | The DNA cleavage reaction of topoisomerase II: wolf in sheep's clothing |
| Q37304105 | The DNA-gate of Bacillus subtilis gyrase is predominantly in the closed conformation during the DNA supercoiling reaction |
| Q41865231 | The Effect of Dimethyl Sulfoxide on Supercoiled DNA Relaxation Catalyzed by Type I Topoisomerases |
| Q24299056 | The Role of Lysine 532 in the Catalytic Mechanism of Human Topoisomerase I |
| Q38313313 | The additional 165 amino acids in the B protein of Escherichia coli DNA gyrase have an important role in DNA binding |
| Q33351069 | The ancestral role of ATP hydrolysis in type II topoisomerases: prevention of DNA double-strand breaks |
| Q35447601 | The dimer state of GyrB is an active form: implications for the initial complex assembly and processive strand passage |
| Q34559593 | The geometry of DNA supercoils modulates the DNA cleavage activity of human topoisomerase I |
| Q36839637 | The geometry of DNA supercoils modulates topoisomerase-mediated DNA cleavage and enzyme response to anticancer drugs |
| Q47871542 | The path of the DNA along the dimer interface of topoisomerase II. |
| Q44019092 | The role of GyrB in the DNA cleavage-religation reaction of DNA gyrase: a proposed two metal-ion mechanism |
| Q44881593 | The synthesis of amino-acid functionalized beta-carbolines as topoisomerase II inhibitors |
| Q34054930 | The use of divalent metal ions by type II topoisomerases. |
| Q37219336 | The β-carboline alkaloid harmine inhibits telomerase activity of MCF-7 cells by down-regulating hTERT mRNA expression accompanied by an accelerated senescent phenotype |
| Q37215405 | Theoretical models of DNA topology simplification by type IIA DNA topoisomerases |
| Q37968253 | Therapeutic intervention by the simultaneous inhibition of DNA repair and type I or type II DNA topoisomerases: one strategy, many outcomes |
| Q33922870 | Topoisomerase II - drug interaction domains: identification of substituents on etoposide that interact with the enzyme. |
| Q33851826 | Topoisomerase II as a target for anticancer drugs: when enzymes stop being nice |
| Q36699035 | Topoisomerase II drives DNA transport by hydrolyzing one ATP |
| Q43589179 | Topoisomerase II from Chlorella virus PBCV-1 has an exceptionally high DNA cleavage activity |
| Q41941444 | Topoisomerase II minimizes DNA entanglements by proofreading DNA topology after DNA strand passage |
| Q37271167 | Topoisomerase II regulates yeast genes with singular chromatin architectures |
| Q42410346 | Topoisomerase II, not topoisomerase I, is the proficient relaxase of nucleosomal DNA. |
| Q50641237 | Topoisomerase II-mediated breaks in spermatozoa cause the specific degradation of paternal DNA in fertilized oocytes. |
| Q37342441 | Topoisomerase II: a fitted mechanism for the chromatin landscape. |
| Q37586018 | Topoisomerase IIbeta is required for proper retinal development and survival of postmitotic cells |
| Q36666233 | Topoisomerase IIβ deficiency enhances camptothecin-induced apoptosis |
| Q34350487 | Topoisomerase IV bends and overtwists DNA upon binding |
| Q46061177 | Topoisomerase action on short DNA duplexes reveals requirements for gate and transfer DNA segments |
| Q36096625 | Topoisomerase assays |
| Q38968355 | Topoisomerases: Resistance versus Sensitivity, How Far We Can Go? |
| Q92532745 | Transcriptional supercoiling boosts topoisomerase II-mediated knotting of intracellular DNA |
| Q38285903 | Translational control of TOP2A influences doxorubicin efficacy |
| Q38291539 | Trypanosomatids topoisomerase re-visited. New structural findings and role in drug discovery |
| Q35690912 | Unlocking and opening a DNA gate |
| Q40703900 | Use of Chlamydomonas reinhardtii mutants for anticancer drug screening |
| Q37219286 | Use of divalent metal ions in the dna cleavage reaction of human type II topoisomerases. |
| Q37323539 | Using 3'-bridging phosphorothiolates to isolate the forward DNA cleavage reaction of human topoisomerase IIalpha |
| Q35222177 | Yeast recombination pathways triggered by topoisomerase II-mediated DNA breaks |
| Q39951018 | topIb, a phylogenetic hallmark gene of Thaumarchaeota encodes a functional eukaryote-like topoisomerase IB. |