| scholarly article | Q13442814 |
| P50 | author | Neil Osheroff | Q88626020 |
| Omari J. Bandele | Q106980819 | ||
| P2093 | author name string | Sara J Clawson | |
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| Dietary bioflavonoids induce cleavage in the MLL gene and may contribute to infant leukemia | Q24676660 | ||
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| Solution and solid state 13C NMR and X-ray studies of genistein complexes with amines. Potential biological function of the C-7, C-5, and C4'-OH groups | Q30883522 | ||
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| Tea and tea polyphenols in cancer prevention | Q33866238 | ||
| Protection against breast cancer with genistein: a component of soy. | Q33933015 | ||
| Mutation of cysteine residue 455 to alanine in human topoisomerase IIalpha confers hypersensitivity to quinones: enhancing DNA scission by closing the N-terminal protein gate | Q33944673 | ||
| Quinone-induced enhancement of DNA cleavage by human topoisomerase IIalpha: adduction of cysteine residues 392 and 405. | Q33957966 | ||
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| Leukemias related to treatment with DNA topoisomerase II inhibitors | Q34243503 | ||
| Therapy-related acute lymphoblastic leukaemia with MLL rearrangements following DNA topoisomerase II inhibitors, an increasing problem: report on two new cases and review of the literature since 1992. | Q34366002 | ||
| Maternal diet and infant leukemia: a role for DNA topoisomerase II inhibitors? | Q34485987 | ||
| Synthesis and structure identification of thiol conjugates of (-)-epigallocatechin gallate and their urinary levels in mice | Q46813985 | ||
| Dual function of (--)-epigallocatechin gallate (EGCG) in healthy human lymphocytes | Q46816296 | ||
| Safety studies on epigallocatechin gallate (EGCG) preparations. Part 1: genotoxicity | Q46858909 | ||
| Safety studies on epigallocatechin gallate (EGCG) preparations. Part 2: dermal, acute and short-term toxicity studies | Q46874859 | ||
| Moving one DNA double helix through another by a type II DNA topoisomerase: the story of a simple molecular machine | Q47278979 | ||
| Eukaryotic DNA topoisomerase II beta | Q47958229 | ||
| Cleavage of DNA by mammalian DNA topoisomerase II | Q48394076 | ||
| Green tea catechins inhibit bacterial DNA gyrase by interaction with its ATP binding site. | Q50701171 | ||
| Double strand DNA cleavage by type II DNA topoisomerase from Drosophila melanogaster | Q52518950 | ||
| Mutagenic properties of topoisomerase-targeted drugs. | Q52531966 | ||
| Polychlorinated biphenyl quinone metabolites poison human topoisomerase IIalpha: altering enzyme function by blocking the N-terminal protein gate. | Q53605501 | ||
| DNA abasic lesions in a different light: solution structure of an endogenous topoisomerase II poison. | Q53781701 | ||
| A yeast type II topoisomerase selected for resistance to quinolones. Mutation of histidine 1012 to tyrosine confers resistance to nonintercalative drugs but hypersensitivity to ellipticine. | Q54182306 | ||
| DNA topoisomerase II expression, stability, and phosphorylation in two VM-26-resistant human leukemic CEM sublines | Q54188038 | ||
| Investigating the biological functions of DNA topoisomerases in eukaryotic cells | Q56765006 | ||
| Cell death induced by topoisomerase-targeted drugs: more questions than answers | Q58290067 | ||
| Inducible overexpression, purification, and active site mapping of DNA topoisomerase II from the yeast Saccharomyces cerevisiae | Q69334654 | ||
| Polyphenolic flavanols as scavengers of aqueous phase radicals and as chain-breaking antioxidants | Q71778889 | ||
| Abasic sites stimulate double-stranded DNA cleavage mediated by topoisomerase II. DNA lesions as endogenous topoisomerase II poisons | Q72036713 | ||
| Plasma concentrations of phyto-oestrogens in Japanese men | Q72656995 | ||
| Infant leukemia, topoisomerase II inhibitors, and the MLL gene | Q72819827 | ||
| Spontaneous DNA damage stimulates topoisomerase II-mediated DNA cleavage | Q73119532 | ||
| Spontaneous DNA lesions poison human topoisomerase IIalpha and stimulate cleavage proximal to leukemic 11q23 chromosomal breakpoints | Q73373909 | ||
| Antioxidant potential of green and black tea determined using the ferric reducing power (FRAP) assay | Q74179310 | ||
| ESR study on the structure-antioxidant activity relationship of tea catechins and their epimers | Q74615802 | ||
| Clinical applications of anticancer drugs targeted to topoisomerase II | Q77333693 | ||
| Secondary leukemias induced by topoisomerase-targeted drugs | Q77333785 | ||
| Possible controversy over dietary polyphenols: benefits vs risks | Q34577752 | ||
| DNA topoisomerase II as a target for cancer chemotherapy. | Q34718447 | ||
| Stabilization of eukaryotic topoisomerase II-DNA cleavage complexes | Q35061157 | ||
| Mechanisms of Cancer Prevention by Tea Constituents | Q35547536 | ||
| Structure, molecular mechanisms, and evolutionary relationships in DNA topoisomerases | Q35771555 | ||
| Potential toxicity of flavonoids and other dietary phenolics: significance for their chemopreventive and anticancer properties | Q35820573 | ||
| Flavonoids in food and their health benefits | Q36023128 | ||
| Topoisomerase II: A specific marker for cell proliferation | Q36216632 | ||
| The antitumor activities of flavonoids | Q36227648 | ||
| Etoposide, topoisomerase II and cancer | Q36230274 | ||
| Interfacial inhibitors of protein-nucleic acid interactions | Q36230291 | ||
| Escherichia coli Mutants Thermosensitive for Deoxyribonucleic Acid Gyrase Subunit A: Effects on Deoxyribonucleic Acid Replication, Transcription, and Bacteriophage Growth | Q36311967 | ||
| Redox properties of tea polyphenols and related biological activities | Q36342680 | ||
| Beneficial effects of tea and its polyphenols against prostate cancer. | Q36373233 | ||
| Pharmaceutical prospects of phytoestrogens | Q36423733 | ||
| The role of genistein and synthetic derivatives of isoflavone in cancer prevention and therapy | Q36448783 | ||
| Topoisomerase II and the etiology of chromosomal translocations | Q36542253 | ||
| Tea and cancer prevention: molecular mechanisms and human relevance | Q36711773 | ||
| DNA topoisomerase II, genotoxicity, and cancer | Q36903197 | ||
| Merbarone inhibits the catalytic activity of human topoisomerase IIalpha by blocking DNA cleavage | Q38335859 | ||
| Flavonoids as DNA topoisomerase antagonists and poisons: structure-activity relationships | Q38531960 | ||
| Induction of apoptosis by epigallocatechin-3-gallate in human lymphoblastoid B cells | Q40084665 | ||
| Exocyclic DNA lesions stimulate DNA cleavage mediated by human topoisomerase II alpha in vitro and in cultured cells. | Q40449702 | ||
| N-acetyl-p-benzoquinone imine, the toxic metabolite of acetaminophen, is a topoisomerase II poison | Q40575481 | ||
| Induction of poly(ADP-ribosyl)ation and DNA damage in human peripheral lymphocytes after treatment with (-)-epigallocatechin-gallate | Q40613285 | ||
| Evaluation of the clastogenic, DNA intercalative, and topoisomerase II-interactive properties of bioflavonoids in Chinese hamster V79 cells | Q40682699 | ||
| 1993 Robert R. deVilliers Lecture. Chromosome translocations: dangerous liaisons | Q40736806 | ||
| Maternal exposure to potential inhibitors of DNA topoisomerase II and infant leukemia (United States): a report from the Children's Cancer Group. | Q40922296 | ||
| Structure-antioxidant activity relationships of flavonoids and phenolic acids | Q41067074 | ||
| Role of topoisomerase II beta in the resistance of 9-OH-ellipticine-resistant Chinese hamster fibroblasts to topoisomerase II inhibitors | Q41087590 | ||
| Dietary phytoestrogens | Q41548581 | ||
| Topoisomerase inhibition by phenolic metabolites: a potential mechanism for benzene's clastogenic effects | Q41671913 | ||
| Type II DNA topoisomerases | Q41728284 | ||
| Site-specific DNA cleavage by mammalian DNA topoisomerase II induced by novel flavone and catechin derivatives | Q42161655 | ||
| Investigations into the concept of a threshold for topoisomerase inhibitor-induced clastogenicity | Q42163613 | ||
| Biochemical and pharmacological properties of p170 and p180 forms of topoisomerase II. | Q42189133 | ||
| Proliferation-dependent regulation of DNA topoisomerase II in cultured human cells. | Q42803837 | ||
| Purification of topoisomerase II from amsacrine-resistant P388 leukemia cells. Evidence for two forms of the enzyme | Q42817208 | ||
| Proliferation- and cell cycle-dependent differences in expression of the 170 kilodalton and 180 kilodalton forms of topoisomerase II in NIH-3T3 cells | Q42828773 | ||
| Stimulation of topoisomerase II-mediated DNA damage via a mechanism involving protein thiolation | Q43547718 | ||
| Benzene metabolites antagonize etoposide-stabilized cleavable complexes of DNA topoisomerase IIalpha | Q43684726 | ||
| Stability, cellular uptake, biotransformation, and efflux of tea polyphenol (-)-epigallocatechin-3-gallate in HT-29 human colon adenocarcinoma cells | Q44260419 | ||
| 1,4-Benzoquinone is a topoisomerase II poison | Q44925131 | ||
| In vitro cytotoxicity of epigallocatechin gallate and tea extracts to cancerous and normal cells from the human oral cavity | Q45123596 | ||
| Double-stranded DNA cleavage/religation reaction of eukaryotic topoisomerase II: evidence for a nicked DNA intermediate | Q45387279 | ||
| P433 | issue | 6 | |
| P407 | language of work or name | English | Q1860 |
| P921 | main subject | poisoning | Q114953 |
| polyphenol | Q290439 | ||
| P304 | page(s) | 1253-60 | |
| P577 | publication date | 2008-06-01 | |
| P1433 | published in | Chemical Research in Toxicology | Q473530 |
| P1476 | title | Dietary polyphenols as topoisomerase II poisons: B ring and C ring substituents determine the mechanism of enzyme-mediated DNA cleavage enhancement | |
| P478 | volume | 21 |
| Q51791622 | A framework for using structural, reactivity, metabolic and physicochemical similarity to evaluate the suitability of analogs for SAR-based toxicological assessments. |
| Q89842982 | Bioflavonoids cause DNA double-strand breaks and chromosomal translocations through topoisomerase II-dependent and -independent mechanisms |
| Q34379629 | Catalytic core of human topoisomerase IIα: insights into enzyme-DNA interactions and drug mechanism |
| Q38679992 | Chemical exposure and infant leukaemia: development of an adverse outcome pathway (AOP) for aetiology and risk assessment research |
| Q38811257 | Cinnamomum verum Component 2-Methoxycinnamaldehyde: A Novel Anticancer Agent with Both Anti-Topoisomerase I and II Activities in Human Lung Adenocarcinoma A549 Cells In Vitro and In Vivo |
| Q36985331 | Cinnamomum verum component 2-methoxycinnamaldehyde: a novel antiproliferative drug inducing cell death through targeting both topoisomerase I and II in human colorectal adenocarcinoma COLO 205 cells |
| Q37045056 | Cuminaldehyde from Cinnamomum verum Induces Cell Death through Targeting Topoisomerase 1 and 2 in Human Colorectal Adenocarcinoma COLO 205 Cells |
| Q38925594 | Cytotoxic and antioxidant properties of phenolic compounds from Tagetes patula flower |
| Q39713158 | Dietary factors and the risk for acute infant leukemia: evaluating the effects of cocoa-derived flavanols on DNA topoisomerase activity |
| Q40168060 | Discovery of a novel anti-cancer agent targeting both topoisomerase I and II in hepatocellular carcinoma Hep 3B cells in vitro and in vivo: Cinnamomum verum component 2-methoxycinnamaldehyde |
| Q36451713 | Discovery of a novel anticancer agent with both anti-topoisomerase I and II activities in hepatocellular carcinoma SK-Hep-1 cells in vitro and in vivo: Cinnamomum verum component 2-methoxycinnamaldehyde |
| Q35679872 | Effects of Olive Metabolites on DNA Cleavage Mediated by Human Type II Topoisomerases |
| Q36895268 | Effects of Secondary Metabolites from the Fungus Septofusidium berolinense on DNA Cleavage Mediated by Human Topoisomerase IIα. |
| Q37064199 | Epimerization of green tea catechins during brewing does not affect the ability to poison human type II topoisomerases |
| Q34477908 | Flavonoid intake in European adults (18 to 64 years). |
| Q44998050 | Flavonoid-enriched apple fraction AF4 induces cell cycle arrest, DNA topoisomerase II inhibition, and apoptosis in human liver cancer HepG2 cells |
| Q59009084 | Genistein Derivatives Regioisomerically Substituted at 7-O- and 4′-O- Have Different Effect on the Cell Cycle |
| Q39552708 | Genotoxicity of dietary, environmental and therapeutic topoisomerase II poisons is uniformly correlated to prolongation of enzyme DNA residence |
| Q39580025 | Green tea constituents (-)-epigallocatechin-3-gallate (EGCG) and gallic acid induce topoisomerase I- and topoisomerase II-DNA complexes in cells mediated by pyrogallol-induced hydrogen peroxide |
| Q42316013 | High-resolution phenotypic profiling of natural products-induced effects on the single-cell level |
| Q36669680 | Inhibition of human DNA topoisomerase IIα by two novel ellipticine derivatives |
| Q47630843 | Methyleugenol and oxidative metabolites induce DNA damage and interact with human topoisomerases |
| Q36563889 | Molecular Mechanism of Cinnamomum verum Component Cuminaldehyde Inhibits Cell Growth and Induces Cell Death in Human Lung Squamous Cell Carcinoma NCI-H520 Cells In Vitro and In Vivo |
| Q39305667 | Natural Compounds as Anticancer Agents Targeting DNA Topoisomerases |
| Q33662233 | Natural products as topoisomerase II poisons: effects of thymoquinone on DNA cleavage mediated by human topoisomerase IIα |
| Q36520921 | Oxidative metabolites of curcumin poison human type II topoisomerases |
| Q49593385 | Phenolic metabolites, biological activities, and isolated compounds of Terminalia muelleri extract |
| Q37658182 | Phytochemicals as Anticancer and Chemopreventive Topoisomerase II Poisons |
| Q46459669 | Plant polyphenols mobilize nuclear copper in human peripheral lymphocytes leading to oxidatively generated DNA breakage: implications for an anticancer mechanism |
| Q90055416 | Protective effects of 2-methoxycinnamaldehyde an active ingredients of Cinnamomum cassia on warm hepatic ischemia reperfusion injury in rat model |
| Q35106541 | Quercetin and cancer chemoprevention |
| Q39325145 | Redox state alters anti-cancer effects of wedelolactone |
| Q37684861 | Resveratrol mobilizes endogenous copper in human peripheral lymphocytes leading to oxidative DNA breakage: a putative mechanism for chemoprevention of cancer |
| Q33893423 | Salivary α-amylase, serum albumin, and myoglobin protect against DNA-damaging activities of ingested dietary agents in vitro |
| Q37108461 | The DNA cleavage reaction of topoisomerase II: wolf in sheep's clothing |
| Q64093644 | The Effect of Green and Black Tea Polyphenols on Deficient Chinese Hamster Cells by Synthetic Lethality through PARP Inhibition |
| Q46120544 | The effects of low and high concentrations of luteolin on cultured human endothelial cells under normal and glucotoxic conditions: involvement of integrin-linked kinase and cyclooxygenase-2. |
| Q37652882 | Topoisomerase II and leukemia |
| Q56637255 | Toxicology and Safety of Flavonoids |
| Q36285113 | Wine Flavonoids in Health and Disease Prevention |
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