Methyleugenol and oxidative metabolites induce DNA damage and interact with human topoisomerases

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Methyleugenol and oxidative metabolites induce DNA damage and interact with human topoisomerases is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1007/S00204-015-1625-3
P698PubMed publication ID26542539

P50authorDoris MarkoQ42314581
P2093author name stringAnika Schroeter
Melanie Esselen
Isabel Anna Maria Groh
Malte Gründken
Olga Rudakovski
P2860cites workDNA topoisomerases: structure, function, and mechanismQ22065417
(-)-Epigallocatechin gallate, a major constituent of green tea, poisons human type II topoisomerasesQ24627296
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Single cell gel/comet assay: guidelines for in vitro and in vivo genetic toxicology testingQ28140019
The comet assay for DNA damage and repair: principles, applications, and limitationsQ28248760
GammaH2AX and cancerQ29614974
Anthocyanidins modulate the activity of human DNA topoisomerases I and II and affect cellular DNA integrityQ33223479
DNA lesions induced by replication stress trigger mitotic aberration and tetraploidy developmentQ33526294
Cell Cycle-Dependent Expression of Phosphorylated Histone H2AX: Reduced Expression in Unirradiated but not X-Irradiated G1-Phase CellsQ34197636
Safety assessment of allylalkoxybenzene derivatives used as flavouring substances - methyl eugenol and estragoleQ34686516
Delphinidin modulates the DNA-damaging properties of topoisomerase II poisonsQ34934083
H2AX: functional roles and potential applicationsQ34982397
Structure, molecular mechanisms, and evolutionary relationships in DNA topoisomerasesQ35771555
PASSCLAIM--diet-related cancerQ35819510
Catalytic function of DNA topoisomerase II.Q36422569
Chemotherapy and dietary phytochemical agentsQ36516033
The efficacy of topoisomerase II-targeted anticancer agents reflects the persistence of drug-induced cleavage complexes in cellsQ37061217
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gammaH2AX: a sensitive molecular marker of DNA damage and repairQ37687078
Molecular analysis of yeast and human type II topoisomerases. Enzyme-DNA and drug interactions.Q38320285
Plant polyphenols and oxidative metabolites of the herbal alkenylbenzene methyleugenol suppress histone deacetylase activity in human colon carcinoma cells.Q39182792
Gene expression profiling of systems involved in the metabolism and the disposition of xenobiotics: comparison between human intestinal biopsy samples and colon cell linesQ39417799
Genotoxicity of dietary, environmental and therapeutic topoisomerase II poisons is uniformly correlated to prolongation of enzyme DNA residenceQ39552708
H2AX phosphorylation as a genotoxicity endpoint.Q39821608
Human cytochrome p450 enzymes of importance for the bioactivation of methyleugenol to the proximate carcinogen 1'-hydroxymethyleugenol.Q40330162
Methyleugenol genotoxicity in the Fischer 344 rat using the comet assay and pathway-focused gene expression profilingQ42732541
Investigation of the role of the 2',3'-epoxidation pathway in the bioactivation and genotoxicity of dietary allylbenzene analogsQ43540847
Catalytic inhibition of human DNA topoisomerase II by interactions of grape cell culture polyphenolsQ46989902
Metabolism of methyleugenol in liver microsomes and primary hepatocytes: pattern of metabolites, cytotoxicity, and DNA-adduct formation.Q48160611
Genotoxic potential of methyleugenol and selected methyleugenol metabolites in cultured Chinese hamster V79 cells.Q48190032
Anthocyanin-rich extracts suppress the DNA-damaging effects of topoisomerase poisons in human colon cancer cells.Q50547051
Cytochrome P450 mediated bioactivation of methyleugenol to 1'-hydroxymethyleugenol in Fischer 344 rat and human liver microsomes.Q51535143
Physiologically based biokinetic model of bioactivation and detoxification of the alkenylbenzene methyleugenol in rat.Q51662672
Genotoxicity and endoreduplication inducing activity of the food flavouring eugenol.Q51808791
Expression of phosphorylated histone H2AX in cultured cell lines following exposure to X-rays.Q51834143
P433issue11
P921main subjectmethyl eugenolQ419829
P304page(s)2809-2823
P577publication date2015-11-05
P1433published inArchives of ToxicologyQ635837
P1476titleMethyleugenol and oxidative metabolites induce DNA damage and interact with human topoisomerases
P478volume90

Reverse relations

Q38716590In vitro genotoxicity of carcinogenic asarone isomers.cites workP2860

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